資源開発研究部門
Medicinal Resources 薬物代謝工学分野 Metabolic Engineering
教 授 服部 征雄 Masao Hattori 准教授 馬 超美 Chao-Mei Ma 助 教（前）鄭 美和 Mi-Hwa Chung 助 教 湯 俊 Jun Tang
◆ 原 著
1) Phuong D.T., Ma C., Hattori M., and Jin J.S.: Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother. Res., 23: 582-584, 2009.
2) Sato N.*, Ma C., Komatsu K., and Hattori M.: Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense. J. Nat.
Prod., 72: 958-961, 2009.
3) Wei Y., Ma C., and Hattori M.: Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases. Bioorg. Med. Chem., 17: 3003-3010, 2009.
4) Ma C., Wei Y., Wang Z., and Hattori M.: Triterpenes from Cynomorium songaricium-analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating. J. Nat. Med., 63: 9-14, 2009.
5) Yu J., Ma C., Long C., Wang X., Shang M., Cai S., Hattori M., and Namba T.: A new aristololactam from Asarum maximum. J.
Chin. Pharm. Sci., 18: 183-185, 2009.
6) El-Mekkawy S., Abdel-Sattar E., Hattori M., Kawahata T., and Otake T.: Screening of medicinal plants in Egypt for anti-human immunodeficiency virus type-1 (HIV-1) activity. JASMR, 4: 1-8, 2009.
7) Wei Y., Ma C., and Hattori M.: Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1 protease activity. Eur. J.
Med. Chem., 44: 4112-4120, 2009.
8) Jin J.S., and Hattori M.: Further studies on a human intestinal bacterium Ruminococcus sp. END-1 for transformation of plant lignans to mammalian lignans. J. Agric. Food Chem., 57: 7537-7542, 2009.
9) Ma L., Yang X.W., Cai B.C., and Hattori M.: Intestinal permeability of antitumor alkaloids from the processed seeds of Strychinos nux-vomica in a caco-2 cell model. Planta Med., 75: 631-634, 2009.
10) Wei Y., Ma C., and Hattori M.: Anti-HIV protease triterpenoids from the acid hydrolysate of Panax ginseng. Phytochem. Lett., 2: 63-66, 2009.
11) Zhang Q., Zuo F., Nakamura N., Ma C., and Hattori M.: Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. J. Nat. Med., 63: 304-310, 2009.
12) Sato N.*, Zhang Q., Ma C., and Hattori M.: Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense. Chem. Pharm. Bull., 57: 1076-1080, 2009.
13) El Dine R.S., El Halawany A.M., Ma C., and Hattori M.: Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum. J. Nat. Prod., 72: 2019-2023, 2009.
14) Sasivimolphan P., Lipipun V., Likhitwitayawuid K., Takemoto M., Pramyothin P., Hattori M., and Shiraki K.: Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro. Antiviral Res., 84: 95-97, 2009.
◆ 学会報告
1) Hattori M.: Survey of anti-HIV/HCV agents among medicinal mushrooms. NRCT-JSPS Core University Program on Natural Medicine in Pharmaceutical Sciences, The 8th Joint Seminar, Innovative Research in Natural Products for Sustainable Development. 2009, 2, 3-4, Bangkok, Thailand. (Invited lecture)
2) Chung M.H.: Estrogenic effects of Tokishakuyakusan (Japanese traditional medicine) and differences between Tokishakuyakusan and 17β-estradiol. NRCT-JSPS Core University Program on Natural Medicine in Pharmaceutical Sciences,
The 8th Joint Seminar, Innovative Research in Natural Products for Sustainable Development, 2009, 2, 3-4, Bangkok, Thailand.
3) Sato N.: Isolation of lanostane type triterpenes from Ganoderma sinense and their anti-protease activity from HIV. NRCT-JSPS Core University Program on Natural Medicine in Pharmaceutical Sciences, The 8th Joint Seminar, Innovative Research in Natural Products for Sustainable Development. 2009, 2, 3-4, Bangkok, Thailand.
4) Hattori M., El Dine R.S., Ma C., and Sato N.: Inhibitory substances from medicinal mushrooms: Ganoderma species against HIV-1 protease. The 50th Annual Meeting of the American Society of Pharmacognosy, 2009, 6, 27- 7, 1, Honolulu, Hawaii.
5) Kitalong C., El-Halawany A.M., Ma C., and Hattori M.: A new benzophenone rhamnoside from Phaleria nisidai with estrogenic activity. The 50th Annual Meeting of the American Society of Pharmacognosy, 2009, 6, 27-7, 1, Honolulu, Hawaii.
