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JAIST Repository: 学術文献分析に基づく市場性の評価アプローチ

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JAIST Repository

https://dspace.jaist.ac.jp/ Title 学術文献分析に基づく市場性の評価アプローチ Author(s) 西島, 陽祐; 安西, 智宏; 仙石, 慎太郎 Citation 年次学術大会講演要旨集, 27: 755-759 Issue Date 2012-10-27

Type Conference Paper Text version publisher

URL http://hdl.handle.net/10119/11131

Rights

本著作物は研究・技術計画学会の許可のもとに掲載す るものです。This material is posted here with permission of the Japan Society for Science Policy and Research Management.

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Ꮫ⾡ᩥ⊩ศᯒ࡟ᇶ࡙ࡃᕷሙᛶࡢホ౯࢔ࣉ࣮ࣟࢳ





żすᓥ 㝧♸ࠊᏳす ᬛᏹ㸦ᮾி኱Ꮫ㸧ࠊ௝▼ ៅኴ㑻㸦ி㒔኱Ꮫ㸧    Ꮫ⾡ᩥ⊩ศᯒ䛿䚸ᨻ⟇ホ౯䜔䝥䝻䝆䜵䜽䝖ホ౯䚸◊✲㛤Ⓨ䝬䝛䝆䝯䞁䝖䛻䛚䛡䜛ά⏝䛰䛡䛷䛺䛟䚸≉䛻䜰䜹䝕 䝭䜰䜢୰ᚰ䛸䛧䛯ᕷሙᙧᡂ䛜㐍⾜䛧䛶䛔䜛㡿ᇦ䛻䛚䛔䛶䛿䛭䛾ᕷሙᛶ䜢ホ౯䛩䜛䛾䛻᭷⏝䛺䝒䞊䝹䛸䛧䛶ᶵ⬟ 䛧䛖䜛䚹ᮏሗ࿌䛷䛿䚸ᖿ⣽⬊◊✲㡿ᇦ䜢஦౛䛸䛧䛶ྲྀ䜚ᢅ䛔䚸ᙜヱ㡿ᇦ䛾ᕷሙᛶ䜔ྛᅜ◊✲ᶵ㛵䛾ᡓ␎䞉ືྥ 䜢ゎᯒ䛩䜛䛺䛹䚸䛭䛾ᐇ㊶ⓗ䛺ά⏝ᡭἲ䛻䛴䛔䛶ሗ࿌䛧䚸ウ㆟䜢⾜䛺䛖䚹㻌 㻌 1 ࡣࡌࡵ࡟ 1.1 Ꮫ⾡ᩥ⊩ศᯒࡢᨻ⟇ホ౯࡬ࡢά⏝  ㏆ᖺࠊィ㔞᭩ㄅᏛⓗᡭἲࡀከࡃࡢ⛉Ꮫᢏ⾡ᨻ⟇ ࡟ᑐࡍࡿホ౯࡟ά⏝ࡉࢀࡘࡘ࠶ࡿࠋࡼࡾලయⓗ࡟ ࡣࠊ◊✲㛤Ⓨ࡟ᢞ㈨ࡉࢀࡓබⓗ㈨㔠ࡀ᭷ຠ࡟㐠⏝ ࡉࢀࠊᨻ⟇ຠᯝࡀ᭷ព⩏࡛࠶ࡗࡓ࠿ࢆṇ☜࡟ホ౯ ࡍࡿࡓࡵࡢᡭἲ࡜ࡋ࡚ࡢ฼⏝ࡀ㐍ࢇ࡛࠸ࡿࠋ≉ᐃ ࡢ◊✲ศ㔝࡛ࡢືྥࢆࠊᐈほⓗ࠿ࡘᐃ㔞ⓗ࡞ᣦᶆ ࢆ⏝࠸࡚ホ౯࡛ࡁࡿࡓࡵࠊฟ∧ㄽᩥᩘࡸ⿕ᘬ⏝ᅇ ᩘ࡞࡝ࡢ⤫ィⓗ࡞㞟ィ㔞࡟ᇶ࡙࠸ࡓィ㔞᭩ㄅᏛ ⓗᡭἲ࡟ࡼࡿᨻ⟇ホ౯ࡣࠊ᪤࡟ྛᅜ࡛ᐇ᪋ࡉࢀ࡚ ࠸ࡿࠋణࡋ༢⣧໬ࡉࢀࡓᐃ㔞ⓗᣦᶆ࡟ᇶ࡙ࡃィ㔞 ᭩ㄅᏛⓗᡭἲ࡟ࡣࠊᑐ㇟◊✲ศ㔝ࡀ㝈ᐃࡉࢀࡿࡇ ࡜ࡸࠊฟ∧ㄽᩥࡸྛ◊✲㡿ᇦ㛫ࡢ㛵ಀᛶࢆศᯒ࡛ ࡁ࡞࠸࡞࡝ࡢㄢ㢟ࡀከࡃࠊ᭦࡞ࡿᨵⰋࡀᚲせ࡛࠶ ࡿ࡜ࡢᣦ᦬ࡶ࠶ࡿ >@  1.2 ◊✲㺪㺽㺹㺚㺼㺈㺖㺢ホ౯ࠊ⤒Ⴀ⟶⌮࡬ࡢά⏝  ⌧≧࡛ࡢ◊✲ࣉࣟࢪ࢙ࢡࢺࡢホ౯ᡭἲ࡜ࡋ࡚ ࡣࠊᚋ᪉ᘬ⏝ᩘࡸ⏘ᴗᢏ⾡ࡢ໬Ꮫ࡬ࡢᐤ୚⋡ࢆ♧ ࡍᣦᶆ࡛࠶ࡿ 6FLHQFH OLQNDJHV ࡟ᇶ࡙ࡃ㉁ⓗホ౯ ࡀᣲࡆࡽࢀࡿ >@ࠋ୰࡛ࡶ◊✲ᡂᯝࡢ♫఍㑏ඖࢆ ┠ⓗࡍࡿࣉࣟࢪ࢙ࢡࢺ࡟࠾࠸࡚ࡣࠊ◊✲㛤Ⓨࢆᇶ ࡟ࡋࡓ≉チฟ㢪௳ᩘࢆィ ᣦᶆ࡜ࡋ࡚⏝࠸ࡓホ ౯ᡭἲࡶేࡏ࡚ά⏝ࡉࢀࡿ஦ࡀ࠶ࡿࠋࡇࡢࡼ࠺࡟ࠊ ホ౯ᣦᶆ࡜࡞ࡾᚓࡿᴗ⦼ࡸᑻᗘࡣࠊ◊✲ศ㔝ࡸᙜ ヱ◊✲ࣉࣟࢪ࢙ࢡࢺࡢᨻ⟇┠ᶆࠊ㐩ᡂ┠ᶆ࡟ࡼࡗ ࡚኱ࡁࡃ␗࡞ࡿࡇ࡜࠿ࡽࠊྛ◊✲ᣐⅬࡢ⤒Ⴀ⟶⌮ ࡟࠾࠸࡚ࡣ㐺ษ࡞ᣦᶆࢆ⤌ࡳྜࢃࡏࡓୖ࡛ࠊࡑࡢ   ᐃ ࡸ ᣦ ᶆ ྥ ୖ ࡟ ྥ ࡅ ࡓ 3'&$ 㸦3ODQ'R&KHFN$FWLRQ㸧ࢧ࢖ࢡࣝࡢᐇ㊶ࡀồࡵࡽ ࢀࡿࠋ౛࠼ࡤࠊ␗ศ㔝⼥ྜᆺ◊✲ᣐⅬ࡟࠾࠸࡚ࡣࠊ .H\3HUIRUPDQFH,QGLFDWRU άືᴗ⦼ᣦᶆ㸸.3, ࢆ฼ ⏝ࡋࡓࠊ◊✲⪅㛫㐃ᦠࡢᗘྜ࠸ࢆໟᣓⓗ࡟ᢕᥱࡍ ࡿࡓࡵࡢィ㔞ᩥ⊩Ꮫⓗᡭἲ࡟ࡼࡿ᳨ウࡀሗ࿌ࡉ ࢀ࡚࠸ࡿ >@ࠋ 1.3 ᕷሙᛶࡢホ౯࡬ࡢά⏝  ィ㔞᭩ㄅᏛⓗᡭἲ࡟ᇶ࡙ࡃศᯒࡣࠊୖグࡢࡼ࠺ ࡟ᨻ⟇ホ౯ࠊ◊✲ࣉࣟࢪ࢙ࢡࢺࡢホ౯ࡸ⤒Ⴀ⟶⌮ ࡬ࡢά⏝ࡀ୰ᚰ࡛࠶ࡗࡓࠋ୍᪉ࠊྛᢏ⾡ศ㔝࡟࠾ ࡅࡿ⏘ᴗ⏺ࠊ࢔࢝ࢹ࣑࢔࡛ࡢ◊✲㛤Ⓨືྥࢆᢕᥱ ࡋࠊྛ௻ᴗ࡟࠾ࡅࡿ㛤Ⓨᡓ␎ࢆศᯒࡍࡿࡓࡵࡢ᪉ ἲㄽ࡜ࡋ࡚ࠊ≉チศᯒࠊ≉チࡢᘬ⏝ㄽᩥศᯒ➼ࡢ ᡭἲࡀ⏝࠸ࡽࢀࡿࡇ࡜ࡀ࠶ࡿࠋ  ࡇࢀࡽࡢィ㔞᭩ㄅᏛⓗ࡞࢔ࣉ࣮ࣟࢳࡣࠊ≉ᐃࡢ ᕷሙᙧᡂࣉࣟࢭࢫࡸᕷሙືྥࢆᢕᥱࡍࡿ㝿࡟ࡶ 㔜せ࡞᝟ሗࢆ୚࠼ࡿࡶࡢ࡜࡞ࡾ࠺ࡿࠋ≉࡟࢔࢝ࢹ ࣑࢔࡛ࡢᢏ⾡㛤Ⓨࡀ୺ᑟࡋ࡚ᕷሙࡀᙧᡂࡉࢀࡿ ẁ㝵࡟࠾࠸࡚ࡣࠊࡑࡢㄽᩥᩘࡀᕷሙ඲యࡢつᶍࡸ ᡂ㛗⋡ࢆ᥎ィࡍࡿ᰿ᣐ࡜ࡶ࡞ࡾ࠺ࡿࡋࠊᕷሙࢆࢭ ࢢ࣓ࣥࢸ࣮ࢩࣙࣥࡸࡑࡢືྥࢆゎᯒࡍࡿࢶ࣮ࣝ ࡜ࡋ࡚ࡶά⏝ࡋ࠺ࡿࠋ᭦࡟ㄽᩥࡢ⿕ᘬ⏝㛵ಀࢆヲ ⣽࡟ゎᯒࡍࡿࡇ࡜࡟ࡼࡾࠊྛ࢔࢝ࢹ࣑࢔࡟࠾ࡅࡿ ᕷሙᙧᡂ㐣⛬࡟㛵ࡍࡿ♧၀ࢆ୚࠼ࡿࡶࡢ࡜࡞ࡿ ࡀࠊᐇ㊶ⓗྲྀࡾ⤌ࡳࡣぢࡽࢀ࡞࠸ࠋ 2 ◊✲ᑐ㇟ 2.1 ࣄࢺᖿ⣽⬊◊✲  ௒ᅇࡣࡑࡢᕷሙᙧᡂࣉࣟࢭࢫࢆゎᯒࡍࡿᑐ㇟ ࡜ࡋ࡚ࠊࣄࢺᖿ⣽⬊◊✲㡿ᇦࢆྲྀࡾୖࡆࡓࠋ⌧ᅾࠊ ศ໬୓⬟ᛶ࡞ࡽࡧ࡟⮬ᕫ」〇⬟࡞࡝ࡢ≉ᚩࢆ᭷ ࡋࡓࣄࢺᖿ⣽⬊ࡣࠊࡑࡢ㛤Ⓨᢏ⾡ࡢ㠉᪂࡟ࡼࡗ࡚ࠊ ෌⏕་⒪ศ㔝ࢆጞࡵ࡜ࡍࡿ་Ꮫ㡿ᇦࡢࡳ࡞ࡽࡎࠊ ་⛉Ꮫࠊ᝟ሗ⛉Ꮫࡸᨻ⟇⛉Ꮫ࡞࡝ࠊᖜᗈ࠸ศ㔝࡟ ࠾࠸࡚◊✲㛤Ⓨࡀᒎ㛤ࡉࢀ࡚࠸ࡿࠋ௒ᚋࡢ་⒪ศ 㔝࡛ࡢᛂ⏝࡬ࡢᮇᚅ࠿ࡽࠊ⏘ᐁᏛ㐃ᦠୗ࡛ࡢᅜᐙ ࣉࣟࢪ࢙ࢡࢺ࡟ᑐࡍࡿ◊✲㛤ⓎຓᡂࡶάⓎ໬ࡋ ࡚࠸ࡿࠋ⌧᫬Ⅼ࡛ࡢࣄࢺᖿ⣽⬊ࡢ୺ࡓࡿ฼⏝⪅ࡣ ኱Ꮫࡸබⓗ◊✲ᶵ㛵࡛࠶ࡾࠊࡑࡢ◊✲ᡂᯝࡣᏛ⾡ ㄽᩥ࡜ࡋ࡚බ⾲ࡉࢀࡿࠋࡑࡢࡓࡵࠊࣄࢺᖿ⣽⬊㡿 ᇦ࡟࠾ࡅࡿᏛ⾡ᩥ⊩ㄪᰝ࡟ࡼࡗ࡚ࠊ◊✲ᶵ㛵࡛ࡢ ᖿ⣽⬊㛵㐃ࡢヨ⸆ࡸᇵᆅࡢ౑⏝≧ἣࢆᢕᥱࡍࡿ ࡇ࡜࡛ࠊࡑࡢᕷሙᙧᡂࢆ⪃ᐹࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ ࡿࠋࣄࢺᖿ⣽⬊◊✲ࡢᡂ㛗ᛶࡸᙳ㡪ຊࢆຍ࿡ࡍࢀ

