犬 Babesia gibsoni 感染症の治療と予防に関する研究

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(1)Title. 犬 Babesia gibsoni 感染症の治療と予防に関する研究( 本文 (Fulltext) ). Author(s). 白永, 伸行. Report No.(Doctoral Degree). 博士(獣医学) 甲第532号. Issue Date. 2019-03-13. Type. 博士論文. Version. ETD. URL. http://hdl.handle.net/20.500.12099/77963. ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。.

(2) ǌ Babesia gibsoni ŒƐǤ*ƭǧ%ʏ(ʋ=ǶȄ. 2018 Ĳ. ĨʍċĖċĖʒɸâǐÔĖǶȄǾ ʮĮĳǛǖċĖʯ. Ǫƪ £Ʌ.

(3) ǌ Babesia gibsoni ŒƐǤ*ƭǧ%ʏ(ʋ=ǶȄ. Ǫƪ £Ʌ.

(4) ǭƛ. ĵɞ ………………………………………………………………………...……………….1. Ȋ 1 Ȉ ǌ B. gibsoni ŒƐǤƭǧ(

(5) =¦ǗʅVteZǧƯ*ƭǧÐƏ%ė½Ō *ɗ …………………………………………………………………………………..…..4 1 ȣɐ …………………………..…………………………………...…..…...…….……..4 2 ƊŶ

(6) :.ŸƯ ………………………………………………………………………..5 3 ȝƏ …………………………………………………………………….…...….…........7 4 Ȫġ ………………………………...…………………………………..……...……….9 5 Ĥť …………………………………………………………………………….……..13. ȊʵȈ ǌ B. gibsoni ŒƐǤ*Àǩʏƞ(ʋ=ǶȄ ………………….…………..21 ȣɐ ………………………………………………………………..……………….……..21 Ȋ 1 ȑ ¦ǗʅVteZǧƯ%O}^sFU*ț4â@ƭǧƯ*ǌ B.. gibsoni ŒƐǤÀǩʏƞÐƏ*Ɩɒ …………………………………………………..22 1 ĵɞ ……………………………………………………………………….......……22 2 ƊŶ

(7) :.ŸƯ ……………………………………………………………………22 3 ȝƏ …………………………………………………………………………………24 4 Ȫġ …………………………………………………………………………………25 Ȋ 2 ȑ DVWsFU%dMUSFO}*ǌ B. gibsoni ŒƐǤÀǩʏƞÐƏ* Ɩɒ ………………..………………..……………….…………………………….……..26 1 ĵɞ …………………………………………………………………………...……26 2 ƊŶ

(8) :.ŸƯ ……………………………………………………………………26 3 ȝƏ ………………………...………………………………………………………27 4 Ȫġ ………………………………………………...………………………………28 Ĥť ……………………………………………………………………………….……….31.

(9) ȊʶȈ ǌ B. gibsoni ŒƐǤƲɅü(

(10) =ǌ* B. gibsoni ʤŌŒƐǍƮ .…..38 1 ȣɐ ………………………………………………...………………………………38 2 ƊŶ

(11) :.ŸƯ …………………………………………………………………...38 3 ȝƏ ………………...……………………………………………………………....40 4 Ȫġ ……………………………………………………...………………………....41 5 Ĥť ……………...…………………………………………………………...…….44. Ȣť ……………………………………………………………………………..…….…..48 ɟɮ ………………………………………………………………………………..….…..51 ŵǏ …………………………………………………………………………………...…..53.

(12) ǜɛ ɍ. CBC. ½ɄǓɑȎ. RBC. ɥɄǓ. Hb. pwPkǀĶ. PCV. ɄǓĝȃ. PLT. ɄĤƍ. T.P. Ȣ]iOǀĶ. AST. aspartate aminotransferase ³. ALT. alanine aminotransferase ³. ALP. alkaline phosphatase ³. T. Cho. ȢRWa~³. T. Bil. Ȣk}~kǀĶ. BUN. ɄĦȘȆȘǀĶ. Cre. OD_fǀĶ. Na. ec}GuǀĶ. K. K}GuǀĶ. Cl. ĄȘǀĶ. Glu. Ʉȕ³. Alb. D~nt³. Ca. K~UGuǀĶ. CRP. C ÝňŌ]iOɤ. IMHA. »ǟûŌƼɄŌɢɄ. EDTA. I_VDtóʂʃ.

(13) ĵ ɞ. ǌhqUDǤ+ǌ*s^fĒŌǢŎ*' $ƃ7ʄɊ'7** !$=[27, 34]ǌhqUDǤ*ǣÚ§%#ÚɃ* Babesia canisB. gibsoniB. vogeli. B. conradae

(14) :. B. rossi Ǵ;>#

(15) <>3$({ì*ùAņ (ÓȔÓƌDm}Kƌ×DVDŻƉAç5ƌDVD3$ĳȒ÷'ǩǕɚ 6;># =[1, 7, 9, 13, 16, 36] ǚǫ(+ B. canis % B. gibsoni AÚõ%= āé1%B&$=ˀ7ˁŻƉ(

(16) =ǌhqUD+ǇĮüÿ*ƫȥ(+ B.. canis 8 B. vogeli Ǖō=7**ċĊŴ+ B. gibsoni $=[25, 46, 52] ǌ(

(17) = B. gibsoni ŒƐǤʮǌ B. gibsoni ŒƐǤ%=ʯ$+ƼɄŌ ɢɄ8ǩǇȳȵʬǠ'&ʄȓ'ǤǍA¢ %ĊƢ(Ⱥ=%7= ƭǧ(+VteZDY_ycʮVteZʯŞÚɃɂ%#ǚ $ĳªǗ># =[10, 57, 60]VteZ+ŗù$+ǉlo|XsǤ( Ģ#Śɚł;># =ǌ B. gibsoni ŒƐǤ(Ģ#+Śɚ># ' VteZ+ǌ(Ģ#ưģʁ¥*Ǹȝ8ǡǥ%%7(ĤȲÂɄ% Ȼëǫ' Í¨ǗAƅ#

(18) <ĤÑǊȸĴĜ(%. #ɾş( ɂÌ$=[7, 10, 57, 60]. ɰĲÍ¨ǗôʀAǭǫ%#ŞÚɃƱŌAŦ!Şȿɂ*ĊÌ©ǗǧƯāé > >;*Şȿɂ*ŞÚɃƱŌ+9=8 $ôŃ(ƀʊ =6 [65]Ň7ȸĴĜ*ďőAł;>=ƭǧƯ$+' *ŀŞs|}Dɂ$ =DchRADVWsFU%©ǗƭǧocR~ǌ B. gibsoni Œ ƐǤ(ƅÐ%āé>[8] *ŀ*ocR~(:=ƭǧ(7Àǩ ɚ6;> [32, 60];(+ B. gibsoni * CYTɿ¡Ĕ*Ƙ'ĈǞǋ(Dc hRȫŌA

(19) =Ɋ'ȅǄĈǞ$= M121I ĈǞƒ*Âǒž; %' [22, 41, 42]*ŀDchR%oPDf~*âÌ*ƅÐŌāé> 8+<Àǩɚ6;>[23] ù¿(

(20) =ǌ B. gibsoni ŒƐǤ*ƭǧ(+ċĊŴ*ȸĴĜVteZAªǗ. 1.

(21) # =VteZ+Ƴĉ$+ 35 mg/kgȌȬ¿ŝAØǎ7+ 2 ôŝ ># =[7, 45, 57, 69] ŸŻƉù¿$+VteZ*ŝʅŝƯÜ. Í¨Ǘ*ʋ¯(! #*Ƭ;*āé(Ā"[50]ƓƭǫƭǧƯ$+' 7** ė½$ʈƆǫ'ǰʋ»ǟł;>=ŸƯ%#[7]VteZ*¦ǗʅɈŴôŝ Ư%# 2 mg/kgʗŻ 3 ôŝƯʮ¦ǗʅVteZǧƯ%=ʯĳ ƁÜ# = *¦ǗʅVteZǧƯ*Í¨Ǘ8ôŃ3$*ɄƶŌǍ* ĈÒ'&+§Ȗǫ(ɗ>#

(22) ;ȸĴǫ(+ƓŤ(Ā" ƭǧƯ('. #. + ' $3Ȋ 1 Ȉ$+ǌ B. gibsoni ŒƐǤƭǧ(¦ǗʅVteZǧ ƯAɅ ôŃ3$*ÑåAɏƎ#ƭǧÐƏ%ė½ŌAɗ ǌ B. gibsoni ŒƐǤ+ÀǩĊ ǢŎ$=%7:Ǵ;># =[4, 10, 73, 74] *ǔǙ%#ǒƀǁ$+ '=ƭǧ$7Ɠƭǫ( B. gibsoni ŒƐAĘ ½(§ĉ/Ūʓ$' ;$=[27, 37]ǌ B. gibsoni ŒƐǤ(

(23) =Àǩ+ żƭǨǍœ*ŀ(Mx}D%'<ǰʋ»ǟ(:. #ÀŒƐ=%'%. 7ȸĴǤǍÀǈ=%$ƀ(ğǕɃɄǤ*ąŏA¢ %7=[7, 27]M x}D$=%+ãƀ(Àǩ*}WOAŠ =%$=ÀǩAȦ<ɱ% ȧŎǌ+Ǖë*Ùʕ(;>=ƚ ą =%('=6ÀǩʏƞĢȍŇ Ɋ$= Ÿ$ǌ B. gibsoni ŒƐǤ*ƭǧ(

(24) #Ɠƭ+öʚ$=ɈŴ *ɂÌAț4â@=ƭǧƯÀǩŜÉ(+ÐƏǫ%Ȫ ;>#

(25) <[8, 65, 42, 73, 74] FtdK~nVteZO}^sFU*ț4â@+ÀǩǑ *¦ ƭǧƯ%#āé># =[37]* O}^sFU+ B. gibsoni (ƅÐ$<ǌ B. gibsoni ŒƐǤ*ƭǧ(:ªǗ># =[37, 71, 73, 74] 3Àǩʏƞ*6(¦ǗʅVteZǧƯ%țâ@ƭǧ[65]7Ʌ@># =O}^sFU*ŝʅ8Ɔʊ*ÀǩʏƞÐƏ+§Ȗǫ(ɗ># ' $Ȋ 2 Ȉ$+ǌ B. gibsoni ŒƐǤ(Ģ=¦ǗʅVteZǧƯŀ* O}^sFUŝ(

(26) =ÀǩʏÐƏ*ƖɒAɅ ;(+ŝƆʊ(ʋ =Ɩɒ%*ɂÌ%*ƧɬAɅ. . 2.