6) Furuhashi K.*, Chung M., and Hattori M.: Effect of Tokishakuyakusan on ovary and hypothalamus Kiss-1 mRNA expression in hypophsectomized rats. The 50th Annual Meeting of the American Society of Pharmacognosy, 2009, 6, 27-7, 1, Honolulu, Hawaii.
7) Mizuno M.*, Chung M., Ma C., and Hattori M.: Metabolism and disposition of antrodin D in rats. The 50th Annual Meeting of the American Society of Pharmacognosy, 2009, 6, 27- 7, 1, Honolulu, Hawaii.
8) 鄭 美和，伊藤絵理，服部征雄：当帰芍薬散のdendritic spine回復に対する効果について．日本薬学会第129年会，
2009, 3, 26-28, 京都.
9) 王 偉*，馬 超美，服部征雄：ラットにおけるRhynchophyllineのA/D/M/E．日本薬学会第129年会，2009, 3, 26-28, 京都．
10) 水野めぐみ*，鄭 美和，陳 琮湜，馬 超美，服部征雄：樟芝菌糸体成分Antrodin Dのラットにおける体内動態．
日本薬学会第129年会，2009, 3, 26-28, 京都．
11) 馬 超美，阿倍 剛，小宮山忠純，服部征雄，Mohsen Daneshtalab：カフェー酸及びキナ酸誘導体の合成と真菌1,3- グルカン合成酵素に対する阻害活性の比較．日本薬学会第129年会，2009, 3, 26-28, 京都．
12) 高田弘弥，萩原由季子，岸 香苗，松本正巳，五十嵐久幸，服部征雄：霊芝エキス抽出法の改良とその機能性評価．
日本薬学会第129年会，2009, 3, 26-28, 京都．
13) 宅江孝修，馬 超美，服部征雄：甘草の新たな腸管収縮抑制成分の探索．第26回和漢医薬学会学術大会，2009, 8, 29-30, 千葉．
14) 王 偉*，馬 超美，服部征雄：Hydroxylation of Rhynchophylline Followed by Glucuronidation with Rat Liver Microsomes． 第26回和漢医薬学会学術大会，2009, 8, 29-30, 千葉．
15) 古橋慶子*，鄭 美和，服部征雄：多嚢胞性卵巣症候群（PCOS）モデルラットに対する当帰芍薬散の効果．第26回 和漢医薬学会学術大会，2009, 8, 29-30, 千葉．
16) El Halawany A.M., El Dine R.S., Ma C., and Hattori M.: Design and Semi-synthesis of HCV NS3/4A Protease Inhibitors Based on Antrodin B Nucleus. 日本生薬学会第56回年会，2009, 10, 3-4, 京都．
17) 馬 紅，鄭 美和，呂 華，服部征雄：春至カプセルの生殖内分泌学的効果と作用メカニズム‐第2報‐．日本生 薬学会第56回年会，2009, 10, 3-4, 京都．
18) 光田聖庸*，水野めぐみ，馬 超美，岩佐衣子，服部征雄：黄連エキスの LC/NMR とラットにおける体内動態．日 本薬学会北陸支部平成21年度第2回総会及び第121回例会，2009, 12, 6, 富山．
◆ その他
1) 馬 超美：Caffeoylquinic acids: Natural occurrence, derivative synthesis and bioactivity. ハワイ大学薬学部のセミナーに 参加，研究発表．2009, 1, 27-28, ヒロ，ハワイ島．
2) 服部征雄：Development of anti HIV and anti HCV agents from natural resources. 桂林医科大学訪問，講演．2009 ,4, 20-27, 桂林，中国．
3) 服部征雄：生薬成分の化学‐ヒト腸内細菌による漢方薬成分の代謝活性化‐．平成21年度漢方薬・生薬研修会，2009,
7, 26, 慶応大学薬学部．
4) 服部征雄：樟芝研究の打合せ．2009, 9, 18-22, 台湾．
5) 服部征雄：Metabolic activation of natural medicines by human intestinal bacteria. 上海交通大学訪問，講演．2009, 9, 27-10, 1, 上海，中国．
6) 服部征雄：東洋人の知恵．富山大学医学薬学祭09特別講演会，2009, 10, 31, 富山．
7) 服部征雄：Antiviral substances from medicinal mushrooms. 大邱カトリック大学にて講演．2009, 11, 18-21, 大邱，韓国．
8) 服部征雄：Development of anti HIV and anti HCV agents from natural resources. アシュート大学，ジャーマン大学にお
いて講演．2009, 12, 16-28, エジプト．
9) 服部征雄：Metabolic activation of natural medicines by human intestinal bacteria. ミネア大学，カイロ大学において講演．
2009, 12, 16-28, エジプト．