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ࡤࠊ᪂ࡓ࡞ᕷሙホ౯ᡭἲࡢᥦ᱌ࡣࠊ㠀ᖖ࡟᭷⏝࡜ ゝ࠼ࡿࠋ 2.2 ヨ⸆࣭ᇵᆅ㡿ᇦ  ᖿ⣽⬊⛉Ꮫᢏ⾡ࡢᢏ⾡㠉᪂ࡢࡓࡵ࡟ࡣࠊ▱ⓗ㈈ ⏘ᡓ␎ࡢほⅬ࠿ࡽࡢ㛤Ⓨᢏ⾡ࡢᶆ‽໬ࢆ᥎㐍ࡍ ࡿᚲせࡀ࠶ࡿࠋ [4] ௒ᚋࠊ᭦࡞ࡿⓎᒎࡀᮇᚅࡉ ࢀࡿࣄࢺᖿ⣽⬊◊✲ࡢᢏ⾡࡟㛵ࡍࡿᅜ㝿ᶆ‽໬ ࡟ᡂຌࡍࢀࡤࠊᖿ⣽⬊ᕷሙ඲యࡢᙧᡂ࠾࠸࡚኱ࡁ ࡞ᙳ㡪ࢆཬࡰࡋ࠺ࡿࡇ࡜࠿ࡽࠊࡑࡢ⤒῭Ἴཬຠᯝ ࡢほⅬ࠿ࡽࡶᙜヱ㡿ᇦ࡟࠾ࡅࡿᶆ‽໬ᡓ␎ࡢ㔜 せᛶࡣᴟࡵ࡚㧗࠸࡜ゝ࠼ࡿࠋ≉࡟ࠊࣄࢺᖿ⣽⬊◊ ✲࡟࠾࠸࡚ࡣࠊ◊✲㛤Ⓨࡸ⮫ᗋ⏝㏵࡛ά⏝ࡉࢀࡿ ⣽⬊ᰴࡸࠊࡑࢀࢆᇵ㣴ࡍࡿࡓࡵࡢヨ⸆࣭ᇵᆅ࡟࠾ ࠸࡚ࡣ࢔࢝ࢹ࣑࢔࡛ࠊࡋ࠿ࡶྛ◊✲ᶵ㛵ࡀ୺ᑟࡍ ࡿᙧែ࡛ࡢᶆ‽໬➇தࡀⓎ⏕ࡋ࡚࠸ࡿࠋࡑࡇ࡛ࠊ ᮏሗ࿌࡛ࡣ≉࡟ヨ⸆࣭ᇵᆅ㡿ᇦ࡟࠾ࡅࡿᕷሙືྥ ࢆࠊࡑࡢᶆ‽໬㐣⛬࡟╔┠ࡋ࡚ゎᯒࢆ⾜ࡗࡓࠋල యⓗ࡟ࡣࠊࣄࢺᖿ⣽⬊㡿ᇦ࡟࠾ࡅࡿ୺せ◊✲ᶵ㛵 ࡛ࡢᇵᆅ⤌ᡂࡢ᭱㐺໬ཬࡧㄪᩚἲ㛤Ⓨࢆ┠ⓗ࡜ ࡋࡓㄽᩥࢆྠᐃࡋࠊࡑࡢヱᙜㄽᩥࢆᘬ⏝ࡋ࡚࠸ࡿ ◊✲ᶵ㛵ࢆㄪᰝࡍࡿࡇ࡜࡛ࠊ୺せ◊✲ᶵ㛵ࡢᅜ㝿 ⓗᶆ‽ᇵᆅసᡂ࡟࠾ࡅࡿᙳ㡪ຊࢆ⪃ᐹࡋ࡚࠸ࡿࠋ 3 ◊✲ᡭἲ  ᮏ◊✲࡛ࡢᏛ⾡ᩥ⊩ㄪᰝࡣࠊSciVerse Scopus1 (Elsevier B.V.♫)ࢆᇶ┙ࡢࢹ࣮ࢱ࣮࣋ࢫ࡜ࡋ࡚⏝ ࠸ ࠊ ᳨ ⣴ ⏝ ㄒ ࡢ 㑅 ᐃ ࡟ ࡣ Medical Subject Headings(MeSH)2 terms ࢆ฼⏝ࡋࡓࠋMeSH terms ࡟ࡣᗈ⩏ⓗព࿡࠿ࡽ⊃⩏ⓗព࿡ࡲ࡛ࡢ་Ꮫ ⏝ㄒࡀ㝵ᒙᵓ㐀࡜ࡋ࡚⤌ࡳ㎸ࡲࢀ࡚࠸ࡿࡓࡵࠊྛ ᖿ⣽⬊㛵㐃ࡢ◊✲㡿ᇦ඲⯡࡟ᑐࡍࡿ᳨⣴ᑐ㇟ࡢ ᢤࡅࡸ₃ࢀࢆ㜵ࡄࡇ࡜ࡀฟ᮶ࡿࠋࡇࡇ࡛ࡣࠊྛᖿ ⣽⬊✀ࡢศ㢮࡟ຍ࠼ࠊ⣽⬊ᇵ㣴ᢏ⾡㛵㐃ࡢศ㢮࡟ 㝈ᐃࡋࡓᩥ⊩ㄪᰝࢆ⾜ࡗࡓࠋᐇ㝿࡟ࡣࠊྛ⏝ㄒ(ࡇ ࡇ࡛ࡣࠊྛᖿ⣽⬊ྡ࡜ࠕCell culture techniquesࠖ) ࡟ඹ㏻ࡋࡓMeSH terms ࡢ Subheadings ࡢ⤌ࡳ ྜࢃࡏ᳨⣴࡟ࡼࡗ࡚ࠊヱᙜㄽᩥࢆ㝈ᐃࡋࡓࠋ࡞࠾ࠊ ᙜ ヱ 㡿 ᇦ ࡟ ࠾ ࡅ ࡿ Subheadings ࡀ SciVerse Scopus ୖ࡛ࡢศ㢮࡟ࡶᏑᅾࡍࡿ஦ࡣ☜ㄆࡉࢀ࡚ ࠸ࡿࠋヱᙜࢹ࣮ࢱ࣮࣋ࢫࡣၟ⏝໬ࡉࢀ࡚࠾ࡾࠊ᪤ ࡟ከࡃࡢබⓗ◊✲ᶵ㛵ࡸ኱Ꮫ࡛ࡢ౑⏝ᐇ⦼ࡀ࠶ ࡿࠋຍ࠼࡚ࠊศᯒࡸホ౯ᡭἲࡢ୍㒊ࡣ⮬ື໬ࡉࢀ ࡚࠸ࡿⅬ࠿ࡽࡶࠊ᪂つࡢศᯒᡭἲࢆ㛤Ⓨࡍࡿࡇ࡜ ࡟ẚ࡭ࠊ⡆౽࡞㐠⏝ࡀᮇᚅ࡛ࡁࠊᮏᡭἲࡢỗ⏝ᛶ ࡣ㧗࠸࡜ゝ࠼ࡿࠋ࡞࠾ࠊ2012 ᖺศࡢㄽᩥゎᯒࡣ 2012 ᖺ 9 ᭶࡟ᐇ᪋ࡋ࡚࠸ࡿࠋ 1 http://japan.elsevier.com/products/scopus/ 2 ⡿ᅜᅜ❧་Ꮫᅗ᭩㤋ࡀᐃࡵࡓ⏕࿨⛉Ꮫ⏝ㄒ㞟 4 ⤖ᯝ 4.1 ᖿ⣽⬊◊✲ࡢㄽᩥᩘ᥎⛣  ᮏሗ࿌࡛ࡣࣄࢺᖿ⣽⬊ࢆࠊiPS ⣽⬊(induced pluripotent stem cells)ࠊES⣽⬊(embryonic stem cells)ࠊ㛫ⴥ⣔ᖿ⣽⬊(mesenchymal stem cells) ࡟ศ㢮ࡋ࡚ゎᯒࢆᐇ᪋ࡋࡓࠋ≉࡟ࠊయෆ඲࡚ࡢ⣽ ⬊࡬ศ໬ࡍࡿᛶ㉁ࢆᣢࡘES ⣽⬊ࠊཷ⢭༸௨እࡢ ⣽⬊࡟୓⬟ᛶࢆㄏᑟࡍࡿࡇ࡜࡛ேᕤⓗ࡟⏕ᡂࡉ ࢀࡿiPS ⣽⬊ࡢᕷሙᛶࢆホ౯ࡍࡿࡇ࡜ࡣࠊ௒ᚋࡢ ་⒪ᛂ⏝࡬ࡢⓎᒎ࡜ᕷሙᙧᡂࡀᮇᚅࡉࢀࡿ஦࠿ ࡽࡶ㔜せ࡜⪃࠼ࡿࠋୖグࡢศ㢮࡟࠾ࡅࡿㄽᩥᩘࡢ 2005 ᖺ࠿ࡽ 2012 ᖺ࡛ࡢ⤒ᖺኚ໬ࢆ㏣ࡗࡓࠋ (Fig.1) ࡑࡢ⤖ᯝࠊiPS ⣽⬊ࠊES ⣽⬊ࠊ㛫ⴥ⣔ᖿ ⣽⬊ࡢࠊㄽᩥᩘࡢᖺᖹᆒᡂ㛗 (compound average growth rate, CAGR)ࡣࡑࢀࡒࢀࠊ30.2%ࠊ12.4%ࠊ 28.0%࡛࠶ࡾࠊㄽᩥᩘࡀ㡰ㄪ࡞ఙࡧࢆ♧ࡋ࡚࠸ࡿ ஦ࡀ☜ㄆࡉࢀࡓࠋ Fig. 1:ྛᖿ⣽⬊ศ㔝ࡢㄽᩥᩘࡢ⤒ᖺኚ໬ 4.2 ᖿ⣽⬊㛵㐃ࡢᶵ㛵ูࡢㄽᩥᩘ᥎⛣  ᖿ⣽⬊◊✲࡟࠾ࡅࡿྛ◊✲ᶵ㛵ࡢୡ⏺ⓗ࡞ࢩ ࢙࢔ࢆ☜ㄆࡍࡿࡓࡵࠊ2005 ᖺ࠿ࡽ 2012 ᖺ࡛ࡢྛ ᶵ㛵ࡢᖿ⣽⬊◊✲࡟㛵ࡍࡿㄽᩥᩘࢆゎᯒࡋࠊࡑࡢ ᩘࡢከ࠸ᶵ㛵࠿ࡽ୪࡭᭰࠼ࢆ⾜ࡗࡓࠋ(Fig. 2) ࡑ ࡢ⤖ᯝࠊୖ఩ࡣ୺࡟⡿ᅜࡢ◊✲ᶵ㛵࡟ࡼࡗ࡚༨ࡵ ࡽࢀ࡚࠸ࡓࡀࠊୖ఩ 10 ᶵ㛵ෆ࡟᪥ᮏࡢி㒔኱Ꮫ ࡀࣛࣥࢡ࢖ࣥࡋ࡚࠸ࡓࠋ

