染色体画像処理のためのマルチエージェントシステ
ム(3.2 第5回情報シナジー研究会, 3. 研究活動報
告)
著者
濱田 智栄子, 山口 傑, 阿部 亨, 木下 哲男
雑誌名
年報
巻
6
ページ
107-111
発行年
2007-07
URL
http://hdl.handle.net/10097/48532
ᨴ⦡↹ಣℂߩߚߩࡑ࡞࠴ࠛࠫࠚࡦ࠻ࠪࠬ࠹ࡓ
ự↰ ᥓᩕሶ(1)㧘 ጊญ வ(2)㧘 㒙ㇱ ੧(3)㧘 ᧁਅ ື↵(3)
(1) ᧲ർᄢቇᎿቇㇱᖱႎᎿቇ⑼
(2) ᧲ർᄢቇᄢቇ㒮ᖱႎ⑼ቇ⎇ⓥ⑼
(3) ᧲ർᄢቇᖱႎࠪ࠽ࠫᯏ᭴ቇⴚᖱႎ⎇ⓥㇱ
శቇ㗼ᓸ㏜↹ߦၮߠ߈㧘ᨴ⦡ߩ⒳ޘߩ⇣Ᏹࠍⷞⷡ⊛ߦ⸻ᢿߔࠆߚߦߪ㧘ᨴ⦡㗔ၞࠍ↹
߆ࠄߒ㧘ฦ㗔ၞ߇⇟ߩᨴ⦡ߦኻᔕߔࠆ߆หቯߔࠆᔅⷐ߇ࠆ㧚ᧄⓂߢߪ㧘1 ᧄߩᨴ⦡
㗔ၞࠍⶄᢙߩㇱಽ㗔ၞ㧔ㇱಽࡃࡦ࠼ࡄ࠲ࡦ㧕ߩㅪߥࠅߣߥߒ㧘ฦㇱಽ㗔ၞࠍ↹ਛߢត⚝ߔ
ࠆಣℂࠍ㗅ߦ➅ࠅߔߎߣߢ㧘ᨴ⦡㗔ၞోߩหቯࠍ㜞♖ᐲ߆ߟᨵエߦⴕ߁ᚻᴺࠍឭ᩺
ߔࠆ㧚ߐࠄߦ㧘ฦㇱಽ㗔ၞࠍ․⇣⊛ߦត⚝ߔࠆࠛࠫࠚࡦ࠻ࠍ↪㧘ߘࠇࠄ߇⋧ߦද⺞ߔࠆࡑ
࡞࠴ࠛࠫࠚࡦ࠻ࠪࠬ࠹ࡓߣߒߡឭ᩺ᚻᴺࠍലᨐ⊛ߦታߔࠆᣇᴺߦߟߡㅀߴࠆ㧚
A Multiagent Based System for Chromosome Image Processing
Chieko HAMADA(1), Suguru YAMAGUCHI(2), Toru ABE(3), Tetsuo KINOSHITA(3)
(1) Faculty of Engineering, Tohoku University
(2) Graduate School of Information Sciences, Tohoku University
(3) Information Synergy Organization, Tohoku University
To make the visual examination of a chromosome image for various chromosome abnormalities,
chromosome regions have to be extracted from the image and classified into distinct chromosome
types in advance. To improve the accuracy and flexibility in examining chromosome images, this
paper proposes a new method for extracting and classifying chromosome regions in an image.
The proposed method regards each chromosome region as a series of subregions (local band
patterns), and iterates a search for every subregion in the image consecutively. In addition to this
method, for achieving effective subregion searches, this paper also proposes a multiagent based
system where each agent searches for a specified subregion individually and cooperates with one
another.
