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医薬品安全性学研究室 Clinical Pharmacy

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医薬品安全性学研究室

Clinical Pharmacy

教 授 橋本 征也 Yukiya Hashimoto 准教授 田口 雅登 Masato Taguchi 助 教 石田 和也 Kazuya Ishida

◆ 原 著

1) Takaai M.*, Sakata J., Ishida K., Taguchi M., and Hashimoto Y.: Mechanisms for transport of methotrexate across apical and basolateral membranes in human intestinal epithelial Caco-2 cells. Jpn. J. Pharm. Health Care Sci., 36: 63-71, 2010.

2) Horiuchi I.*, Kato Y., Nakamura A., Ishida K., Taguchi M., and Hashimoto Y.: Inhibitory and stimulative effects of amiodarone on metabolism of carvedilol in human liver microsomes. Biol. Pharm. Bull., 33: 717-720, 2010.

3) Masago M.*, Takaai M., Sakata J., Horie A., Ito T., Ishida K., Taguchi M., and Hashimoto Y.: Membrane transport mechanisms of quinidine and procainamide in renal LLC-PK1 and intestinal LS180 cells. Biol. Pharm. Bull., 33: 1407-1412, 2010.

4) Hirono K., Yoshimura N., Taguchi M., Watanabe K., Nakamura T., Ichida F., and Miyawaki T.: Bosentan induces clinical and hemodynamic improvement in candidates for right-sided heart bypass surgery. J. Thorac. Cardiovasc. Surg., 140: 346-351, 2010.

5) Utsunomiya Y., Hara Y., Ito H., Okonogi H., Miyazaki Y., Hashimoto Y., and Hosoya T.: Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome. Int. J. Clin.

Pharmacol. Ther., 48: 751-755, 2010.

6) Ishida K., Takaai M., Yotsutani A., Yokota A., Sakamoto T., Taguchi M., Matsukura H., Miyawaki T., and Hashimoto Y.:

Mechanisms responsible for the different uptakes of mizoribine and ribavirin in human epithelial LS180 cells. Jpn. J. Pharm.

Health Care Sci., 36: 900-905, 2010.

◆ 学会報告

1) Taguchi M.,Ibuki K., Saito K.,Watanabe K.,Hirono K., Kato Y., Horiuchi I., Ichida F., and Hashimoto Y.: Effect of age and VKORC1 genotype on warfarin dose requirements in Japanese pediatric patients. The 3rd Congress of Asia-Pacific Pediatric Cardiac Society, 2010, 7, 6-8, Chiba.

2) Ishida K., Takaai M., Uemura O., Nagai T., Satomura K., Kaneda H., Ohta K., Fujieda M., Wada N., Goto Y., Morooka M., and Hashimoto Y.: Optimal limited sampling designs to estimate maximal concentration and area under the curve of mizoribine in pediatric patients with renal disease. Pharmaceutical Sciences World Congress 2010, 2010, 11, 14-18, New Orleans.

3) 真砂美希*，坂田淳平，西條早紀，鷹合麻里，堀江明日佳，伊藤俊和，石田和也，田口雅登，橋本征也：腎上皮LLC-PK1 および腸上皮LS180細胞におけるプロカインアミドの膜輸送機構解析．日本薬学会第130年会，2010，3，28-30，

岡山．

4) 石田和也，真砂美希，坂田淳平，鷹合麻里，堀江明日佳，伊藤俊和，田口雅登，橋本征也：腸上皮LS180細胞を用 いたプロカインアミドの膜輸送特性解析．日本薬剤学会第25年会，2010，5，12-14，徳島．

5) 石田和也，鷹合麻里，上村 治，永井琢人，里村憲一，金田 尚，太田和秀，藤枝幹也，和田尚弘，後藤芳充，諸 岡正史，橋本征也：小児腎疾患患者におけるミゾリビンのAUCとCmax予測のための最適少数採血デザインの評価．

第45回日本小児腎臓病学会学術集会，2010，7，2-3，大阪．

6) Taguchi M, Ichida F,Hirono K, Yoshimura N, Nakamura T, Akita C, Nakayama T, Saji T, Kato Y, Horiuchi I, and Hashimoto Y: The pharmacokinetics of bosentan in routinely treated Japanese pediatric patients with pulmonary arterial hypertension. 第 46回日本小児循環器学会学術集会，2010，7，7-10，千葉.

7) 石田和也，鷹合麻里，上村 治，永井琢人，里村憲一，金田 尚，太田和秀，藤枝幹也，和田尚弘，後藤芳充，諸 岡正史，橋本征也：小児腎疾患患者におけるミゾリビンの最適少数採血デザインの評価．医療薬学フォーラム2010，

2010，7，10-11，広島．

8) Horiuchi I*, Kato Y, Nakamura A, Ishida K, Taguchi M, and Hashimoto Y.: Inhibitory and stimulative effects of amiodarone on stereoselective metabolism of carvedilol in human and rat liver microsomes. 日本薬物動態学会第25回年会，2010，10，7-9， 大宮．

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