JAIST Repository
https://dspace.jaist.ac.jp/ Title 学術文献分析に基づく市場性の評価アプローチ Author(s) 西島, 陽祐; 安西, 智宏; 仙石, 慎太郎 Citation 年次学術大会講演要旨集, 27: 755-759 Issue Date 2012-10-27Type Conference Paper Text version publisher
URL http://hdl.handle.net/10119/11131
Rights
本著作物は研究・技術計画学会の許可のもとに掲載す るものです。This material is posted here with permission of the Japan Society for Science Policy and Research Management.
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Ꮫ⾡ᩥ⊩ศᯒᇶ࡙ࡃᕷሙᛶࡢホ౯ࣉ࣮ࣟࢳ
żすᓥ 㝧♸ࠊᏳす ᬛᏹ㸦ᮾிᏛ㸧ࠊ▼ ៅኴ㑻㸦ி㒔Ꮫ㸧 Ꮫ⾡ᩥ⊩ศᯒ䛿䚸ᨻ⟇ホ౯䜔䝥䝻䝆䜵䜽䝖ホ౯䚸◊✲㛤Ⓨ䝬䝛䝆䝯䞁䝖䛻䛚䛡䜛ά⏝䛰䛡䛷䛺䛟䚸≉䛻䜰䜹䝕 䝭䜰䜢୰ᚰ䛸䛧䛯ᕷሙᙧᡂ䛜㐍⾜䛧䛶䛔䜛㡿ᇦ䛻䛚䛔䛶䛿䛭䛾ᕷሙᛶ䜢ホ౯䛩䜛䛾䛻᭷⏝䛺䝒䞊䝹䛸䛧䛶ᶵ⬟ 䛧䛖䜛䚹ᮏሗ࿌䛷䛿䚸ᖿ⣽⬊◊✲㡿ᇦ䜢䛸䛧䛶ྲྀ䜚ᢅ䛔䚸ᙜヱ㡿ᇦ䛾ᕷሙᛶ䜔ྛᅜ◊✲ᶵ㛵䛾ᡓ␎䞉ືྥ 䜢ゎᯒ䛩䜛䛺䛹䚸䛭䛾ᐇ㊶ⓗ䛺ά⏝ᡭἲ䛻䛴䛔䛶ሗ࿌䛧䚸ウ㆟䜢⾜䛺䛖䚹㻌 㻌 1 ࡣࡌࡵ 1.1 Ꮫ⾡ᩥ⊩ศᯒࡢᨻ⟇ホ౯ࡢά⏝ ㏆ᖺࠊィ㔞᭩ㄅᏛⓗᡭἲࡀከࡃࡢ⛉Ꮫᢏ⾡ᨻ⟇ ᑐࡍࡿホ౯ά⏝ࡉࢀࡘࡘ࠶ࡿࠋࡼࡾලయⓗ ࡣࠊ◊✲㛤Ⓨᢞ㈨ࡉࢀࡓබⓗ㈨㔠ࡀ᭷ຠ㐠⏝ ࡉࢀࠊᨻ⟇ຠᯝࡀ᭷ព⩏࡛࠶ࡗࡓࢆṇ☜ホ౯ ࡍࡿࡓࡵࡢᡭἲࡋ࡚ࡢ⏝ࡀ㐍ࢇ࡛࠸ࡿࠋ≉ᐃ ࡢ◊✲ศ㔝࡛ࡢືྥࢆࠊᐈほⓗࡘᐃ㔞ⓗ࡞ᣦᶆ ࢆ⏝࠸࡚ホ౯࡛ࡁࡿࡓࡵࠊฟ∧ㄽᩥᩘࡸ⿕ᘬ⏝ᅇ ᩘ࡞ࡢ⤫ィⓗ࡞㞟ィ㔞ᇶ࡙࠸ࡓィ㔞᭩ㄅᏛ ⓗᡭἲࡼࡿᨻ⟇ホ౯ࡣࠊ᪤ྛᅜ࡛ᐇࡉࢀ࡚ ࠸ࡿࠋణࡋ༢⣧ࡉࢀࡓᐃ㔞ⓗᣦᶆᇶ࡙ࡃィ㔞 ᭩ㄅᏛⓗᡭἲࡣࠊᑐ㇟◊✲ศ㔝ࡀ㝈ᐃࡉࢀࡿࡇ ࡸࠊฟ∧ㄽᩥࡸྛ◊✲㡿ᇦ㛫ࡢ㛵ಀᛶࢆศᯒ࡛ ࡁ࡞࠸࡞ࡢㄢ㢟ࡀከࡃࠊ᭦࡞ࡿᨵⰋࡀᚲせ࡛࠶ ࡿࡢᣦࡶ࠶ࡿ >@ࠋ 1.2 ◊✲㺪㺽㺹㺚㺼㺈㺖㺢ホ౯ࠊ⤒Ⴀ⟶⌮ࡢά⏝ ⌧≧࡛ࡢ◊✲ࣉࣟࢪ࢙ࢡࢺࡢホ౯ᡭἲࡋ࡚ ࡣࠊᚋ᪉ᘬ⏝ᩘࡸ⏘ᴗᢏ⾡ࡢᏛࡢᐤ⋡ࢆ♧ ࡍᣦᶆ࡛࠶ࡿ 6FLHQFH OLQNDJHV ᇶ࡙ࡃ㉁ⓗホ౯ ࡀᣲࡆࡽࢀࡿ >@ࠋ୰࡛ࡶ◊✲ᡂᯝࡢ♫㑏ඖࢆ ┠ⓗࡍࡿࣉࣟࢪ࢙ࢡࢺ࠾࠸࡚ࡣࠊ◊✲㛤Ⓨࢆᇶ ࡋࡓ≉チฟ㢪௳ᩘࢆィ ᣦᶆࡋ࡚⏝࠸ࡓホ ౯ᡭἲࡶేࡏ࡚ά⏝ࡉࢀࡿࡀ࠶ࡿࠋࡇࡢࡼ࠺ࠊ ホ౯ᣦᶆ࡞ࡾᚓࡿᴗ⦼ࡸᑻᗘࡣࠊ◊✲ศ㔝ࡸᙜ ヱ◊✲ࣉࣟࢪ࢙ࢡࢺࡢᨻ⟇┠ᶆࠊ㐩ᡂ┠ᶆࡼࡗ ࡚ࡁࡃ␗࡞ࡿࡇࡽࠊྛ◊✲ᣐⅬࡢ⤒Ⴀ⟶⌮ ࠾࠸࡚ࡣ㐺ษ࡞ᣦᶆࢆ⤌ࡳྜࢃࡏࡓୖ࡛ࠊࡑࡢ ᐃ ࡸ ᣦ ᶆ ྥ ୖ ྥ ࡅ ࡓ 3'&$ 㸦3ODQ'R&KHFN$FWLRQ㸧ࢧࢡࣝࡢᐇ㊶ࡀồࡵࡽ ࢀࡿࠋ࠼ࡤࠊ␗ศ㔝⼥ྜᆺ◊✲ᣐⅬ࠾࠸࡚ࡣࠊ .H\3HUIRUPDQFH,QGLFDWRUάືᴗ⦼ᣦᶆ㸸.3,ࢆ ⏝ࡋࡓࠊ◊✲⪅㛫㐃ᦠࡢᗘྜ࠸ࢆໟᣓⓗᢕᥱࡍ ࡿࡓࡵࡢィ㔞ᩥ⊩Ꮫⓗᡭἲࡼࡿ᳨ウࡀሗ࿌ࡉ ࢀ࡚࠸ࡿ >@ࠋ 1.3 ᕷሙᛶࡢホ౯ࡢά⏝ ィ㔞᭩ㄅᏛⓗᡭἲᇶ࡙ࡃศᯒࡣࠊୖグࡢࡼ࠺ ᨻ⟇ホ౯ࠊ◊✲ࣉࣟࢪ࢙ࢡࢺࡢホ౯ࡸ⤒Ⴀ⟶⌮ ࡢά⏝ࡀ୰ᚰ࡛࠶ࡗࡓࠋ୍᪉ࠊྛᢏ⾡ศ㔝࠾ ࡅࡿ⏘ᴗ⏺ࠊ࢝ࢹ࣑࡛ࡢ◊✲㛤Ⓨືྥࢆᢕᥱ ࡋࠊྛᴗ࠾ࡅࡿ㛤Ⓨᡓ␎ࢆศᯒࡍࡿࡓࡵࡢ᪉ ἲㄽࡋ࡚ࠊ≉チศᯒࠊ≉チࡢᘬ⏝ㄽᩥศᯒ➼ࡢ ᡭἲࡀ⏝࠸ࡽࢀࡿࡇࡀ࠶ࡿࠋ ࡇࢀࡽࡢィ㔞᭩ㄅᏛⓗ࡞ࣉ࣮ࣟࢳࡣࠊ≉ᐃࡢ ᕷሙᙧᡂࣉࣟࢭࢫࡸᕷሙືྥࢆᢕᥱࡍࡿ㝿ࡶ 㔜せ࡞ሗࢆ࠼ࡿࡶࡢ࡞ࡾ࠺ࡿࠋ≉࢝ࢹ ࣑࡛ࡢᢏ⾡㛤Ⓨࡀᑟࡋ࡚ᕷሙࡀᙧᡂࡉࢀࡿ ẁ㝵࠾࠸࡚ࡣࠊࡑࡢㄽᩥᩘࡀᕷሙయࡢつᶍࡸ ᡂ㛗⋡ࢆ᥎ィࡍࡿ᰿ᣐࡶ࡞ࡾ࠺ࡿࡋࠊᕷሙࢆࢭ ࢢ࣓ࣥࢸ࣮ࢩࣙࣥࡸࡑࡢືྥࢆゎᯒࡍࡿࢶ࣮ࣝ ࡋ࡚ࡶά⏝ࡋ࠺ࡿࠋ᭦ㄽᩥࡢ⿕ᘬ⏝㛵ಀࢆヲ ⣽ゎᯒࡍࡿࡇࡼࡾࠊྛ࢝ࢹ࣑࠾ࡅࡿ ᕷሙᙧᡂ㐣⛬㛵ࡍࡿ♧၀ࢆ࠼ࡿࡶࡢ࡞ࡿ ࡀࠊᐇ㊶ⓗྲྀࡾ⤌ࡳࡣぢࡽࢀ࡞࠸ࠋ 2 ◊✲ᑐ㇟ 2.1 ࣄࢺᖿ⣽⬊◊✲ ᅇࡣࡑࡢᕷሙᙧᡂࣉࣟࢭࢫࢆゎᯒࡍࡿᑐ㇟ ࡋ࡚ࠊࣄࢺᖿ⣽⬊◊✲㡿ᇦࢆྲྀࡾୖࡆࡓࠋ⌧ᅾࠊ ศ⬟ᛶ࡞ࡽࡧ⮬ᕫ」〇⬟࡞ࡢ≉ᚩࢆ᭷ ࡋࡓࣄࢺᖿ⣽⬊ࡣࠊࡑࡢ㛤Ⓨᢏ⾡ࡢ㠉᪂ࡼࡗ࡚ࠊ ⏕་⒪ศ㔝ࢆጞࡵࡍࡿ་Ꮫ㡿ᇦࡢࡳ࡞ࡽࡎࠊ ་⛉Ꮫࠊሗ⛉Ꮫࡸᨻ⟇⛉Ꮫ࡞ࠊᖜᗈ࠸ศ㔝 ࠾࠸࡚◊✲㛤Ⓨࡀᒎ㛤ࡉࢀ࡚࠸ࡿࠋᚋࡢ་⒪ศ 㔝࡛ࡢᛂ⏝ࡢᮇᚅࡽࠊ⏘ᐁᏛ㐃ᦠୗ࡛ࡢᅜᐙ ࣉࣟࢪ࢙ࢡࢺᑐࡍࡿ◊✲㛤ⓎຓᡂࡶάⓎࡋ ࡚࠸ࡿࠋ⌧Ⅼ࡛ࡢࣄࢺᖿ⣽⬊ࡢࡓࡿ⏝⪅ࡣ Ꮫࡸබⓗ◊✲ᶵ㛵࡛࠶ࡾࠊࡑࡢ◊✲ᡂᯝࡣᏛ⾡ ㄽᩥࡋ࡚බ⾲ࡉࢀࡿࠋࡑࡢࡓࡵࠊࣄࢺᖿ⣽⬊㡿 ᇦ࠾ࡅࡿᏛ⾡ᩥ⊩ㄪᰝࡼࡗ࡚ࠊ◊✲ᶵ㛵࡛ࡢ ᖿ⣽⬊㛵㐃ࡢヨ⸆ࡸᇵᆅࡢ⏝≧ἣࢆᢕᥱࡍࡿ ࡇ࡛ࠊࡑࡢᕷሙᙧᡂࢆ⪃ᐹࡍࡿࡇࡀྍ⬟࡛࠶ ࡿࠋࣄࢺᖿ⣽⬊◊✲ࡢᡂ㛗ᛶࡸᙳ㡪ຊࢆຍࡍࢀࡤࠊ᪂ࡓ࡞ᕷሙホ౯ᡭἲࡢᥦࡣࠊ㠀ᖖ᭷⏝ ゝ࠼ࡿࠋ 2.2 ヨ⸆࣭ᇵᆅ㡿ᇦ ᖿ⣽⬊⛉Ꮫᢏ⾡ࡢᢏ⾡㠉᪂ࡢࡓࡵࡣࠊ▱ⓗ㈈ ⏘ᡓ␎ࡢほⅬࡽࡢ㛤Ⓨᢏ⾡ࡢᶆ‽ࢆ᥎㐍ࡍ ࡿᚲせࡀ࠶ࡿࠋ [4] ᚋࠊ᭦࡞ࡿⓎᒎࡀᮇᚅࡉ ࢀࡿࣄࢺᖿ⣽⬊◊✲ࡢᢏ⾡㛵ࡍࡿᅜ㝿ᶆ‽ ᡂຌࡍࢀࡤࠊᖿ⣽⬊ᕷሙయࡢᙧᡂ࠾࠸࡚ࡁ ࡞ᙳ㡪ࢆཬࡰࡋ࠺ࡿࡇࡽࠊࡑࡢ⤒῭Ἴཬຠᯝ ࡢほⅬࡽࡶᙜヱ㡿ᇦ࠾ࡅࡿᶆ‽ᡓ␎ࡢ㔜 せᛶࡣᴟࡵ࡚㧗࠸ゝ࠼ࡿࠋ≉ࠊࣄࢺᖿ⣽⬊◊ ✲࠾࠸࡚ࡣࠊ◊✲㛤Ⓨࡸ⮫ᗋ⏝㏵࡛ά⏝ࡉࢀࡿ ⣽⬊ᰴࡸࠊࡑࢀࢆᇵ㣴ࡍࡿࡓࡵࡢヨ⸆࣭ᇵᆅ࠾ ࠸࡚ࡣ࢝ࢹ࣑࡛ࠊࡋࡶྛ◊✲ᶵ㛵ࡀᑟࡍ ࡿᙧែ࡛ࡢᶆ‽➇தࡀⓎ⏕ࡋ࡚࠸ࡿࠋࡑࡇ࡛ࠊ ᮏሗ࿌࡛ࡣ≉ヨ⸆࣭ᇵᆅ㡿ᇦ࠾ࡅࡿᕷሙືྥ ࢆࠊࡑࡢᶆ‽㐣⛬╔┠ࡋ࡚ゎᯒࢆ⾜ࡗࡓࠋල యⓗࡣࠊࣄࢺᖿ⣽⬊㡿ᇦ࠾ࡅࡿせ◊✲ᶵ㛵 ࡛ࡢᇵᆅ⤌ᡂࡢ᭱㐺ཬࡧㄪᩚἲ㛤Ⓨࢆ┠ⓗ ࡋࡓㄽᩥࢆྠᐃࡋࠊࡑࡢヱᙜㄽᩥࢆᘬ⏝ࡋ࡚࠸ࡿ ◊✲ᶵ㛵ࢆㄪᰝࡍࡿࡇ࡛ࠊせ◊✲ᶵ㛵ࡢᅜ㝿 ⓗᶆ‽ᇵᆅసᡂ࠾ࡅࡿᙳ㡪ຊࢆ⪃ᐹࡋ࡚࠸ࡿࠋ 3 ◊✲ᡭἲ ᮏ◊✲࡛ࡢᏛ⾡ᩥ⊩ㄪᰝࡣࠊSciVerse Scopus1 (Elsevier B.V.♫)ࢆᇶ┙ࡢࢹ࣮ࢱ࣮࣋ࢫࡋ࡚⏝ ࠸ ࠊ ᳨ ⣴ ⏝ ㄒ ࡢ 㑅 ᐃ ࡣ Medical Subject Headings(MeSH)2 terms ࢆ⏝ࡋࡓࠋMeSH terms ࡣᗈ⩏ⓗពࡽ⊃⩏ⓗពࡲ࡛ࡢ་Ꮫ ⏝ㄒࡀ㝵ᒙᵓ㐀ࡋ࡚⤌ࡳ㎸ࡲࢀ࡚࠸ࡿࡓࡵࠊྛ ᖿ⣽⬊㛵㐃ࡢ◊✲㡿ᇦ⯡ᑐࡍࡿ᳨⣴ᑐ㇟ࡢ ᢤࡅࡸ₃ࢀࢆ㜵ࡄࡇࡀฟ᮶ࡿࠋࡇࡇ࡛ࡣࠊྛᖿ ⣽⬊✀ࡢศ㢮ຍ࠼ࠊ⣽⬊ᇵ㣴ᢏ⾡㛵㐃ࡢศ㢮 㝈ᐃࡋࡓᩥ⊩ㄪᰝࢆ⾜ࡗࡓࠋᐇ㝿ࡣࠊྛ⏝ㄒ(ࡇ ࡇ࡛ࡣࠊྛᖿ⣽⬊ྡࠕCell culture techniquesࠖ) ඹ㏻ࡋࡓMeSH