1
ᰁⰍయ⏬ീฎ⌮䛾䛯䜑䛾
䝬䝹䝏䜶䞊䝆䜵䞁䝖䝅䝇䝔䝮
℈⏣ ᬛᰤᏊ(1), ᒣཱྀ ഔ(2), 㜿㒊 (3), ᮌୗ ဴ⏨(3) (1) ᮾᏛᕤᏛ㒊ሗᕤᏛ⛉ (2) ᮾᏛᏛ㝔ሗ⛉Ꮫ◊✲⛉ (3) ᮾᏛሗ䝅䝘䝆䞊ᶵᵓᏛ⾡ሗ◊✲㒊 2➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ
➨䠎❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ
➨䠏❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯
➨䠐❶ ⤖ㄽ
┠ḟ
3 ➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ•
ᰁⰍయ[1,2]
–㑇ఏሗ䜢ᢸ䛖⣽⬊᰾ෆ䛾⏕య≀㉁ –䝠䝖䛾⣽⬊᰾1ಶ䛻䛿䚸㏻ᖖ䚸ᖖᰁⰍయ44ᮏ(22✀㢮ྛ2ᮏ)䛸ᛶᰁⰍయ2ᮏ•
ගᏛ㢧ᚤ㙾䛷ほ 䛧䛯ᰁⰍయ⏬ീ䛾ゎᯒ
–ᰁⰍయ䛾␗ᖖ䜢どぬⓗ䛻デ᩿ •ᰁⰍయ␗ᖖ䛻㉳ᅉ䛩䜛䛾ண㜵䞉⒪ •ᰁⰍయ␗ᖖ䜢ㄏⓎ䛩䜛≀㈨➼䛾ุᐃ1.1 ◊✲䛾⫼ᬒ
ከᵝ䛺␗ᖖ䜢ྠ䛻デ᩿ྍ⬟ ືཎయ cen ▷⭎p 㛗⭎q 9␒䛾ᖖᰁⰍయ ᰁⰍ䛻䜘䜚⌧䜜䜛⦤ ᶍᵝ(䝞䞁䝗䝟䝍䞊䞁)ᰁⰍయ⏬ീゎᯒ䛾◊✲䛜㐍䜑䜙䜜䛶䛔䜛
4•
ᰁⰍయ⏬ീゎᯒ䛾୍⯡ⓗ䛺ᡭ㡰
䐟ᰁⰍయ䜢ᰁⰍ䛧ගᏛ㢧ᚤ㙾⏬ീ䜢ᙳ 䐠ගᏛ㢧ᚤ㙾⏬ീ䛛䜙ᰁⰍయ㡿ᇦ䜢ᢳฟ 䐡ᰁⰍయ㡿ᇦ䛾ྠᐃ •ྛ㡿ᇦ䛜ఱ␒䛾ᰁⰍయ䛻ᑐᛂ䛩䜛䛛Ỵᐃ 䐢ᰁⰍయ㡿ᇦ䛾ゎᯒ •ྛ㡿ᇦ䛾≧ែ䛛䜙✀䚻䛾␗ᖖ䜢どぬⓗ䛻デ᩿•
ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ
–ᰁⰍయ⏬ീ䛾ゎᯒ䛻ᚲ㡲䛾ฎ⌮ –༑ศ䛺⢭ᗘ䛜ᚓ䜙䜜䜛ᡭἲ䛿ᐇ⌧䛥䜜䛶䛔䛺䛔 ➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ1.2 ᰁⰍయ⏬ീゎᯒ
ගᏛ㢧ᚤ㙾⏬ീ ྛᰁⰍయ㡿ᇦ䜢ᢳฟ䞉ྠᐃ䛧 ᰁⰍయ␒ྕ㡰䛻୪䜉䛯⤖ᯝ ᐇ㝿䛾ᰁⰍయ⏬ീゎᯒ䛻㝿䛧䛶䛿䚸ᑓ㛛ᐙ䛻䜘 䜛ᡭసᴗ䛷ᢳฟ䞉ྠᐃ䛜⾜䜟䜜䜛ሙྜ䛜ከ䛔1.3 ᰁⰍయ㡿ᇦᢳฟ䞉ྠᐃ䛻䛚䛡䜛ㄢ㢟
➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ•
