病理診断学講座
Diagnostic Pathology
教 授 高野 康雄 Yasuo Takano 准教授 常山 幸一 Koichi Tsuneyama 助 教 林 伸一 Shinichi Hayashi 助 教 野本 一博 Kazuhiro Nomoto 助 教 高橋 博之 Hiroyuki Takahashi 技術専門職員 八田 秀樹 Hideki Hatta
◆ 原 著
1) Nomoto K., Tsuneyama K., Takahashi H., Murai Y. and Takano Y.: Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease. Appl.
Immunohistochem Mol. Morphol., 16: 71-75, 2008.
2) Miwa S.*, Nakajima T., Murai Y., Takano Y. and Sugiyama T.: Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs). J. Gastroenterol., 43: 531-537, 2008.
3) Nakanishi Y.*, Tsuneyama K., Nomoto K., Fujimoto M., Salunga T.L., Nakajima T., Miwa S., Murai Y., Hayashi S., Kato I., Hiraga K., Hsu D.K., Liu F.T. and Takano Y.: Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice. Hepatol. Res., 38: 1241-1251, 2008.
4) Nakanishi Y.*, Tsuneyama K., Fujimoto M., Salunga T.L., Nomoto K., An J.L., Takano Y., Iizuka S., Nagata M., Suzuki W., Shimada T., Aburada M., Nakano M., Selmi C. and Gershwin M.E.: Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. J. Autoimmun., 30: 42-50, 2008.
5) Kutsuna T.*, Zheng H., Abdel-Aziz H.O., Murai Y., Tsuneyama K., Furuta I. and Takano Y.: High JC virus load in tongue carcinomas may be a risk factor for tongue tumorigenesis. Virchows Arch., 452: 405-410, 2008.
6) Fujimoto M.*, Tsuneyama K., Kainuma M., Sekiya N., Goto H., Takano Y., Terasawa K., Selmi C., Gershwin M.E. and Shimada Y.: Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver. Exp. Biol. Med., 233: 328-337, 2008.
7) Li X.H.*, Zheng H.C., Wang Z.G., Takahashi H., Yang X.H., Guan Y.F. and Takano Y.: The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue microarrays.
Anticancer Res., 28: 1061-1067, 2008.
8) Li X.H.*, Zheng H.C., Wang Z.G., Takahashi H., Yang X.H., Guan Y.F. and Takano Y.: The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue microarrays.
Anticancer Res., 28: 1061-1067, 2008.
9) Li X.H.*, Zheng H.C., Hara T., Takahashi H., Masuda S., Wang Z., Yang X., Guan Y. and Takano Y.: Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Int. J.
Oncol., 33: 69-79, 2008.
10) Abdel-Aziz H.O., Murai Y., Takasaki I., Tabuchi Y., Zheng H.C., Nomoto K., Takahashi H., Tsuneyama K., Kato I., Hsu D.K., Liu F.T., Hiraga K. and Takano Y.: Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study. J. Cancer Res. Clin. Oncol., 134: 777-788, 2008.
11) Zheng H.C.*, Zheng Y.S., Li X.H., Takahashi H., Hara T., M.asuda S., Yang X.H., Guan Y.F. and Takano Y.: Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma. Anticancer Res., 28(4B): 2225-2232, 2008.
12) Zheng H.C.*, Saito H., Masuda S., Wang Z.G. and Takano Y., Cytoplasmic and nuclear maspin expression in lung carcinomas:
an immunohistochemical study using tissue microarrays. Appl. Immunohistochem. Mol. Morphol., 16: 459-465, 2008
13) Zheng H.C.*, Takahashi H., Li X.H., Hara T., Masuda S., Guan Y.F. and Takano Y.: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum. Pathol., 39: 1042-1049, 2008.
14) Zheng H.C.*, Li X.H., Hara T., Masuda S., Yang X.H., Guan Y.F. and Takano Y.: Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch., 52: 525-534, 2008.
15) Zheng H.C.*, Takahashi H., Li X.H., Hara T., Masuda S., Guan Y.F. and Takano Y.: Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Virchows Arch. 452: 147-155, 2008.
16) Zheng H.C.*, Tsuneyama K., Takahashi H., Miwa S., Sugiyama T., Popivanova B.K., Fujii C., Nomoto K., Mukaida N. and Takano Y.: Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. J.
Cancer Res. Clin. Oncol., 134: 481-488, 2008.
17) Zlobec I., Vuong T., Compton C.C., Lugli A., Michel R.P., Hayashi S. and Jass J.R.: Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. Br. J. Cancer, 98(2):450-456. 2008.
18) Oertelt-Prigione S., Mao T.K., Selmi C., Tsuneyama K., Ansari A.A., Coppel R.L., Invernizzi P., Podda M. and Gershwin M.E.:
Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis.
Autoimmunity. 41: 91-99, 2008.
19) Wakabayashi K., Lian Z.X., Leung P.S., Moritoki Y., Tsuneyama K., Kurth M.J., Lam K.S. Yoshida K., Yang G.X., Hibi T., Ansari A.A., Ridgway W.M., Coppel R.L., Mackay I.R. and Gershwin M.E.: Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology, 48:
531-540. 2008.
20) Akashi T., Koizumi K., Tsuneyama K., Saiki I., Takano Y. and Fuse H.: Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci., 99: 539-42, 2008.
21) Matsuda N., Yamazaki H., Takano K., Matsui K., Takano Y., Kemmotsu O. and Hattori Y.: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem. Pharmacol., 75: 1065-1075, 2008.
22) Kamiyama K., Matsuda N., Yamamoto S., Takano K., Takano Y., Yamazaki H., Kageyama S., Yokoo H., Nagata T., Hatakeyama H., Tsukada K. and Hattori Y.: Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone. Am. J. Physiol. Lung Cell Mol. Physiol., 295: 998-1006, 2008.
23) Kato S., Omagari K., Tsuneyama K., Fukazawa E., Tsukuda H., Inohara C., Kuroda Y., Shiraishi K. and Mune M.: A possible rat model for non-alcoholic steatohepatitis: Histological findings in SHR/NDmcr-cp rats. Hepatol. Res., 38: 743-744, 2008.
24) Omagari K., Kato S., Tsuneyama K., Inohara C., Kuroda Y., Tsukuda H., Fukazawa E., Shiraishi K. and Mune M.: Effects of a long-term high-fat diet and switching from a high-fat to low-fat, standard diet on hepatic fat accumulation in sprague-dawley rats. Dig. Dis. Sci., 53: 3206-3212, 2008.
25) Yang G.X., Lian Z.X., Chuang Y.H., Moritoki Y., Lan R.Y., Wakabayashi K., Ansari A.A., Flavell R.A., Ridgway W.M., Coppel R.L., Tsuneyama K., Mackay I.R. and Gershwin ME.: Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology, 47: 1974-1982, 2008.
26) Shimoda S., Harada K., Niiro H., Yoshizumi T., Soejima Y., Taketomi A., Maehara Y., Tsuneyama K., Nakamura M., Komori A., Migita K., Nakanuma Y., Ishibashi H., Selmi C. and Gershwin ME.: Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology, 47: 958-965, 2008.
◆ 症例報告
1) Ogawa J., Kanegane H., Tsuneyama K., Kanezaki R., Futatani T., Nomura K., Ishizawa S., Sasahara M., Ito E. and Miyawaki T.: Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder. Eur. J. Haematol., 81: 58-64, 2008.
2) Hamada H., Kurimoto M., Hayashi N., Nagai S., Kurosaki K., Nomoto K., Kanegane H., Nomura K. and Endo S.: Pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage. Case report. J. Neurosurg. Pediatrics, 1: 244-246, 2008.
3) Kawaguchi Y., Ishihara H., Abe Y., Seki S., Tokunaga A., Urushizaki A., Takahashi H., Tsuneyama K. and Kimura T.: Fatal prognosis of an atypical meningioma in the cervical spine. J. Orthop. Sci., 13: 155-159, 2008.
4) 市川亮子，田澤賢一，福田啓之，長田拓哉，野本一博，堀隆，亀田圭介，宇野立人，塚田一博：術前FDG-PET検査 にて異常集積を認めた直径8mmの甲状腺微小乳頭癌の1例．癌の臨床，54: 281-285, 2008.
◆ 学会報告
1) Nakanishi Y., Tsuneyama K., Fujimoto M., Salunga T.L., Nomoto K., An J.L., Takano Y., Iizuka S., Nagata M., Suzuki W., Shimada T., Aburada M., Nakano M., Selmi C. and Gershwin E.M.: Monosodium glutamate injection induces a new
comprehensive model of lifestyle-related non alcoholic fatty liver disease with neoplastic nodules. The 43rd Annual Meeting of the European Association for the Study of the Liver (EASL), 2008, 4, Milan.
2) Hsu W., Tsuneyama K., Moritoki Y., Wakabayashi K., Ansari A.A., Lian Z.X. and Gershwin M.E.: Differential effector mechanismsfor the pathogenesis of autoimmune cholangitis and inflammatory bowel disease in interleukin 2 receptor αknock out mice (IL-2Rα-/-). The 59th Annual Meeting of The American Association for The Study of Liver Diseases, 2008, 11, San Francisco.
3) Moritoki Y., Lian Z.X., Tsuneyama K., Wakabayashi K., Yang G.X., Yoshida K., Ueno Y. and Gershwin ME. B cell defiiciency exacerbates liver and intestinal inflammation in a murine model of autoimmune cholangitis. The 59th Annual Meeting of The American Association for The Study of Liver Diseases. 2008, 11, San Francisco.
4) Ruth R., Lian Z.X., Tsuneyama K., Yang G.X., Moritoki Y., Ansari A.A., Coppel R.L. and Gershwin M.E. Preferential hepatic induction of Th17 cells in IL-2 receptorα Knockout (IL2RαKO)mice: a murine model of primary biliary cirrhosis (PBC). The 59th Annual Meeting of The American Association for The Study of Liver Diseases. 2008, 11, San Francisco.