terms ࡢ Subheadings ࡢ⤌ࡳ ྜࢃࡏ᳨⣴ࡼࡗ࡚ࠊヱᙜㄽᩥࢆ㝈ᐃࡋࡓࠋ࡞࠾ࠊ ᙜ ヱ 㡿 ᇦ ࠾ ࡅ ࡿ Subheadings ࡀ SciVerse Scopus ୖ࡛ࡢศ㢮ࡶᏑᅾࡍࡿࡣ☜ㄆࡉࢀ࡚ ࠸ࡿࠋヱᙜࢹ࣮ࢱ࣮࣋ࢫࡣၟ⏝ࡉࢀ࡚࠾ࡾࠊ᪤ ከࡃࡢබⓗ◊✲ᶵ㛵ࡸᏛ࡛ࡢ⏝ᐇ⦼ࡀ࠶ ࡿࠋຍ࠼࡚ࠊศᯒࡸホ౯ᡭἲࡢ୍㒊ࡣ⮬ືࡉࢀ ࡚࠸ࡿⅬࡽࡶࠊ᪂つࡢศᯒᡭἲࢆ㛤Ⓨࡍࡿࡇ ẚࠊ⡆౽࡞㐠⏝ࡀᮇᚅ࡛ࡁࠊᮏᡭἲࡢỗ⏝ᛶ ࡣ㧗࠸ゝ࠼ࡿࠋ࡞࠾ࠊ2012 ᖺศࡢㄽᩥゎᯒࡣ 2012 ᖺ 9 ᭶ᐇࡋ࡚࠸ࡿࠋ 1 http://japan.elsevier.com/products/scopus/ 2 ⡿ᅜᅜ❧་Ꮫᅗ᭩㤋ࡀᐃࡵࡓ⏕⛉Ꮫ⏝ㄒ㞟 4 ⤖ᯝ 4.1 ᖿ⣽⬊◊✲ࡢㄽᩥᩘ᥎⛣ ᮏሗ࿌࡛ࡣࣄࢺᖿ⣽⬊ࢆࠊiPS ⣽⬊(induced pluripotent stem cells)ࠊES⣽⬊(embryonic stem cells)ࠊ㛫ⴥ⣔ᖿ⣽⬊(mesenchymal stem cells) ศ㢮ࡋ࡚ゎᯒࢆᐇࡋࡓࠋ≉ࠊయෆ࡚ࡢ⣽ ⬊ศࡍࡿᛶ㉁ࢆᣢࡘES ⣽⬊ࠊཷ⢭༸௨እࡢ ⣽⬊⬟ᛶࢆㄏᑟࡍࡿࡇ࡛ேᕤⓗ⏕ᡂࡉ ࢀࡿiPS ⣽⬊ࡢᕷሙᛶࢆホ౯ࡍࡿࡇࡣࠊᚋࡢ ་⒪ᛂ⏝ࡢⓎᒎᕷሙᙧᡂࡀᮇᚅࡉࢀࡿ ࡽࡶ㔜せ⪃࠼ࡿࠋୖグࡢศ㢮࠾ࡅࡿㄽᩥᩘࡢ 2005 ᖺࡽ 2012 ᖺ࡛ࡢ⤒ᖺኚࢆ㏣ࡗࡓࠋ (Fig.1) ࡑࡢ⤖ᯝࠊiPS ⣽⬊ࠊES ⣽⬊ࠊ㛫ⴥ⣔ᖿ ⣽⬊ࡢࠊㄽᩥᩘࡢᖺᖹᆒᡂ㛗 (compound average growth rate, CAGR)ࡣࡑࢀࡒࢀࠊ30.2%ࠊ12.4%ࠊ 28.0%࡛࠶ࡾࠊㄽᩥᩘࡀ㡰ㄪ࡞ఙࡧࢆ♧ࡋ࡚࠸ࡿ ࡀ☜ㄆࡉࢀࡓࠋ Fig. 1:ྛᖿ⣽⬊ศ㔝ࡢㄽᩥᩘࡢ⤒ᖺኚ 4.2 ᖿ⣽⬊㛵㐃ࡢᶵ㛵ูࡢㄽᩥᩘ᥎⛣ ᖿ⣽⬊◊✲࠾ࡅࡿྛ◊✲ᶵ㛵ࡢୡ⏺ⓗ࡞ࢩ ࢙ࢆ☜ㄆࡍࡿࡓࡵࠊ2005 ᖺࡽ 2012 ᖺ࡛ࡢྛ ᶵ㛵ࡢᖿ⣽⬊◊✲㛵ࡍࡿㄽᩥᩘࢆゎᯒࡋࠊࡑࡢ ᩘࡢከ࠸ᶵ㛵ࡽ୪᭰࠼ࢆ⾜ࡗࡓࠋ(Fig. 2) ࡑ ࡢ⤖ᯝࠊୖࡣ⡿ᅜࡢ◊✲ᶵ㛵ࡼࡗ࡚༨ࡵ ࡽࢀ࡚࠸ࡓࡀࠊୖ 10 ᶵ㛵ෆ᪥ᮏࡢி㒔Ꮫ ࡀࣛࣥࢡࣥࡋ࡚࠸ࡓࠋ
