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【論文】自閉スペクトラム症の病理における遺伝と環境に関する近年の研究動向―遺伝、BAP、環境、エピジェネティクスについて―

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⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕ࡢ⑓⌮࡟࠾ࡅࡿ㑇ఏ࡜⎔ቃ࡟㛵ࡍࡿ㏆ᖺࡢ◊✲ືྥ

̿㑇ఏࠊ%$3ࠊ⎔ቃࠊ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫ࡟ࡘ࠸࡚̿

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 㸯㸬ၥ㢟࣭┠ⓗ  ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕㸦$XWLVP6SHFWUXP 'LVRUGHU$6'㸧ࡣࠊ♫఍ⓗࢥ࣑ࣗࢽࢣ࣮ࢩࣙ ࣥࡢᅔ㞴࡜⯆࿡㛵ᚰࡸ⾜ືࡢ㝈ᒁࢆ≉ᚩ࡜ࡍ ࡿ⚄⤒Ⓨ㐩⑕࡛࠶ࡿࠋ$6'ᴫᛕࡣ⌧ᅾࡶ◊✲ ▱ぢࢆཷࡅⓎᒎࡋࠊ་Ꮫⓗデ᩿ᇶ‽࡛࠶ࡿ '60㸦$PHULFDQ3V\FKLDWULF$VVRFLDWLRQ㸧 ࡶࡑࡢᙳ㡪ࢆཷࡅ࡚࠸ࡿࠋ'60࡛㏣ຍࡉࢀ ࡓឤぬ⑕≧࡛ࡣࠊ$6'ࡢ࠶ࡿᏊ࡝ࡶࡢ㸣࡟ ឤぬ㐣ᩄࡀ࠶ࡿ࡜ሗ࿌ࡋࡓㄪᰝ㸦/LVVHWDO 㸧ࢆࡣࡌࡵࠊⓎ㐩ึᮇࡢឤぬㄪ⠇୙඲ࡸ ▱ぬฎ⌮ࡢၥ㢟ࡀ♫఍ⓗᶵ⬟࡟୚࠼ࡿᙳ㡪ࡀ ♧၀ࡉࢀ࡚࠸ࡿ㸦7K\HHWDOSUHSULQW㸧ࠋࡲࡓ $6'࡜ὀពḞዴከື⑕㸦$WWHQWLRQ'HILFLW +\SHUDFWLYLW\'LVRUGHU$'+'㸧ࡢ㑇ఏࠊ⬻ᶵ ⬟ࠊㄆ▱ࠊ⾜ື㠃࡞࡝ከ㔜ࡢ࣮࢜ࣂ࣮ࣛࢵࣉ ࡢ▱ぢ㸦review࡜ࡋ࡚ࠊRommelse et al., 2011ࢆཧ↷㸧࠿ࡽࠊ'60࡛ࡣ$6'࡜$'+' ࡢྜేデ᩿ࢆㄆࡵࡿࡼ࠺࡟࡞ࡗࡓࠋ  $6'ࡢ⑓⌮࡟㛵ࡍࡿ⏕≀⛉Ꮫⓗ࢔ࣉ࣮ࣟ ࢳࡢⓎᒎࡣ┠ぬࡲࡋࡃࠊ$6'࡟㛵㐃ࡍࡿ㑇ఏ ᅉᏊ࡜⎔ቃᅉᏊ࡟㛵ࡍࡿሗ࿌ࡀከࡃฟ࡚࠸ࡿࠋ ᮏ◊✲࡛ࡣࠊ㏆ᖺࡢ▱ぢࢆᴫほࡋࠊ$6'ࡢ⑓ ⌮ⓗ⌮ゎ࡟ࡘ࠸࡚⪃ᐹࡍࡿࠋ  㸰㸬⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ⑕࡟㛵㐃ࡍࡿ㑇ఏⓗせ ᅉ࡟㛵ࡍࡿ᭱㏆ࡢືྥ  ; ᰁⰍయࡢ )05 㑇ఏᏊࡢ␗ᖖ࡟ࡼࡗ࡚ࠊ ▱ⓗ㞀ᐖࢆక࠺⬤ᙅᛶ;⑕ೃ⩌ࡀ⏕ࡌࡿࡇ࡜ ࡀ▱ࡽࢀ࡚࠸ࡿࠋ$6' ࡛ࡶྠᵝ࡟ࠊ; ᰁⰍయ ࡟࠶ࡿࢽ࣮ࣗࣟࣜࢪࣥ㸦1/*1㸧㑇ఏᏊࡢ ✺↛ኚ␗ࡀࠊᐙ᪘ᛶࡢ▱ⓗ㞀ᐖࡸ $6' ࡢᝈ ⪅⩌࠿ࡽⓎぢࡉࢀ࡚࠸ࡿ㸦/DXPRQQLHUHWHWDO  㸧ࠋ ࡲࡓ $6' ࡜ࡋࡤࡋࡤẚ㍑ࡉࢀࡿ࢘࢕ࣜ࢔ ࣒ࢬ⑕ೃ⩌ࡣ ␒ᰁⰍయ␗ᖖ࡟ࡼࡗ࡚⏕ࡌࡿࠋ ࢘࢕ࣜ࢔࣒ࢬ⑕ೃ⩌ࡣ▱ⓗ㞀ᐖࢆక࠺ࡇ࡜ࡀ ከ࠸㞀ᐖ࡛࠶ࡾࠊ$6' ࡜཯ᑐ࡟ど✵㛫ㄆ▱⬟ ຊ࡟ẚ࡭ඃࢀࡓゝㄒ⬟ຊࡸ♫஺ⓗ⾜ືࢆ♧ࡍ ࡇ࡜ࢆ≉ᚩ࡜ࡍࡿࠋ6DGDNDWDHWDO㸦㸧ࡣࠊ  ␒ᰁⰍయࡢ T㸪 ࡢ &$'36 㑇ఏᏊࢆ ࣀࢵࢡ࢔࢘ࢺࡋࡓ࣐࢘ࢫࡀࠊ௰㛫࡜ࡢ┦஫஺ ΅ࡢῶᑡ࡞࡝ $6' ᵝࡢ⾜ືᵝᘧࢆぢࡏࡓ࡜ ሗ࿌ࡋ࡚࠸ࡿࠋࡉࡽ࡟6DGDNDWD ࡽࡣࠊ$6' ⪅ ࡢ &$'36 㑇ఏᏊࡢⓎ⌧ࣃࢱࣥࢆ᳨ウࡋࡓ ⤖ᯝࠊ&$'36 ࡢኚ␗ࡀ⚄⤒ᰤ㣴ᅉᏊࡢศἪ ␗ᖖࢆ㉳ࡇࡋ⚄⤒ࢿࢵࢺ࣮࣡ࢡᙧᡂࡢ㠀ᐃᆺ ࢆࡶࡓࡽࡍྍ⬟ᛶࢆ♧၀ࡋ࡚࠸ࡿࠋ 1/*1 㑇ఏᏊࡶ &$'36 㑇ఏᏊࡶࠊࡑࡢ ኚ␗ࡣ $6' ⾲⌧ᆺࡢⓎ⌧࡟㛵୚ࡍࡿ࡜⪃࠼ ࡽࢀࡿࠋࡋ࠿ࡋࠊ࠸ࡎࢀࡢ◊✲࡛ࡶ㑇ఏᏊኚ ␗ࡀ࠶ࡗ࡚ࡶ$6' ⾲⌧ᆺࡀぢࡽࢀ࡞࠸ሙྜࠊ ࡲࡓࡣ $6' デ᩿ࡀ࠶ࡗ࡚ࡶࡇࢀࡽࡢ㑇ఏᏊ ኚ␗ࡀぢࡽࢀ࡞࠸ሙྜࡶᣦ᦬ࡉࢀ࡚࠾ࡾࠊ 1/*1 ࡢኚ␗ࡶ &$'36 ࡢኚ␗ࡶ $6' ࡢⓎ ⌧᮲௳࡜࠸࠺ࡼࡾࡶࠊ$6' ࡢⓎ⌧ࣜࢫࢡࢆቑ ຍࡉࡏࡿせᅉ࡜⪃࠼ࡓ᪉ࡀ㐺ษ࡛࠶ࡿࠋ ࡇࡢ௚࡟ࡶࠊ$6' ࡢࣜࢫࢡせᅉ࡜ࡋ࡚ೃ⿵ ࡟ᣲࡆࡽࢀࡿ㑇ఏᏊࡣ௚࡟ࡶከࡃ࠶ࡿࠋࢩࢼ ࣉ ࢫ ࢱ ࣥ ࣃ ࢡ ㉁ ࡟ 㛵 ࢃ ࡿ 㑇 ఏ Ꮚ ࡛ ࠶ ࡿ 1/*1ࠊ1/*1ࠊࢽ࣮ࣗࣞ࢟ࢩࣥ 㸦15;1㸧ࠊ 6+$1. ࡞࡝ࡀᣲࡆࡽࢀࡿࠋࡇࢀࡽࡢ㑇ఏᏊ ኚ␗ࡣࢩࢼࣉࢫཷᐜయ࡜఍ྜࡍࡿࢩࢼࣉࢫศ Ꮚࡲࡓࡣ⣽⬊㉁ศᏊࡢ᥋╔ศᏊࢆྵࡴࢩࢼࣉ ࢫࢱࣥࣃࢡ㉁࡟ᙳ㡪ࢆ୚࠼ࡿࠋࡇࢀࡽࡢ㑇ఏ Ꮚኚ␗࡟㛵ࡍࡿ▱ぢ࠿ࡽࠊ$6' ᵝࡢኚ␗ࡣࠊ 㑇ఏᏊࡢࢥ࣮ࢻ㓄ิ࡛ࡣ࡞ࡃࠊࡴࡋࢁ㑇ఏᏊ ㌿෗ࡢࣃࢱࣥࢆㄪ⠇ࡍࡿ㠀ࢥ࣮ࢻ㓄ิࢆྵࡴ 㸫  㸫 作新学院大学心理学研究科臨床心理センター

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࡜⪃࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࠋᚑࡗ࡚ࠊ༢୍㑇ఏᏊ ⑌ᝈࡢࡼ࠺࡞ࢥ࣮ࢻ㓄ิࡢ㠀ᐃᆺ࡟ࡼࡿ࡜⪃ ࠼ࡿࡼࡾࡣࠊ」ᩘࡢ⚄⤒ఏ㐩࠾ࡼࡧ⚄⤒Ⓨ㐩 ࡟࠾ࡅࡿࢩࢼࣉࢫୖࡢ㠀ᐃᆺࡢຍ㔜࡟ࡼࡗ࡚ $6' ᵝࡢㄆ▱ⓗ࣭⾜ືⓗ≉ᚩࢆ⾲⌧ࡍࡿ࡜⪃ ࠼ࡽࢀࡿࠋࡇࡢࡼ࠺࡞㑇ఏⓗ⫼ᬒ࡟⏕ᚋࡢ⎔ ቃᅉᏊࡀຍࢃࡿࡇ࡜࡛ࠊ$6' ࡟࠾ࡅࡿ♫఍ᛶ 㞀ᐖࡢࢫ࣌ࢡࢺ࣒ࣛᛶ࡜࠸ࡗࡓከᵝ࡞ $6' ⾲⌧ᆺ࡟⮳ࡿ࡜⪃࠼ࡽࢀࡿࠋ  㸱㸬ᗈᇦ࡞⮬㛢ⓗ⾲⌧ᆺ㸦%URDGHU $XWLVP 3KHQRW\SH%$3㸧ࡢㄆ▱⚄⤒⏕⌮Ꮫⓗ◊✲ $6' ࡢ࠶ࡿᏊ࡝ࡶࢆࡶࡘ୧ぶࡸࡁࡻ࠺ࡔ ࠸࡟࠾࠸࡚ࠊデ᩿㜈ୗ࡛࠶ࡿࡶࡢࡢࠊ$6' ᵝ ࡢഴྥࢆ♧ࡍࡇ࡜ࡀ࠶ࡿࡇ࡜ࡣ⮫ᗋⓗ࡟ࡼࡃ ▱ࡽࢀ࡚࠸ࡿࠋ㏆ᖺ࡛ࡣࠊ$6' ࡢ࠶ࡿேࡢᐙ ᪘ࢆᑐ㇟࡟ࠊ$6' 㛵㐃㑇ఏᏊ࡜ $6' ᵝࡢ⚄ ⤒⏕⌮Ꮫⓗ཯ᛂࡸ⾜ືഴྥࡢ㛵ಀᛶࢆ᫂ࡽ࠿ ࡟ࡋࠊከᵝ࡞ $6' ⾲⌧ᆺࡢㄝ᫂ࢆヨࡳࡿ◊ ✲ࡀ⾜ࢃࢀ࡚࠸ࡿࠋࡑࡢࡼ࠺࡞◊✲࡛ࡣࠊデ ᩿ⓗᐃ⩏࡟ࡼࡿ $6' ࡼࡾࡶከᵝ࡞≧ែࢆ♧ ࡍデ᩿㜈ୗࡢ $6' ᵝ⾲⌧ᆺࢆࠊ%URDGHU $XWLVP3KHQRW\SH%$3㸦ᗈỗ࡞⮬㛢ⓗ⾲⌧ᆺ㸧 ࡜࿧ࢇ࡛࠸ࡿ㸦3LYHQHWDO㸧ࠋ  :KHHOZULJKWHWDO   ࡣ$6'࡜ᐃᆺⓎ㐩 ࡢ࠶ࡿᏊ࡝ࡶࡢ୧ぶࢆᑐ㇟࡟ࠊ⮬㛢ࢫ࣌ࢡࢺ ࣒ࣛᣦᩘ㸦$XWLVP4XRWLHQW$4%DURQ&RKHQ  HWDO㸧ࢆ⏝࠸࡚୧ぶࡢ %$3 ≉ᛶࢆㄪᰝ ࡋࡓࠋ:KHHOZULJKW ࡽࡣࠊ୧ぶࡢ $4 ᚓⅬࡢᖹ ᆒࡼࡾ6' ௨ୖ 6' ᮍ‶࡛ $4 ᚓⅬࡀ᭷ព ࡟㧗࠸ࢢ࣮ࣝࣉࢆ%$3ࠊ6' ௨ୖ $6' ᮍ‶ ࡢࢢ࣮ࣝࣉࢆ0HGLXP$XWLVWLF3KHQRW\SH0$3ࠊ 6' ௨ୖ $4 ᚓⅬࡀ㧗࠸ࢢ࣮ࣝࣉࢆࠊࡼࡾ᫂ ☜࡟ $6' ࡟㏆࠸ࢢ࣮ࣝࣉ࡜ࡋ࡚ 1DUURZ $XWLVP 3KHQRW\SH㸦1$3ࠊ⊃⩏ࡢ⮬㛢ⓗ⾲⌧ ᆺ㸸ࡼࡾ඾ᆺⓗ࡞⮬㛢⑕≧ࢆ♧ࡍ㸧࡜᧯సⓗ ࡟ᐃ⩏ࡋࡓࠋ ㄪᰝࡢ⤖ᯝࠊ$6' ࡢ࠶ࡿᏊ࡝ࡶࡢ୧ぶ⩌࣭ ᐃᆺⓎ㐩୧ぶ⩌࡜ࡶ࡟⮫ᗋⓗ࡞௓ධࡢᚲせᛶ ࡀ࡞ࡃ࡚ࡶ $6' ഴྥࢆᣢࡘࢢ࣮ࣝࣉࡀᏑᅾ ࡍࡿࡇ࡜ࢆ♧ࡋࡓࠋ≉࡟ࠊ$6' ࡢᏊ࡝ࡶࢆࡶ ࡘ∗ぶ⩌㸦Q  ྡ㸧ࡣࠊ%$3 ࠿ࡽ 1$3 ࡲ ࡛ࢆྜࢃࡏࡿ࡜㸣ࡢேࡀ $6' ᵝࡢ⾜ື࣭ ᛶ᱁ഴྥࢆ♧ࡋ࡚࠾ࡾࠊ$6' ẕぶ⩌ 㸣ࠊ ᐃᆺⓎ㐩∗ぶ⩌㸣ࠊᐃᆺⓎ㐩ẕぶ⩌ 㸣࡜ ẚ࡭≉ᚩⓗ࡛࠶ࡗࡓࠋᚑࡗ࡚ࠊ:KHHOZULJKW ࡽࡣ$4 ࡀ⮫ᗋⓗࢫࢡ࣮ࣜࢽࣥࢢࡔࡅ࡛࡞ࡃࠊ デ᩿㜈ୗࡢ $6' ᵝ≉ᛶ࡟㛵㐃ࡍࡿ㑇ఏⓗ㢮 ఝᛶ࡟ࡘ࠸࡚ࠊ㛫᥋ⓗ࡟ホ౯࡛ࡁࡿ࡜ㄽࡌ࡚ ࠸ࡿࠋ %$3 ◊✲࡛ࡣ $4 ࡛ホ౯ࡉࢀࡿ୺ほⓗ࡞⾲ ⌧ᆺࡔࡅ࡛࡞ࡃࠊ%$3 ࡢㄆ▱≉ᛶࡸ⚄⤒⏕⌮ ᏛⓗほⅬ࠿ࡽࡢ᳨ウࡶ࠶ࡿࠋ౛࠼ࡤࠊ᪥㧗 㸦㸧ࡸ +LGDNDHWDO  ࡣࠊ⾲᝟ㄆ▱ㄢ 㢟࡜஦㇟㛵㐃㟁఩ࢆ⏝࠸࡚ࠊ$6' ≉ᛶࡀ㧗࠸ ᐃᆺⓎ㐩㟷ᖺ࡯࡝ࠊ⾲᝟⌮ゎ࡟㛵ࢃࡿ஦㇟㛵 㐃㟁఩ᡂศ1 ࡜ᩥ⬦࠿ࡽࡢ㐓⬺᳨ฟ࡟㛵 ࢃࡿ1 ࡀῶ⾶ࡍࡿࡇ࡜ࢆሗ࿌ࡋࠊ%$3 ࡶ ࡲࡓ⾲᝟࡜࠸࠺♫఍่⃭ࡢฎ⌮ࡀ㠀ᐃᆺ࡛࠶ ࡿྍ⬟ᛶࢆㄽࡌ࡚࠸ࡿࠋࡲࡓI05, ◊✲࡛ࡶ ྠᵝ࡟ࠊᐃᆺⓎ㐩୧ぶ⩌ࡸ %$3 ࢆ♧ࡉ࡞࠸ $6' ୧ぶ⩌࡜ẚ࡭ࠊ$6' ࡢ࠶ࡿᏊ࡝ࡶࡢ୧ ぶࡢ୰࡛ࡶ%$3 ࢆ♧ࡍ୍⩌ࡣࠊ()07 ㄢ㢟୰ ࡟⣳㗽≧ᅇ࡜ᡥ᱈యࡀ㐣๫άᛶࡋ࡚࠸ࡿࡇ࡜ ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋ $6' ࡢᐙ᪘࡟࠾ࡅࡿ %$3 ◊✲ࡸࣜࢫࢡඣ ࡢⓎ㐩ึᮇ◊✲ࡣࠊࡑࡢ╔᝿࡜ࡋ࡚ࠊ୧ぶࢆ $6' ࡟㛵㐃ࡍࡿ㑇ఏᏊࢆࡶࡘಖᅉ⪅࡜ࡋ࡚ ᢅࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋ୍᪉ࠊ$6' ࡢ࠶ࡿ ᡂேࡢ⤖፧ࡸฟ⏘ࡢㄢ㢟ࢆ㋃ࡲ࠼࡚ࠊ:DOVKHW DO   ࡣࠊ$6' 㛵㐃㑇ఏᏊࡀࢲ࣮࢘࢕ࣥ ⓗ࡞㈇ࡢ㑅ᢥ㸦QHJDWLYHVHOHFWLRQ㸧ࣔࢹࣝ࡟㏫ ⾜ࡋ࡚࠸ࡿࡇ࡜ࢆᣦ᦬ࡋ࡚࠸ࡿࠋࡘࡲࡾࠊᏊ Ꮮࢆṧࡍ☜⋡ࡀᑠࡉ࠸$6' ⪅࠿ࡽ $6' ࣜࢫ ࢡせᅉࡢ㑇ఏⓗఏ㐩ࡀ⥔ᣢࡉࢀࡿ࡜ࡣ⪃࠼࡟ ࡃ࠸ࠊ࡜࠸࠺ࡶࡢ࡛࠶ࡿࠋࡑࡇ࡛:DOVK ࡽࡣࠊ ▱ⓗ㞀ᐖࠊ࡚ࢇ࠿ࢇࠊඛኳᛶᚰ⑌ᝈ࡜ྠᵝ࡟ࠊ $6' ࡢࣜࢫࢡせᅉ࡛࠶ࡿ㑇ఏᏊࡢ✺↛ኚ␗ 㸫  㸫 作新学院大学心理学研究科臨床心理センター