(4)

Fig.2:ᖿ⣽⬊㛵㐃ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵 (2005-2012 ᖺ) 4.3 ⣽⬊ᇵ㣴㛵㐃ࡢㄽᩥᩘ᥎⛣  ᖿ⣽⬊◊✲࡟࠾࠸࡚ࡶ≉࡟ᶆ‽໬࡟㛵ࡍࡿྲྀ ࡾ⤌ࡳࡀ㢧ᅾ໬ࡋ࡚࠸ࡿ⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲ ࢆྲྀࡾୖࡆࠊゎᯒࢆ⾜ࡗࡓࠋࡇࡇ࡛ࡣ᳨⣴࢝ࢸࢦ ࣮ࣜ࡜ࡋ࡚ࠕStem Cell࡛ࠖ⤠㎸ࡳࢆ⾜ࡗࡓ࠺࠼ ࡛ࠕCell culture techniquesࠖࢆ฼⏝ࡋࠊᙜヱ㡿 ᇦ࡟࠾ࡅࡿㄽᩥᩘࡢ 2005 ᖺ࠿ࡽ 2012 ᖺ࡛ࡢ⤒ ᖺኚ໬ࢆゎᯒࡋࡓࠋ(Fig.3) ᙜヱ㡿ᇦ࡟࠾ࡅࡿㄽ ᩥᩘࡢᖺᖹᆒᡂ㛗⋡ࡣࠊ2005 ᖺ࠿ࡽ 2011 ᖺࡢᮇ 㛫࡟࠾࠸࡚ 9.2%࡛࠶ࡾࠊᖿ⣽⬊ࡢྛ⣽⬊✀ࡼࡾ ࡶᡂ㛗⋡ࡣ㧗ࡃ࡞࠸⤖ᯝࡀᚓࡽࢀࡓࠋ

Fig.3:Cell culture techniques ศ㔝ࡢ ㄽᩥᩘࡢ⤒ᖺኚ໬ 4.4 ⣽⬊ᇵ㣴㛵㐃ࡢᶵ㛵ูࣛࣥ࢟ࣥࢢ  ᭦࡟⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲࡟࠾࠸࡚ࠊ2005 ᖺ ࠿ࡽ 2012 ᖺࡢ㛫࡛⥲Ⓨ⾜ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵 ࡢୖ఩ 10 ᶵ㛵ࢆ๭ࡾฟࡋࡓࠋ(Fig.4) ࡑࡢ⤖ᯝࠊ ᖿ⣽⬊◊✲࡜ࡣ඲యࡢഴྥࡀⱝᖸ␗࡞ࡿࡇ࡜ࡀ ほᐹࡉࢀࡓ୍᪉ࠊᖿ⣽⬊◊✲඲య࡛ㄽᩥᩘࡀከ࠿ ࡗࡓி㒔኱ᏛࠊHarvard Medical School ཬࡧ University of Tronto ࡀࠊᇵ㣴ᢏ⾡㛵㐃ࡢศ㔝࡛ ࡶୖ఩ࢆ༨ࡵࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋ Fig. 4:ᇵ㣴ᢏ⾡㛵㐃ㄽᩥᩘࡢከ࠸◊✲ᶵ㛵  ࡉࡽ࡟ࠊୖグࡢ୺せᶵ㛵㸦ୖ఩㸳ᶵ㛵㸧ࡢᖿ⣽ ⬊ࡢ⣽⬊ᇵ㣴ᢏ⾡࡟㛵ࡍࡿㄽᩥࢆᘬ⏝ࡋ࡚࠸ࡿ ◊✲ᶵ㛵࡟㛵ࡍࡿゎᯒࢆ⾜ࡗࡓࠋ(Fig.5) ࠸ࡎࢀ ࡢᶵ㛵࡟࠾࠸࡚ࡶࠊ⮬㌟࡟ࡼࡿᘬ⏝௳ᩘࡀ᭱ࡶከ ࠸Ⅼ࡟ࡘ࠸࡚ࡣඹ㏻ࡋ࡚࠸ࡓࡀࠊMassachusetts Institute of Technology(MIT)ࡢࡼ࠺࡟௚ࡢᶵ㛵 ࡢㄽᩥ࡟ࡘ࠸࡚ࡶ✚ᴟⓗ࡟ᘬ⏝ࡋ࡚࠸ࡿ◊✲ᶵ 㛵ࡀ࠶ࡿ୍᪉ࠊி㒔኱Ꮫࡢࡼ࠺࡟௚ࡢୖ఩ᶵ㛵ࡀ Ⓨ⾲ࡋࡓㄽᩥࢆ࠶ࡲࡾᘬ⏝ࡋ࡞࠸◊✲ᶵ㛵ࡀ࠶ ࡿࡇ࡜ࡶศ࠿ࡗࡓࠋ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ig.5:ᇵ㣴ᢏ⾡ࡢୖ఩ᶵ㛵ࡢㄽᩥᘬ⏝ᶵ㛵୍ぴ ㄽᩥ௳ᩘ䝷䞁䜻䞁䜾䠄ୖ఩䠑ᶵ㛵䠅 ఩ ఩ ఩ ఩ ఩