Fig.2:ᖿ⣽⬊㛵㐃ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵 (2005-2012 ᖺ) 4.3 ⣽⬊ᇵ㣴㛵㐃ࡢㄽᩥᩘ᥎⛣ ᖿ⣽⬊◊✲࠾࠸࡚ࡶ≉ᶆ‽㛵ࡍࡿྲྀ ࡾ⤌ࡳࡀ㢧ᅾࡋ࡚࠸ࡿ⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲ ࢆྲྀࡾୖࡆࠊゎᯒࢆ⾜ࡗࡓࠋࡇࡇ࡛ࡣ᳨⣴࢝ࢸࢦ ࣮ࣜࡋ࡚ࠕStem Cell࡛ࠖ⤠㎸ࡳࢆ⾜ࡗࡓ࠺࠼ ࡛ࠕCell culture techniquesࠖࢆ⏝ࡋࠊᙜヱ㡿 ᇦ࠾ࡅࡿㄽᩥᩘࡢ 2005 ᖺࡽ 2012 ᖺ࡛ࡢ⤒ ᖺኚࢆゎᯒࡋࡓࠋ(Fig.3) ᙜヱ㡿ᇦ࠾ࡅࡿㄽ ᩥᩘࡢᖺᖹᆒᡂ㛗⋡ࡣࠊ2005 ᖺࡽ 2011 ᖺࡢᮇ 㛫࠾࠸࡚ 9.2%࡛࠶ࡾࠊᖿ⣽⬊ࡢྛ⣽⬊✀ࡼࡾ ࡶᡂ㛗⋡ࡣ㧗ࡃ࡞࠸⤖ᯝࡀᚓࡽࢀࡓࠋ
Fig.3:Cell culture techniques ศ㔝ࡢ ㄽᩥᩘࡢ⤒ᖺኚ 4.4 ⣽⬊ᇵ㣴㛵㐃ࡢᶵ㛵ูࣛࣥ࢟ࣥࢢ ᭦⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲࠾࠸࡚ࠊ2005 ᖺ ࡽ 2012 ᖺࡢ㛫࡛⥲Ⓨ⾜ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵 ࡢୖ 10 ᶵ㛵ࢆࡾฟࡋࡓࠋ(Fig.4) ࡑࡢ⤖ᯝࠊ ᖿ⣽⬊◊✲ࡣయࡢഴྥࡀⱝᖸ␗࡞ࡿࡇࡀ ほᐹࡉࢀࡓ୍᪉ࠊᖿ⣽⬊◊✲య࡛ㄽᩥᩘࡀከ ࡗࡓி㒔ᏛࠊHarvard Medical School ཬࡧ University of Tronto ࡀࠊᇵ㣴ᢏ⾡㛵㐃ࡢศ㔝࡛ ࡶୖࢆ༨ࡵࡿࡇࡀ☜ㄆࡉࢀࡓࠋ Fig. 4:ᇵ㣴ᢏ⾡㛵㐃ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵 ࡉࡽࠊୖグࡢせᶵ㛵㸦ୖ㸳ᶵ㛵㸧ࡢᖿ⣽ ⬊ࡢ⣽⬊ᇵ㣴ᢏ⾡㛵ࡍࡿㄽᩥࢆᘬ⏝ࡋ࡚࠸ࡿ ◊✲ᶵ㛵㛵ࡍࡿゎᯒࢆ⾜ࡗࡓࠋ(Fig.5) ࠸ࡎࢀ ࡢᶵ㛵࠾࠸࡚ࡶࠊ⮬㌟ࡼࡿᘬ⏝௳ᩘࡀ᭱ࡶከ ࠸Ⅼࡘ࠸࡚ࡣඹ㏻ࡋ࡚࠸ࡓࡀࠊMassachusetts Institute of Technology(MIT)ࡢࡼ࠺ࡢᶵ㛵 ࡢㄽᩥࡘ࠸࡚ࡶ✚ᴟⓗᘬ⏝ࡋ࡚࠸ࡿ◊✲ᶵ 㛵ࡀ࠶ࡿ୍᪉ࠊி㒔Ꮫࡢࡼ࠺ࡢୖᶵ㛵ࡀ Ⓨ⾲ࡋࡓㄽᩥࢆ࠶ࡲࡾᘬ⏝ࡋ࡞࠸◊✲ᶵ㛵ࡀ࠶ ࡿࡇࡶศࡗࡓࠋ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ig.5:ᇵ㣴ᢏ⾡ࡢୖᶵ㛵ࡢㄽᩥᘬ⏝ᶵ㛵୍ぴ ㄽᩥ௳ᩘ䝷䞁䜻䞁䜾䠄ୖ䠑ᶵ㛵䠅