ᚑ᮶ᡭἲ䛷䛾䜰䝥䝻䞊䝏
–
ᰁⰍయ㡿ᇦ䛾ᢳฟ[3,4,5]
➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ•
ᰁⰍయ㡿ᇦ䛾ᢳฟ䛻䛚䛡䜛ၥ㢟(P1)
–
ಶ䚻䛾ᰁⰍయ㡿ᇦ䛾ṇ☜䛺ᢳฟ䛜ᅔ㞴䛺⟠ᡤ䛜Ꮡᅾ
1.3 ᰁⰍయ㡿ᇦᢳฟ䞉ྠᐃ䛻䛚䛡䜛ㄢ㢟
7
•
ᰁⰍయ㡿ᇦ䛾ྠᐃ䛻䛚䛡䜛ၥ㢟
(a)యⓗ≉ᚩ䜢⏝䛔䜛ᡭἲ(P2-1)
•
ᰁⰍయ㡿ᇦ䛜ṇ☜䛻ᢳฟ䛥䜜䛺䛔ሙྜ䛻䛿ᑐᛂ䛜ᅔ㞴
•
ᵓ㐀␗ᖖ(㏻ᖖ䛸䛿␗䛺䜛䝞䞁䝗䝟䝍䞊䞁䜢♧䛩)䛜Ꮡᅾ䛩
䜛ሙྜ䜈䛾ᑐᛂ䛜ᅔ㞴
(b)㒊ศⓗ≉ᚩ䜢⏝䛔䜛ᡭἲ(P2-2)
•
⏝䛷䛝䜛ሗ䛜ᑡ䛺䛔
•
㒊ศⓗ≉ᚩ䛾ᢳฟ⤖ᯝ䛜㡿ᇦᢳฟ䛾⢭ᗘ䜔ᵓ㐀␗ᖖ䛾
᭷↓䛻ᕥྑ䛥䜜䜛
➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ1.3 ᰁⰍయ㡿ᇦᢳฟ䞉ྠᐃ䛻䛚䛡䜛ㄢ㢟
8•
◊✲䛾┠ⓗ
–
㧗⢭ᗘ䛛䛴ຠ⋡ⓗ䛺ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ䛾ᐇ⌧
•
ᥦᡭἲ
–
1ᮏ䛾ᰁⰍయ㡿ᇦ䜢」ᩘ䛾㒊ศ㡿ᇦ䛾㐃䛺䜚䛸䜏䛺䛧䚸ྛ㒊
ศ㡿ᇦ䛾᥈⣴䜢㡰䛻⧞䜚㏉䛩䛣䛸䛷䚸ᰁⰍయ㡿ᇦయ䜢ᢳฟ䞉
ྠᐃ
•㒊ศ㡿ᇦ༢䛷ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ䜢ྠ䛻⾜䛔P1䜈ᑐᛂ •㒊ศ㡿ᇦ䛷䛾᥈⣴⤖ᯝ䜢⤫ྜ䛩䜛䛣䛸䛷P2䜈ᑐᛂ•
ᐇ⌧᪉ἲ
–
ྛ㒊ศ㡿ᇦ䜢⏬ീ୰䛷≉␗ⓗ䛻᥈⣴䛩䜛䜶䞊䝆䜵䞁䝖䜢ᑟධ
䛧䚸䛭䜜䜙䜢┦䛻༠ㄪ䛥䛫䜛䛣䛸䛷ᐇ⌧
➨䠍❶ ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃ1.4 ᮏ◊✲䛾䜰䝥䝻䞊䝏
9•
ฎ⌮䛾ὶ䜜
–ᰁⰍయ1ᮏศ䛾᥈⣴ 䐟㉳Ⅼ䛸䛺䜛㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢᥈⣴ 䐠㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢Ⓨぢ䛧䛯⟠ᡤ䛾㏆ഐ䛷䚸 㞄᥋䛩䜛㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢᥈⣴ 䐡㒊ศ䝞䞁䝗䝟䝍䞊䞁䛾᥈⣴䜢㡰䛻⧞䜚㏉䛧䚸୍ ᮏ䛾ᰁⰍయ䜢᥈⣴ (㞄᥋䛩䜛㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢Ⓨぢ䛷䛝䛺䛔ሙྜ 䛿᥈⣴⠊ᅖ䞉㡰ᗎ䜢ኚ᭦) –䛾⟠ᡤ䜢㉳Ⅼ䛻᥈⣴䜢⧞䜚㏉䛧ᰁⰍయ㡿ᇦ䜢 ᢳฟ䞉ྠᐃ ➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ•
‽ഛ
–ᰁⰍయ䛾✀㢮䛤䛸䛻⏝ព䛥䜜䛯ཧ↷䝟䝍䞊䞁䜢 ྛ䚻」ᩘ䛾㒊ศ䛻ศ(㒊ศ䝞䞁䝗䝟䝍䞊䞁) – ␒ᰁⰍయ䛾 ␒㒊ศ䝞䞁䝗䝟䝍䞊䞁䠖2.1 ᥦᡭἲ䛻䛚䛡䜛ฎ⌮䛾ὶ䜜
) (i m bp i m ) ( 1 j n bp ) ( j n bp bp() 1 j n bp(i) m bp() 1 i m bp() 1 i m bp() 2 i m bp() 2 i m 7␒䛾ᰁⰍయ䛾ཧ ↷䝞䞁䝗䝟䝍䞊䞁 ) 7 ( 4 bp ) 7 ( 3 bp ) 7 ( 2 bp ) 7 ( 1 bp 㒊ศ䝞䞁䝗 䝟䝍䞊䞁 10•
ᥦᡭἲ䛷ᮇᚅ䛷䛝䜛ຠᯝ
–
䛾⟠ᡤ䛾᥈⣴⤖ᯝ䜢⏝䛧䛺䛜䜙䚸㒊ศ䝞䞁䝗䝟䝍䞊䞁༢
䛷䛾ᢳฟ䛸ྠᐃ䜢ྠ䛻ᐇ⾜
ᵝ䚻䛺≧ែ䛻䛒䜛ᰁⰍయ㡿ᇦ䛾ṇ☜䛺ᢳฟ䜢ᐇ⌧
–
㒊ศ䝞䞁䝗䝟䝍䞊䞁䛾᥈⣴㡰ᗎ䜔᥈⣴⠊ᅖ䜢≧ἣ䛻ᛂ䛨ไᚚ
᥋ゐ䚸㔜䛺䜚➼䛜⏕䛨䛶䛔䜛ᰁⰍయ㡿ᇦ䜔䚸ᵓ㐀␗
ᖖ䜢ྵ䜐ᰁⰍయ㡿ᇦ䛾ᰂ㌾䛺ྠᐃ䜢ᐇ⌧
2.1 ᥦᡭἲ䛻䛚䛡䜛ฎ⌮䛾ὶ䜜
➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ 11•
ᥦᡭἲ䛾≉ᚩ
–
㒊ศ㡿ᇦ䜢⊂❧䛻᥈⣴
–
᥈⣴⤖ᯝ䛾┦⏝䛜ᚲせ
–
ಶ䚻䛾≧ἣ䛻ᛂ䛨䛯ฎ⌮䛾ไᚚ䛜ᚲせ
–
ᑓ㛛ᐙ䛾⤒㦂䞉▱㆑䛾ฎ⌮䜈䛾ᑟධ䛜ᚲせ
ྛ㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢≉␗ⓗ䛻᥈⣴䛩䜛
䜶䞊䝆䜵䞁䝖䜢ᑟධ䛧䚸䛭䜜䜙䛜┦䛻༠ㄪ
䛩䜛䝬䝹䝏䜶䞊䝆䜵䞁䝖䝅䝇䝔䝮䛸䛧䛶ᐇ⌧
㒊ศ㡿ᇦ䛾᥈⣴䛜ྛ䚻⮬ᚊ
ⓗ䛻⾜䜟䜜䜛ᶵᵓ䛜᭷ຠ
2.2 䝬䝹䝏䜶䞊䝆䜵䞁䝖䛻䜘䜛ᥦᡭἲ䛾ᐇ⌧
➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ 12•
䜶䞊䝆䜵䞁䝖䛾ᵓᡂ
