Acta med. Nagasaki 16 : 79-81
Effect of Atropine on the Microvibration
of the Body Surface
Toshiyuki OZAKI * The First Department of Physiology, Hirosaki University School of Medicine,
Hirosaki, Japan,
Receined for publication, January 30, 1972
It was reported by OzAKI2) and FUZIWARA1) that adrenaline and nora- drenaline were capable of increasing and decreasing the microvibration
(MV) of the body surface over the thigh muscles in the rabbit respec- tively, according to smaller and larger doses injected intravenously.
Further more, OzAKI3) has suggested that the MV of the body surface was decreased by the muscarine-like action of acetylcholine. The pre-
sent study was performed to clarify the effects on the MV of atropine, which blocks the periphery of the parasympathetic nerves and inhibits the effects of acetylcholine. Experiments were done on rabbits non- anesthetized or nembutalized lightly. The MV of the body surface over the thigh muscles was recorded at the same time as the electro- encyphalogram (EEG), electrocardiogram (EKG) and heart beat.
Following intravenous injection of atropine, the MV and EEG were found to represent the augmentative and inhibitory changes according to smaller (0.2-0.5 mg./kg.) and larger (5-20 mg./kg.) doses of atropine given respectively, as shown in Fig. 1. In the heart beat and EKG, on the other hand, the inhibitory effect of atropine on the MV was not observed so clearly, although there was recognized the augmentative effect of it.
These experimental findings suggest that the effects of atropine on the MV might be caused not only by blocking the parasympathetic nerves or both parasympathetic and sympathetic nerves, but also by facilitating or inhibiting the activity of the cerebral cortex indicated in the EEG pattern.
＊尾 崎 俊 行
79
80
1)
2)
3)
T. OZAKI REFERENCE
FUZIWARA, K. , : Effects of adrenaline and noradrenaline upon on the body surface, Acta Med. Nagasaki., 1 1 , 72‑83, 1966.
: Some evidences on Minor Tremor, Proc. ̲X:Ilth OzAKI, T. ,
EEG Soc. , 155,1965.
OZAKI,T. , : Effect of acetylcholine on the microvibration of Acta Med. Nagasaki. , 15, 1‑2,1971.
Vol. 16
the microvibration A, l,. IW et. Japal, the body surface,
1 97 1 EFFECT OF ATROPlNE ON THE MICROVIBRATION OF BODY SURFACE 81
;
;
i
,
+>*
* ;
!̲
̲1̲
J
:; r
r̲* ‑ ,
. E:
‑
?
1' : ;
̲ S̲
‑‑','=‑= =
‑ *
!̲
J :F !
J‑
‑
z'̲
IZ
=
; T
‑
: . +
,L ‑ .
(:
O:zGO
LLJ
.: '.
' : E E'
! ::
‑ t
'
=' :
'̲'̲
S ‑' l;
:,'‑
:‑""
: i:E
' i S "̲
‑?: ..
‑1 .r‑
"‑‑̲ 1=‑'P ",̲
::̲{ Pj
1 ;
"i . .‑:̲̲'
= "=r'r
:
' 1'̲
,b̲̲̲
: :
d
4'
(¥t L(1 rr) O::
o
̲
: =
̲i.=̲̲
: =+ ̲
=
= ?
‑ :‑
i ,̲
̲
Cv ttl
,¥J L'I m
OC:
ac
l̲
"
.
}
,
f
̲F IE '
*''.
;
‑
f
I
f̲
.‑
:
̲
"ir̲
̲ )'‑
: ; ,
̲ ‑‑
‑ =**‑
: "‑
= : = :̲
‑ ‑
:
i
‑.
*
*
!
, .
;
f
;'
‑ ' ‑ ' J i̲
1
‑
:'‑
r *= ̲
=
l'̲
! L
‑ Ft
!̲
:*
:
i
i
‑
l .
+) d
rr)
C¥l LO rr)
O
= :
,
l
;
¥
,)
<
)
r̲
i
'';
i
.
;{
'= *.
*
* {
. .I
fr,
+' 1:$
rr) c¥l 1 ,r)
O
Fig 1. EEG (1. occipito‑parietal lead) , MV (r. thigh) , HB (heart best) and EKG (1ead II) tracings before (A) and after (B, O intravenous injection of atropine in a dose of 0.5 mg. (L) or 5mg. (R)/kg.
A : Control EEG, MV, heart and EKG before atropine iniection.
B : EEG, MV, heart beat and EKG after atropine iniection.
Each calibration shows 50 pV in the EEG and I mV in the MV, heart beat and EKG respectively.