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5 ⪃ᐹ 5.1 ᖿ⣽⬊ᇵ㣴ᢏ⾡࠾ࡅࡿᶆ‽ᡓ␎ ᖿ⣽⬊ࡢᇵ㣴ᢏ⾡㡿ᇦ࠾࠸࡚ࠊฟ∧ㄽᩥᩘࡢ ᭱ࡶከ࠸ᶵ㛵ࡣி㒔Ꮫ࡛࠶ࡗࡓࡀࠊࡢୖᶵ 㛵ࡀฟ∧ࡍࡿᇵ㣴ᢏ⾡㛵ࡍࡿㄽᩥࢆᘬ⏝ࡋ࡚ ࠸ࡿഴྥࡣ☜ㄆ࡛ࡁ࡞ࡗࡓࠋ㸦Fig.5㸧୍᪉࡛ࠊ MIT ࡣᖿ⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲࡛ࡢㄽᩥᩘࡀከ ࡃࠊࡢ◊✲ᶵ㛵ࡢᙳ㡪ຊࢆಖ᭷ࡋࡘࡘࡶࠊྠ 㡿ᇦ࡛ࡢฟ∧ㄽᩥᩘࡢୖᶵ㛵ࡢㄽᩥࢆᘬ⏝ ࡋ࡚࠸ࡿࡇࡀศࡿࠋࡇࡢࡇࡽࠊᖿ⣽⬊㛵 㐃ࡢᇵᆅ࣭ヨ⸆ศ㔝࡛ࡢᶆ‽ᡓ␎ࡘ࠸࡚ࠊி 㒔Ꮫࡣ⮬ࡽ◊✲㛤Ⓨࡸヨ⸆ㄪᩚࢆ⾜࠸ࠊ᭱㐺࡞ ᖿ⣽⬊ᇵ㣴ᢏ⾡ࡢ☜❧ࢆ㐍ࡵࡿ୍᪉࡛ࠊMIT ࡣࠊ ⮬ࡽᢏ⾡ࢆᨵⰋࡍࡿྠࠊᶵ㛵ࡢ㛤Ⓨࡋ࡚ ࠸ࡿ⣽⬊ᇵ㣴ᢏ⾡ࢆᘬ⏝ࡋ࡚࠸ࡿࡓࡵࠊᡤᒓᶵ㛵 ࡛ࣞ࣋ࣝ⏝ࡍࡿᇵᆅࡸヨ⸆ࡢ⤫୍ࡣ࡞ࡉࢀ࡚ ࠾ࡽࡎࠊಶููᶵ㛵ࡢᇵᆅࢆཧ⪃ࡋ࡚࠸ࡿഴ ྥࡀ࠶ࡿ᥎ ࡉࢀࡿࠋHarvard Medical School ࡣࠊᇵ㣴ᢏ⾡㛵㐃ࡢㄽᩥᩘ࡛ࡣ6 ࡛࠶ࡿࡀࠊࣛ ࣥ࢟ࣥࢢୖࡢᶵ㛵ࡢㄽᩥࢆ✚ᴟⓗᘬ⏝ࡍࡿ ഴྥࡀぢࡽࢀࡿࠋᐇ㝿➹⪅ࡀᙜヱᶵ㛵ࣄࣜ ࣥࢢㄪᰝࢆ⾜ࡗࡓ⤖ᯝࠊ⮬㌟࡛ࡢᇵ㣴ᢏ⾡㛤Ⓨ ࡢྲྀࡾ⤌ࡳࡣ㝈ᐃⓗ࡛࠶ࡾࠊᶵ㛵ࡢ㛤Ⓨࡋࡓᇵ 㣴ᢏ⾡ࢆ࣮ࣘࢨ࣮ࡋ࡚✚ᴟⓗᑟධࡋ࡚࠸ࡿ ࡀ᳨ドࡉࢀࡓ㸦ࢹ࣮ࢱࡣ㠀㛤♧㸧ࠋࡇࡢࡼ࠺ࠊ ㄽᩥ᭩ㄅᏛᇶ࡙ࡃゎᯒᡭἲࡣᶆ‽ືྥࢆᢕ ᥱࡍࡿࡓࡵࡶ᭷ຠ࡛࠶ࡿゝ࠼ࡿࠋ 5.2 ᕷሙホ౯ࡢᛂ⏝ྍ⬟ᛶ ᮏሗ࿌ࡣࠊ≉࢝ࢹ࣑ᑟ⏘Ꮫ㐃ᦠࡼ ࡿᕷሙᙧᡂࡀ࡞ࡉࢀࡿ㡿ᇦ࠾࠸࡚ࠊᩥ⊩ศᯒࡀ ᕷሙศᯒࡢ୍ࡘࡢࣉ࣮ࣟࢳ࡞ࡾ࠺ࡿࡇࢆ ♧ࡍࡶࡢ࡛࠶ࡿࠋࡦࡘࡢࡋ࡚ࠊゎᯒ⤖ᯝ ࡽࠊES ⣽⬊ẚ࡚ iPS ⣽⬊ࡢㄽᩥᩘࡣᑡ࡞࠸ ࡶࡢࡢࠊᡂ㛗⋡ࡣ㧗࠸ഴྥࡀぢࡽࢀࡓࠋ⪃࠼ࡽࢀ ࡿࡑࡢ⌮⏤ࡢࡦࡘࡋ࡚ࠊ⏘ᴗᵓ㐀ᑂ㆟ࠊ᪂ ⏘ᴗᵓ㐀㒊ࡢሗ࿌᭩ࡼࡿࠊ2020 ᖺࡣ ⏕་⒪㛵㐃ࡢୡ⏺ᕷሙࡀࠊ2010 