(27) hqUD+Ğ(ŒƐŀƭǧ(:. #48 (ƈƕɄ ;Ƶč=șȡ. ¿ǬȖ(ƾĞ%*ʊ(ǰʋ»ǟAŖȇ#ʤŌŒƐ%'=ˀ7, 14, 59ˁ. B. gibsoni *ǌ/*ŒƐ+m]cQ_s^fAɆ%=s^f*Êì(:=Œ Ɛ%ɭɄ8ʌǌ(:=ß¶'&s^fA' ǯŬ¡ű(:=ŒƐ=[10, 16]ŒƐŀ(7ǩǤƭǧAÞǌ$+'ȹǄôŃ8ƇǩǤ'&$ȫɻ Ăâ(7ʤŌŒƐ%'=ʤŌŒƐǌ*ǩǤ(+ȳȷŰÂ8»ǟŜÉǍ œʋ# =[29, 34, 39]ȸĴǒĂ(

(28) =ǌ B. gibsoni ŒƐǤ*ɕŷ(+Ʉ ƶăŢƖƑ(

(29) =ŒƐÚɃ*ƖÂǗ ;># = ʤŌŒƐ$+ƈ ƕɄ(Âǒ=ŒƐÚɃ*Ŵʝį(ĥ'ʇƖ$+ƖÂöʚ'%7=[7, 24, 43]>;ʤŌŒƐAśů=(+ʫŒĶ'ÃĔǕǊĖǫɕŷŸƯ%# PCRʮpolymerase chain reactionʯǗ ;>=PCR +ƈƕɄ(ŒƐɥɄǓ 10 ° / µl >, B. gibsoni AƖÂàȯ$<ǌ B. gibsoni ŒƐǤ*ǟĖɝƑ( 7ňǗ># =[24, 25, 64] PCR (7ƖÂʑǚ<ʔŌ$. #7. ŒƐAæę=%+$' *6ʤŌŒƐAƟǹ(ũ; =6(+ PCR (Ï #źľơ7ȪŔ0$=%?ǌ B. gibsoni ŒƐǤ*ǟĖɝƑ (

(30) #źľơAȪŔ7*+āé># ' ǌ B. gibsoni ŒƐǤ(

(31) =ʤŌŒƐ*ĚŐAśů=%+ǋ(ƲɅü(

(32) =ʤŌŒƐ*ʤŌÒ(:=Àǩ8ƇŒƐǌ/*ŒƐ*}WOAġǴ=% (ÐƏǫ%Ȫ ;>ȸĴǫőȩċ >3$ɝƑ># ' $ Ȋ 3 Ȉ$+ǌ B. gibsoni ŒƐǤ*ƲɅü(

(33) =ǟĖǫǶȄ%#3ȸĴµ ķ'ǌ* B. gibsoni ʤŌŒƐǍƮAźľơAç6#ɝƑ;(B. gibsoni ŒƐ*}WOmCO]AɏƎ=%%7(ʱ B. gibsoni *ʤŌŒƐǌ%ʝŒƐ ǌ*ɄƶŌǍAƧɬ. 3.

(34) Ȋ 1 Ȉ ǌ B. gibsoni ŒƐǤƭǧ(

(35) =¦ǗʅVteZǧƯ*ƭǧÐƏ%ė½ Ō*ɗ. 1. ȣɐ ŻƉ(

(36) =ǌhqUDǤ*Úõ%'. # =*+12ċĊŴ B. gibsoni $. =[25, 46, 52]ǌ B. gibsoni ŒƐǤ$+B. gibsoni Ğ*ɥɄǓ¿(®¼ ğǕąƤAȦ<ɱ#ɥɄǓAǷĆ*ȝƏ%#Ğ(ƼɄŌɢɄĺ ɧ>=[69] ǌ B. gibsoni ŒƐǤ*ƭǧ(Ǘ =ŞÚɃɂ(+(VteZǚ$ĳ ªǗ># =[57, 60] VteZ(+Í¨Ǘ%Àǩ#ɁȃƦŌ ïʣǁ%'. # =Í¨Ǘ+ĤȲÂɄ(:=Ȼëǫ'ǼȜǤǍ8ưģʁ¥*Ǹ. ȝ8ǡǥ'&$=6*ªǗAŕŉ=ǐÔĭ7 =[7, 10, 56, 59] ƃɰ $+Í¨Ǘ*ĥ' ƭǧƯ%#vcf^\~dMUSFO}DVW sFU'& B. gibsoni (ƅÐ% @># =Şȿɂ*ĊÌ©ǗǧƯ[65]Şs |}Dɂ$=DchR(DVWsFUA©ǗocR~[8, 32, 41, 42, 60]3DchR%oPDf~*âÌ%dMUSFO}A©Ǘo cR~[23]'&ǌ B. gibsoni ŒƐǤ/*Ƙ'ƭǧƯāé># = ŒƐhqUD+>;*ƭǧƯ(:. #7Ę½(§¿ ;Ūʓ>=%. +' [10, 23, 37, 65] ǌ B. gibsoni ŒƐǤ*ƭǧ(

(37) =VteZ*ŝocR~+ƜȔ$+ 35 mg/kg Øǎ7+ 2 ô*ȌȬ¿ŝ%># =[7, 45, 54, 69] ŻƉù¿$+*Ǘʅ$+Í¨Ǘ%#ǼȜǤǍ'&ɚ6;>āé=[33, 35]*ŀƬ;ĚʪŒƐǌAǗ ǶȄ(:<1.45 mg/kgʗŻ 4 ô* Ǭŝė½'ǗƯ$=%āé#ʐ [50]ŻƉ$+*ocR~= +ʥ¤*¦ǗʅʗŻɈŴôŝ$*ƭǧʮ¦ǗʅVteZǧƯʯƁÜ. 4.

(38) #

(39) <ǒǍ$+ƲɅüAņ( 2 mg/kg *ǬŝAʗŻ$ʶʷôĚŹ# =ǐÔĭĊ ė½ŌAʄɌ¦ǗʅVteZǧƯ(ʋ#+ *ƭǧÐƏ8Í¨Ǘ'&AȸĴǫ(əș'Ɩɒ+># ' $ƉȈ$+ǌ B. gibsoni ŒƐǤ(

(40) =¦ǗʅVteZǧƯ*ƭǧÐƏ 8ė½ŌAž; (=6(¦ǗʅVteZǧƯ(:<ƭǧAɅ. ǌ B.. gibsoni ŒƐǤǤ«AĢɡ(ƭǧȚ3$*ɥɄǓȖi|v]ʮRBC, PCV, Hbʯ%ɄĤƍŴʮPLTʯ*ŝȚ3$*ŭǿAɏƎ=%¾(Í¨Ǘ*ǩǕǍ ƮAɝƑ. 2. ƊŶ

(41) :.ŸƯ 2 – 1. ƊŶ 2000 Ĳ ; 2009 Ĳ3$(ħßǱê×Ĭ* ÑǊǣʒ(ƋʒƇƭǧ*ŋŌǌ. B. gibsoni ŒƐǤ%ɕŷ>ƭǧʉĐŻ(Ȋ 1 ǣŻ)(¦ǗʅVteZǧƯAÞ 242 «AĢɡ%#ɕǧɓʆAôʦǫ(ɝƑŋŌǌ B. gibsoni ŒƐǤ* ɕŷ+ȁé8ȸĴǤǍʮʧƝŨ¸ƨ¦3+ɉȽĦ'&ʯɪ§ƖƑŘɋ %%7(ɄƶƖƑ8ĦƖƑŘɋAȪŔ#ºĖʤńʇ$ 1,000 ±*±Ǒ(

(42) #|FcNuTƐȽA

(43) '. ɄƶăŢƙƉ*ɥɄǓ¿( B. gibsoni Ƀ§A. ƖÂĂâ%. 2 2ʲ¦ǗʅVteZǧƯocR~ ¦ǗʅVteZǧƯ+VteZ(LeZÒʼgh~aEWDfs~p~Wƒ Ĺ ǻ˂ƌ) 2 mg/kgʗŻ 3 ôʮȊ 1ʱ3ʱ5 ǣŻʯ*ǬŝAɅ. ŲŦǧ. Ư%#VteZŝËŀ(+½«(ndGȕÏʃ}Q~ƶʮ[~|Oc Dʼa~wƒĹ ǻƌʯ510 ml/kg/hr *ʅ*ʜȱ¿ɭƶA 23 ƀʊɅ. 5. .

(44) ɭɄ%ÍȴǬɤr~wʮodf\ưģƶ NZ : ŻƉ½ɂĪƗƒĹ ǻǽ ĩʯŝ+ɕġƀ(ʄĶ*ɢɄ(:. #Ǖë*Ùƚ$=%ÆŷǤ«(Ʌ. . 2 3ʲɝƑŸƯ%ʠǭ';.(Āƻ ¦ǗʅVteZǧƯʉĐƀ*ɔȸĴǤǍCBC (RBC, Hb, PCV, PLT)Ʉ ƶÒĖƖƑĦƖƑ+ɕǧɓʆ:<%<3%6 ūɄ+VteZ*ǬŝË(ʮȊ 1ʱ3ʱ5 ǣŻʯ

(45) :.ŝȚŀ*Ȋ 8 ǣ Ż(Ʌ. Ȋ 1ʱ3ʱ5ʱ8 ǣŻ+VteZŝ(

(46) =ɥɄǓȖi|v]. % PLT *ŭǿAɎġ3ɢɄ*ȀĶ(:=ɥɄǓȖi|v]*ŭǿ* ɼ Až; (=6Ǥ«AʝɢɄȨʮRBC ʿ6.0 × 106 /µlʯ%%7(ɫĶ ɢɄȨʮRBC : 4.05.9 × 106 /µlʯ ȋĶɢɄȨʮRBC : 2.03.9 × 106 /µlʯ ʄ ĶɢɄȨʮRBC : ʽ1.9 × 106 /µlʯ*ʷȨ(ÃȊ 8 ǣŻ3$* RBC *ąƸAɲ ɩ3ɄƶăŢƖƑ+Ȋ 1 ǣŻ%Ȋ 8 ǣŻ* CBC %ãƀ(Ʌ B. gibsoni Ƀ§*ƅǃAɝƑ CBC +ȹÑɄǓɑȎƚʮCelltac-αʼŻƉºʛƒĹ ǻƌʯAǗ #ƖƑ ɄƶÒĖƖƑ+ɄƶÒĖƹęòʮFUJI DRYCHEM 5000V, 7000VʼĠćmF ~uƒĹ ǻƌʯAªǗɄƶÒĖƖƑʠǭ%#+ AST, ALT, ALP, T. Cho, T. Bil, BUN, CRE, Na, K, Cl, Alb, Glu, Ca *ƹęAɅ ÑƹęƚòʮArrows. CRP + CRP ȹ. Laser CRP2ʼDXƒĹ ǻċʎʯAǗ #ƹę. CRP ³ƹęƚò*ʑ 20 mg/dl Aɨ =Ăâ+ 20 mg/dl %#ÁǔʬǠ ŧŴ*ȎÂ+ʬǠŧŴƍʮʬǠŧŴƍʼʫǘvbERƒĹ ǻʼƌʯAǗ ĦƖƑ+ĦƖƑɘʪȗʮJOUzWaEÒWʴʳEAʼDOFƒĹ ǻʼ ƌʯAǗ ɢɄ+ RBC 5.5 × 106 /µl Hb 12.0 g/dlPCV 37 ʭ* ½#Aƺ7*%ɄĤƍƸĥǤ+ PLT 150 × 10ʶ/µl %ę6k }~kĦ+ 2ʰAʖŌ%ʬǠ+ʬǠŧŴ 5 %Ʉȏ¿ƼɄ. 6.