–㒊ศ䝞䞁䝗䝟䝍䞊䞁䛻ᑐᛂ䛩䜛⟠ᡤ䜢⏬ീ ୰䛷᥈⣴ •㉳Ⅼ᥈⣴䜶䞊䝆䜵䞁䝖(AS) –⏬ീయ䛷ᑐᛂ⟠ᡤ(㉳Ⅼೃ⿵)䜢᥈⣴ •㒊ศ᥈⣴䜶䞊䝆䜵䞁䝖(AP) –ᣦ♧䛥䜜䛯⠊ᅖෆ䛷ᑐᛂ⟠ᡤ䜢᥈⣴ –䜶䞊䝆䜵䞁䝖䛾ືస䜢ไᚚ䛧᥈⣴⤖ᯝ䜢⤫ྜ •䝬䝛䞊䝆䝱䜶䞊䝆䜵䞁䝖(AM) –ᰁⰍయ䛾᥈⣴య䜢ไᚚ •䝍䝇䜽䜶䞊䝆䜵䞁䝖(AT) –㏻▱䛥䜜䛯⟠ᡤ䜢㉳Ⅼ䛸䛧䛯ᰁⰍయ1ᮏศ 䛾᥈⣴䜢ไᚚ2.2 䝬䝹䝏䜶䞊䝆䜵䞁䝖䛻䜘䜛ᥦᡭἲ䛾ᐇ⌧
➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ 䝬䝛䞊䝆䝱䜶䞊䝆䜵䞁䝖(AM) ᥈⣴ ⤖ᯝ 㒊ศ᥈⣴䜶䞊 䝆䜵䞁䝖(AP) 䝍䝇䜽䜶䞊 䝆䜵䞁䝖(AT) ㉳Ⅼ᥈⣴䜶䞊 䝆䜵䞁䝖(AS) 㒊ศ᥈⣴䜶䞊 䝆䜵䞁䝖(AP) ㉳Ⅼೃ⿵ ㉳Ⅼ ᥈⣴ ⤖ᯝ ᥈⣴ ⠊ᅖ ᥈⣴ ⤖ᯝ ᥈⣴ ⠊ᅖ13 䐣᪂䛯䛺 䜢䜃ฟ䛩
2.2 䝬䝹䝏䜶䞊䝆䜵䞁䝖䛻䜘䜛ᥦᡭἲ䛾ᐇ⌧
➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ STEP2(᪂䛯䛺㉳Ⅼ䛛䜙䛾᥈⣴㛤ጞ) 䐢㉳Ⅼೃ⿵䛾୰䛛䜙 ᪂䛯䛺㉳Ⅼ䜢㑅ᢥ ) (i m AT ) (i m AT AM STEP1(᥈⣴㉳Ⅼ䛾ೃ⿵䜢᥈⣴) 䐟 䛻ᑐᛂ 䛩䜛⟠ᡤ䜢⏬ ീయ䛷᥈⣴ 䐡㉳Ⅼೃ ⿵䜢㏻▱ ) (i m bp ) (i m AS AM 䐠㉳Ⅼೃ ⿵䜢Ⓨぢ ᰁⰍయ 㡿ᇦ 142.2 䝬䝹䝏䜶䞊䝆䜵䞁䝖䛻䜘䜛ᥦᡭἲ䛾ᐇ⌧
➨2❶ 㒊ศ㡿ᇦ䜢༢䛸䛧䛯ᰁⰍయ㡿ᇦ䛾ᢳฟ䞉ྠᐃᡭἲ STEP3(ᰁⰍయ1ᮏศ䛾᥈⣴) ) (i m AT 䐥 䛻 ᑐ䛧᥈⣴⤖ ᯝ䜢㏻▱ 䐤AP䛻ᑐ䛧 ᥈⣴⠊ᅖ䜢 ᣦ♧ AP() 1 i m AP() 1 i m AM AT(i) m ᥈⣴⠊ᅖ AP() 2 i m AP() 2 i m AP() 3 i m STEP4(ᰁⰍయ1ᮏศ䛾᥈⣴⤖ᯝ䛾ホ౯) 䐦㞄᥋䛩䜛APྠኈ 䛜᥈⣴⤖ᯝ䜢䛧䚸 㡿ᇦ䜢䜘䜚ṇ☜䛻Ỵ ᐃ䛷䛝䜛䜘䛖⮬㌟䛾 䝟䝷䝯䞊䝍䜢ㄪᩚ 䐧ᰁⰍయ 1ᮏศ䛾 ᥈⣴⤖ᯝ 䜢ホ౯ 䐨ホ౯⤖ᯝ 䜢㏻▱ 䐩᪂䛯䛺㉳Ⅼ䜢㑅ᢥ AM 15 ➨3❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯3.1 ヨస䝅䝇䝔䝮
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ᐇ㦂┠ⓗ
