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Summary Assessment of Myocardial Fatty Acid Metabolism in Patients with Angina Pectoris and Diabetes Mellitus Using

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Summary

Assessment of Myocardial Fatty Acid Metabolism in Patients with Angina Pectoris and Diabetes Mellitus Using

123

I-BMIPP Myocardial Scintigraphy

Kazuki I

TO

*, Hiroki S

UGIHARA

**, Takuji T

ANABE

*, Tatsuya Y

UBA

*, Tomoki D

OUE

*, Yoshihiko A

DACHI

*, Shuuji K

ATOH

*, Akihiro A

ZUMA

** and Masao N

AKAGAWA

**

*Department of Cardiology, Murakami Memorial Hospital, Asahi University

**Second Department of Medicine, Kyoto Prefectural University of Medicine

[Purpose] We studied the effect of myocardial is- chemia and diabetes mellitus (DM) on the myocardial fatty acid metabolism using 123I-BMIPP myocardial scintigraphy. [Methods] We performed 123I-BMIPP myocardial scintigraphy in 50 patients with myocar- dial ischemia and without DM (AP), in 30 patients with myocardial ischemia and DM (AP+DM), 12 pa- tients with DM and without myocardial ischemia (DM), and in 10 normal subjects (N). Myocardial up- take rate of 123I-BMIPP was obtained using the time activity curve. Myocardial washout rate of 123I- BMIPP was calculated using the polar images of early and delayed SPECT images. [Results] Myocardial up- take rate of 123I-BMIPP (%) were AP: 4.9±0.6, AP+

DM: 5.5±0.5, DM 5.7±0.5 and N: 5.0±0.4. 123I-

BMIPP myocardial uptake rate was increased in AP+

DM and DM. 123I-BMIPP myocardial washout rate (%) were AP: 30.2±4.3, AP+DM: 24.5±3.9, DM:

16.1±2.8 and N: 19.4±3.2. 123I-BMIPP myocardial washout rate was increased in AP and AP+DM. 123I- BMIPP myocardial washout rate was increased par- ticularly in patients with multi-vessels disease. 123I- BMIPP myocardial washout rate was decreased in DM. [Conclusion] The present study suggested that diabetes mellitus increased myocardial fatty acid up- take and decreased myocardial fatty acid washout, and that myocardial ischemia increased myocardial fatty acid washout.

Key words: Myocardial fatty acid metabolism, Angina pectoris, Diabetes mellitus, 123I-BMIPP.

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