(47) +ɄƷ3+ɄƽȬǲǫ(ƼɄ# Ăâ(ʖŌ%ǩǇ+ 39.7% ". & $. #&%!! . 2 – 4. ȞɑɏƎ VteZ 3 ôŝȚ3$*ɥɄǓȖi|v]';.( PLTs *ȜƀǫĈ Ò+ MannWhitney U test $Ɩę[19]ȞɑÁǔ+½#*ȞɑɏƎ+ Microsoft Excel [mcGHDʮXLSTATʼAddinsoft, New York, USAʯAǗ # ĚŹƅőƩƻ+ 5 ʭ%. 3. ȝƏ ŋŌǌ B. gibsoni ŒƐǤ 242 «(

(48) =Åɕƀ*ɔ3+ȸĴǤǍ%# ʧƝŨʮ87.6 ʭʯ%¸ƨƵčʮ83.1 ʭʯʫǑ(ɚ6;>ɉȽĦ7 48.3 ʭ (ɋ;>3ñäʮ9.9 ʭʯǦʮ9.1 ʭʯ§Ōǥʮ14.0 %ʯ7ɚ6;> ǌ/*s^fǳAɔ%#Þɕǌ7 2.9 ʭ(ĕûʮɆ 1 1ʯ Åɕƀ*ȸĴǣǔĖǫǋŅ%#+ɢɄʮ86.4 ʭʯɄĤƍƸĥǤʮ98.3 ʭʯ k}~kĦʮ91.7 ʭʯʫ ǩǕǑAǺ Ÿ$ʬǠ+ 28.5 ʭ$<3 Ʉȏ¿ƼɄ+ 5.0 ʭ$. ǩǇ+ 41.7 ʭ(ɚ6;>ʮɆ 1 2ʯáɥɄ. ǓȖi|v]*Č³+>> RBCs 3.46 × 106 /µlʮĀƻȒ÷ʼ5.50 ~ 8.85 × 106 /µlʯ Hb 7.9 g/dlʮĀƻȒ÷ʼ12.0 ~ 20.5 g/dlʯ PCV 24.0 ʭʮĀƻȒ÷ʼ 37 ~ 61 ʭʯ$. 3 PLTs *Č³+ 43 × 10ʶ /µlʮĀƻȒ÷ : 150.0 ~ 485.0. × 10ʶ /µlʯ$. ʮø 1 1ʯ Åɕƀ*ɄƶÒĖƖƑ*Č³+ ALP % CRP. ʫ³AǺʮɆ 1 3ʯ. 7.

(49) ¦ǗʅVteZǧƯA ½ 242 «13 Ǥ«ȊʺǣŻ3$(Ƣ 3Ç*ʹǤ«(+Ȋ 8 ǣŻ3$(ɭɄĚŹ>3Ȋ 8 ǣŻ3$(+À ǩ«+ɚ6;>'. ɥɄǓȖi|v]% PLT *ŭǿ(! #+Ƣ«%. ɭɄ«Aʓ 222 «(! #ɝƑ* 222 «½#*Ǥ«ƭǧʉĐŀ. B. gibsoni Ƀ§+ɷ8 (ƵɳɢɄ%ɄĤƍƸĥ*ôŃ(¢ #Ȋ 8 ǣŻ( +ȸĴǤǍ*Ƶč%§ɝ*ôŃAǺ3ɄƶăŢƖƑ(

(50) =Ȋ 8 ǣŻ$ * B. gibsoni Ƀ§*ƖÂ+ 222 «*½«$ǹɚ=%$'. . Ȋ 8 ǣŻ3$*ɥɄǓȖi|v]*ŭǿAø 1 2 (ǺRBC +Ȋ 1 ǣŻ(Ƨ0#Ȋ 3 ǣŻ(+ƅő(Ƹĥʮp < 0.05ʯ3ȊʸǣŻ( Hb Ȋ 8 ǣŻ(+½#*i|v]Ȋ 1 ǣŻ:<ƅő(ąÏȊ 8 ǣŻ3$* RBC AʝɢɄȨɫĶȀĶʄĶɢɄȨ* 4 Ȩ(Ã#ąƸAɲɩȝƏA ø 1 – 3 (Ǻ ʝɢɄȨ$+ȊʶǣŻ(ɫĶɢɄȨ$+Ȋ 3

(51) :.Ȋ 5 ǣŻ * RBC *ƅő'Ƹĥɚ6;>ʮp < 0.05ʯ ȋĶ

(52) :.ʄĶƸĥȨ$ +ȊʶǣŻ*ƅő'Ƹĥɚ6;>'. *ŀȋĶʄĶƸĥȨ$+Ȋ. 5 ǣŻʐ*ƅő'ąÏɚ6;>ʮp < 0.01ʯPLT *ŭǿ+ø 1 4 (Ǻ 3ʱ5ʱ8 ǣŻ%ȜŻƥ(ƅő(ąÏʮp < 0.01ʯ ¦ǗʅVteZǧƯAÞ 242 Ǥ«*Í¨Ǘ*¿ĝ%*ǩǤǍƮAɝƑ %?ǼȜǤǍAǩǒǤ«+½ɚ6;>'. ưģʁ¥*Ǹȝ8ǡ. ǥ 9 «ʮ3.7 ʭʯ(ɚ6;>Ȋ 8 ǣŻ3$*Ƣ«+ 13 «ʮ5.4 ʭʯ$ *ƢǔǙ+ȴ½ 5 «ƿ Ʉȏ¿ƼɄ 2 «»ǟûŌƼɄŌɢ ɄʮIMHAʯ*©ǩ 4 «$<>;+ƭǧË*Åɕƀ*ƖƑ$$(ɚ6;> # 3¦ǗʅVteZǧƯAÞ#7ɢɄ8ȸĴǤǍųð(Ƣ. 8.

(53) «+ 2 «$. . 4. Ȫġ ƉǶȄ$+ǌ B. gibsoni ŒƐǤ(

(54) =¦ǗʅVteZǧƯ*ƭǧÐƏÜ. ė½Ō*ɗAɅ 63Ģɡ%'=ƲɅü$*ǌ B. gibsoni ŒƐǤ*ȸĴŐ āAɝƑÅɕƀ*ɔÜ.ȸĴǤǍ$+ʧƝŨ8¸ƨƵčʫ ǩǕʢĶ $<ǩǇ8ɉȽĦ+ÖŴAɨ =1&$+'3ñä8Ǧ

(55) :.§Ōǥ ¦ ǩǕʢĶ(=%ǹɚ$ȸĴǣǔŘɋ%#ɢɄ8ɄĤƍƸĥǤ k}~kĦ+ʝį(ʫ ǩǕʢĶ$ɚ6;>ʬǠ+ ȼǫ$' ȏ¿ƼɄ+ 5.0ʭ%¦ ǩǕʢĶ$. Ʉ. . ǌ B. gibsoni ŒƐǤ*ƼɄ*vKfXu+ÚɃ*ɥɄǓ/*ŒƐąƤ(:= ǷĆ8ɥɄǓ*ƴɵúšŞ*¦(:=ɥɄǓȶ*ȰĻÒ(:=Ʉȏ¿ƼɄȪ ;># [75] ȸĴǫ(+¦ ÚɃğǕǑ$7ɢɄʄǤÒ=% ŧŰ># =6[75]ŞɥɄǓȶŞ§ǖǕ(:=sOmCV8 NK șȮ '&*ɥɄǓɣʧ*ƚ *ąÏ8[2, 5, 38, 47]ɥɄǓ*ʃÒʙě[49]'&ǯŬǫ 'ɥɄǓ/*ʙěĉ*vKfXu7Ůî># =>;*ɥɄǓ+ȳȷ8ș ȡ¿ǬȖ$Ūʓ>=[48, 54];(ŞɥɄǓȶŞ§*ąÏ+ B. gibsoni ʝŒƐ ɥɄǓ(7ȝâʙěA =%ÚɃğǕǑ¦#7ɢɄʄĶ('= Úõ%Ȫ ;># =[55]>+ IMHA (

(56) =ɄȏĉƼɄ*ƚĵ%ʥ¤# =[12, 75]ô+ğǕǑ*ɝƑ+Ʌ@># ' 6ğǕǑ%ƼɄ*ŒƐŌ+ ž$. Ʉȏ¿ƼɄ$>,ɄȽȘĦAè[12]ɄȏĉƼɄ+k}~. kĦ%#Ýſ=6ɄȏĉƼɄ*ǩǕʢĶ+ɀʫ %Ǻí> ɄƶÒĖƖƑ$+ ALP *ąÏɚ6;>*Úõ+ȧŎWcW(ɧõ=¿. 9.

(57) õŌR~_\~(:=7*%Ŋ@>[13, 28]3 CRP ³*ąÏ7ɚ6;>Ł Ƌ*ǌ B. gibsoni ŒƐǤ$āé># =ȸĴǣǔŘɋ%ãƘ(ǋŅǫ'¹²$ =%ôÀǹɚ>*% ;ô*Ǥ«Ȩ+¦ǗʅVteZ ǧƯ*ƭǧÐƏ%ė½ŌAɗ=ƉȈ*ƊŶ%#+´<'ɽÄ'7*% Ȫ ;> [7, 27, 28, 35, 40, 51, 52, 65] ƛ(¦ǗʅVteZǧƯ(

(58) =VteZ 3 ôŝȚŀ3$*ÐƏ(! #ɝƑɥɄǓȖi|v]+Ȋ 3 ǣŻ( RBC ƅő(Ƹĥ#Ȋ 8 ǣŻ (+Ȋ 1 ǣŻ:<ƅő(ąÏȊ 3 ǣŻ* RBC *ʐ+ B. gibsoni Vte Z(:. #ʩɃ>ŒƐɥɄǓÁǔ>6%Ŋ@>=:. #ƭǧÅƆ. +ɢɄ*ɹɅ'&ȧŎǌ*§ɝ ƀǫ(ŏÒ=àȯŌAưő0$= Ȋ 8 ǣŻ(+½#*i|v]ƅő(ąÏɢɄ*ȀĶA 4 Ȩ(Ã $ʝɢɄȨ%ɫĶƸĥȨ$+ȊʶȊʸǣŻ(ƅő(ʐ#

(59) <ȋĶ ʄĶƸĥȨ+ɴ(ȊʸǣŻ ;ƅő(Ž#

(60) <ɢɄȋĶ ;ʄĶ*Ăâ +ƭǧ(:. #ɢɄ*ɹɅŜÉ>%Ȫ ;>:. #¦ǗʅVteZ. ǧƯ$+ƭǧʉĐ ;ɥɄǓȖi|v]ôŃ(å (+

(61) : 4 ŻËŀŇ Ɋ'%*ƀ(ɢɄ' = +ɫĶ*Ăâ+ɢɄ ƀǫ(ɹɅ #

(62) <ʄǤ*Ăâ(+48 (ôŃAǺ%Ɖƭǧ*Ɵ ŧƙ%#ǆ Ǵ#

(63) 0$= Åɕƀ*ɄĤƍƸĥǤ+ 98 ʭ*Ǥ«(ɚ6;>PLT +Ȋ 8 ǣŻ3$ƹę ƥ(ƅő'ąÏɋ;>¦ǗʅVteZƭǧ(

(64) # ƀǫ(Ƹĥ=ɥɄ ǓȖi|v](Ƨ0#PLT +ƭǧ(:<ȜŻǫ(ąÏ=%Ǻ> ¦ǗʅVteZǧƯ(

(65) =Í¨Ǘ*ǩǕǑ

(66) :.ƢǑ(! #ɝƑ. 10.

