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＜シンポジウム1＞神経内科における大規模臨床治験Aim

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＜シンポジウム 1＞神経内科における大規模臨床治験

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Department of Neurology, Nagoya University Graduate School of Medicine Department of Neurology, Columbia University Medical Center

Gen Sobue, M.D.

Hiroshi Mitsumoto, M.D.

（臨床神経 2010;50:830）

In the field of neurology, there have been an increasing number of large-scale clinical trials for neurological diseases. To conduct large-scale clinical trials for neurological diseases, there are issues to be worked out. We need good infrastruc-tures including multicenter-based consortia. We need better measures to evaluate the efficacy of the treatment, which are particularly important for the clinical trial of

disease-modifying therapy . Since neurodegenerative diseases are slowly progressive diseases, we may need a long duration for assessing the clinical efficacy. We need sensitive measures including surrogate markers. This symposium will focus on recent achievements of clinical trials for neurological dis-eases, discussing on issues and future directions of large-scale clinical trials.

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