• 検索結果がありません。

Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13

N/A
N/A
Info
ダウンロード
Protected

Academic year: 2021

シェア "Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13"

Copied!
1
0
0

読み込み中.... (全文を見る)

今ダウンロードする ( 1 ページ )

全文

(1)

1

ABSTRACT

Background: p16INK4a (p16) expression in tongue cancer (TC) is reportedly not

associated with human papillomavirus (HPV). Mutations of KRAS in cancer cells are

most frequently observed within codon 12. However, few reports have investigated the

association between KRAS mutations and p16 status in TC.

Objectives: This study aimed to evaluate the influence of KRAS mutations on TC.

Methods: Clinical records and surgically resected specimens of 85 TC patients were

analyzed. Tumor samples were analyzed for mutations of KRAS located within codons

12 and 13. p16 staining was performed and considered positive in cases with moderate

to strong nuclear and cytoplasmic staining.

Results: Positive p16 staining was observed in 10 cases (11.8%). A KRAS mutation was

detected in one case (1.2%). The case with KRAS mutation showed negative p16

staining. Despite being at an early stage, the patient died of lung metastasis at 43

months from initial treatment.

Conclusions and Significance: KRAS mutations are not associated with p16 expression

in TC and may predict poor prognosis in TC patients. Further analysis of mutations in

regions other than codons 12 and 13 of KRAS will be necessary to determine the

relationship between KRAS mutations and prognosis of this disease.

参照

今ダウンロードする ( PDF - 1 ページ - 9.98 KB )

関連したドキュメント

Accurate Asymptotic Formulas for Eigenvalues and Eigenfunctions of

Based on the asymptotic expressions of the fundamental solutions of 1.1 and the asymptotic formulas for eigenvalues of the boundary-value problem 1.1, 1.2 up to order Os −5 ,

NUMERICAL METHODS OF COMPUTATION OF SINGULAR AND HYPERSINGULAR INTEGRALS

This review is devoted to the optimal with respect to accuracy algorithms of the calculation of singular integrals with fixed singu- larity, Cauchy and Hilbert kernels, polysingular

Existence and Uniqueness of

Shen, “A note on the existence and uniqueness of mild solutions to neutral stochastic partial functional differential equations with non-Lipschitz coefficients,” Computers

Domain decomposition tech- niques and non-uniform relaxation parameters were used to characterize the solution of the new system

We have presented in this article (i) existence and uniqueness of the viscous-inviscid coupled problem with interfacial data, when suitable con- ditions are imposed on the

Methods of Proof Methods of Proof

 Although the vacuous proof example on slide Although the vacuous proof example on slide 40 is a contradiction.. 40 is

For control of certain grasses and broadleaf weeds.

Where a rate range is specified, the higher rates should be used (a) in fields with a history of severe weed pressure, (b) when the time between early preplant tank mix and

For control of certain grasses and broadleaf weeds.

TriCor 4F herbicide tank mix combinations are recommended for preplant incorporated applications, pre-emergence surface applications, Split-Shot application and Extended

FOR CONTROL OF CERTAIN GRASSES AND BROADLEAF WEEDS

Apply specified dosages of Dimetric EXT and Gramoxone Inteon in at least 10 gallons of water per acre with aerial equipment or at least 20 gallons of water per acre with