(67) VteZ*Í¨Ǘ+ĤȲÂɄ%ưģʁ¥*Ǹȝ8ǡǥ=% @>#

(68) <ǋ (ĤȲÂɄ+Ȼëǫ$=[10]ƉǶȄ*ŝƯ+Í¨Ǘôʀ*6(ȪƔ> 7*$=ȸĴ«$ȖȞǫ(ɗ># ' [50]ĊŴ*ȸĴ«AĢɡ( ô*ɝƑ$+ǼȜǤǍAǩǤǤ«+' # '. 6Ȼëǫ'ĤȲÂɄ+ɧ. %Ŋ@>=ưģʁ¥*Ǹȝ8ǡǥ+ 3.7 ʭ(ɚ6;>$. <¦ǗʅVteZǧƯ+ė½Ō*ʫ ƭǧƯ$=%ǹɚ$3ʱ Ƣ« 13 «*ǔǙ%#ȴ½ 5 «%ƿ Ʉȏ¿ƼɄ 2 «IMHA *©ǩ 4 «ƭǧ(Ýň'. ʄȓ'ɢɄƢʵ«$. >;+ǌ B. gibsoni Œ. ƐǤ*Ȼëǫ'ǤǍ%#āé># =[31, 76]ƉɝƑ$+ȴ½Ʉȏ¿ƼɄ Ü.ʄȓ'ɢɄ+¦ǗʅVteZǧƯË(Ǖ# =6VteZŝ%* ǯŬǫ'õƏʋ¯+'VteZ*Í¨Ǘ$+' %Ŋ@>;(ɭɄA Ź>Ç* 7 Ǥ«Aʓĉ=%ô*ɝƑ$+ 222 «¦ǗʅVteZǧƯ (:. #Ȋ 8 ǣŻ3$(ôŃAǺɄƶăŢƖƑ(:=ğǕɃɄǤ7ɚ6;>' :. #¦ǗʅVteZǧƯ(:=ôŃǑ+ 91.7 ʭ%ȎÂ>3. Ȋ 8 ǣŻ3$(+Àǩ+½«(ɚ6;>' Ɔʊǵ 6ƅÐŌ3$+ǹɚ$'. ƉǶȄ$+Àǩ*Ɏġ. *ƭǧƯ*ôŃǑ+Vte. ZʫǗʅǧƯʮ35 mg/kgʯ$+ 91.7ʭ [33]DchR(DVWsFU A©ǗŸƯ$+ 90.9ʭ[8]DchR%oPDf~*âÌ(dMUSFO} *©ǗŸƯ$+ 100ʭ[23]$<¦ǗʅVteZǧƯ*ôŃǑ+>; *ƭǧ%ãȋ%Ŋ@> *Ǵɋ ;ƲɅü$ɝƑǌ B. gibsoni ŒƐǤ(

(69) =¦ǗʅVteZ ǧƯ+ɢɄ żɹɅ=7**ųð*ƭǧƯ%ãȋ*ôŃǑAǺ. 11.

(70) >3$*VteZ*ªǗƯ$ŕŉ>Ȼëǫ'Í¨ǗAǩǕ' %Ǻ >. 12.

(71) 5. Ĥť ǌ B. gibsoni ŒƐǤ(

(72) =¦ǗʅVteZǧƯ*ɗAɅ 6ȸĴŐāA ôʦǫ(ɏƎ#Ɩɒ3¦ǗʅVteZǧƯ*Ģɡ%'=ŻƉ*ƲɅü $*ǌ B. gibsoni ŒƐǤ*ȸĴŐāAɝƑÅɕƀ(+ʧƝŨ8¸ƨƵč ʫ ʢĶ$=1 (ǩǇ8ɉȽĦ+ÖÃ1&(3ñäǦ8§Ōǥ¦ʢ Ķ(=%ǹɚ$ȸĴǣǔŘɋ%#ɢɄ8ɄĤƍƸĥǤk}~k Ħ+ʝį(ʫ ʢĶ$ɚ6;>=ʬǠ8Ʉȏ¿ƼɄ+ ȼǫ$'. . ƛ(¦ǗʅVteZ 3 ôŝ(

(73) =ÐƏAɝƑ3ɥɄǓȖi|v ]% PLT *ȜɻAɲɩɥɄǓȖi|v]+Ȋ 3 ǣŻ( ż¦ #Ȋ 8 ǣŻ(+ôŃ Ÿ$ PLT +ȜŻƥ(Žƭǧ*ÐƏƹ%# ÈǗ$=àȯŌǺ>3 RBC A 4 Ȩ(@#ôŃ3$*əșAɝƑ *ȝƏRBC +Ȋ 8 ǣŻ*Æę3$*ʊ(ʝɢɄȨ+ ż¦=ʄĶ ɢɄȨ+ȜŻƥ(Ž¦ǗʅVteZǧƯ$+ɢɄ*ʄǤĶ(ň#ôŃ( ɼ =%Ǻ>Ɖƭǧ(

(74) =Í¨Ǘ+ 3.7 ʭ(ŬȂʁ¥*Ǹȝ8ǡ ǥ=ǼȜǤǍ+½ɚ6;>'. 242 « 222 «Ȋ 8 ǣŻ3$(. ôŃAǺôŃǑ+ 91.7 ʭ%ȎÂ>:. #ƲɅü$*ǌ B. gibsoni Œ. ƐǤ(

(75) =¦ǗʅVteZǧƯ+ƭǧÐƏʫė½'ŸƯ$=%ȝɞ> . 13.

(76) Ɇ 1 1. ŋŌǌ B. gibsoni ŒƐǤAǩǤǌ 242 «(

(77) =¦ǗʅVt eZǧƯʉĐƀ*ɔ / ȸĴǤǍ ɔ / ȸĴǤǍ. . ǩǕŴ. %. ʧƝŨ. 212. 87.6. ʮ 212 / 242 ʯ. ¸ƨƵč. 201. 83.3. ʮ 201 / 242 ʯ. ɉȽĦ. 117. 49.9. ʮ 117 / 242 ʯ. ñä. 24. 15.4. ʮ 24 / 242 ʯ. Ǧ. 22. 14.1. ʮ 22 / 242 ʯ. §Ōǥ. 34. 12.0. ʮ 34 / 242 ʯ. s^fǳ. 7. 2.8. ʮ 7 / 242 ʯ. 14.

(78) Ɇ 1 2. ŋŌǌ B. gibsoni ŒƐǤAǩǤǌ 242 «(

(79) =¦ǗʅVt eZǧƯʉĐƀ*ÅɕƀȸĴǣǔĖǫŘɋ ɔ / ȸĴǤǍ. ǩǕŴ. %. ɢɄ. 209. 86.4. ʮ 209 / 242 ʯ. ɄĤƍƸĥǤ. 238. 98.3. ʮ 238 / 242 ʯ. k}~kĦ. 222. 91.7. ʮ 222 / 242 ʯ. ʬǠ. 69. 28.5. ʮ 69 / 242 ʯ. Ʉȏ¿ƼɄ. 12. 5.0. ʮ 12 / 242 ʯ. ǩǇ. 101. 41.7. ʮ 101 / 242 ʯ. 15.

(80) Ɇ 1 3.. ŋŌǌ B. gibsoni ŒƐǤAǩǤǌ 242 «(

(81) =¦ǗʅVte. ZǧƯʉĐƀ*ɄƶÒĖƖƑȝƏ . . ƹęŴ. Č³. ÛȪ³*. T.P. ( g/dl ). 242. 6.4. (. 6.0. . 8.0. ). AST. ( U/l ). 223. 43.0. (. 9. . 69. ). ALT. ( U/l ). 223. 39.0. (. 13. . 53. ). ALP. ( U/l ). 223. 356.0. (. 14. . 142 ). T. cho. ( mg/dl ). 223. 198.5. (. 70. . 303 ). T. Bil. ( mg/dl ). 242. 0.7. (. 0.3. . 0.9. BUN. ( mg/dl ). 242. 16.4. (. 4.8. 31.4 ). Cre. ( mg/dl ). 242. 0.6. (. 0.2. . 1.6. Na. ( mEq/l ). 137. 146.0. (. 137. . 150 ). K. ( mEq/l ). 137. 4.0. (. 3.4. . 5.2. Cl. ( mEq/l ). 137. 111.0. (. 102. . 117 ). Glu. ( mEq/l ). 201. 100.0. (. 50. . 124 ). Alb. ( g/dl ). 242. 2.8. (. 2.6. . 3.3. Ca. ( mg/dl ). 201. 8.7. (. 7.9. 12.2 ). CRP**. ( mg/dl ). 111. 13.5. (. 0.0. . 1.0. * ƹęƚòvK*ŭĎ=ÛȪĀƻȒ÷[67]AǗ ** CRP ³ƹęƚò*ʑǚʮ20 mg/dlʯAɨ =Ăâ+ 20 mg/dl %. 16. ). ). ). ). ).

(82) ( x106/µl). (%). (g/dl). 25.0. 9.00. ( x103/µl). 400. 60. 8.00 20.0. 7.00. 350. 50. 300 40. 6.00. 250. 15.0 5.00 30 4.00. 200. 10.0. 150. 20. 3.00. 100. 2.00. 5.0. 10. 50. 1.00 0 0.00. ø 1 1.. RBC RBC. 0.0 0. 0 Hb. PCV. 0. PLT PLT. ŋŌǌ B. gibsoni ŒƐǤAǩǤǌ 242 «(

(83) =¦ǗʅVteZ. ǧƯʉĐƀ* RBCʮɥɄǓŴʯ, HbʮpwPk³ʯ, PCVʮɄƶĝȃʯ, PLT ʮɄĤƍŴʯ*Č³*Ȑ-øȐ*Č*Ȥ+Č³þȤ+jQ*ȉ+ƃ ċ³ȉ+ƃĤ³AǺ. 17.

(84) ( x106 / µl ) RBC. 8.00 . 6.00 4.00. . 2.00 0.00 0 Hb. ( g / dl ). 1. 3. 5. 8. 15. . 10 5 0 (%) PCV. 50 40 30 20 10 0. . 01. 3 2. 5 4. 78. . ø 1 2. ¦ǗʅVteZǧƯA ŋŌǌ B. gibsoni ŒƐǤ 222 «(

(85) = VteZ 3 ôŝʮȊ 1, 3, 5 ŻʯȚŀʮȊ 8 Żʯ3$* RBCʮɥɄǓŴʯ, Hb ʮpwPk³ʯ, PCVʮɄƶĝȃʯ*Ȋ 8 ǣŻ3$*ŭǿásK*þȤ +ƙƻ´īAǺDW]}WO+>>*ƖƑ³Ȋ 1 ǣŻ*ƖƑ³%*ƅő ī=%AǺʮ* ʾ p < 0.05,. ** ʾ p < 0.01ʯ. 18.

(86) (x106/µl). . 8.00. .

(87) . . 7.00 . . 6.00 5.00. . . 4.00. . . 3.00 2.00 1.00 0 0.00. 1. 3. 5. 8.

(88) . ø 1 3. ¦ǗʅVteZǧƯA ŋŌǌ B. gibsoni ŒƐǤ 222 «(

(89) = VteZ 3 ôŝʮȊ 1, 3, 5 ŻʯȚŀʮȊ 8 Żʯ3$*ʝɢɄȨɫĶɢɄȨ ȋĶɢɄȨʄĶɢɄȨ* RBCʮɥɄǓŴʯ*ŭǿásK*þȤ+ƙƻ´ īAǺDW]}WO+>>*ƖƑ³Ȋ 1 ǣŻ*ƖƑ³%*ƅőī= %AǺʮ* ʾ p < 0.05,. ** ʾ p < 0.01ʯ. 19.