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ࡀGH QRYR ኚ␗࡜ࡋ࡚㢖⦾࡟⏕ࡌ࡚࠸ࡿ࡜⪃ ࠼࡚࠸ࡿࠋ $6' ࡢ㑇ఏⓗせᅉࢆ $6' 㛵㐃㑇ఏᏊࡢಖ ᅉ࡜ఏ㐩࡜࠸࠺༢୍ࡢᅗᘧ࡛⪃࠼ࡿࡇ࡜ࡣࠊ 㠀ᖖ࡟༢⣧໬ࡉࢀࡓ࣓ࣥࢹࣝⓗⓎ᝿࡜ゝ࠺ࡇ ࡜ࡀ࡛ࡁࡿࠋࡲࡓ $6' ࡢ≉ᛶࡸ⑕≧ࡀ≉ᐃ ࡢ㑇ఏᏊࡢ᭷↓ࡔࡅ࡛Ỵᐃࡉࢀࡿࡢ࡛࠶ࢀࡤࠊ ⑕≧ࡢ㔜⠜ᗘࡸ %$3 ࡜࠸ࡗࡓ㢮ఝࡢከᵝ࡞ ⾲⌧ᆺࡀ⏕ࡌࡿࡇ࡜ࢆㄝ᫂ࡋ࡟ࡃ࠸ࠋᚑࡗ࡚ࠊ $6' ࡢ㑇ఏⓗࣜࢫࢡࡣࠊ$6' 㛵㐃㑇ఏᏊࡢ ᐙ᪘㞟✚ᛶ࡜ࠊ㧗☜⋡࡛⏕ࡌࡿGH QRYR ኚ␗ ࡟ࡼࡿ $6' 㛵㐃㑇ఏᏊࡢ⋓ᚓࠊ཮᪉࡟ࡼࡿ ࡜⪃࠼ࡓ᪉ࡀྜ⌮ⓗ࡛࠶ࡿࠋ㑇ఏⓗኚ␗ࡢ㉁ ࡸᩘ࡟ࡼࡗ࡚ࠊ$6' ⾲⌧ᆺࡢⓎ⑕ࣜࢫࢡࡸ㔜 ⠜ᗘࠊ%$3 ࡜࠸ࡗࡓከᵝ࡞⾲⌧ᆺࡀ⏕ࡌࡿ࡜ ࠸ࡗࡓ᪉ࡀ $6' ࡢࢫ࣌ࢡࢺ࣒ࣛᛶ࡜࠸࠺⌧ ㇟ࢆࡼࡃㄝ࡛᫂ࡁࡿࡔࢁ࠺ࠋ ࡇࢀࡲ࡛ᴫほࡋࡓ࡜࠾ࡾࠊከࡃࡢ␗࡞ࡿ㑇 ఏᏊࡢኚ␗ࡀᗈỗ࡞ $6' ≉ᛶࡢ⾲⌧࡟㛵୚ ࡍࡿࠋࡑࡋ࡚Ⓨ㐩㐣⛬࡟࠾࠸࡚ࠊࡑࡢಶయࡀ ⏕άࡍࡿ⎔ቃ࡜ࡢ┦஫స⏝࡟ࡼࡗ࡚ࠊ⚄⤒Ⓨ 㐩࡜⾜ື≉ᛶࡢ㠀ᐃᆺࡀḟ➨࡟ᙧసࡽࢀࡿ࡜ ⪃࠼ࡽࢀࡿࠋḟ⠇࡛ࡣࠊ$6' ࡟㛵㐃ࡍࡿ⎔ቃ せᅉ࡟ࡘ࠸࡚㏆ᖺࡢ◊✲ᡂᯝࢆ᳨ウࡍࡿࠋ  㸲㸬$6'࡟࠾ࡅࡿ⎔ቃせᅉ࡟㛵ࡍࡿ㏆ᖺࡢ◊ ✲ືྥࠊ࠾ࡼࡧྰᐃࡉࢀࡿ⎔ቃⓗ௓ධ㸦࣡ࢡ ࢳࣥᅇ㑊ࠊ࣮࢟ࣞࢺ⒪ἲࠊ㣗஦⒪ἲ㸧 ࢖ࣥࢱ࣮ࢿࢵࢺ࡛ㄪ࡭ࡿࡇ࡜ࡢ࡛ࡁ$6' ⒪⫱࡟㛵ࡍࡿ᝟ሗ࡛ࡣࠊᵝࠎ࡞⎔ቃせᅉࡀྲྀ ࡾୖࡆࡽࢀ࡚࠸ࡿࡀࠊ⛉Ꮫⓗドᣐ࡟ᨭ࠼ࡽࢀ ࡓ᝟ሗ࡜ࠊㄗࡗࡓ᝟ሗࡸಶேࡢಙᛕ࡟ࡶ࡜࡙ ࡃẸ㛫ಙ௮ࡢࡼ࠺࡞᝟ሗࡀ➼౯࡟ᢅࢃࢀ࡚࠸ ࡿࠋࡑࡢࡓࡵࠊ᪥ᮏ࡛ࡣᖺ᭶࡟ࠊ་⒪ ࡸ೺ᗣ࡟㛵ࡍࡿከࡃࡢ࣮࢟ࣗࣞࢩࣙࣥࢧ࢖ࢺ ࡀࠊಙ㢗ᛶ࡟Ḟࡅ⿕ᐖࢆࡶࡓࡽࡍ࠾ࡑࢀࡀ࠶ ࡿ࡜ࡋ࡚බ㛤ࢆ୰Ṇࡋࡓࠋࡑࡇ࡛ᮏ◊✲࡛ࡣ $6'࡟࠾ࡅࡿ⎔ቃせᅉ࡟ࡘ࠸࡚㏆ᖺࡢሗ࿌ ࡟⤠ࡗ᳨࡚ウࡋ࡚࠸ࡃࠋ Ⓨ㐩ึᮇࢆᢅࡗࡓ཮⏕ඣ◊✲࡛ࡣࠊ$6'⾲ ⌧ᆺࡢⓎ⌧࡟࠾ࡅࡿ㑇ఏⓗせᅉࡢᙳ㡪ࡣ㸣 ௨ୖ࡛࠶ࡾࠊ⎔ቃⓗせᅉࡢᙳ㡪ࡣᑡ࡞࠸࡜ࡉ ࢀࡿ㸦5RQDOG +RHNVWUD㸧ࠋ୍᪉ࠊ$6' ⾲⌧ᆺ࡟ᙳ㡪ࢆ୚࠼ࡿ⎔ቃせᅉ࡟㛵ࡍࡿ኱つ ᶍㄪᰝ࡛ࡣ⎔ቃせᅉࡢࡀ$6'⾲⌧ᆺ ࡟ᙳ㡪ࢆ୚࠼ࡿྍ⬟ᛶࢆᣦ᦬ࡋ࡚࠸ࡿ 㸦UHYLHZ࡜ࡋ࡚0RGDEEHUQLDHWDOࢆཧ ↷㸧ࠋ ⎔ቃせᅉ࡟㛵ࡍࡿ◊✲࡛ࡣࠊ㐣ཤ࡟␲ࢃࢀ ࡓࡶࡢࡀ⌧ᅾྰᐃࡉࢀ࡚࠸ࡿࡶࡢࡶከ࠸ࠋ౛ ࠼ࡤࠊ$6'ࡢ⎔ቃせᅉ࡜ࡋ࡚㐣ཤᣦ᦬ࡉࢀࡓ ẕぶࡢዷፎ୰ࡢႚ↮࡟ࡘ࠸࡚ࠊ㏆ᖺࡢࣞࣅࣗ ࣮࡛ࡣࠊฟ⏘ᚋࡢ$6'࡜ࡢ㛵㐃ࢆぢ࠸ࡔࡏ࡚ ࠸࡞࠸㸦5RVHQHWDO㸧ࠋ⫾ෆ࡛ࡢࢽࢥࢳ ࣥᭀ㟢࡟ࡼࡿඛኳወᙧ࡞࡝ࡢၥ㢟ࡣ㐣ᑠホ౯ ࡉࢀࡿ࡭ࡁ࡛ࡣ࡞࠸ࡀࠊ$6'Ⓨ⑕ࣜࢫࢡ࡜ࡣ ศࡅ࡚㆟ㄽࡍࡿᚲせࡀ࠶ࡿࡔࢁ࠺ࠋ ࣡ࢡࢳࣥࡢண㜵᥋✀ࠊ࠶ࡿ࠸ࡣ࣡ࢡࢳࣥࡢ ಖᏑ๣࡜ࡋ࡚ྵࡲࢀࡿࢳ࣓ࣟࢧ࣮ࣝ㸦࢚ࢳࣝ Ỉ㖟໬ྜ≀㸧ᭀ㟢࡟ࡘ࠸࡚ࡶࠊ$6'Ⓨ⑕ࣜࢫ ࢡ࡜ࡢ㛵㐃ᛶࡣྰᐃࡉࢀ࡚࠸ࡿࠋ7D\ORUHWDO   ࡣࠊࡘࡢࢥ࣮࣍ࢺ◊✲ࢆ࣓ࢱศᯒࡋࠊ ୕✀ΰྜ࣡ࢡࢳࣥࠊࢳ࣓ࣟࢧ࣮ࣝ㸦࢚ࢳࣝỈ 㖟㸧࡜$6'ࡢⓎ⑕ࣜࢫࢡ࡟ࡘ࠸᳨࡚ウࡋࡓ⤖ ᯝࠊࡑࡢ㛵㐃ᛶࡀぢࡽࢀ࡞࠿ࡗࡓ࡜⤖ㄽ࡙ࡅ ࡚࠸ࡿࠋࡉࡽ࡟$6'ࡔࡅ࡛࡞ࡃ$'+'➼⚄⤒ Ⓨ㐩⑕࡬ࡢᙳ㡪ࡶྵࡵࡓ࣓ࢱศᯒ㸦<RVKLPDVX HWDO㸧ࡶ⾜ࢃࢀ࡚࠸ࡿࠋ<RVKLPDVXࡽࡢ ศᯒ࡛ࡶࠊ࣡ࢡࢳࣥ᥋✀ࠊࢳ࣓ࣟࢧ࣮ࣝ࡜ $6'ࠊ$'+'ࡢⓎ⑕ࣜࢫࢡ࡜ࡢ㛵ಀࡣㄆࡵࡽ ࢀ࡞࠿ࡗࡓࠋ≉࡟<RVKLPDVXࡽࡣࠊ⫾ඣᮇ࡟࠾ ࡅࡿ⎔ቃ࠿ࡽࡢỈ㖟ᭀ㟢࡟㛵ࡍࡿ◊✲ࡣᑡ࡞ ࡃៅ㔜࡞ゎ㔘ࡀᚲせ࡛࠶ࡾࠊࡲࡓฟ⏘ᚋ࡟⤒ 㦂ࡍࡿⓎ㐩ึᮇࡢỈ㖟ᭀ㟢࡜⚄⤒Ⓨ㐩⑕ࡢ㛵 ಀࡣㄆࡵࡽࢀ࡞࠸࡜ሗ࿌ࡋ࡚࠸ࡿࠋ ᪥ᮏ࡟࠾ࡅࡿ࣡ࢡࢳࣥ࡜ࢳ࣓ࣟࢧ࣮ࣝࡢྲྀ ࡾᢅ࠸ືྥࡣࠊᶓ὾ᕷ⾨⏕ᒁࡢሗ࿌࡟ࡼࡿ࡜ ࢳ࣓ࣟࢧ࣮ࣝῧຍࡢ࣡ࢡࢳࣥࢆஙᗂඣࡀᦤྲྀ 㸫  㸫 作新学院大学心理学研究科臨床心理センター