5) Hsu W.M., Zhang W., Tsuneyama K., Moritoki Y., Ridgway W.M., Ansari A., Lian Z.X. and Gershwin M.E.: Differential Mechanisms for the Pathogenesis of Autoimmune Cholangitis Versus IBD in IL-2R alpha knockout Mice. 4th Federation of Immunological Societies of Asia-Oceania Congress. 2008, 10, Taipei.
6) Chen S.Y., Tsuneyama K., Sytwu H.K. and Chen Y.C.: Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. 5th Federation of Immunological Societies of Asia-Oceania Congress. 2008, 10, Taipei.
7) 常山幸一, 中西ゆう子, 藤本誠, 高野康雄：MSG マウス 肥満，2 型糖尿病を背景として発症する非アルコール性脂 肪性肝疾患／脂肪性肝炎の新たな動物モデル．第44回日本肝臓学会総会，2008, 6, 愛媛．
8) 中西ゆうこ, 常山幸一, 藤本誠, 野本一博, 中嶋隆彦, 三輪重治, 村井嘉寛, 林伸一, 高野康雄：MSGマウス 非アル コール性脂肪性肝疾患/脂肪性肝炎の新たな動物モデル．第97回日本病理学会総会，2008, 5, 石川．
9) 中西ゆう子, 常山幸一, 野本一博, 藤本誠, 中嶋隆彦, 三輪重治, 村井嘉寛, 林伸一, 高野康雄：ガレクチン3ノック アウトマウスにおける非アルコール性脂肪性肝炎と肝細胞癌．第97回日本病理学会総会，2008, 5, 石川．
10) 田中伴典, 北野晴久, 堀隆, 坂井祐太, 釜谷寛之, 影山俊一郎, 野本一博，福岡順也：肺癌研究における新たなエンテ ィティとテクノロジー 高集積組織アレイ研究から試みる肺癌の個別化医療．第 97 回日本病理学会総会，2008, 5, 15-17, 石川．
11) 木屋千恵子, 堀隆, 中川加奈子, 松島貴子, 石井陽子, 野本一博, 石澤伸, 福岡順也：メトトレキサート治療中の患者 における肺リンパ腫様肉芽腫症（Pulmonary Lymphomatoid Granulomatosis in the Patient on Methotrexate）．第49回日本 臨床細胞学会総会．2008, 6, 6-8, 東京．
12) 田中淳, 堀場千尋, 尾矢剛志, 野本一博, 福岡順也, 徳永綾乃, 濱島丈, 石井陽子, 石澤伸, 笹原正清：診断困難な脳 室発生の高悪性度紡錘形細胞腫瘍の一例．第97回日本病理学会総会，2008, 5, 15-17, 石川．
13) 瀧川章子, 岩田実, 岡澤光代, 小橋親晃, 宇野立人, 石木学, 薄井勲, 山崎勝也, 浦風雅春, 戸辺一之, 森田誠市, 湯 口卓, 塚田一博, 富澤岳人, 蔭山昌成, 野本一博, 中本美郁, 赤川直次：血中プロインスリン測定及び選択的動脈内カ ルシウム注入試験(ASVS)により診断しえたインスリノーマの一例．第81回日本内分泌学会学術総会，2008, 5, 16-18, 青森．
14) 嶋香菜子, 村上純, 在田幸太郎, 米澤和美, 宮園卓宜, 三原弘, 折原正周, 杉山敏郎, 田口芳治, 道具伸浩, 高嶋修太 郎, 野本一博, 石澤伸, 高野康雄：IgM-M 蛋白を伴う慢性炎症性脱髄性多発神経炎の経過中に発症した小腸 MALT リンパ腫．第70回日本血液学会総会，2008, 10, 10-12, 京都．
◆ その他
1) 野本一博，堀隆，中川加奈子，木屋千恵子，福岡順也：腹腔細胞診の診断に難渋した腹膜播種を伴う卵巣移行上皮 癌の1例．第25回日本臨床細胞学会富山県支部総会，2008, 3, 8, 富山．
2) 常山幸一：肝移植病理ショートレクチャー～最近経験した症例を交えて～．呉西肝移植勉強会，2008, 9, 12, 富山．
（招待講演）
3) 八田秀樹：特定化学物質障害予防規則（ホルムアルデヒドに関する法）改正の現状と対応．平成20年度機器・分析 技術研究会，2008, 9, 25-26，愛媛．
4) 常山幸一：基礎から臨床へのトランスレーション：PBC,NASH モデル動物が教えてくれること．第33回神奈川肝臓 病理研究会，2008, 10, 18, 神奈川．（招待講演）
5) 野本一博，高野康雄：乳腺myofibroblastomaの 1 例．第20回北陸病理集談会, 2008, 11, 8, 富山．