(90) . 400. 300. 200 . 100. 0 1. ø 1 4.. 3. 5. 8. . ¦ǗʅVteZǧƯA ŋŌǌ B. gibsoni ŒƐǤ 222 «(

(91) . =VteZ 3 ôŝʮȊ 1, 3, 5 ŻʯȚŀʮȊ 8 Żʯ3$* PLTʮɄĤƍŴʯ *ŭǿásK*þȤ+ƙƻ´īAǺDW]}WO+>>*ƖƑ³ Ȋ 1 ǣŻ*ƖƑ³%*ƅőī=%AǺʮ** ʾ p < 0.01ʯ. 20.

(92) ȊʵȈ ǌ B. gibsoni ŒƐǤ*Àǩʏƞ(ʋ=ǶȄ. ȣɐ ǌ B. gibsoni ŒƐǤ+B. gibsoni ɥɄǓ(®¼#ąƤAȦ<ɱ%( :<ƼɄĺɧ>#ɢɄAŅ%=ǢŎ$=ǌ(Ģ= B. gibsoni * ǣÚŌ+ļŒƐǌ$+¸ƨʧƝ*¦ɢɄǩǇʬǠȳȵ'&ɚ6; >=[69]3ǌ B. gibsoni ŒƐǤ$+ÀǩĊ %Ǵ;># =[4, 10] ǌ B. gibsoni ŒƐǤ*ƭǧɂ(+Ƙ'7*=B. gibsoni AŒƐǌ*§¿ ;Ę½(Ūʓ=ƓƭǫƭǧƯ+ 3āé># ' [10, 23, 37, 65]ŻƉ $+ǌ B. gibsoni ŒƐǤ*ƭǧɂ%#(VteZªǗ># =Í ¨Ǘ%#ĤȲÂɄ8ưģʁ¥*Ǹȝ8ǡǥɧ=%Ǵ;># =[7, 10, 29, 58, 60]Ȋ 1 Ȉ$+*Í¨ǗAôʀ=6(ǒûĳƁÜ># =¦Ǘ ʅVteZǧƯ*ôŃǑ%ė½ŌAɗ#ƅÐ$=%Až; ( ¦ǗʅVteZǧƯ$7ÀǩǕ=%+ʀ;>ɈŴô*ƭǧA ŇɊ%=Ăâ(+VteZ*ɁȃƦŌ8ȫŌƒ*Âǒŕŉ>=[57,58] ŸB. gibsoni *ąƤAŜÉ=ŞȿɂɈŴāé>#

(93) <[44, 65, 74] À ǩʏƞ*6(¦ǗʅVteZǧƯ%©Ǘ=ŸƯɘ4;># =[65]% (O}^sFU+¦ǗʅVteZǧƯŀ*Àǩʏƞɂ%#:ªǗ> # = O}^sFU*ŝʅ8Ɔʊ*ÀǩʏƞÐƏ'&+§Ȗǫ (ɗ>#' $ƉȈ$+Ȋ 1 ȑ(

(94) #ǌ B. gibsoni ŒƐǤ(Ģ=¦ǗʅVteZ ǧƯŀ*O}^sFUŝ*ÀǩʏÐƏAƖɒ3Ȋ 2 ȑ$+¦Ǘ ʅVteZǧƯŀ*O}^sFUĉ*Şȿɂ%#B. gibsoni ÐƏAƅ =DVWsFU%dMUSFO}(

(95) =ÀǩʏƞÐƏAƧɬƖɒ. 21.

(96) Ȋ 1 ȑ ¦ǗʅVteZǧƯ%O}^sFU*ț4â@ƭǧƯ*ǌ B.. gibsoni ŒƐǤÀǩʏƞÐƏ*Ɩɒ. ʴʲĵɞ O}^sFU+}RsFUȖŞǕǊɤ$<ndGǓȿ8ēƨŌȿ' &*șȿŒƐ(Ǘ ;>=[56]cM[o|Xs8s|}D(7Ǘ ;>#

(97) < ŞÚɃ¨ǗAƅ=%āé># =[51, 69]B. rodhaini ŒƐ(Ģ#+ ɣʧÐƏ%sOmCV*ÒĖɦŌAʫ6#»ǟÎA# =%Ȫ ;># = [72] *6O}^sFU+ǌ B. gibsoni ŒƐǤ*¦ǗʅVteZǧƯ*À ǩʏƞɂ%#:ªǗ># = O}^sFU*ŝʅ8Ɔʊ *ÀǩʏƞÐƏ'&+§Ȗǫ(+ɗ># ' *6Ɖȑ$+ǌ B.. gibsoni ŒƐǤ(Ģ=¦ǗʅVteZǧƯŀ*O}^sFUŝ*Àǩʏ ƞÐƏAƖɒ. 2ʲƊŶ

(98) :.ŸƯ 2000 Ĳ ; 2009 Ĳ3$(ħßǱê×Ĭ* ÑǊǣʒ(ƋʒƇƭǧ*ŋŌǌ. B. gibsoni ŒƐǤ 242 «* VteZ(LeZÒʼgh~aEWDfs~p ~WƒĹ ǻ˂ƌ) 2 mg/kg *ǬŝAƭǧʉĐ ;ʗŻʮ48 ƀʊ%ʯ(ʶô ŝAÞ 222 «AĢɡ%Ģɡǌ+ƭǧʉĐŻAȊ 1 ǣŻ%#Ȋ 8 ǣ Ż(0#§ɝ*ôŃAǺ# =VteZÅôŝƀ(+½«(ŲŦǧƯ% #ndGȕÏʃ}Q~ƶʮ[~|Oc Dʼa~wƒĹ ǻƌʯ510 ml / kg / hr *ʅ*ʜȱ¿ɭƶAVteZŝËŀ( 23 ƀʊɅ. '

(99) ɭɄ3. +ÍȴǬɤr~wŝAĚŹǤ«+ƉǶȄ(+ç6# ' ǌ B.. 22.

(100) gibsoni ŒƐǤ*ɕŷ+ȸĴǤǍʮʧƝŨ¸ƨ¦3+ɉȽĦ'&ʯ( Ï #ºĖʤńʇ$ 1,000 ±*±Ǒ(

(101) #|FcNuTƐȽA

(102) ' ɄƶăŢƙƉ*ɥɄǓɆʞ( B. gibsoni Ƀ§AƖÂĂâ% Àǩʏƞɂ%#O}^sFUʮ^|UʼmCFTƒĹ ǻƌ25 mg/kgʴŻʵôʯ*ȜßŝAȊ 8 ǣŻ ;Ȋ 29 ǣŻ3$ȟȠŝO} ^sFU*ŝĢɡǌ+ǃ¨ǂ(ţÂʨ (ɜž*ãőAł 80 « %ʮDC Ȩʯƣ<* 142 «+Ȋ 29 ǣŻ3$ǃŝɂ%#ĢǅȨ% ƉɝƑ+ɕǧɓʆ(:<ôʦǫ(%<3%6;>Àǩ+¦ǗʅVteZ ǧƯŀ ĶƵčǌ B. gibsoni ŒƐǤ(ɚ6;>=ɢɄǩǇ¸ƨʧƝ¦ ȳȵ'&*ȸĴǤǍAÀ.èɄƶăŢƙƉ$Ƶč# B. gibsoni ÀƖÂ >Ăâ%ɕġ+ 710 Żƥ(Ʌ@>ɶ(ȸĴǤǍɚ6;>ǌ$ +Àǩ*ǹɚAɅ. Ȋ 29 ǣŻ3$(Àǩ%Æę>ʘ(+Ȋ 29 ǣŻ3$. ȜɻAɎġŀ(ǌ B. gibsoni ŒƐǤƭǧAɅ. . ƖƑʠǭ+Ȋ 1, ʺ, 29 ǣŻ( RBC, Hb, PCV, PLT

(103) :. CRP Awf] RBC, Hb, PCV, PLT +ȹÑɄǓɑȎƚʮCelltac-αʼŻƉºʛ

(104) ƌʯ AǗ CRP + CRP ȹÑƹęòʮArrows Laser CRP 2ʼDX

(105) ċʎʯAǗ #ƹęCRP ³ƹęƚò*ʑ 20 mg/dl Aɨ =Ăâ+ 20 mg/dl %#Áǔ Ȋ 29 ǣŻ(

(106) =O}^sFUƭǧŀ*ÀǩǑ+KFƖęAǗ #ɝ 0Ȋ 18ʱ29 ǣŻ* DC Ȩ

(107) :.ĢǅȨ* RBC, Hb, PCV, PLT

(108) :. CRP *ƅőī;( RBC, Hb, PCV, PLT

(109) :. CRP *ÀǩȨ%ʝÀǩȨ*ī+ One Way ANOVA[19]$ƖęȨ*ÀǩŻ*Ƨɬ7ãƖęAǗ ½#*Ȟɑ ɏƎ+ Microsoft Excel [mcGHDʮXLSTATʼAddinsoft, New York, USAʯA Ǘ #ĚŹƅőƩƻ+ 5ʭ%. 23.

(110) 3ʲȝƏ ƉɝƑ(

(111) =Ģɡǌ+¦ǗʅVteZǧƯ(:. #Ȋ 8 ǣŻ3$(§ɝ*. ôŃ%ɄƶăŢƙƉ(:=ğǕɃɄǤ*ƵčAɚ6Àǩ+ĢǅȨ* 142 « 42 «ʮ29.6 ʭʯ(Àǩɋ;>*(ĢDC Ȩ$+ 13 / 80 «ʮ16.3 ʭʯÀǩ DC Ȩ*ÀǩǑ+ĢǅȨ*ÀǩǑ:<7ƅő(¦. ʮp < 0.05ʯDC Ȩ.

(112) :.ĢǅȨ*ıýÀǩŻ+>> 27.4 ± 1.0 Ż

(113) :. 27.5 ± 0.8 Ż$< ƅőī+'. . DC Ȩ%ĢǅȨ*Ȋ 1, 8, 29 ǣŻ(

(114) =áƖƑ³AɆ 2 1 (ǺȊ 1 ǣ Ż( DC Ȩ%ĢǅȨ%*ʊ$ RBC, PCV, Hb, PLT

(115) :. CRP (Ȟɑǫ'ī+ɋ; >'. Ȋ 8 ǣŻ$+ĢǅȨ%Ƨɬ#DC Ȩ* RBC +¦³$. PCV, Hb, PLT

(116) :. CRP (+ƅőī'. Ȋ 29 ǣŻ$+DC Ȩ*. RBC

(117) :. PCV *ıý³+ĢǅȨ%Ƨɬ#ƅő(ʫ

(118) :. CRP * 2 Ȩʊ*ƅőī+'. . Hb, PLT. . 3 DC ȨĢǅȨ$*ÀǩȨ* RBC, PCV, Hb

(119) :. PLT *Ȋ 29 ǣŻ*ıý ³+ʝÀǩȨ:<ƅő(¦CRP *ıý³+ʝÀǩȨ%Ƨɬ#ƅő(ʫ. . ;(DC Ȩ%ĢǅȨ*ÀǩȨ(

(120) =Ȋ 1 ǣŻ* RBC % Hb *ıý³%Ȋ 8 ǣŻ* RBC % PCV *ıý³+DC ȨĢǅȨ:<ƅő(¦. (7 @;. Ȋ 29 ǣŻ* RBCPCV

(121) :. Hb *ıý³+ DC ȨĢǅȨ:<ƅő(ʫ '

(122) ɘʪƆʊO}^sFUŝ(:=%4;>=Í¨Ǘ+ɚ6;> '. . 4ʲȪġ. 24.

