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秋 田 医 学 Akita J Med 45 (Suppl): 195~196, 2018

著     書

1)阿部史人,中西広樹,田川博之,佐々木雄彦

(2017) がんにおけるホスホイノシタイド代 謝.実験医学増刊Vol. 35, No. 10, 94-97.

原 著 論 文 A. 審査を経た論文

1) Lin, S.-H., Steinhoff, M., Ikoma, A., Chang, Y.-C., Cheng, Y.-R., Kopparaju, R.C., Ishii, S., Sun, W.-H. and Chen, C.-C. (2017) Involvement of TRPV1 and TDAG8 in pruriception associated with noxious acidosis. J. Invest. Dermatol., 137, 170-178.

2) Abe, F., Kitadate, A., Ikeda, S., Yamashita, J., Nakanishi, H., Takahashi, N., Asaka, C., Teshima, K., Miyagaki, T., Sugaya, M. and Tagawa, H.

(2017) Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma. Oncotarget, 8, 7572-7585.

3) Kimura, H., Eguchi, S., Sasaki, J., Kuba, K., Nakanishi, H., Takasuga, S., Yamazaki, M., Goto, A., Watanabe, H., Itoh, H., Imai, Y., Suzuki, A., Mizushima, N. and Sasaki, T. (2017) Vps34 regulates myofibril proteostasis to prevent hy- pertrophic cardiomyopathy. JCI Insight, 1, e89462.

4) Dai, S.-P., Huang, Y.-H., Chang, C.-J., Huang,

Y.-F., Hsieh, W.-S., Tabata, Y., Ishii, S. and Sun, W.-H. (2017) TDAG8 involved in initiating in- flammatory hyperalgesia and establishing hyper- algesic priming in mice. Sci. Rep., 7, 41415.

5) Matsumoto, J., Nakanishi, H., Kunii, Y., Sugiura, Y., Yuki, D., Wada, A., Hino, M., Niwa, S., Kondo, T., Waki, M., Hayasaka, T., Masaki, N., Akatsu, H., Hashizume, Y., Yamamoto, S., Sato, S., Sasaki, T., Setou, M. and Yabe, H. (2017) 

Decreased 16 : 0/20 : 4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. Scientific Reports, 7, 45050.

6) Nakagawa, Y.-Y., Hara, H., Nakanishi, H., Tasaka, T. and Hara, A. (2017) Acute exposure to an electric field induces changes in human plasma lysophosphatidylcholine (lysoPC)-22 : 4 levels : Molecular insight into the docking of ly- soPC-22 : 4 interaction with TRPV2. Integr.

Mol. Med., 2, 1-7.

7) Shindou, H., Koso, H., Sasaki, J., Nakanishi, H., Sagara, H., Nakagawa, K.M., Takahashi, Y., Hishikawa, D., Iizuka, Y.-H., Tokumasu, F., Noguchi, H., Watanabe, S., Sasaki, T. and Shimizu, T. (2017) Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. 

J. Biol. Chem., 292, 12054-12064.

8) Iizuka, Y.-H., Hishikawa, D., Sasaki, J., Takubo, K., Goto, M., Nagata, K., Nakanishi, H., Shindou,

生 体 情 報 研 究 セ ン タ ー

セ ン タ ー 長 石 井   聡

助 教 中 西 広 樹

特 任 助 教 木 村 洋 貴(~10月)

技術系スタッフ 栗  林  栄 里 佳

Akita University

(2)

―196 ―

(196) 生体情報研究センター

第45巻増刊号

H., Okamura, T., Ito, C., Toshimori, K., Sasaki, T.

and Shimizu, T. (2017) Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem., 292, 12065-12076.

9) Takara, K., Eino, D., Ando, K., Yasuda, D., Naito, H., Tsukada, Y., Iba, T., Wakabayashi, T., Muramatsu, F., Kidoya, H., Fukuhara, S., Mochizuki, N., Ishii, S., Kishima, H. and Takakura, N. (2017) Lysophosphatidic acid receptor 4 activation augments drug delivery in tumors by tightening endothelial cell-cell contact. Cell Rep., 20, 2072-2086.

10) Kimura, H., Matsuyama, Y., Araki, S., Koizumi, A., Kariya, Y., Takasuga, S., Eguchi, S., Nakanishi, H., Sasaki, J. and Sasaki, T. (2017) 

The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod. Rheumatol., 7, 1-12.

11) Nakagawa, Y.-Y., Hara, H., Nakanishi, H., Kanai, C. and Hara, A. (2017) Molecular insight into the docking of lysophosphatidylethanolamine

(lysoPE)-22 : 6 interaction with GPR119 : Acute exposure to an electric field induces changes in human plasma lysoPE-22 : 6 and ly- soPE-20 : 4 levels. Integr. Mol. Med., 5, 1-7.

12) Tanishima, M., Takashima, S., Honda, A., Yasuda, D., Tanikawa, T., Ishii, S. and Maruyama, T.

(2017) Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling. J. Biol. Chem., 292, 17250-17257.

13) Malek, M., Kielkowska, A., Chessa, T., Anderson, K., Barneda, D., Pir, P., Nakanishi, H., Eguchi, S., Koizumi, A., Sasaki, J., Juvin, V., Kiselev, V.,

Niewczas, I., Gray, A., Valayer, A., Spensberger, D., Imbert, M., Felisbino, S., Habuchi, T., Beinke, S., Cosulich, S., Novere, N., Sasaki, T., Clark, J., Hawkins, P. and Stephens, L. (2017) PTEN regulates PI(3,4)P2 signaling downstream of class I PI3K. Molecular Cell, 68, 566-580.

学 会 発 表

A. 国際会議

1. FA S E B S u m m e r Re s e a rc h C o n f e re n c e s ; Lysophospholipid and Related Mediators : From Bench to Clinic, August, New Orleans, USA 1) Yasuda, D. and Ishii, S. (2017) Gα12/13-

coupled LPA receptors mediate novel angioge- nesis mechanism

B. 国内会議

(c)研究会

(ii)地方規模

1. 第3回生体調節研究所内分泌代謝シンポジウム,

11月,群馬

1)安田大恭,石井 聡 (2017) 血管新生に働く リゾホスファチジン酸シグナルの分子機構

そ  の  他

1. Thermo Fisher Scientific主催 質量分析フォー ラム,7月,東京,大阪

1)中 西 広 樹(2017)  医 療 応 用 を 見 据 え た Lipidomics解析法の構築

2. 第510-514回東北大学大学院薬学研究科セミ ナー,薬物送達学分野主催講演会 質量分析東 北セミナー,8月,仙台

1)中西広樹(2017) 質量分析からわかってきた リン脂質の機能と疾患とのかかわり

3. 日本ウォーターズ株式会社主催 MSフォーラム

─ライフサイエンス,10月,大阪,東京 1)中西広樹(2017) 病態関連リピドミクス解析

の基礎から臨床応用まで

Akita University

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