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ࡍࡿᶵ఍ࡣ୕✀ΰྜ࣡ࢡࢳࣥࡢࡳ࡛࠶ࡾࠊࡲ ࡓࢳ࣓ࣟࢧ࣮ࣝᭀ㟢㔞ࡶ࢔࣓ࣜ࢝࡟ẚ࡭ࡿ࡜ ᴟࡵ࡚ప࠸್࡟࡞ࡗ࡚࠸ࡿ㸦$6'࡜࣡ࢡࢳࣥ ᥋✀ࠊỈ㖟ࡢ㛵ಀ࡟ࡘ࠸࡚ࠊヲ⣽ࡣᶓ὾ᕷ⾨ ⏕ᒁࢆཧ↷㸧ࠋ ࢳ࣓ࣟࢧ࣮ࣝ➼࢚ࢳࣝỈ㖟࡟㛵㐃ࡋ࡚ࠊ㔜 㔠ᒓ࡟ࡼࡿẘᛶ᭚㟢ࡢ┤᥋ⓗ࡞ᙳ㡪࡜$6' ࡜ࡢ㛵㐃࡟ࡘ࠸࡚ࠊ5RVVLJQROHWDO   ࡀ⣔ ⤫ⓗࢩࢫࢸ࣒ࣞࣅ࣮ࣗࢆ⾜ࡗ࡚࠸ࡿࠋ 5RVVLJQROࡽࡣࠊ↓ᶵỈ㖟ࠊ㖄ࠊ࢝ࢻ࣑࣒࢘ࠊ ࢔࣑ࣝࢽ࣒࢘ࠊ࠾ࡼࡧࣄ⣲࡟ࡘ࠸࡚ࠊ⾑ᾮࠊ ẟ㧥ࠊṑࠊᒀࠊ⬻࡟࠾ࡅࡿ㔠ᒓ⃰ᗘ࡟㛵ࡍࡿ ␿Ꮫ◊✲ࢆศᯒࡋࡓ⤖ᯝࠊ༙ศ௨ୖࡢ◊✲࡛ࠊ ᑐ↷⩌࡜ẚ㍑ࡋࡓ$6'⩌࡟᭷ព࡞ୖ᪼ࡣ♧ ࡉࢀࡎࠊ▱ぢࡀ୍㈏ࡋ࡞࠸࡜ሗ࿌ࡋ࡚࠸ࡿࠋ ࡉࡽ࡟5RVVLJQROࡽࡣࠊ↓ᶵỈ㖟ࡸ㖄࡜$6'ࡢ 㔜⑕ᗘࡀ┦㛵ࡍࡿ࡜ࡋࡓࡢ◊✲࡜ࠊయෆࡢỈ 㖟࡞࡝᭷ᐖ㔠ᒓࢆ᤼ฟࡍࡿ࣮࢟ࣞࢺ⒪ἲࡀ $6'ࡢ⑕≧ࢆᨵၿࡋࡓ࡜ࡍࡿࡢ◊✲ࢆศ ᯒࡋ࡚࠸ࡿࠋࡇࢀࡽࡢ௳ࡢ◊✲࡟ࡘ࠸࡚ࠊ ࣉࣛࢭ࣎⩌࡞࡝㐺ษ࡞ホ౯᪉ἲ࡟ࡼࡿ◊✲ࢹ ࢨ࢖ࣥࡀࡉࢀ࡚࠾ࡽࡎࠊ$6'⑕≧࡜㔜㔠ᒓࡢ 㛵ಀࡸ࣮࢟ࣞࢺ⒪ἲ࡟ࡼࡿᨵၿຠᯝ࡟ࡘ࠸࡚ ṇᙜ࡞ホ౯ࡣᅔ㞴࡛࠶ࡿ࡜ࡋ࡚࠸ࡿࠋ 㔜㔠ᒓ࡜$6'⑕≧࡜ࡢᅉᯝ㛵ಀࡀド᫂ࡉ ࢀ࡞࠸ࡲࡲࠊ$6'⒪⫱࡟࣮࢟ࣞࢺ⒪ἲࡀཧධ ࡍࡿࡇ࡜࡟ࡘ࠸࡚ࠊ㔜せ࡞ࣞࣅ࣮ࣗࡀⓎ⾲ࡉ ࢀ࡚࠸ࡿ㸦-DPHVHWDO㸧ࠋ-DPHVࡽࡣࠊ $6'ࡢ࠶ࡿᏊ࡝ࡶ࡟ᑐࡍࡿ࣮࢟ࣞࢺ⒪ἲ࡟ ࡘ࠸࡚ࠊࣉࣛࢭ࣎࡜ẚ㍑ࡋࡓࣛࣥࢲ࣐࢖ࢬẚ ㍑ヨ㦂ࡢ▱ぢࡔࡅࢆ㞟ࡵ࡚ศᯒࢆ⾜ࡗࡓࠋࡑ ࢀࡽࡢ◊✲࡛ࡣ㧗⃰ᗘࡢ㔜㔠ᒓ᤼ฟࢆࡋࡓᏊ ࡝ࡶ࡟ᑐࡋ࡚ࠊ⤒ཱྀࢪ࣓ࣝ࢝ࣉࢺࢥࣁࢡ㓟 㸦'06$㸧ࢆᢞ୚ࡋࡓ㝿ࡢ᭷ຠᛶ࡟ࡘ࠸࡚ࣉ ࣛࢭ࣎࡜ẚ㍑ࡋ࡚࠸ࡿࠋ-DPHVࡽࡣࠊࡇࢀࡽࡢ ◊✲ࡀ඲య࡜ࡋ࡚⤒ཱྀ'06$ࡀ$6'⑕≧࡟ᙳ 㡪ࢆཬࡰࡋ࡚࠸࡞࠸ࡇ࡜ࠊ࣮࢟ࣞࢺ⒪ἲ࡟ࡼ ࡿప࢝ࣝࢩ࣒࢘⾑⑕ࡸ⭈㞀ᐖ࡞࡝ࡢ㔜⠜࡞᭷ ᐖ஦㇟ࡢࣜࢫࢡ࡟ぢྜ࠺ຠᯝࡀ࡞࠸ࡇ࡜ࢆᣦ ᦬ࡋࠊ$6'ࡢ⑕≧⟶⌮ࡢࡓࡵ࡟࣮࢟ࣞࢺ⒪ἲ ࢆ⾜࠺࡭ࡁ࡛ࡣ࡞࠸࡜⤖ㄽ࡙ࡅ࡚࠸ࡿࠋ ᰤ㣴ᡂศࡶࡋࡤࡋࡤ㆟ㄽ࡟࡞ࡿ⎔ቃせᅉࡢ ࡘ࡛࠶ࡿࠋ0RGGDEHPLDࡽࡣ」ᩘࡢ࣓ࢱࣞࣅ ࣮ࣗ◊✲ࢆࡶ࡜࡟ࠊⴥ㓟ࡸȰ⬡⫫㓟ࠊࣅࢱ ࣑ࣥ࡟ࡘ࠸࡚ㄽࡌ࡚࠸ࡿࠋ౛࠼ࡤࠊ⫾ඣᮇ࡟ ࠾ࡅࡿⴥ㓟ࡢḞஈࡣࠊ≉࡟ዷፎึᮇ࡟࠾ࡅࡿ ஧ศ⬨᳝࡞࡝ࡢ⚄⤒⟶㛢㙐㞀ᐖ࡜ࡢ㛵㐃ࡀ᭷ ྡ࡛࠶ࡿࡀࠊ$6'ࡢⓎ⑕ࣜࢫࢡ࡜ࡢ㛵ಀࡣỴ ᐃⓗ࡛࡞࠸ࠊ࡜ሗ࿌ࡋ࡚࠸ࡿࠋ ฟ⏕ᚋࡢᰤ㣴Ꮫⓗ࡞どⅬ࡛ࡣࠊ$'+'ࡢ࠶ ࡿᏊ࡝ࡶࡢȰ⬡⫫㓟ࡢḞஈࡣከື⑕≧࡜㛵 㐃ࡍࡿ㸦5LFKDUGVRQ㸧࡜࠸࠺▱ぢࡸࠊȰ ⬡⫫㓟ࡢ⿵඘ࡀ࣮࣡࢟ࣥࢢ࣓ࣔࣜㄢ㢟ᡂ⦼ ࢆྥୖࡉࡏࡿ㸦ࡋ࠿ࡋࠊᩍᖌ࡟ࡼࡿ⾜ືホᐃ ࡟ࡣ㛵㐃ࡋ࡞࠿ࡗࡓࠋ:LGHQKRUQ0OOHUHWDO 㸧࡜࠸࠺▱ぢࡶ࠶ࡿࠋࡋ࠿ࡋࠊ$6'ࣜࢫ ࢡ࡜ࡢ㛵㐃ࡣ」ᩘࡢ▱ぢ୍࡛㈏ࡋ࡚࠸࡞࠸ࠋ ࡲࡓࣅࢱ࣑ࣥ࡟ࡘ࠸࡚ከࡃࡢ⣔⤫ⓗࣞࣅࣗ ࣮࡟࠾࠸࡚ࠊ⫾ඣᮇ࣭ฟ⏕ᚋࡢ$6'ࣜࢫࢡ࡜ ࡢ㛵㐃ࡀ୙᫂░࡛࠶ࡗࡓࡀࠊ$6'ࡢ࠶ࡿᏊ࡝ ࡶ࡛ࡣࣅࢱ࣑ࣥ'ࡢḞஈࡀ୍㈏ࡋ࡚࠶ࡿ࡜ࡢ ሗ࿌ࡀ࠶ࡿ㸦:DQJHWDO㸧ࠋࣅࢱ࣑ࣥ' Ḟஈ࡜Ⓨ⑕ࣜࢫࢡࡸ⑕≧ࡢ㔜⠜ᗘ࡜ࡢ㛵㐃ࡣ ௒ᚋࡶ᳨ウㄢ㢟࡛࠶ࡿࡀࠊ:DQJࡽ࡟ᑐࡍࡿࢥ ࣓ࣥࢺㄽᩥ࡛ࡣࠊ$6'࡟࠾ࡅࡿࣅࢱ࣑ࣥ'Ḟ ஈࡣ៏ᛶⓗ࡞⎔ቃ12㸦ள㓟໬❅⣲㸧᭚㟢ࡢ ቑຍ࡟ᑐࡍࡿᜏᖖᛶࡢ࠶ࡿᛂ⟅ࡢྍ⬟ᛶࡀᣦ ᦬ࡉࢀ࡚࠸ࡿ㸦)OXHJJH㸧ࡓࡵࠊ:DQJࡽ ࡢ⤖ᯝࡢゎ㔘ࡣៅ㔜࡟⾜࠺ᚲせࡀ࠶ࡿࡔࢁ࠺ࠋ ⫾ඣᮇ࡟࠾ࡅࡿᰤ㣴ᡂศ࡜Ⓨ⑕ࣜࢫࢡࠊ࠾ ࡼࡧฟ⏕ᚋࡢᰤ㣴ᡂศ࡜⑕≧ࡢ㔜⠜ᗘ࡟ࡘ࠸ ࡚ࡣࠊ௒ᚋࡶ᳨ウࡀᚲせ࡛࠶ࡿࠋᚑࡗ࡚ࠊᰤ 㣴ᡂศࡔࡅ࡟$6'ࣜࢫࢡࡢཎᅉࢆồࡵࡓࡾࠊ ⿵ຓⓗ἞⒪ࡸ௦᭰⒪ἲ࡜ࡋ࡚ண㜵ຠᯝࡸ἞⒪ ຠᯝࡀ࠶ࡿ࡜ࡋࡓࡾࡍࡿ࡯࡝ᙉᅛ࡞▱ぢࡣ࡞ ࠸ࠋ⌧ẁ㝵࡟࠾࠸࡚ࡣࠊᮇᚅࡍ࡭ࡁ◊✲㡿ᇦ ࡜ㄆ㆑ࡍࡿ࡜࡜ࡶ࡟ࠊ࠸ࡲࡔຠᯝࡀ୙☜࠿࡞ ࡶࡢ࡜ࡋ࡚ࠊ$6'ࡢ࠶ࡿᏊ࡝ࡶࡸࡑࡢಖㆤ⪅ 㸫  㸫 作新学院大学心理学研究科臨床心理センター