(123) ǌ B. gibsoni ŒƐǤ*ƭǧ(+Ø *ɂÌ:<ɈŴ*ɂÌ*ț4â@(:=ƭ ǧƯ*ŸÐƏǫ$=%Ǵ;># =[37]ô+ B. gibsoni ŒƐ(Ǘʅ¬ ĕǫ(ƅÐ'ŞǕǊɤ$=O}^sFU(ưǭ[37, 71, 73, 74]*Àǩ ʏƞÐƏAɲɩɝƑô*ȝƏ ;DC Ȩ*ÀǩŻ+ĢǅȨ%ī+' ÀǩǑ+ĢǅȨ%Ƨɬ# DC Ȩƅő(¦. ɄƶƖƑ(:= DC Ȩ. %ĢǅȨ%*Ƨɬ$+Ȋ 1 ǣŻ$+ī'Ȋ 8 ǣŻ( DC Ȩ* RBC ƅő (Ƹĥ# =7**DC Ȩ* RBC +Ȋ 8 ǣŻ(Ƹĥ*i|v] 8§ɝ*ôŃ(ī'. >;+ȨÃ*ǃ¨ǂŌAǹɚ=ȝƏ%'. . ;(DC Ȩ+ĢǅȨ:<ȊʵʻǣŻ$+ RBC % PCV ƅő(ąÏ#

(124) < Àǩǌ(

(125) =ɢɄ+ĢǅȨ%Ƨɬ#ɫĶ$. *% ;¦ǗʅV. teZǧƯ(O}^sFUAț4â@Ÿǩǣ ;ɢɄ*ôŃ8Àǩ ƀ*ʄǤÒ*ŜÉ(7ĽʟAÜ2# =àȯŌȪ ;>ô*O}^s FUŝʅ+Ơêǣ'&(ªǗ=Ǘʅʮ5mg/kg 1 Ż 2 ôʯ:<7ʫǗʅ$ . [18]DC Ȩ(+ʤɀ'Í¨Ǘ+ɋ;>*ė½Ō(ïʣ' %. Ǻí>>;*Ǵɋ ;VteZ%O}^sFU(:=ț4â@ *ƭǧ+Àǩʏƞ*ƭǧ*ɾşȭ%#ƅÐ !ė½'ŸƯ$=%Ŋ@>. 25.

(126) Ȋ 2 ȑ DVWsFU%dMUSFO}*ǌ B. gibsoni ŒƐǤÀǩʏƞÐƏ *Ɩɒ. 1ʲĵɞ Ȋʴȑ$+¦ǗʅVteZǧƯ%O}^sFU*ț4â@ƭǧ(:= ÀǩʏƞÐƏAɖžŞÚɃÐƏAƅ=ɂÌ%#+(7DVWsF U%dMUSFO}āé>#

(127) <ǌ B. gibsoni ŒƐǤ*ƭǧ(7ňǗ ># =[7, 44, 65, 66, 68] Ȋ 2 ȑ$+ǌ B. gibsoni ŒƐǤ(

(128) =DVWsFU%dMUSFO} *¦ǗʅVteZǧƯŀ*ÀǩʏƞÐƏ(! #Ɩɒ3ŝƆʊAĸ ʈ%*ƅÐŌAɗ=6(Ȋ 1 ȑ* 28 Żʊ:<7ɂÌ*ŝƆʊA ĸʈ#ÀǩʏƞÐƏ(! #ƖɒAɅ. . ʵʲƊŶ

(129) :.ŸƯ ƉǶȄ+ 3 !*ƭǧƯAƧɬËåǶȄ%#Ʌ. ʝǮƖ*ȸĴɘʪ$. =ƊŶ+ 2010 Ĳ ; 2017 Ĳ*ʊ(ƲɅü$=ħßǱê×Ĭ* ÑǊǣʒ(Þ ɕ#Åǩ*ŋŌǌ B. gibsoni ŒƐǤ%ɕŷ> 140 ʡ*ǌ%* 140 ʡ+ÅƆƭǧ(¦ǗʅVteZǧƯ%#Ȋ 1 ǣŻ(VteZʮLeZ` Oʼgh~aEWDfs~p~WƒĹ ǻƌʯA 2 mg/kgʗŻ 3 ô*Ǭư ģAɅ. *ŀȊʺǣŻ ;ɇƖɂAȜßŝɇƖɂ+DVWsF. UʮVWsÒʼmCFTƒĹ ǻƌ10 mg/kg1 Ż 1 ôȜßŝʯ dMUSFO}ʮkn|sFUʼmCFTƒĹ ǻƌ10 mg/kg1 Ż 2 ôȜßŝʯ3Ģǅ%#Ȋ 1 ȑ$Ǘ O}^sFUʮ^|Uʼ mCFTƒĹ ǻƌ25 mg/kgʴŻ 2 ôȜßŝʯ* 3 ȂʥAªǗ ŝƆʊ+1 ƄŝȨ+ȊʺǣŻ ;Ȋ 29 ǣŻ3$3 ƄŝȨ+ȊʺǣŻ ;Ȋ 84 ǣŻ3$%ɇƖȨ*Ũ<Ã+ɂÌ%ŝƆʊÍ¨Ǘƭǧ. 26.

(130) RWc*ɜžAɅ. ŀ(ʨ (ɾşAđ)*ȝƏDVWsFU+. 26 ʡdMUSFO}+ 27 ʡO}^sFU+ 87 ʡ(ªǗ>áɂ Ì* 1 ƄŝȨ% 3 ƄŝȨ+>>DVWsFU 16 ʡ% 10 ʡ dMUSFO} 16 ʡ% 11 ʡO}^sFU 56 ʡ% 31 ʡ%'. ɶ. ŝƆʊ*ĈƂ+ɚ6'. 3Àǩ«+Àǩ%ɕŷƀǁ$ɇƖ. ɂ*ŝAȚ#ƭǧAɅ. ŝȚŀ7Àǩ*ƅǃAáȨ%7Ȋ 180 ǣ. Ż3$Ɏġǌ B. gibsoni ŒƐǤ*ɕŷ+ʧƝŨǩǇʬǠ'&*ǋŅǫ 'ȸĴǤǍ%%7(ƈƕɄ*|FcNuTƐȽăŢƙƉ$* B. gibsoni *Ƀ§ǹ ɚ(:. #ǹę%Àǩ*ęȩ+ żųðȸĴǤǍ8ȸĴǣǔĖǫǞį. À.ǒ> !Ƶɳ B. gibsoni Ƀ§ɄƶăŢ$ƖÂ>ƀ% ɄƶƖƑ+Ȋ 1, 8, 29, 85 Żǭ

(131) :.ÀǩŻ(Ʌ. ƹęʠǭ+ RBC, PCV,. Hb, PLT

(132) :. CRP %ɂÌÇ(ÀǩŴ%*ÀǩŻAɝƑ3áȨ *Àǩ«(

(133) #ɇƖɂ*ŝƆʊ(

(134) =ÀǩǑAɝ0 áŝȨ(

(135) =ÀǩǑ+KFƖę[72]AǗ #ƅőīAɝƑáȨ* ÀǩŻŴ';.(Ȋ 1, 8, 29, 85 Żǭ

(136) :.(ÀǩŻ* RBC, PCV, Hb, PLT, CRP *ƅőī+ Krusukal Wallis Ɩę[72]AɅ ÃƎ0#*ȞɑɏƎ+ Microsoft Excel [mcGHDʮXLSTATʼAddinsoft, New York, USAʯAǗ # ɝƑ#

(137) <ƅőƩƻA 0.05 %. ʶʲȝƏ DVWsFUdMUSFO}O}^sFUŝŀ*ÀǩǑ+1 ƄŝȨ>> 63ʭʱ50ʭ25ʭ$<3 ƄŝȨ+>> 80ʭʱ 46ʭ16ʭ$. 1 ƄŝȨ3 ƄŝȨ>>(

(138) = 3 Ì*ÀǩǑ. *Ƨɬ$+Ȩ%7(O}^sFUȨ* 2 Ì:<ƅő(ÀǩǑ¦. . ɂÌ*ŝƆʊÇ(

(139) =Ƨɬ%# 3 ƄŝȨ% 1 ƄŝȨ$ÀǩǑAɝƑ ī+ɚ6;>'. ʮɆ 2 − 2ʯ. 27.

(140) áɂÌŝ(

(141) =ÀǩŻ*ıý³+ 1 ƄŝȨ>>46.1 ± 13.7 Ż 41.5 ± 11.5 Ż77.6 ± 28.7 Ż$. 3 ƄŝȨ+>> 85.0 ± 33.4 Ż. 77.8 Ż ± 25.2 Ż114.4 ± 16.5 Ż$. DVWsFUȨ%O}^sF. UȨ(+ 1 ƄȨ% 3 ƄȨ(

(142) =ÀǩŻ*ƅőīɚ6;>ʮɆ 2 − 3ʯ Ɇ 2 − 4 (+áȨ*Àǩ«(

(143) #ɇƖɂ*ŝƆʊ(

(144) =ÀǩǑAǺ1 ƄŝȨ$+DVWsFUȨ%dMUSFO}Ȩ+>> 10ʭ13ʭ ŝƆʊ(ÀǩO}^sFUȨ*Àǩ*âɑ 14 «+ŝƆʊ(+ Àǩ+4;>½« 1 Ƅʊ*ŝȚŀ(Àǩ3 ƄŝȨ$+ŝ Ɔʊ*ÀǩǑ+DVWsFUȨ 50 ʭdMUSFO}Ȩ 60 ʭ%ą ÏO}^sFUȨ+ 3 Ƅŝ(

(145) #7Àǩ«+ŝƆʊ¿(+4 ;>'. Ɇ 2 − 5 (+ 1 ƄŝȨɆ 2 − 6 (+ 3 ƄŝȨÇ*ɄƶƖ. ƑȝƏAǺ1 ƄŝȨ$+Ȋ 1 ǣŻ*dMUSFO}Ȩ%O}^sF UȨ*âɑ(

(146) # PLT (īɚ6;>3 ƄŝȨ$+dMUSFO} Ȩ%O}^sFUȨ(

(147) = RBC, Hb, PCV (īɚ6;>3dMUS FO}Ȩ*ÀǩȨȊ 8 ǣŻ( RBC, PCV *ıý³O}^sFUȨ(Ƨɬ #ƅő(ʫ 6;>'. '

(148) ô*Ɔʊ >*ɂÌŝ*°§(7Í¨Ǘ+ɚ. . ʷʲȪġ ô*ǶȄ(Ǘ ɂÌ+DVWsFUdMUSFO}O}^sF U* 3 Ì$=>;*ɂÌ+ >7ǌ B. gibsoni ŒƐǤ(ƅÐ !ŻƉ $¼řàȯ$=[44]ƉǶȄ$+>;A¦ǗʅVteZǧƯ%ț4â@ #ÀǩǑ%ıýÀǩŻŴ3ŝƆʊ*ÀǩʏƞÐƏAɗ7*$= DVWsFU+sO|FdȖŞǕǊɤ$<ÚɃ(Ģ=¨Ǘƚĵ+ɏ ž># ' s|}D(Ģ=ƱŌAǺin vivo $+ B. gibsoni (ƅÐ% ># =[8, 43]DchR%*©Ǘ$ǌ B. gibsoni ŒƐǤ(Ǘ ;># =. 28.