ᖺࡢ 10 ಸ௨ୖࡢ ⣙8700 ൨ᛴ㏿ᣑࡍࡿぢ㎸ࡲࢀ࡚࠸ࡿࠋ ᙜヱ㡿ᇦࡢᕷሙᙧᡂࡣࠊᨻᗓࡢබⓗຓᡂ㔠ࡀࡑࡢ ཎ㈨࡞ࡗ࡚㐍ࡵࡽࢀࡿࡀከࡃᐃࡉࢀࡿࡇ ࡽࠊᕷሙつᶍࡢ㛫᥋ⓗ࡞ᣦᶆࡋ࡚ᨻᗓࡢண ⟬ᢞධ㢠ࡀά⏝ࡉࢀ࠺ࡿࠋ࠼ࡤiPS ⣽⬊ࢆ ྲྀࡿࠊࣛࣇࢧ࢚ࣥࢫPT ୰㛫ࣇ࢛࣮ࣟࢵ ࣉ㈨ᩱࡼࡾ⤒῭⏘ᴗ┬ࡀసᡂࡋࡓࢹ࣮ࢱࡼࡿ ࠊ᪥ᮏᅜෆ࡛ 2006 ᖺᗘࡣ 1 ൨ 1500 ࡔࡗࡓiPS ⣽⬊◊✲ࡢண⟬ᢞධ㢠ࡀࠊ2007 ᖺ ᗘࡣ5 ൨ 6000 ࠊ2008 ᖺᗘࡣྜィ 40 ൨ ࠊண⟬ᢞධ㢠ࡀᛴ㏿ቑࡉࢀ࡚࠸ࡿࡇࡀ ศࡿࠋᅜ㝿ⓗᖿ⣽⬊㛵㐃◊✲ศ㔝࠾࠸࡚᭱ ඛ➃ࡢ⡿ᅜ࠾࠸࡚ࡶࠊ10 ࢝ᖺィ⏬࡚ྜィ 40 ൨ࢻࣝࡶࡢ㐃㑥ᨻᗓண⟬ࡀiPS⣽⬊◊✲ᢞධࡋ ࡚࠸ࡿࠋࡇࡢࡇࡽࠊ㛵㐃◊✲ᚑࡍࡿᶵ㛵 ⮬యࡢᩘࡀቑࡍࡿࡇࡀணࡉࢀࡿࡓࡵࠊᕷሙ ᙧᡂࡢ୰ᚰⓗ࡞ᙺࢆᯝࡓࡍ⪃࠼ࡽࢀࠊᚋࡢ iPS ⣽⬊◊✲ᕷሙࡢᡂ㛗⋡ࡢ㧗ࡉࢆ᥎ ࡉࡏࡿ ᚋࡢiPS⣽⬊◊✲ᕷሙࡢᡂ㛗⋡ࡢ㧗ࡉࡀ࠺ࡀ࠼ ࡿࠋ3, 4 ᐇ㝿ᐩኈ⤒῭ࡢண ࡼࡿES ⣽⬊࡞ ࡽࡧ iPS ⣽⬊ࡢᅜෆᕷሙ᥎⛣ࡢணࡼࡿࠊ 2009 ᖺᗘ 0.1 ൨ࡽ 2013 ᖺᗘࡣ⣙ 1.6 ൨ ࡲ࡛ᡂ㛗ࡍࡿண ࡋ࡚࠸ࡿࠋ5 ࡇࡢࡼ࠺ᩥ⊩ ศᯒࡢ⤖ᯝࡣᕷሙつᶍࡢ᥎ィࡸࡑࡢഐド࡞ࡿ ࢹ࣮ࢱᩚྜࡋࠊᕷ㈍ࡉࢀ࡚࠸ࡿᖿ⣽⬊㛵㐃ࡢᕷ ሙ࣏࣮ࣞࢺ࠾࠸࡚ࡶᕷሙᡂ㛗⋡ࡢ᥎ィ࠾࠸ ࡚ㄽᩥࡢఙࡧࢆ༢⣧እᤄࡍࡿࡶࡢࡶぢࡽࢀࡿࠋࡇ ࡢࡇࡽࠊィ㔞᭩ㄅᏛⓗࣉ࣮ࣟࢳࡣ◊✲㛤Ⓨ ᑟࡢᕷሙᙧᡂࣉࣟࢭࢫ㛵ࡍࡿゎᯒࢶ࣮ࣝ ࡋ࡚ࡶά⏝࡛ࡁࡿࡇࡀᮇᚅࡉࢀࡿࠋ ᭦ᮏゎᯒࢶ࣮ࣝࡣࠊ▱㈈ᙧᡂᶆ‽ࡀ㐍⾜ ࡍࡿ⣽⬊ᇵ㣴ᢏ⾡࠾࠸࡚ࡶᴟࡵ࡚ヲ⣽࡞ሗ ࢆ࠼ࡿࠋᮏሗ࿌࡛ࡶᖿ⣽⬊㛵㐃ࡢᇵ㣴ᢏ⾡㛤Ⓨ ࢆᑟࡍࡿ◊✲ᶵ㛵ࢆྠᐃࡍࡿࡇࡀ࡛ࡁࡓࠋ᭦ ࠊ⿕ᘬ⏝ᩘࡢከ࠸ㄽᩥࢆⓎ⾜ࡋࡓ◊✲ᶵ㛵ࢆྠ ᐃ࡛ࡁࡿ࠺࠼ࠊࡇࢀࡽᙳ㡪ຊࡢࡁ࠸◊✲ᶵ㛵ࡀ ࡢࡼ࠺࡞ᇵᆅࡸヨ⸆ࢆ㛤Ⓨࡋ࡚࠸ࡿࠊཬࡧࡑ ࡢࣉࣟࢺࢥࣝࡘ࠸࡚ࡶಶูㄽᩥࡢMaterials & Methods ࢆゎᯒࡍࡿࡇ࡛ᢕᥱࡍࡿࡀྍ⬟ ࡞ࡿ࡛࠶ࢁ࠺ࠋࡇࢀࡽࡣࠊᅜ㝿ⓗᶆ‽ࡉࢀࡿ ࡼࡗ࡚ࡁ࡞ᕷሙᙧᡂ⧅ࡀࡿࡀ᥎ ࡉ ࢀࠊᙳ㡪ຊࡢ࠶ࡿ◊✲ᶵ㛵ࡸࡑࡢᇵ㣴ᢏ⾡㸦ᇵ ᆅ࣭ヨ⸆➼㸧ࢆᢕᥱࡍࡿࡇࡀྍ⬟࡞ࡿࠋ᭦ࠊ ᴗࡀᙜヱ㡿ᇦࡢᘬ⏝ㄽᩥࢆⓎ⾲ࡋ࡚࠸ࡿሙྜࠊ ࡶࡋࡃࡣ᪤ᕷ㈍ࡉࢀ࡚࠸ࡿၟ⏝ࡢᇵᆅ࣭ヨ⸆ࢆ ά⏝ࡋ࡚࠸ࡿሙྜࡣࠊྛᴗྡࢆ࣮࣮࢟࣡ࢻࡋ ࡚ᩥ᳨⣴ࡍࡿࡇࡼࡾྛᴗࡢᙜヱ㡿ᇦ ࠾ࡅࡿࣉࣞࢮࣥࢫࡸᕷሙ༨᭷⋡ࢆ᥎ィࡍࡿࡇ ࡀྍ⬟࡞ࡿࠋࡇࡢࡼ࠺ࠊᩥ⊩ゎᯒࡣᕷሙつᶍ ࡢࡳ࡞ࡽࡎࠊᕷሙࡢࢭࢢ࣓ࣥࢸ࣮ࢩࣙࣥࡸࡑࡢື ྥࠊ୪ࡧά⏝ࡉࢀ࡚࠸ࡿ〇ရࡸࣉࣟࢺࢥࣝ⮳ ࡿࡲ࡛ࢆヲ⣽ゎᯒࡍࡿࡇࢆྍ⬟ࡍࡿࠋ 5.3 ศ㔝ࡢᛂ⏝ྍ⬟ᛶ㝈⏺
ᮏ◊✲ᡭἲࡣࠊMeSH terms ࡢ Subheadings ࢆ⏝ࡍࡿࡇ࡛ࠊᖿ⣽⬊㡿ᇦ௨እࡢศ㔝ࡢ 3http://www.meti.go.jp/committee/sankoushin/ shinsangyou/007_giji.html 4http://www.nedo.go.jp/content/100109934.pdf 5http://www.group.fuji-keizai.co.jp/mgz/ mg1208/1208b1m.html
ᛂ⏝ࡀ᳨ウ࡛ࡁࡿࠋణࡋࠊᖿ⣽⬊ࡢࡼ࠺㛵㐃ศ 㔝࡛ࡢㄽᩥᩘࡀᛴ⃭ୖ᪼ࡋࠊ⏘ᴗ⏺ࡼࡾࡶ ࢝ࢹ࣑ᑟ࡛ࡢᕷሙᙧᡂࡀ⾜ࢃࢀ࡚࠸ࡿ◊ ✲ศ㔝㛵ࡋ࡚ࡣࠊࡑࡢᶆ‽㐣⛬ࡸᡂ㛗ᛶࡢ㧗 ࠸㡿ᇦࡘ࠸࡚ࡶ㔜せ࡞ሗࢆ࠼ࡿ୍᪉ࠊ᪤ ᡂ⇍ࡋࡓᕷሙࡸ⏘ᴗศ㔝࡛ࡢᛂ⏝ࡸᕷሙᙧᡂࡀ 㐍⾜ࡋ࡚࠸ࡿ㡿ᇦࡣ༑ศ࡞㐺⏝ࡀᅔ㞴࡛࠶ࡿ ᛮࢃࢀࡿࠋ ཧ⪃ᩥ⊩(ᢤ⢋) [1] Ლᕝ⿱▮ࠊᰘ⏣ᑦᶞࠊᆏ⏣୍㑻͆㢮ఝᗘศᯒ ࢆ⏝࠸ࡓ⛉Ꮫᢏ⾡▱㆑ࡢ࣐ࢵࣆࣥࢢᡭἲ͇ 2010 ᖺ ◊✲࣭ᢏ⾡ィ⏬Ꮫ➨ 25 ᅇᖺḟᏛ⾡ ⣖せ [2] Ᏻすᬛᏹࠊᑠ⋢⿱அࠊ▼ៅኴ㑻͆␗ศ㔝⼥ ྜᆺ◊✲ᣐⅬࡢ࣐ࢿࢪ࣓ࣥࢺࡑࡢከ㠃ⓗホ ౯͇2011 ᖺ ◊✲࣭ᢏ⾡ィ⏬Ꮫ➨ 26 ᅇᖺḟ Ꮫ⾡⣖せ [3] Ᏻすᬛᏹࠊ▼ៅኴ㑻͆ᨻ⟇◊✲ࡢ㐃ᦠࢆ ┠ᣦࡋ࡚ ◊✲㛤Ⓨ⌧ሙࡢ㐃ᦠࡢ࠶ࡾ᪉͇ 2012 ᖺ ࣀ࣮࣋ࢩ࣐ࣙࣥࢿࢪ࣓ࣥࢺࢢ࣮ࣝ ࣉ࣮࣡࢟ࣥࢢ࣮࣌ࣃ࣮ vol3 [4] ▼ៅኴ㑻ࠊ㝮ⶶᗣ୍ࠊἈಇᙪ͆ᖿ⣽⬊ᢏ⾡ ࡢᶆ‽▱㈈ᙧᡂࡢᅜ㝿ືྥ͇2011 ᖺ ᪥ ᮏ▱㈈Ꮫ ➨9 ᅇᖺḟᏛ⾡◊✲Ⓨ⾲. [5] ▼ៅኴ㑻ࠊᑠ⋢⿱அ͆ඹᘬ⏝ᩥ⊩ࢡࣛࢫࢱ ࣮ศᯒᇶ࡙ࡃᏛ㝿࣭⼥ྜ◊✲ࡢከ㠃ⓗホ౯,͇ 2011 [6] ⋢⏣ಇᖹኴࠊᑠ⋢ᩥ㞝ࠊ⋞ሙබつ͆᪥ᮏ࠾ ࡅࡿࢧ࢚ࣥࢫ࣭ࣜࣥࢣ࣮ࢪࡢ ᐃ,͇ 2003