with Yusho clinical manifestations and laboratory results in subjects chlorodibenzofuran (PeCDF) in blood: correlation with Individuals' half livesfor 2 ， 3 ， 4 ， 7 ， 8 penta-

(1)

1 'slaudividnI flah se^圃vil 2rof

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2 anrfuzonbeiodorlch (PeCDF) bni:dool noitalerroc hitw

3 lacinilc snoitatsefinam and lyrotaroba stluser snistcejbu

4 h Ywit usho

5

6 Syahin Matsumoto S21， Manabu Akahane ， kiyushiYo Kanagawa 1_ラJunboku K司ⁱ^w^a^r^d ^， 7 Thiaska Todaka 4， Fumiko Yasukawa 4， ihsoriH Uchi¥ Masutaka ueurF ，4 and Tomoaki

8 Imamura 2 9

1 0 1 1 1

2 noisiviDl of Slaico inedicMe ^ラeatuadGr loohSc cineofMedi ， The Uytisrevin ofTokyo ^ラ 1

3 Tokyo ， anapJ 1

4 tmenrtpa2De of Pcilbu htaleH ， hltaeH Management and Pycilo ^ラNara Maldice 1

5 ytisrevinU olochS ofMedicine ^ラraaihshaK ，J pana 1

6 ³Fukuoka etutitsnI Hofhltae and Eltaennmrovin secneicS ^ラFukuoka ^ラanapJ 1

7 tmenrtpa4De ofDermatology ， eatuadGr loohSc lofMedica secneicS ， Kyushu 1

8 ytisrevinU ^ラFukuoka ^ラnpaJa 1

9

20 ailEm :sesserdda 2

1 SM: synih 抑制p.j.acin@umkyo-totm 22 MA: mjp-u.ac.naramedahane@ak

(2)

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お5 tω:TTdo :紘aka@f 臥i^社^也he^凶p.s^戸er^{託王印白白}ouk1 ^依kaJ吋.

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8 MF:pj.ac.u-ushuy白kd.em.oltamrde@eur 2

9 i:ITp.jacn.mi@u-tramuma 3

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1 gind~ onpsrerCo rohtua 3

2 noisiviD laicofSo inedicMe ， etaduaGr lohocS eofMedicin ， The Uytisrevin ofTokyo ， 3

3 7^・3^・1Hongo ， Bunkyo ^田ku，Tokyo 311 ^・5586 ，anapJ 3

4 :eonhP 31-+8 ^・5800 ^・8716;Fax:+8 ト3^・5800 ^・7658 3

5 :liam-E ^剥sih^註mya 3

6 3 7 3 8

(3)

3

9 telluB stnioP eseht( secnetnes lliw remove srof)noissimbu

4

0 snoitalerroC weenbet efil-flah 2fo ム4^ラ7^ラ8-PeCDF d san ymptoms re ewe.detaulav 4

1 Symptoms tahtetarelecca noitercxe sdipilfo may l tdae a oretrohs .efil-flah 42 Red bdool sllec reradetale tot hehefil-fla of2 ^ラ3^ヲ4，7，8平eCDF.

4

3 rehtruF seiduts reraderiuqe ioettagitsevn eehtyrotercx mechanism of2 ，3人7，8^園 4

4 PeCDF. 4 5 4 6 ctrabstA

4 7 ndkgrouBac 4

8 1nI896 ^ラmany pelpoe deoplevde nixoid gninosiop )oshu(Y Jni.napa noitsegnI fo 4

9 2^ラ3，4，7naruf^ラozne8bidorolh^田catnep 2(ム4^ラ7，8-PeCDF) was cderedisno bot te ceh esua 5

0 sihtfo .gninosiop ghoulthA some pstneita d hha chgisnoitartnecno of2 ，3，4，7ラふ 5

1 PeCDF tnirieh doobl 'slaudi， vidni sevil-flah of2 ，3，4，7，8-PeCDF re lwe .gno

5 2 sevitcejbO 5

3 To eetaulav rehtpihsnoitale entwebe lacinilc lndayrotaroba sretemarap d tan eh 5

4 laudividni efil-flah of2 ，3，4^ラ7，8-PeCDF bni.dool

5 5 Methods 5

6 lacinilC landyrotaroba watad re ce detcello gnirud launna kechc ^圃s fpu rom 2 t010 o 5

7 .8002 We edellorn p17stneita ^ラwho wre me edasure more t 3 nah semit ， wnda ho had 5