(149) [8]¦ǗʅVteZǧƯ%*ț4â@ƭǧ(:=ÀǩʏƞÐƏ(! #+Ɩɒ >%' $ ǝʫ. ô*Ɩɒ$+DVWsFUȨ$+ÀǩǑ+ʶÌ*. ŝƆʊA 3 Ƅ(ĸʈ=%ıýÀǩŻŴ+ƅő(ĸʈ#.

(150) < ę*ɺĸÐƏ+=7**ÀǩǑ+ƸĥÀǩ«*ŝƆʊ*Àǩ Ǒ+ąÏ:. #DVWsFU*ÀǩʏƞÐƏ+ %Ŋ@>. dMUSFO}+ac|SFO}ȖâŖŞȿɂ$<I~}`jDǤ( ƱŌAǺ%Ǵ;># =[43]dMUSFO}+ B. canis (+ in vivo $ ƱŌAǺ[70]B. gibsoni (

(151) #+ in vitro $ŒÞŌ=in vivo $+ Øǎŝ$+ÐƏ' [7, 68]dMUSFO}+ĊÌ©ǗǧƯocR~( ț4ɯ3># =7**¦ǗʅVteZǧƯ(ț4â@ÀǩʏƞÐƏ+ ž$. ô*Ɩɒ$+dMUSFO}Ȩ+DVWsFUȨ:<Àǩ. Ǒ+ȾİƸĥ# =ʫŝƆʊAĸʈ#7ıýǩǤŻŴ(ī'À ǩǑ712Ĉ@;'. 3Àǩ«(

(152) =ŝƆʊ*ÀǩǑ+ ǝʫ. ƆʊAĸʈ#7DVWsFUȨãƘ(ŝƆʊ*ÀǩǑ+ąÏ: #dMUSFO}* 1 Ƅ*ŝ+ÐƏǫ$' %Ŋ@> ¦ǗʅVteZǧƯŀ(ț4â@=ɂÌ%#DVWsFU%dMU SFO}$+ÀǩʏƞÐƏ+ÕÃ$. ȸĴǒĂ$ ę*ÀǩʏƞÐƏ. (ƆĿ#ªǗ=Ăâ(+1 ƄA6&(ǵƆƭǧ(ʑęǫ$=%ɚɠ =ŇɊ=%Ŋ@> Ģǅ$Ǘ O}^sFU+DVWsFUdMUSFO}(Ƨ0 =%ƅő(ÀǩǑ¦3 Ƅ(ŝƆʊAĸʈ=%ÀǩǑ+¦Ƹ#

(153) < ÀǩŜÉ8ɺĸÐƏ(ƅÐ$=%ž; %'. O}^sFU+D. VWsFU8dMUSFO}:<¦ǗʅVteZǧƯŀ*ț4â@(ƅ Ð'ÀǩʏƞɂÌ$=%Ȫ ;> ŝȨÇ*ɄƶƖƑAƹęáȨ*ţÂ(´<' %AɝƑdMU SFO}Ȩ$ŝË*¦ǗʅVteZǧƯ*Ȋ 1ʱ8 ǣŻ(O}^sF. 29.

(154) UȨ(Ģ#âɑ³8ÀǩȨ%*ʊ(ƅőīAɚ6=ʠǭ. ŝŀ+. īɋ;>ɢɄ8ɄĤƍƸĥǤ*ʄǤĶ8ôŃ*Ķâ ÀǩǑ(ĽʟAÜ 2%+'. :. #ɄƶƖƑ³ ;áȨ*ţÂ(+Àǩ(ĽʟAÜ2´. <' %ǹɚ$. 30.

(155) Ĥť Ȋ 1 ȑ$+ǌ B. gibsoni ŒƐǤ(

(156) #ė½Ō8ƅÐǑAǹɚ¦ǗʅVte ZǧƯAĚŹ 80 «(Àǩʏƞ*6(Ǘʅ¬ĕǫ(ŞÚɃ¨ǗAƅ= O}^sFUAȊ 29 ǣŻ3$ŝ#ÀǩʏƞÐƏAɗ*ȝƏ O}^sFUŝȨ*ÀǩǑ+ĢǅȨ%Ƨɬ#ƅő(ÀǩǑ¦ ǩƀ*ɢɄ+ĢǅȨ:<ɫĶ$ ¨Ǘ+ɚ6;>'. À. 3O}^sFUŝ(+ʄċ'Í. . Ȋ 2 ȑ$+ǌ B. gibsoni ŒƐǤ(

(157) =¦ǗʅVteZǧƯŀ(ț4â@= ɂÌ*ÀǩʏƞÐƏAƖɒ=6DVWsFU%dMUSFO}AO} ^sFU%Ƨɬ;(ŝƆʊ(:=ÀǩʏƞÐƏAɝƑDVW sFU$+ 1 ƄŝȨ*ÀǩǑ+ 3 Ì*$ ǝʫ. ŝƆʊA 3 Ƅ. (ĸʈ=%ıýÀǩŻŴ+ƅő(ĸʈ#

(158) < ę*ÀǩɺĸÐƏ+=7* *ÀǩǑ+ƸĥÀǩ«*ŝƆʊ*ÀǩǑ+ąÏdMUSFO} 7ÀǩǑ+ʫŝƆʊAĸʈ#712Ĉ@;ıýǩǤŻŴ7ī' 3Àǩ«*ŝƆʊ*ÀǩǑ+ 3 Ì*$ ǝʫ ŸO}^sF U+ 1 Ƅŝƀ*Ƨɬ$+* 2 Ì:<ƅő(ÀǩǑ¦ŜÉÐƏÕ Ã(ɚ6;>3ŝƆʊA 3 Ƅ(ĸʈ=%ÀǩǑ*¦Ƹ(ƅÐ$< Àǩ«7ŝƆʊ(+ÀǩŜÉ># :<¦ǗʅVteZǧƯŀ*O}^sFUŝ+ǌ B. gibsoni ŒƐ Ǥ*ÀǩŜÉ(ƅÐ$=%@. 3O}^sFU+ŞÚɃÐƏA. ƅ=DVWsFU8dMUSFO}(Ƨɬ#ǌ B. gibsoni ŒƐǤ*Àǩ ŜÉ(·>ŝƆʊAĸʈ>,:<ÐƏǫ$=%Ǻí>¦Ǘʅ VteZǧƯŀ*O}^sFU 3 Ƅŝ+ǌ B. gibsoni ŒƐǤ(ƅÐŌ ʫ ƭǧƯ%Ȫ ;>. 31.

(159) (%). ( g / dl ). ( x103 / µl ). PCV. Hb. PLT. ( x106 / µl ). (%). ( g / dl ). ( x103 / µl ). RBC. PCV. Hb. PLT. (%). ( g / dl ). ( x103 / µl ). PCV. Hb. PLT. . ( mg / dl ). ( x106 / µl ). RBC. CRP. ( mg / dl ). . CRP. ( mg / dl ). . ±. ±. 13.3. 4.4. ±. ±. ±. 234.3. 3.6. ±. ±. 12.6. 39.4. 5.7. ±. 204.1. NE. ±. 10.4. ±. ±. 45.8. 33.2. ±. ±. ±. 8.4. 24.8. 3.5. 80. 5.0. 17.8. 3.6. 9.6. 1.6. 150.1. 2.7. 7.1. 1.2. 5.2. 39.6. 2.7. 9.0. 1.5. . *. *. *. . 2.0. 269.2. 13.0. 41.2. 5.9. 214.0. 10.5. 33.6. 4.4. 13.0. 49.8. 8.4. 24.5. 3.4. ±. ±. ±. ±. ±. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. 67. 6-. 2.5. 168.5. 3.4. 8.4. 1.5. 157.1. 2.6. 6.9. 1.2. 5.1. 40.7. 3.6. 9.1. 1.5. **. **. **. **. **. . . 11.8. 56.8. 10.0. 30.5. 4.4. 153.1. 10.0. 31.4. 4.2. 14.7. 24.5. 8.6. 26.5. 3.9. ±. ±. ±. ±. ±. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. 13. -. 32. NE< %2 *<DC /

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(165) . . .29 ,#. .8 ,#. ( x106 / µl ). RBC. .1 ,#. CRP. . N. . . 6.5. 10.8. 3.6. 10.4. 1.7. 98.0. 2.9. 7.6. 1.2. 5.5. 2.4. 2.9. 8.4. 1.5. . #. #. #. #. #. #. #. . 5.6. 219.7. 12.2. 35.6. 5.2. 170.9. 10.1. 32.6. 4.7. 13.4. 43.5. 8.4. 25.1. 3.8. ±. ±. ±. ±. ±. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. 142. 1. 7.0. 186.5. 8.8. 11.2. 1.8. 112.5. 2.7. 7.5. 1.3. 5.5. 28.0. 3.0. 8.9. 1.6. . . . 1.7. 290.0. 13.6. 39.9. 5.9. 162.9. 9.9. 31.9. 4.6. 13.4. 43.6. 8.1. 24.3. 3.8. ±. ±. ±. ±. ±. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. 100. 6-. */. DC /. 1. 8. 0: 9. . 1, ;, 29 ,# DC /

(166) */ RBC, PCV, Hb, PLT, CRP 7 ! ± &). 5.8. 39.5. 3.5. 10.0. 1.4. 140.4. 2.5. 7.5. 1.2. 4.8. 33.1. 2.9. 8.9. 1.5. **. **. **. **. **. . . 15.5. 42.1. 8.5. 25.3. 3.4. 190.3. 10.6. 34.1. 4.9. 13.2. 43.1. 9.2. 27.1. 4.2. ±. ±. ±. ±. ±. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. 42. -. 1.5. 174.7. 9.9. 8.5. 1.4. 98.0. 2.7. 7.4. 1.3. 5.7. 25.6. 3.0. 8.8. 1.6.

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(169) = B. gibsoni 17@(B> M!52"C. N!52"C. O. I(B. (B. (%). O. I(B. (B. (%). . 16. 6. 10. J63K. 10. 2. 8. J80K. . 16. 8. 8. J50K. 11. 6. 5. J46K. . 56. 42. 14. J25K. 31. 26. 5. J16K. F8C. . & L. . 0.01L. 1 !52"C +D*

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(173) +D*2").,(B43. ( .,& ± 9<'-) F8C. O. M!52"C. . O. N!52"C. . . 16. 46.1. ±. 13.7 4. 10. 85.0 ± 33.4 4 *. . 16. 41.5. ±. 11.5 4. 11. 77.8 ± 25.2 4. . 56. 77.6. ±. 28.7 4. 31 114.4 ± 16.5 4 **. . * . $? M!52"C N!52"C 60-. ( p <0.01) **. . $? M!52"C N!52"C 60-. ( p <0.05). 34.

(174) ;)>Q*1H(S) X X W. 4N(S) 10 \ 14. &#'. !%'. %' #'. K3. X(<;)J. L 2 − 4. 1H. M?K;)>Q*1HD. 35. [. [. 13 0. \. 4N(S). 10. 1HDUTV. [. Y. Z. ;)>Q*1H(S). Y(<;)J. 0. 60. 50. 1HDUTV.