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5 ⪃ᐹ 5.1 ᖿ⣽⬊ᇵ㣴ᢏ⾡࡟࠾ࡅࡿᶆ‽໬ᡓ␎  ᖿ⣽⬊ࡢᇵ㣴ᢏ⾡㡿ᇦ࡟࠾࠸࡚ࠊฟ∧ㄽᩥᩘࡢ ᭱ࡶከ࠸ᶵ㛵ࡣி㒔኱Ꮫ࡛࠶ࡗࡓࡀࠊ௚ࡢୖ఩ᶵ 㛵ࡀฟ∧ࡍࡿᇵ㣴ᢏ⾡࡟㛵ࡍࡿㄽᩥࢆᘬ⏝ࡋ࡚ ࠸ࡿഴྥࡣ☜ㄆ࡛ࡁ࡞࠿ࡗࡓࠋ㸦Fig.5㸧୍᪉࡛ࠊ MIT ࡣᖿ⣽⬊ᇵ㣴ᢏ⾡㛵㐃◊✲࡛ࡢㄽᩥᩘࡀከ ࡃࠊ௚ࡢ◊✲ᶵ㛵࡬ࡢᙳ㡪ຊࢆಖ᭷ࡋࡘࡘࡶࠊྠ 㡿ᇦ࡛ࡢฟ∧ㄽᩥᩘࡢ௚ୖ఩ᶵ㛵ࡢㄽᩥࢆᘬ⏝ ࡋ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡿࠋࡇࡢࡇ࡜࠿ࡽࠊᖿ⣽⬊㛵 㐃ࡢᇵᆅ࣭ヨ⸆ศ㔝࡛ࡢᶆ‽໬ᡓ␎࡟ࡘ࠸࡚ࠊி 㒔኱Ꮫࡣ⮬ࡽ◊✲㛤Ⓨࡸヨ⸆ㄪᩚࢆ⾜࠸ࠊ᭱㐺࡞ ᖿ⣽⬊ᇵ㣴ᢏ⾡ࡢ☜❧ࢆ㐍ࡵࡿ୍᪉࡛ࠊMIT ࡣࠊ ⮬ࡽᢏ⾡ࢆᨵⰋࡍࡿ࡜ྠ᫬࡟ࠊ௚ᶵ㛵ࡢ㛤Ⓨࡋ࡚ ࠸ࡿ⣽⬊ᇵ㣴ᢏ⾡ࢆᘬ⏝ࡋ࡚࠸ࡿࡓࡵࠊᡤᒓᶵ㛵 ࡛ࣞ࣋ࣝ౑⏝ࡍࡿᇵᆅࡸヨ⸆ࡢ⤫୍ࡣ࡞ࡉࢀ࡚ ࠾ࡽࡎࠊಶู࡟ูᶵ㛵ࡢᇵᆅࢆཧ⪃࡟ࡋ࡚࠸ࡿഴ ྥࡀ࠶ࡿ࡜᥎ ࡉࢀࡿࠋHarvard Medical School ࡣࠊᇵ㣴ᢏ⾡㛵㐃ࡢㄽᩥᩘ࡛ࡣ6 ఩࡛࠶ࡿࡀࠊࣛ ࣥ࢟ࣥࢢୖ఩ࡢᶵ㛵ࡢㄽᩥࢆ✚ᴟⓗ࡟ᘬ⏝ࡍࡿ ഴྥࡀぢࡽࢀࡿࠋᐇ㝿࡟➹⪅ࡀᙜヱᶵ㛵࡟ࣄ࢔ࣜ ࣥࢢㄪᰝࢆ⾜ࡗࡓ⤖ᯝࠊ⮬㌟࡛ࡢᇵ㣴ᢏ⾡㛤Ⓨ࡬ ࡢྲྀࡾ⤌ࡳࡣ㝈ᐃⓗ࡛࠶ࡾࠊ௚ᶵ㛵ࡢ㛤Ⓨࡋࡓᇵ 㣴ᢏ⾡ࢆ࣮ࣘࢨ࣮࡜ࡋ࡚✚ᴟⓗ࡟ᑟධࡋ࡚࠸ࡿ ஦ࡀ᳨ドࡉࢀࡓ㸦ࢹ࣮ࢱࡣ㠀㛤♧㸧ࠋࡇࡢࡼ࠺࡟ࠊ ㄽᩥ᭩ㄅᏛ࡟ᇶ࡙ࡃゎᯒᡭἲࡣᶆ‽໬ືྥࢆᢕ ᥱࡍࡿࡓࡵ࡟ࡶ᭷ຠ࡛࠶ࡿ࡜ゝ࠼ࡿࠋ 5.2 ᕷሙホ౯࡬ࡢᛂ⏝ྍ⬟ᛶ  ᮏሗ࿌ࡣࠊ≉࡟࢔࢝ࢹ࣑࢔୺ᑟ࡜⏘Ꮫ㐃ᦠ࡟ࡼ ࡿᕷሙᙧᡂࡀ࡞ࡉࢀࡿ㡿ᇦ࡟࠾࠸࡚ࠊᩥ⊩ศᯒࡀ ᕷሙศᯒࡢ୍ࡘࡢ࢔ࣉ࣮ࣟࢳ࡜࡞ࡾ࠺ࡿࡇ࡜ࢆ ♧ࡍࡶࡢ࡛࠶ࡿࠋࡦ࡜ࡘࡢ౛࡜ࡋ࡚ࠊゎᯒ⤖ᯝ࠿ ࡽࠊES ⣽⬊࡟ẚ࡭࡚ iPS ⣽⬊ࡢㄽᩥᩘࡣᑡ࡞࠸ ࡶࡢࡢࠊᡂ㛗⋡ࡣ㧗࠸ഴྥࡀぢࡽࢀࡓࠋ⪃࠼ࡽࢀ ࡿࡑࡢ⌮⏤ࡢࡦ࡜ࡘ࡜ࡋ࡚ࠊ⏘ᴗᵓ㐀ᑂ㆟఍ࠊ᪂ ⏘ᴗᵓ㐀㒊఍ࡢሗ࿌᭩࡟ࡼࡿ࡜ࠊ2020 ᖺ࡟ࡣ෌ ⏕་⒪㛵㐃ࡢୡ⏺ᕷሙࡀࠊ2010 ᖺࡢ 10 ಸ௨ୖࡢ ⣙8700 ൨෇࡟ᛴ㏿࡟ᣑ኱ࡍࡿ࡜ぢ㎸ࡲࢀ࡚࠸ࡿࠋ ᙜヱ㡿ᇦࡢᕷሙᙧᡂࡣࠊᨻᗓࡢබⓗຓᡂ㔠ࡀࡑࡢ ཎ㈨࡜࡞ࡗ࡚㐍ࡵࡽࢀࡿ஦ࡀከࡃ᝿ᐃࡉࢀࡿࡇ ࡜࠿ࡽࠊᕷሙつᶍࡢ㛫᥋ⓗ࡞ᣦᶆ࡜ࡋ࡚ᨻᗓࡢண ⟬ᢞධ㢠ࡀά⏝ࡉࢀ࠺ࡿࠋ౛࠼ࡤiPS ⣽⬊ࢆ౛࡟ ྲྀࡿ࡜ࠊࣛ࢖ࣇࢧ࢖࢚ࣥࢫPT ୰㛫ࣇ࢛࣮ࣟ࢔ࢵ ࣉ㈨ᩱࡼࡾ⤒῭⏘ᴗ┬ࡀసᡂࡋࡓࢹ࣮ࢱ࡟ࡼࡿ ࡜ࠊ᪥ᮏᅜෆ࡛ 2006 ᖺᗘ᫬࡟ࡣ 1 ൨ 1500 ୓෇ ࡔࡗࡓiPS ⣽⬊◊✲࡬ࡢண⟬ᢞධ㢠ࡀࠊ2007 ᖺ ᗘ࡟ࡣ5 ൨ 6000 ୓෇ࠊ2008 ᖺᗘ࡟ࡣྜィ 40 ൨ ෇࡜ࠊண⟬ᢞධ㢠ࡀᛴ㏿࡟ቑ኱ࡉࢀ࡚࠸ࡿࡇ࡜ࡀ ศ࠿ࡿࠋᅜ㝿ⓗ࡟ᖿ⣽⬊㛵㐃◊✲ศ㔝࡟࠾࠸࡚᭱ ඛ➃ࡢ⡿ᅜ࡟࠾࠸࡚ࡶࠊ10 ࢝ᖺィ⏬࡟࡚ྜィ 40 ൨ࢻࣝࡶࡢ㐃㑥ᨻᗓண⟬ࡀiPS⣽⬊◊✲࡟ᢞධࡋ ࡚࠸ࡿࠋࡇࡢࡇ࡜࠿ࡽࠊ㛵㐃◊✲࡬ᚑ஦ࡍࡿᶵ㛵 ⮬యࡢᩘࡀቑ኱ࡍࡿࡇ࡜ࡀண᝿ࡉࢀࡿࡓࡵࠊᕷሙ ᙧᡂࡢ୰ᚰⓗ࡞ᙺ๭ࢆᯝࡓࡍ࡜⪃࠼ࡽࢀࠊ௒ᚋࡢ iPS ⣽⬊◊✲ᕷሙࡢᡂ㛗⋡ࡢ㧗ࡉࢆ᥎ ࡉࡏࡿ௒ ᚋࡢiPS⣽⬊◊✲ᕷሙࡢᡂ㛗⋡ࡢ㧗ࡉࡀ࠺࠿ࡀ࠼ ࡿࠋ3, 4 ᐇ㝿࡟ᐩኈ⤒῭ࡢண ࡟ࡼࡿES ⣽⬊࡞ ࡽࡧ࡟ iPS ⣽⬊ࡢᅜෆᕷሙ᥎⛣ࡢண᝿࡟ࡼࡿ࡜ࠊ 2009 ᖺᗘ 0.1 ൨෇࠿ࡽ 2013 ᖺᗘ࡟ࡣ⣙ 1.6 ൨෇ ࡲ࡛ᡂ㛗ࡍࡿ࡜ண ࡋ࡚࠸ࡿࠋ5 ࡇࡢࡼ࠺࡟ᩥ⊩ ศᯒࡢ⤖ᯝࡣᕷሙつᶍࡢ᥎ィࡸࡑࡢഐド࡜࡞ࡿ ࢹ࣮ࢱ࡜ᩚྜࡋࠊᕷ㈍ࡉࢀ࡚࠸ࡿᖿ⣽⬊㛵㐃ࡢᕷ ሙ࣏࣮ࣞࢺ࡟࠾࠸࡚ࡶᕷሙᡂ㛗⋡ࡢ᥎ィ࡟࠾࠸ ࡚ㄽᩥࡢఙࡧࢆ༢⣧እᤄࡍࡿࡶࡢࡶぢࡽࢀࡿࠋࡇ ࡢࡇ࡜࠿ࡽࠊィ㔞᭩ㄅᏛⓗ࢔ࣉ࣮ࣟࢳࡣ◊✲㛤Ⓨ ୺ᑟࡢᕷሙᙧᡂࣉࣟࢭࢫ࡟㛵ࡍࡿゎᯒࢶ࣮ࣝ࡜ ࡋ࡚ࡶά⏝࡛ࡁࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ  ᭦࡟ᮏゎᯒࢶ࣮ࣝࡣࠊ▱㈈ᙧᡂ࡜ᶆ‽໬ࡀ㐍⾜ ࡍࡿ⣽⬊ᇵ㣴ᢏ⾡࡟࠾࠸࡚ࡶᴟࡵ࡚ヲ⣽࡞᝟ሗ ࢆ୚࠼ࡿࠋᮏሗ࿌࡛ࡶᖿ⣽⬊㛵㐃ࡢᇵ㣴ᢏ⾡㛤Ⓨ ࢆ୺ᑟࡍࡿ◊✲ᶵ㛵ࢆྠᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋ᭦ ࡟ࠊ⿕ᘬ⏝ᩘࡢከ࠸ㄽᩥࢆⓎ⾜ࡋࡓ◊✲ᶵ㛵ࢆྠ ᐃ࡛ࡁࡿ࠺࠼ࠊࡇࢀࡽᙳ㡪ຊࡢ኱ࡁ࠸◊✲ᶵ㛵ࡀ ࡝ࡢࡼ࠺࡞ᇵᆅࡸヨ⸆ࢆ㛤Ⓨࡋ࡚࠸ࡿ࠿ࠊཬࡧࡑ ࡢࣉࣟࢺࢥࣝ࡟ࡘ࠸࡚ࡶಶูㄽᩥࡢMaterials & Methods ࢆゎᯒࡍࡿࡇ࡜࡛ᢕᥱࡍࡿ஦ࡀྍ⬟࡜ ࡞ࡿ࡛࠶ࢁ࠺ࠋࡇࢀࡽࡣࠊᅜ㝿ⓗ࡟ᶆ‽໬ࡉࢀࡿ ஦࡟ࡼࡗ࡚኱ࡁ࡞ᕷሙᙧᡂ࡟⧅ࡀࡿ஦ࡀ᥎ ࡉ ࢀࠊᙳ㡪ຊࡢ࠶ࡿ◊✲ᶵ㛵ࡸࡑࡢᇵ㣴ᢏ⾡㸦ᇵ ᆅ࣭ヨ⸆➼㸧ࢆᢕᥱࡍࡿࡇ࡜ࡀྍ⬟࡟࡞ࡿࠋ᭦࡟ࠊ ௻ᴗࡀᙜヱ㡿ᇦࡢᘬ⏝ㄽᩥࢆⓎ⾲ࡋ࡚࠸ࡿሙྜࠊ ࡶࡋࡃࡣ᪤࡟ᕷ㈍ࡉࢀ࡚࠸ࡿၟ⏝ࡢᇵᆅ࣭ヨ⸆ࢆ ά⏝ࡋ࡚࠸ࡿሙྜࡣࠊྛ௻ᴗྡࢆ࣮࣮࢟࣡ࢻ࡟ࡋ ࡚඲ᩥ᳨⣴ࡍࡿࡇ࡜࡟ࡼࡾྛ௻ᴗࡢᙜヱ㡿ᇦ࡟ ࠾ࡅࡿࣉࣞࢮࣥࢫࡸᕷሙ༨᭷⋡ࢆ᥎ィࡍࡿࡇ࡜ ࡀྍ⬟࡜࡞ࡿࠋࡇࡢࡼ࠺࡟ࠊᩥ⊩ゎᯒࡣᕷሙつᶍ ࡢࡳ࡞ࡽࡎࠊᕷሙࡢࢭࢢ࣓ࣥࢸ࣮ࢩࣙࣥࡸࡑࡢື ྥࠊ୪ࡧ࡟ά⏝ࡉࢀ࡚࠸ࡿ〇ရࡸࣉࣟࢺࢥࣝ࡟⮳ ࡿࡲ࡛ࢆヲ⣽࡟ゎᯒࡍࡿࡇ࡜ࢆྍ⬟࡟ࡍࡿࠋ 5.3 ௚ศ㔝࡬ࡢᛂ⏝ྍ⬟ᛶ࡜㝈⏺

