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Table 1. Suggested components related to lipid metabolism the levels of which were altered in the kidney of male SelenBP1-KO mice by metabolomics analysis.

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Table 1. Suggested components related to lipid metabolism the levels of which were altered in the kidney of male SelenBP1-KO mice by metabolomics analysis.

Representative components altered in mice

Sample Increased X-flod Decreased X-flod

Tryptophan metabolism

Melatonin

7.8 6-hydroxymelatonin

12.6

C21-steroid hormone metabolism 17α-Hydroxycortexone 54.5 20α-Hydroxycholesterol 8.3

SelenB P1(-) vs Control

Androgen and estrogen metabolism

16α-hydrodehydroepiandrosterone 4.9 Estrone 3-glucuronide 63.9 Estrone 12.5

Ubiquinone biosynthesis

Vitamin K2 65.6

Prostaglandin and leukotriene metabolism 20-carboxy-leukotriene B4 5.2 11-epi-prostaglandin F2a 6.3 Fatty acid biosynthesis

Palmitic acid (PAL) 2.6 TCA cycle

Cis-Aconitate 9

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