–ᥦᡭἲ䛻ᇶ䛵䛝ヨస䝅䝇䝔䝮䜢ᐇ䛧䠈䝅䝭䝳䝺䞊䝅䝵䞁⏬ീ䜢ᑐ㇟ 䛸䛧䛶ືస᳨ド 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y ISCN(International System for Human Cytogenetic Nomenclature)䛻䜘䜛ᰁⰍయᶍᘧᅗ16 ➨3❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯
3.1 ヨస䝅䝇䝔䝮
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ᐇ⎔ቃ
–
DASH(䜶䞊䝆䜵䞁䝖䝣䝺䞊䝮䝽䞊䜽)[6,7]
ୖ䛾䜶䞊䝆䜵䞁䝖䛸䛧䛶ᐇ⌧
•ྛ䜶䞊䝆䜵䞁䝖䛿䚸3䛴䛾䝰䝆䝳䞊䝹䛷ᵓᡂ –KM䛿䝯䝑䝉䞊䝆䜔BPไᚚ䛾䛯䜑䛾▱㆑䜢ಖᣢ –CM䜢⏝䛔䛶䝯䝑䝉䞊䝆䜢⾜䛔┦䛻༠ㄪ –AM䜢⏝䛔䛶BP䜢ไᚚ䛧䚸䛘䜙䜜䛯䝍䝇䜽䜢ᐇ⾜ •BP䛿Java➼䛷ᐇ䛥䜜䛯ィ⟬ᶵ䝥䝻䝉䝇 –ྛ䜶䞊䝆䜵䞁䝖䛾᥈⣴ᶵ⬟䛿BP䛻䜘䜚ᐇ⌧–
PC(CPU Xeon 3.06GHz䚸䝯䝰䝸1.00 GB䚸
WindowsXP Professional)ୖ䛻ᐇ
䝧䞊䝇䝥䝻䝉䝇(BP) ㏻ಙ䝰䝆䝳䞊䝹(CM) ▱㆑ฎ⌮䝰䝆䝳䞊䝹(KM) ᧯స䝰䝆䝳䞊䝹(AM) 䝯䝑䝉䞊䝆 䜶䞊䝆䜵䞁䝖 䛾䜶䞊䝆䜵䞁䝖3.1 ヨస䝅䝇䝔䝮
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ヨస䝅䝇䝔䝮䛷⏝䛔䛯䜶䞊䝆䜵䞁䝖䛾✀㢮
–㒊ศ䝞䞁䝗䝟䝍䞊䞁䜢᥈⣴䛩䜛䜶䞊䝆䜵䞁䝖 ➨3❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯3.2 䝅䝭䝳䝺䞊䝅䝵䞁⏬ീ䚸ཬ䜃䚸㒊ศ䝞䞁䝗䝟䝍䞊䞁
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䝅䝭䝳䝺䞊䝅䝵䞁⏬ീ(400㽢300⏬⣲)
–ISCN(International System for Human Cytogenetic Nomenclature)䛻䜘䜛ᰁⰍయ䛾ᶍᘧᅗ䛛䜙సᡂ
19 •ᐇ㦂1: ヨస䝅䝇䝔䝮䛾ືస᳨ド䠄1ᮏ䛾ᰁⰍయ䠅 –10␒ᰁⰍయ1ᮏ䜢⏬ീ୰䛻㓄⨨ –ᶍᘧᅗ䛾ศᩘ䛿6 –㉳Ⅼ᥈⣴䜶䞊䝆䜵䞁䝖䠗