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࡟୙฼┈ࢆ⏕ࡌࡉࡏࡿ༴㝤ᛶࡶేᏑࡋ࡚࠸ࡿ ࡇ࡜ࢆ⌮ゎࡍࡿᚲせࡀ࠶ࡿࠋ  㸳㸬ࣜࢫࢡࣇ࢓ࢡࢱ࣮࡜ࡋ࡚ࡢ⎔ቃせᅉ࡟㛵 ࡍࡿ◊✲ୖࡢㄢ㢟 $6'ࡢⓎ⑕ࣜࢫࢡ࡜ࡋ࡚ᨭᣢⓗ▱ぢࡀ୍ ㈏ࡋ࡚ᚓࡽࢀ࡚࠸ࡿ⎔ቃせᅉࡶᏑᅾࡍࡿࠋ 0RGGDEHPLDࡽࡣ」ᩘࡢ࣓ࢱࣞࣅ࣮ࣗ࠿ࡽࠊ $6'ࡢࣜࢫࢡࢆ㧗ࡵࡿࡶࡢ࡜ࡋ࡚ࠊ୧ぶࡢᖺ 㱋ࠊẕぶࡢ⫧‶ࠊẕయ⢾ᒀ⑓ࠊᖇ⋤ษ㛤࡞࡝ ࡢ௚ࡢዷፎ㛵㐃せᅉࡀ$6'ࡢࣜࢫࢡ࡜㛵㐃 ࢆ♧ࡋ࡚࠸ࡿ࡜ࡋ࡚࠸ࡿࠋࡲࡓእയࡸ⹫⾑࠾ ࡼࡧప㓟⣲࡟㛵㐃ࡍࡿㄌ⏕ࡢྜే⑕ࡶ$6' ࡜ᙉ࠸㛵㐃ᛶࢆ♧ࡋ࡚࠸ࡿ࡜ሗ࿌ࡋ࡚࠸ࡿࠋ ࡋ࠿ࡋࠊࡇࢀࡽࡀ┤᥋$6'⾲⌧ᆺࡢᅉᯝ㛵ಀ ࡟࡞ࡗ࡚࠸ࡿ࡜ࡣ⪃࠼࡟ࡃࡃࠊ␲ఝ┦㛵㛵ಀ ࡀ␲ࢃࢀ࡚࠸ࡿࠋ ⎔ቃᅉᏊ࡜$6'࡜ࡢ㛵㐃ࡢ࣓࢝ࢽࢬ࣒࡟ ࡘ࠸࡚㆟ㄽࡉࢀ࡚࠸ࡿࡀࠊ␿Ꮫㄪᰝࢆ୰ᚰ࡜ ࡍࡿࡓࡵࠊ஺⤡ࡋࡸࡍࡃࠊ༢୍ࡢ▱ぢࡸ௬ㄝ ࡟ࡼࡗ࡚㆟ㄽࡍࡿࡇ࡜ࡣៅ㔜࡟࡞ࡿᚲせࡀ࠶ ࡿࡔࢁ࠺ࠋ஺⤡ࢆྵࡴ㠀ᅉᯝ㛵ಀࡢ᥎ᐃࡸࣔ ࢹࣝ໬ࠊ㑇ఏᏊ࡟୚࠼ࡿຠᯝࠊ⚄⤒Ⓨ㐩࡟୚ ࠼ࡿᙳ㡪ࠊ⚄⤒ఏ㐩≀㉁ࡢኚ໬ࠊෆศἪ⣔ࡢ ኚ໬࡞࡝ࢆࡘࡘᐇドࡍࡿᚲせࡀ࠶ࡿࠋᚑࡗ ࡚ࠊ$6'ࡢ㑇ఏᏛⓗ◊✲࡜ẚ࡭ࠊ⎔ቃࣜࢫࢡ ࡢ◊✲ࡣࡲࡔⓎᒎ㏵ୖ࡛࠶ࡾࠊ᪉ἲㄽୖ࡟ไ ⣙ࡀ࠶ࡿ㸦0RGDEEHPLDHWDO㸧࡜ゝ࠼ࡿࠋ $6'ࡢࣜࢫࢡせᅉࡢ◊✲ࡣࠊⓎ㐩ẁ㝵ୖ㔜せ ࡞᫬ᮇ࡟ࠊ࡝ࡢ఩ࡢᮇ㛫ࠊ࡝ࡢ⛬ᗘࡢ᭚㟢㔞 ࡞ࡢ࠿࡜࠸ࡗࡓࠊ⢭⚄⑓⌮Ꮫ࡟Ⓨ㐩ⓗどⅬࢆ ຍ࠼ࡿࡇ࡜࡛ࠊ㑇ఏᏊ࡜⎔ቃࡢືⓗ┦஫స⏝ ࢆ᳨ウ࡛ࡁࡿࡔࢁ࠺ࠋ  ᪥ᮏ࡟࠾࠸࡚ࡣ$6'ࡢ⎔ቃⓗࣜࢫࢡ࡟㛵 ࡍࡿ⦪᩿ⓗࢥ࣮࣍ࢺ◊✲ࡣᑡ࡞࠸ࡀࠊ⌧ᅾ⎔ ቃ┬ࡀࠕᏊ࡝ࡶࡢ೺ᗣ࡜⎔ቃ࡟㛵ࡍࡿㄪᰝ࢚ ࢥࢳࣝㄪᰝࠖࢆᖺ࠿ࡽᐇ᪋ࡋ࡚࠸ࡿࠋ ᖺ⌧ᅾࡶ⥅⥆୰ࡢㄪᰝ࡛࠶ࡿࡓࡵࠊࡲࡔ$6' ࡢ⎔ቃⓗࣜࢫࢡᅉᏊ࡟㛵ࡍࡿⓎ⾲ࡣぢࡽࢀ࡞ ࠸ࠋ௒ᚋࡢ㏣㊧ㄪᰝ࡟ࡼࡗ࡚ࠊ⫾ඣᮇࠊஙᗂ ඣᮇࠊඣ❺ᮇ࡟࠾ࡅࡿ⎔ቃせᅉ࡜$6'࡞࡝ࡢ ⚄⤒Ⓨ㐩⑕ࡢ㛵ಀᛶ࡟ࡘ࠸࡚᪂ࡋ࠸▱ぢࡀぢ ࡘ࠿ࡿࡇ࡜ࢆᮇᚅࡋࡓ࠸ࠋ  㸴㸬㑇ఏ࡜⎔ቃࡢ┦஫స⏝ࡢ」㞧ࡉ࡜࢚ࣆࢪ ࢙ࢿࢸ࢕ࢵࢡᶵᵓ  ୖ㏙ࡋࡓࡼ࠺࡟ࠊ$6'ࡢⓎ⑕ࣜࢫࢡ࡟ࡘ࠸ ࡚⎔ቃせᅉ࠿ࡽࡢᙳ㡪ࡢከࡃࡀࠊㄝᚓຊࡢ࠶ ࡿㄝ᫂࡟࡞ࡗ࡚࠸࡞࠸ࠋࡉࡽ࡟$6'ࣜࢫࢡ࡟ ᑐࡋ࡚⎔ቃࡢᅉᯝⓗຠᯝ࡜ࡋ࡚ゎ㔘ࡉࢀࡿሗ ࿌ࡢከࡃࡀࠊ$6'ࣜࢫࢡࡣ⎔ቃせᅉࡔࡅ࡛ㄝ ᫂ࡀ㞴ࡋࡃࠊ㑇ఏᏊ̺⎔ቃࡢ┦஫స⏝࡟ࡼࡗ ࡚⏕ࡌ࡚࠸ࡿྍ⬟ᛶࡀ㧗࠸ࡇ࡜ࢆᣦ᦬ࡋ࡚࠸ ࡿࠋ౛࠼ࡤࠊ$6'ࡣ㟷ᖺᮇ௨㝆࡟࠺ࡘ⑓ࢆྜ ేࡍࡿࡇ࡜ࡀከࡃࠊࡑࡢᐙ᪘ࡶ࠺ࡘ⑓ࡢ⑌ᝈ Ṕࡀ࠶ࡿࡇ࡜ࡀከ࠸ࡓࡵࠊ$6'࡜࠺ࡘ⑓࡟࠾ ࡅࡿ㑇ఏⓗ࣮࢜ࣂ࣮ࣛࢵࣉࠊඹ᭷ࡢࣜࢫࢡ࣓ ࢝ࢽࢬ࣒ࡀ࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ 㸦*KD]LXGGLQHWDO㸧ࠋᚑࡗ࡚ࠊ⫾ඣᮇ࡟ ࠾ࡅࡿ⸆≀ࡢᙳ㡪ࡣ༑ศ࡟㓄៖ࡉࢀࡿ࡭ࡁࡇ ࡜࡛࠶ࡿࡀࠊ$6'࡜࠺ࡘ⑓ࡀ㑇ఏⓗ࣮࢜ࣂ࣮ ࣛࢵࣉࢆࡶࡘ௨ୖࠊ⫾ඣᮇ࡟࠾ࡅࡿẕయࡢ㑅 ᢥⓗࢭࣟࢺࢽࣥ෌ྲྀࡾ㎸ࡳ㜼ᐖ๣㸦665,㸧ࡢ ᦤྲྀࡀ$6'Ⓨ⑕ࣜࢫࢡࢆቑᙉࡍࡿ࡜࠸࠺༢ ୍ࡢᅉᯝ㛵ಀ࡛ㄝ᫂ࡍࡿࡇ࡜ࡣᅔ㞴࡛࠶ࡿ࡜ ゝ࠼ࡿࠋ  ࡑࡇ࡛㏆ᖺὀ┠ࢆ㞟ࡵ࡚࠸ࡿࡢࡀࠊ࢚ࣆࢪ࢙ ࢿࢸ࢕ࢡࢫ㸦HSLJHQHWLFV㸧ᶵᵓ࡛࠶ࡿࠋ࢚ࣆࢪ ࢙ࢿࢸ࢕ࢡࢫ࡜ࡣࠊ⎔ቃᅉᏊ࡟ࡼࡗ࡚㑇ఏᏊ 㓄ิࡢⓎ⌧ࢆไᚚࡍࡿᚋ⏕ⓗಟ㣭ࡢࡇ࡜࡛࠶ ࡿࠋ⾲⌧ᆺ࡜ࡋ࡚Ⓨ⌧ࡍࡿࡓࡵ࡟㑇ఏᏊⓎ⌧ ࡢ࢜ࣥ࢜ࣇࢆ⾜࠺࣓࢝ࢽࢬ࣒࡜ゝ࠼ࡿࠋ࢚ࣆ ࢪ࢙ࢿࢸ࢕ࢡࢫࡣ୍༸ᛶ཮⏕ඣࡢᕪ␗ࡀ⏕ࡌ ࡿᶵᗎࡸࠊࡀࢇࠊ⢾ᒀ⑓࡞࡝⏕ά⩦័࡟㛵ࢃ ࡿ⑌ᝈࡢཎᅉ࡜࡞ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋ  ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫ࡜Ⓨ㐩ࡢ㛵ಀ࡟ࡘ࠸࡚ ᭱ึ࡟ሗ࿌ࡋࡓ:HDYHUHWDO  ࡣࠊẕぶࣛ ࢵࢺࡢ㣴⫱⾜ືࡢ㢖ᗘ࡟ࡼࡗ࡚ᾏ㤿ࡢ'1$ 㸫  㸫 作新学院大学心理学研究科臨床心理センター