(175) 3.4. 8.4. 3.0. 11.2. 5.1. 5.8 ±. NE NE NE NE. NE. NE. NE. NE. (%). (g/dl). (x103/µl). PLT. CRP† (mg/dl). NE. 6.5. 4.1. 11.6. 2.2. 7.0. 8.3. ± 137.8. ±. NE. ±. 293.3. ±. ±. ±. Hb. RBC. 3.1. 162.3. 2.5. 7.1. 1.3. 5.5. 39.7. 1.8. 6.2. 1.0. ± 262.8. ±. ±. ±. ±. ±. ±. ±. PCV. (x106/µl). CRP† (mg/dl). ±. ±. 13.6. (x103/µl) 298.6. (g/dl). PLT. Hb. 35.8. 9.9. ±. 40.1. (%). 5.2. PCV. 1.7. ±. 5.6. (x106/µl). 6.1. RBC. 6.3. ±. 340.2. 4.7. 228.8. CRP† (mg/dl). ±. ±. 10.5. (x103/µl) 297.1. (g/dl). PLT. Hb. 26.8. 8.4. ±. 32.1. (%). PCV. 3.7. 12.4. ±. 4.4. 1.3. ±. 13.6. 6.1. 5.3. 59.7. (x106/µl). 37.6. RBC. ±. 16.7. ±. ±. ±. ±. ±. ±. ±. ±. ±. 10. 2.6. 7.6. 1.1. 6.2. 34.0. 3.7. 10.6. 1.5. 10.0. 30.9. 4.0. 16.4. 65.9. 6.8. 20.9. 2.8. ±. ±. ±. ±. 5.1. 6.9. 1.1. 5.6. 13.7. 41.8. 5.7. 5.5. 7.3. 30.9. 9.2. 28.8. 3.9. 0.4. ±. ±. ±. ±. ±. ±. 0.6. 23.0. 2.5. 8.4. 1.2. 0.5. 3.1. 302.6 ± 178.4 239.0. 15.3. 43.4. 6.0. 3.8. 271.2 ± 201.3 286.6. 11.8. 35.3. 4.8. 14.3. 39.2. 7.8. 23.1. 3.3. NE. NE. NE. NE. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 16. 5.8. 18.3. 2.4. 6.2. 138.3. 2.6. 6.7. 1.2. 5.2. 169.4. 2.6. 7.2. 1.1. 3.6. 36. 8. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 3.6. NE. NE. NE. NE. NE. ±. 201.9 ±. 14.0. 42.3. 5.9. 7.2. 327.0 ±. 9.9. 31.4. 4.0. 16.8. 40.7 * 70.8. 2.7. 8.0. 1.2. *]!%'J%' #'J=:8 ( p < 0.05) ]CRP / C7@5RFU20 mg/dlVO64 20 mg/dl . . 29. 8. ±. 6.9. 46.9. (g/dl). (x103/µl). Hb. PLT. 9.7. 2.4. CRP† (mg/dl). ±. 20.7. (%). PCV. 1.4. 7.4. 108.1. 2.9. 7.4. 1.4. 6.3. 186.2. 1.7. 5.4. 0.7. 3.2. 17.8. 1.2. 3.8. 0.5. 6. ±. 16. 2.9. . (x106/µl). N. RBC. . 1. .

(176) . .

(177) . . . . 1 . 8. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 7.1. 33.1. 7.7. 23.6. 3.2. 2.2. ±. ±. ±. ±. ±. ±. 281.4 ±. 13.3. 41.3. 5.5. 3.9. 246.3 ±. 10.1. 30.5. 4.0. 16.0. 61.1. 7.8. 23.5. 3.3. 10.4. 32.5. 4.4. 12.4. 34.3. 8.8. 26.3. 3.9. 14.8. 44.2. 6.5. 7.2. 0.4. 47.5. 3.3. 8.3. 1.4. 2.1. 2.6. 155.8 272.2. 2.1. 5.8. 0.9. 3.4. NE. NE. NE. NE. NE. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 56 1.8. 5.1. 136.6. 2.7. 7.4. 1.3. 5.1. 127.5. 3.1. 8.2. 1.5. 5.8. 28.2. 3.8. 11.0.

(178) . 139.4 217.1. 3.3. 8.7. 1.5. 3.9. 54.3. 3.4. 9.9. 1.5. . *. . . ±. ±. ±. ±. ±. ±. ±. ±. 42. 3.6. 9.8. 1.7. 5.7. 30.8. 3.9. 11.1. 1.9. ±. ±. ±. ±. 3.6. 10.4. 1.7. 5.7. 2.8. NE. NE. NE. NE. NE. ±. 5.1. 263.9 ± 130.6. 14.9. 44.6. 6.7. 6.8. 200.0 ± 112.4. 10.6. 33.0. 4.6. 12.4. 35.4. 9.2. 27.6. 4.1. . . . L 2 5. ,EP$"'GB9I4

(179) AGE K32 RBC, PCV, Hb, PLT, CRPU 1 (<;)J V. 7.5. 46.1. 9.5. 29.7. 4.1. 0.1. 301.3. 14.4. 42.8. 6.1. 4.6. 268.6. 9.7. 30.7. 4.0. 12.3. 31.1. 7.6. 22.1. 3.3. 3.3. 9.5. 1.5. 2.4. 6.2. 1.1. 6.1. 1.7. 4.6. 0.9. 3.4. ±. ±. ±. ±. ±. ±. 0.6. 51.3. 1.5. 5.0. 0.7. 0.0. ± 165.4. ±. ±. ±. ±. ± 159.7. ±. ±. ±. ±. ± 177.4. ±. ±. ±. 14. .

(180) . N. ±. ±. 10.2. (g/dl). (x103/µl) 186.3. ±. ±. ±. 43.0. 14.0. (x103/µl) 244.4. CRP†. (x103/µl). PLT. (mg/dl). (g/dl). Hb. CRP†. (%). PCV. (mg/dl). (x106/µl). . . 59.2. (x103/µl) 222.3. RBC. CRP†. PLT. . 3.4. 13.8. Hb. NE. 9.3. 41.5. (%). (g/dl). PCV. (x106/µl). 1.8. 5.4. 128.3. 2.3. 6.4. 1.1. 5.4. 5.9. (mg/dl). (g/dl). Hb. PLT. (%). PCV. ±. ±. 5.9. 4.3. ±. 6.8. (mg/dl). (x106/µl). 152.1. . ±. 31.1. (%). 1.1. 3.9. 16.4. . NE. 270.0. 13.2. 39.5. 5.6. 0.7. 152.0. 11.9. 37.0. 4.9. 8.4. 162.5. 2.7. 9.9. 45.5. 8.9. . ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. . 0.0. 3.5. 10.5. 1.9. 0.0. 136.0. 0.9. 1.0. 0.8. 4.6. 139.5. 2.1. 6.5. 0.9. 2.1. 14.5. 4.6. 11.5. 1.8. 8. ± ± ± ± ±. 35.4 11.8 31.1 7.5. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 5.2. NE. 198.5. 14.2. 42.5. 6.0. 6.2. 267.5. 14.6. 44.5. 6.2. 6.4. 192.3. 11.2. 33.0. 4.5. 17.8. 18.4. 8.6. 25.8. 3.7. 13.0. 38.9. 5.2. 16.1. 29.7. 9.9. 28.9. 4.2. 15.7. 46.4. 6.5. 4.6. 0.2. 0.2. . NE. 267.8. 16.3. 48.5. 7.0. 0.2. 237.5. 15.5. 46.2. 6.4. 5.0. 249.2. * 10.6. 6. . ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. . 124.4. 4.2. 9.5. 1.8. 0.2. 74.3. 1.1. 2.4. 0.4. 4.2. 152.5. 3.6. 8.7. 1.3. 5.6. 14.3. 3.9. 10.6. 1.8. . . 10.9. 30.4. 4.6. NE. 89.0. 14.1. 41.0. 6.3. 0.1. 209.8. 15.9. 46.6. 6.7. 4.0. 37. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 5. 0.8. 29.7. 2.1. 5.8. 0.8. 3.0. 2.7. 7.0. 9.2. 0.0. 52.1. 1.3. 4.2. 0.6. 8.0. 52.1. 1.3. 4.2. 0.6. 2.0. 12.0. 2.3. 6.6. 1.1. . 209.8. 15.9. 46.6. 6.7. 18.6. 29.2. 10.8. 30.8. 4.6. 7.0. . 132.7. 4.0. 9.5. 1.7. 4.0. 13.6. * 32.5. *. 30.2. 9.1. 27.3. 3.9. 0.7 . ±. 66.6. 1.2. 3.3. 0.5. 6.2. 119.6. 3.9. 9.9. 1.7. 4.9. 13.3. 3.4. 9.1. 1.6. . 29.6 . NE. 223.1. 15.8. 46.6. 6.8. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 11.

(181) . 30.2. 3.0. 8.2. 1.3. 59.6. 3.4. 8.5. 1.8. 5.8. 115.3 224.9. 2.2. 6.3. 1.0. 5.5. 154.5 231.3. 2.1. 7.2. 0.9. 2.3. 11.6. 2.2. 6.8. 1.0. . 3 . *]0-/ %' #'J!%'J=:8 ( p < 0.05) **]1HJ !%'J + 2 3=:8 ( p < 0.05) ]CRP / C7@5RFU20 mg/dlVO64 20 mg/dl . . ±. 4.2. RBC. CRP†. PLT. Hb. PCV. 85 RBC. . 6.7. 2.8. ±. 16.2. (mg/dl). (x106/µl). CRP†. 8 RBC. 29. 23.5. 8.0. ±. 23.8. (x103/µl). PLT. 2.8. 26.5. ±. 8.6. (%). (g/dl). Hb. 8.0. ±. 25.9. 3.7. 2. . ±. 1.2. 10. 3.7. . (x106/µl). PCV. 1 RBC. .

(182) . . **. **. . NE. 270.8. 15.6. 45.6. 7.0. 0.2. 341.1. 14.3. 43.0. 6.2. 9.0. 242.9. 9.0. 28.9. 3.7. 14.1. 34.8. 7.3. 22.2. 3.1. . ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 31. 3.3. 9.5. 1.4. . 149.7. 3.8. 10.5. 1.8. 0.2. 150.3. 3.0. 8.9. 1.5. 6.8. 181.3. 2.9. 8.6. 1.3. 6.6. 32.8.

(183) . . *. *. *. . ±. ±. ±. ±. ±. ±. ±. ±. 26. ±. ±. ±. ±. . NE. 274.6. 16.1. 46.8. 7.2. 0.2. . ±. 346.1 ±. 14.5. 43.8. 6.3. 9.5. 235.7 ±. 9.1. 29.2. 3.7. 14.2. 36.1. 7.6. 23.3. 3.2. . 130.9. 3.8. 10.7. 1.8. 0.2. 134.2. 3.1. 9.2. 1.4. 7.4. 165.0. 2.8. 8.5. 1.3. 6.5. 32.0. 3.4. 9.8. 1.5. . . . . L 2 6. ,EP$"'GB9I4

(184) AGE K32 RBC, PCV, Hb, PLT, CRPU Y(<;)J V. 7.5. 22.2. 7.8. 23. 3.6. NE. 251.0. 13.0. 39.4. 5.8. 0.2. 315.0. 12.9. 38.6. 5.6. 4.1. 280.0. 8.6. 27.6. 3.7. 14.1. 28.2. 6.0. 16.8. 2.6. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. ±. 5. 1.3. 24.8. 2.8. 7.6. 1.6. 222.1. 2.4. 6.2. 1.4. 0.2. 213.4. 2.0. 5.8. 1.6. 2.6. 245.9. 3.0. 8.7. 1.2. 7.6. 35.8. 2.2. 5.2. 0.8. . . **. **. . .

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