8 2^ラ3，4^ラ7^ラ8-PeCDF snoitartnecnoc bnidool >50 pg g ll-.dipi The hflae of^園il f2 ，3，4^ラ7，-8 5

9 PeCDF erof phca tneita was edetamits gnisu raenil .noisserger rMoreove ，

(4)

6

0spihsnoitaler ntweebe lacinilc landyrotaroba p^{町田}sreten d ianlaudividn lah^岡^.^fe wfil ere 6

1 detagitsevni by lraeni .noisserger

6 2 stluseR 6

3 A sdenetroh laudividni lιeafhil 2rof ム⁴，7，ιPeCDF was syltnacifingi detalerroc htiw 6

4 iandesaercn bder odol llec tnuoc des， aercni suocsiv snoiterces tfrom meh eibomian 6

5 sdnalg gni， tsixe kcalb comedones ， and sereve radec nellop .ygrella

6 6 nsiosluncCo 6

7 Symptoms 由剖etarelecca noitercxe of lsdipi 企om t beh ody ， h acus vssuocsi 6

8 snoiterces 企om t meh eibomian sdnalg ， may l tdae a oretrohs lah^刷^.^fe ofil f2 ム⁴，7，8^・ 6

9 PeCDF. Red bdolo sllec reradetale tot hehefil-fla of2 ，3人7，払PeCDF. However ， 7

0 rehtruf seiduts reraderiuqe ioettagitsevn eehtyrotercx mechanism of2 ，34，ス 8^・ 7

1 PeCDF. 7 2 7

3 Keywords 7

4 anrfuozenbDi ， radec nellop ygrella ， Yusho ， lιeafhil ， bder odol llec ， 2ム⁴ス⁸^・

7 5narufoznebidorolhcatnep

(5)

7 6 7 7 snoitaiverbbA 7

8 PeCDF: narufoznebidorolhcatnep 7

9 PCB: pdetanirolhcylo lynehpib 8

0 RAST: oidartnebrosogrella tset

8

1 .1noitcudortnI

8

2 1nI896 ^ラn uanknown esaesid was ddesongai pnistneita Wniestem J wanap ho had 8

3 detneserp shtiw lareve gnitatsaved .omsmptsy dsihT esaesi was named “".oshuY 8

4 seheT stneitap ihaddetsegn ecir ^咽n oarb clidetnaimatno ehtiw ylemertx hgih 8

5 snoitartnecnoc suoiravfo detanirolhcylop slynehpib dndaekil-nixoi compounds 8

6 euruF( alte.;5002 Yoshimura .)3002 At t teh emi ， gninosiop e tdu podetanirolhcylo 8

7 slynehpib was tthguoh bot te ceh esua o.Yushof However t， neuqesbus lacimech 8

8 sesylana d man lacdie snoitagitsevni delaever ttaht dehekil-nixoi compound 2ム4ス⁸^目

的narufoznebidorolhcatnep 2(ム4ス⁸^-^Pê^C^D^F⁾ ^wâ^s^t^mê^h âⁱⁿ^cê^vⁱ^tâ^sûâ ^tⁿê^gâ êû^rû^F⁽ âl^tê^.

9

0 ;5002 iI eda alt.;3002 Imamura alte.;7791 Toyoda alte.:9991 Yoshimura .)3002 9

1 ecniS 001 ， 2 lacidem snoitanimaxe e bavh cene detucdno yllaunna snistcejbu htiw 9

2 Yusho moteas ^旧et cehsnoitartnecno f donixoi e ck^開il ompounds (Kanagawa dan 9

3 Imamura ;5002 Todaka alte..)3002 Such dnixoi e c^同kil ompound ntsmeureasme era 9

4 tedsu eoetamits hehtfla se^田vil of2 ^ラ3人7^ラ8-PeCDF inilaudividn .stneitap rnItnece 9

5 sraey ^ラr ruohcraese team h psadehsilbu lareves selcitra on t aehnoitaicoss entwebe 9

6 htlaeh escomuto nd Pa CDF eerusopx ， gnisu a htlaew dfo aata indretn aila -atad 9

7 gininm .sodhtem olsA cit^ラenik snoitaluclac e bhav en pe dehsilbu reilrae gnisu eht 9

8 yranib ragol c^惜illll eulav efo dhca nixoi noitartnecnoc a sa tnedenped elbairav d tan eh