3.3 ᐇ㦂⤖ᯝ
) 10 ( 3 AS ➨3❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯ ᥈⣴2ᅇ┠ AP䛻䜘䜛᥈⣴ MSE=6346 AP┦䛾 ༠ㄪ䛻䜘䜛 ㄪᩚ⤖ᯝ MSE=334 ኻᩋ䛸ุ᩿䚸 ⤖ᯝ䜢◚Რ ᡂຌ䛸ุ᩿䚸 ⤖ᯝ䜢☜ᐃ AP┦䛾 ༠ㄪ䛻䜘䜛 ㄪᩚ⤖ᯝ ᥈⣴1ᅇ┠ AP䛻䜘䜛᥈⣴ MSE=17233 ᥈⣴㉳Ⅼ (ㄗ䜚) MSE=12672 AP┦䛾 ༠ㄪ䛻䜘䜛 ㄪᩚ⤖ᯝ ᥈⣴㉳Ⅼ (ṇゎ) 20 ( 䚸 䚸 䚸 ) •ᐇ㦂2: ヨస䝅䝇䝔䝮䛾ືస᳨ド䠄」ᩘᮏ䛾ᰁⰍయ䠅 –᥈⣴⤖ᯝ –⏬ീ୰䛾ᰁⰍయ䛾ᩘ䛻䜘䜛ฎ⌮㛫䛸ືస䛩䜛䜶䞊䝆䜵䞁䝖ᩘ(䛾䜉)3.3 ᐇ㦂⤖ᯝ
3 1 2 1 ᥈⣴ኻᩋ䛾ᅇᩘ 143 87 79 46 ฎ⌮㛫(⛊) 34 3 33 2 56 18 ືస䛩䜛䜶䞊䝆䜵䞁䝖ᩘ(䛾䜉) 4 1 ᰁⰍయ䛾ᩘ ᕥ䛛䜙11䚸10␒ᰁⰍయ ( 䚸AS(310) 䛜✌ື) ) 11 ( 2 AS ᕥ䛛䜙11䚸10䚸9␒ᰁⰍయ ( 䚸(9) 䚸 ) 2 AS (10) 3 AS (11) 2 AS ᕥ䛛䜙11䚸12䚸10䚸9␒ᰁⰍయ ) 12 ( 5 AS ) 9 ( 2 AS (10) 3 AS (11) 2 AS ➨3❶ ヨస䝅䝇䝔䝮䛻䜘䜛ᐇ㦂䛸ホ౯ 21 ➨4❶ ⤖ㄽ4.1 ᮏ◊✲䛾䜎䛸䜑
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⌧ẁ㝵䛷䛾䜎䛸䜑
–
1ᮏ䛾ᰁⰍయ㡿ᇦ䜢」ᩘ䛾㒊ศ㡿ᇦ䛾㐃䛺䜚䛸䜏䛺䛧䚸㒊
ศ㡿ᇦ༢䛷ᢳฟ䛸ྠᐃ䛸䜢ྠ䛻⾜䛖ᡭἲ䜢ᥦ
–
ྛ㒊ศ㡿ᇦ䜢≉␗ⓗ䛻᥈⣴䛩䜛䜶䞊䝆䜵䞁䝖䜢ᑟධ䛧䚸䛭
䜜䜙䜢┦䛻༠ㄪ䛥䛫䜛䛣䛸䛻䜘䜚ᐇ⌧
–
ᥦᡭἲ䛾୍㒊䜢ヨస䝅䝇䝔䝮䛸䛧䛶ᐇ䛧ືస䜢᳨ド
22 ➨4❶ ⤖ㄽ4.2 ᚋ䛾ㄢ㢟
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ᵝ䚻䛺≧ែ䜢䛸䜛ᰁⰍయ㡿ᇦ䛻ᑐᛂ䛩䜛䛯䜑䛾ヲ
⣽タィ䚸ᐇ䚸ホ౯
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ᰁⰍయ䛾ྛ㒊ศ䛜ᵝ䚻䛺᪉ྥ䜢ྥ䛔䛶䛔䜛ሙྜ