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࣓ࢳࣝ໬࡜࠸࠺࢚ࣆࢪ࢙ࢿࢸ࢕ࢵࢡ࡞ኚ໬ࡀ ⏕ࡌࠊ⤖ᯝⓗ࡟ࢫࢺࣞࢫ⪏ᛶࡀῶᑡࡍࡿࡇ࡜ ࢆ♧ࡋࡓࠋ௨㝆ࠊ⹢ᚅ⤒㦂࡜࢚ࣆࢪ࢙ࢿࢸ࢕ ࢵࢡ࡞ኚ໬࡟ࡼࡿ⬻⚄⤒ࡢ㠀ᐃᆺⓎ㐩࡜⾜ື ഴྥ࡟ࡘ࠸࡚◊✲ࡀ㐍ࢇ࡛࠸ࡿ㸦UHYLHZ࡜ࡋ ࡚6]\IHWDOࡸ௒ᮧࢆཧ↷㸧ࠋ  $6'࡟࠾ࡅࡿ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫࡣࡲࡔ ᑡ࡞ࡃᮍゎ᫂࡞㒊ศࡀከ࠸ࡀࠊ$6'㛵㐃㑇ఏ Ꮚ࡜ࡉࢀࡿ๓㏙ࡢ␒ᰁⰍయTࡢ࢚ࣆࢪ࢙ ࢿࢸ࢕ࢵࢡ࡞ኚ໬ࡣⓎ⑕ࣜࢫࢡࡢ㛵ಀࡀᑠࡉ ࠸㸦%RQRUDHWDO㸧ࠊṚᚋ⬻ゎ๗ࡼࡾ ␒ᰁⰍయT̺T࡛ࡢ࢚ࣆࢪ࢙ࢿࢸ࢕ࢵࢡ ࡞ኚ໬ࡀㄆࡵࡽࢀࡿ㸦<DVXLHWDO㸧࡞࡝ ࡢሗ࿌ࡀ♧ࡉࢀ࡚࠸ࡿࠋࡲࡓᚋኳⓗ࡞ᙳ㡪࡟ ࡼࡗ࡚࢚ࣆࢪ࢙ࢿࢸ࢕ࢵࢡ࡞ኚ໬ࡀ⏕ࡌࡿࡇ ࡜ࢆ฼⏝ࡋࠊࣂࣝࣉࣟ㓟࡟ࡼࡗ࡚࢚ࣆࢪ࢙ࢿ ࢸ࢕ࢵࢡ࡞ኚ໬ࢆࡋࡓ㑇ఏᏊࡢಟ㣭࡜Ⓨ⌧ࢆ ᅇ᚟ࡉࡏࡿྍ⬟ᛶࡀ࠶ࡿࡇ࡜ࡶᣦ᦬ࡉࢀ࡚࠸ ࡿ㸦.XERWD 0RFKL]XNL㸧ࠋ  ࡇࢀ࠿ࡽࡢᒎᮃ࡜ࡋ࡚ࠊ$6'ࡢ⑓⌮࡟࠾࠸ ࡚࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫᶵᵓࡀ㛵ࢃࡿ▱ぢࡀ⵳ ✚ࡉࢀࡿ࡜ண᝿ࡉࢀࡿࠋ$6'࡜࢚ࣆࢪ࢙ࢿࢸ ࢕ࢡࢫᶵᵓࡢ㛵୚࡟ࡘ࠸࡚࡝ࡢࡼ࠺࡞⤖ㄽ࡟ ࡞ࡿ࠿ࡣࡲࡔศ࠿ࡽ࡞࠸ࠋࡋ࠿ࡋࠊ࢚ࣆࢪ࢙ ࢿࢸ࢕ࢡࢫᶵᵓ࡟ࡼࡗ࡚Ⓨ㐩ึᮇ࡟࠾ࡅࡿ⎔ ቃ࠿ࡽࡢᙳ㡪ࡀ⏕≀Ꮫⓗኚ໬ࢆ⏕ࡌࡉࡏࠊࡸ ࡀ࡚$6'ᵝࡢᚰ⌮࣭⾜ືࢆ♧ࡍࡼ࠺࡟࡞ࡿ࡜ ࡍࡿ࡞ࡽࡤࠊ⒪⫱࡞࡝ࡢ᪩ᮇ௓ධ࡟᪂ࡋ࠸ど Ⅼࢆᥦ౪ࡍࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࡔࢁ࠺ࠋ  ᘬ⏝ᩥ⊩