 ᮏ◊✲ᡭἲࡣࠊMeSH terms ࡢ Subheadings ࢆ฼⏝ࡍࡿࡇ࡜࡛ࠊᖿ⣽⬊㡿ᇦ௨እࡢ௚ศ㔝࡬ࡢ 3http://www.meti.go.jp/committee/sankoushin/ shinsangyou/007_giji.html 4http://www.nedo.go.jp/content/100109934.pdf 5http://www.group.fuji-keizai.co.jp/mgz/ mg1208/1208b1m.html

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ᛂ⏝ࡀ᳨ウ࡛ࡁࡿࠋణࡋࠊᖿ⣽⬊ࡢࡼ࠺࡟㛵㐃ศ 㔝࡛ࡢㄽᩥᩘࡀᛴ⃭࡟ୖ᪼ࡋࠊ⏘ᴗ⏺ࡼࡾࡶ୺࡟ ࢔࢝ࢹ࣑࢔୺ᑟ࡛ࡢᕷሙᙧᡂࡀ⾜ࢃࢀ࡚࠸ࡿ◊ ✲ศ㔝࡟㛵ࡋ࡚ࡣࠊࡑࡢᶆ‽໬㐣⛬ࡸᡂ㛗ᛶࡢ㧗 ࠸㡿ᇦ࡟ࡘ࠸࡚ࡶ㔜せ࡞᝟ሗࢆ୚࠼ࡿ୍᪉ࠊ᪤࡟ ᡂ⇍ࡋࡓᕷሙࡸ⏘ᴗศ㔝࡛ࡢᛂ⏝ࡸᕷሙᙧᡂࡀ 㐍⾜ࡋ࡚࠸ࡿ㡿ᇦ࡟ࡣ༑ศ࡞㐺⏝ࡀᅔ㞴࡛࠶ࡿ ࡜ᛮࢃࢀࡿࠋ ཧ⪃ᩥ⊩(ᢤ⢋) [1] Ლᕝ⿱▮ࠊᰘ⏣ᑦᶞࠊᆏ⏣୍㑻͆㢮ఝᗘศᯒ ࢆ⏝࠸ࡓ⛉Ꮫᢏ⾡▱㆑ࡢ࣐ࢵࣆࣥࢢᡭἲ͇ 2010 ᖺ ◊✲࣭ᢏ⾡ィ⏬Ꮫ఍➨ 25 ᅇᖺḟᏛ⾡ ኱఍⣖せ [2] Ᏻすᬛᏹࠊᑠ⋢⿱அࠊ௝▼ៅኴ㑻͆␗ศ㔝⼥ ྜᆺ◊✲ᣐⅬࡢ࣐ࢿࢪ࣓ࣥࢺ࡜ࡑࡢከ㠃ⓗホ ౯͇2011 ᖺ ◊✲࣭ᢏ⾡ィ⏬Ꮫ఍➨ 26 ᅇᖺḟ Ꮫ⾡኱఍⣖せ [3] Ᏻすᬛᏹࠊ௝▼ៅኴ㑻͆ᨻ⟇࡜◊✲ࡢ㐃ᦠࢆ ┠ᣦࡋ࡚ ◊✲㛤Ⓨ⌧ሙ࡜ࡢ㐃ᦠࡢ࠶ࡾ᪉͇ 2012 ᖺ ࢖ࣀ࣮࣋ࢩ࣐ࣙࣥࢿࢪ࣓ࣥࢺࢢ࣮ࣝ ࣉ࣮࣡࢟ࣥࢢ࣮࣌ࣃ࣮ vol3 [4] ௝▼ៅኴ㑻ࠊ㝮ⶶᗣ୍ࠊἈಇᙪ͆ᖿ⣽⬊ᢏ⾡ ࡢᶆ‽໬࡜▱㈈ᙧᡂࡢᅜ㝿ືྥ͇2011 ᖺ ᪥ ᮏ▱㈈Ꮫ఍ ➨9 ᅇᖺḟᏛ⾡◊✲Ⓨ⾲. [5] ௝▼ៅኴ㑻ࠊᑠ⋢⿱அ͆ඹᘬ⏝ᩥ⊩ࢡࣛࢫࢱ ࣮ศᯒ࡟ᇶ࡙ࡃᏛ㝿࣭⼥ྜ◊✲ࡢከ㠃ⓗホ౯,͇ 2011 [6] ⋢⏣ಇᖹኴࠊᑠ⋢ᩥ㞝ࠊ⋞ሙබつ͆᪥ᮏ࡟࠾ ࡅࡿࢧ࢖࢚ࣥࢫ࣭ࣜࣥࢣ࣮ࢪࡢ ᐃ,͇ 2003

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