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ᰁⰍయྠኈ䛜㔜䛺䜛ሙྜ䜔䚸ᰁⰍయ㡿ᇦ䛻ᵓ㐀␗ᖖ䛜
䛒䜛ሙྜ
–
ᐇ⏬ീ䜈㐺⏝䛩䜛䛯䜑䛾㒊ศ㡿ᇦ᥈⣴ᡭἲ䛻䛴
䛔䛶䛾᳨ウ
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䜘䜚ຠᯝⓗ䞉ຠ⋡ⓗ䛻ᢳฟ䞉ྠᐃ䜢⾜䛖䛯䜑䛾䜶䞊
䝆䜵䞁䝖㛫༠ㄪᡭἲ䛻䛴䛔䛶䛾᳨ウ
23 [1]᪂ᕝ , ”㑇ఏ་Ꮫ䜈䛾ᣍᚅ ᨵゞ➨3∧,” ༡Ụᇽ, 2005. [2]L. G. Shaffer et al. “ISCN2005: An international system for humancytogenetic nomanclature,” S.Karger AG, 2005.
[3]Qiang Wu et al. “Subspace-Based Prototyping and Classification of Chromosome Images,” IEEE Trans. Pattern Anal. Machine Intel., Vol.14, No.9, pp.1277-1287, 2005.
[4]F. C. A. Groen et al, “Human chromosome classification based on local band descriptors,” Pattern Recognit. Lett., Vol.9, no.3, pp211-222, 1989. [5]M. Moradi et al, “New features for automatic classification of human
chromosomes: A feasibility study,” Pattern Recognit. Lett., Vol.27, no.1, pp19-28, 2006.
[6]”DASH-Distributed agent system based on hybrid architecture,”
http://www.agent-town.com/dash/. [7]ཎ , “䜶䞊䝆䜵䞁䝖ᆺศᩓ䝅䝇䝔䝮㛤Ⓨ䝒䞊䝹DASH䛾タィ䛸ᐇ,” ྜྠ 䜶䞊䝆䜵䞁䝖䝽䞊䜽䝅䝵䝑䝥䠃䝅䞁䝫䝆䜴䝮 2003 ㅮ₇ㄽᩥ㞟, pp.147-154, 2003. 㘓䠄ཧ⪃ᩥ⊩䠅