American Psychiatric Association. (2014).

DSM-5 ⢭⚄⑌ᝈࡢデ᩿࣭⤫ィ࣐ࢽࣗ࢔ ࣝ. (㧗ᶫ୕㑻, ኱㔝⿱, ᰁ▮ಇᖾ, ⚄ᗞ㔜

ಙ, ᑿᓮ⣖ኵ, ୕ᮧᑘ, & ᮧ஭ಇဢ, ⩻ヂ ⪅). ᮾி: ་Ꮫ᭩㝔.

Baron-Cohen, S., Wheelwright, S., Skinn er, R., Martin, J., & Clubley, E. (200 1). The autism-spectrum quotient (A

Q): evidence from Asperger syndrome /high-functioning autism, males and f emales, scientists and mathematician s. Journal of Autism and Developme ntal Disorders, 31(1), 5–17.

Bonora, E., Bacchelli, E., Levy, E. R., Bl asi, F., Marlow, A., Monaco, A. P., … International Molecular Genetic Stu dy of Autism Consortium (IMGSAC). (2002). Mutation screening and impr inting analysis of four candidate gene s for autism in the 7q32 region. Mol ecular Psychiatry, 7(3), 289–301. Fluegge, K. (2016). A reply to Wang T,

Shan L, Du L, Feng J, Xu Z, Staal WG, Jia F. Serum concentration of 2 5-hydroxyvitamin D in autism spectr um disorder: a systematic review and meta-analysis. Eur Child Adolesc Ps ychiatry. 2015; doi: 10.1007/s00787-01 5-0786-1. European Child & Adolesce nt Psychiatry, 25(4), 453–454. Ghaziuddin, M., Ghaziuddin, N., & Gred

en, J. (2002). Depression in persons with autism: implications for researc h and clinical care. Journal of Autis m and Developmental Disorders, 32

(4), 299–306.

Hidaka, M., Morotomi, T., & Murohashi, H. (2013). N170 response to change in facial expressions is correlated wi th autistic traits: An event-related po tential study. Clinical Neurophysiolog y, 124(8), e35.

James, S., Stevenson, S. W., Silove, N., & Williams, K. (2015). Chelation for autism spectrum disorder (ASD). The Cochrane Database of Systematic Re views, (5), CD010766.

(7)

Kubota, T., & Mochizuki, K. (2016). Epi genetic Effect of Environmental Facto rs on Autism Spectrum Disorders. In ternational Journal of Environmental Research and Public Health, 13(5), 504.

Laumonnier, F., Bonnet-Brilhault, F., Go mot, M., Blanc, R., David, A., Moizar d, M.-P., … Briault, S. (2004). X-Link ed Mental Retardation and Autism A re Associated with a Mutation in the NLGN4 Gene, a Member of the Ne uroligin Family. The American Journ al of Human Genetics, 74(3), 552–55 7.

Liss, M., Saulnier, C., Fein, D., & Kinsb ourne, M. (2006). Sensory and attenti on abnormalities in autistic spectrum disorders. Autism, 10(2), 155–172. Modabbernia, A., Velthorst, E., & Reiche

nberg, A. (2017). Environmental risk factors for autism: an evidence-based review of systematic reviews and m eta-analyses. Molecular Autism, 8(1), 13.

Piven, J., Palmer, P., Jacobi, D., Childre ss, D., & Arndt, S. (1997). Broader a utism phenotype: evidence from a fa mily history study of multiple-inciden ce autism families. The American Jo urnal of Psychiatry, 154(2), 185–190. Richardson, A. J. (2006). Omega-3 fatty

acids in ADHD and related neurodev elopmental disorders. International R eview of Psychiatry (Abingdon, Engla nd), 18(2), 155–172.

Rommelse, N. N. J., Geurts, H. M., Fra nke, B., Buitelaar, J. K., & Hartman, C. A. (2011). A review on cognitive

and brain endophenotypes that may be common in autism spectrum disor der and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neuroscience and Biobehavioral Reviews, 35(6), 1363–1 396.

Ronald, A., & Hoekstra, R. A. (2011). A utism spectrum disorders and autistic traits: a decade of new twin studies.

American Journal of Medical Geneti cs. Part B, Neuropsychiatric Genetics: The Official Publication of the Inter national Society of Psychiatric Geneti cs, 156B(3), 255–274.

Rosen, B. N., Lee, B. K., Lee, N. L., Ya ng, Y., & Burstyn, I. (2015). Materna l Smoking and Autism Spectrum Dis order: A Meta-analysis. Journal of Au tism and Developmental Disorders, 4 5(6), 1689–1698.

Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014). Environmental toxicants and autism spectrum disorders: a sy stematic review. Translational Psychi atry, 4, e360.

Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., … F uruichi, T. (2007). Autistic-like phenot ypes in Cadps2-knockout mice and a berrant CADPS2 splicing in autistic patients. The Journal of Clinical Inve stigation, 117(4), 931–943.

Szyf, M., Weaver, I., & Meaney, M. (200 7). Maternal care, the epigenome and phenotypic differences in behavior. R eproductive Toxicology (Elmsford, N. Y.), 24(1), 9–19.

Taylor, L. E., Swerdfeger, A. L., & Eslic

(8)

k, G. D. (2014). Vaccines are not ass ociated with autism: an evidence-base d meta-analysis of case-control and c ohort studies. Vaccine, 32(29), 3623–3 629.

Thye, M. D., Bednarz, H. M., Herringsh aw, A. J., Sartin, E. B., & Kana, R. K. (preprint). The impact of atypical sensory processing on social impairm ents in autism spectrum disorder. De velopmental Cognitive Neuroscience. Walsh, C. A., Morrow, E. M., & Rubenst ein, J. L. R. (2008). Autism and brai n development. Cell, 135(3), 396–400. Wang, T., Shan, L., Du, L., Feng, J., Xu, Z., Staal, W. G., & Jia, F. (2016). Se rum concentration of 25-hydroxyvita min D in autism spectrum disorder: a systematic review and meta-analysi s. European Child & Adolescent Psyc hiatry, 25(4), 341–350.

Weaver, I. C. G., Cervoni, N., Champag ne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., … Meaney, M. J. (20 04). Epigenetic programming by mate rnal behavior. Nature Neuroscience, 7

(8), 847–854.

Wheelwright, S., Auyeung, B., Allison, C., & Baron-Cohen, S. (2010). Defini ng the broader, medium and narrow autism phenotype among parents usi ng the Autism Spectrum Quotient (A Q). Molecular Autism, 1, 10. h Widenhorn-Müller, K., Schwanda, S., Sc

holz, E., Spitzer, M., & Bode, H. (201 4). Effect of supplementation with lo ng-chain ǚ-3 polyunsaturated fatty ac ids on behavior and cognition in chil dren with attention deficit/hyperactivi

ty disorder (ADHD): A randomized pl acebo-controlled intervention trial. Pr ostaglandins, Leukotrienes and Essen tial Fatty Acids (PLEFA), 91(1), 49–6 0.

Yasui, D. H., Scoles, H. A., Horike, S.-I., Meguro-Horike, M., Dunaway, K. W., Schroeder, D. I., & Lasalle, J. M. (2 011). 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHR NA7 with deficiencies in Rett and au tism brain. Human Molecular Geneti cs, 20(22), 4311–4323.

Yoshimasu, K., Kiyohara, C., Takemura, S., & Nakai, K. (2014). A meta-anal ysis of the evidence on the impact of prenatal and early infancy exposure s to mercury on autism and attentio n deficit/hyperactivity disorder in the childhood. Neurotoxicology, 44, 121– 131. ௒ᮧ᫂. (2013). ⿕⹢ᚅඣ࡜Ⓨ㐩㞀ᐖඣࡢ࢚ ࣆࢪ࢙ࢿࢸ࢕ࢵࢡኚ໬ࡢ㛵୚ࡢྍ⬟ᛶ. ⢭⚄⚄⤒Ꮫ㞧ㄅ, (➨ 108 ᅇ᪥ᮏ⢭⚄⚄⤒ Ꮫ఍Ꮫ⾡⥲఍≉ูྕ), 346–355. ᪥㧗ⱱᬸ. (2011). ⮬㛢⑕ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ ࡟࠾ࡅࡿᩥ⬦࡟ࡶ࡜࡙ࡃ⾲᝟ㄆ▱㐣⛬. ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔ᩍ⫱Ꮫ◊✲㝔⣖せ, 114, 101–121.  㸫  㸫 作新学院大学心理学研究科臨床心理センター

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