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We have 4 reported that the coronary atherosclerotic burden is associated with the serum A-FABP 5 concentration

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Abstract

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Background: Adipocyte fatty acid-binding protein (A-FABP) is expressed in both adipocytes

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and macrophages. Recent studies have shown that A-FABP is secreted by adipocytes and that the

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A-FABP concentration is associated with obesity, insulin resistance, and atherosclerosis. We have

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reported that the coronary atherosclerotic burden is associated with the serum A-FABP

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concentration. In the present study, we investigated whether the serum A-FABP concentration is

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associated with prognosis in patients with stable angina pectoris who have undergone

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percutaneous coronary intervention (PCI).

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Methods: This was a prospective single-center trial. In total, 130 patients with stable angina

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pectoris undergoing their first PCI were enrolled from August 2008 to July 2010 at Kagawa

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Prefectural Central Hospital. The primary endpoints were cardiovascular death, nonfatal

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myocardial infarction, nonfatal stroke, revascularization, and hospitalization for heart failure.

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Results: During the follow-up (median, 50 months; interquartile range, 23–66 months), 49

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cardiovascular events occurred. Kaplan–Meier analysis showed that the cumulative incidence of

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the primary endpoints in the high A-FABP group (median A-FABP concentration of ≥18.6 ng/ml)

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was greater than that in the low A-FABP group. Cox analysis showed that the A-FABP

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concentration was an independent predictor of cardiovascular events adjusted for age and the

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presence of multi-vessel disease (hazard ratio, 1.03; 95% confidence interval, 1.01–1.04; p=0.01).

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Conclusion: The serum A-FABP concentration is associated with prognosis in patients with

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stable angina undergoing PCI, suggesting that the serum A-FABP concentration could be useful

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for risk assessment of secondary prevention.

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Trial registration: UMIN Clinical Trials Registry UMIN000029283 (registration date: September

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25, 2017), retrospectively registered.

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(2)

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Abbreviations

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A-FABP: adipocyte fatty acid-binding protein

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PCI: percutaneous coronary intervention

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