ᆅ ᇦ ᅾ ఫ ୰ 㧗 㱋 ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ཬ ࡧ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ 㛵 㐃 ᛶ ࡢ ᳨ ウ
⏦ ㄳ ⪅ ᘯ ๓ Ꮫ Ꮫ 㝔 ་ Ꮫ ◊ ✲ ⛉
⥲ ྜ ་ ⒪ ࣭ ᗣ ⛉ Ꮫ 㡿 ᇦ
♫ ་ ⒪ ⥲ ྜ ་ Ꮫ ᩍ ⫱ ◊ ✲ ศ 㔝
Ặ ྡ ⣆ ㇂ ᫀ ᚿ
ᣦ ᑟ ᩍ ᤵ ⱝ ᯘ Ꮥ ୍
1
ᢒ 㘓
ᮏ ◊ ✲ ࡣ ࠊᆅ ᇦ ᅾ ఫ ࡢ 60 ṓ ௨ ୖ ࡢ ⪅ ࢆ ᑐ ㇟ ࡋ ࡚ ࠊㄆ ▱ ᶵ ⬟ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ
ࣥ ࢻ ࣟ ࣮ ࣒ ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ 㛵 㐃 ࢆ ᳨ ウ ࡍ ࡿ ࡇ ࢆ ┠ ⓗ ࡋ ࡓ ࠋ ◊ ✲ ཧ ຍ ⪅ ࡣ ࠊ 㟷 ᳃ ┴ ᘯ ๓ ᕷ ᒾ ᮌ ᆅ ༊ ᅾ ఫ ࡢ ⏨ ᛶ 101 ྡ ࠊ ዪ ᛶ 167 ྡ ࡛ ࠶ ࡗ ࡓ ࠋ◊ ✲ ཧ ຍ ⪅ ᑐ ࡋ ࡚ ࠊㄆ ▱ ᶵ ⬟ ᳨ ᰝ ࠊ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ㸦 ⭡ ᅖ ࠊ ⾑ ᅽ ࠊ ⾑ ୰ ⬡ ㉁ ࠊ ⾑ Ύ ⾑ ⢾ 㸧 ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ 㸦 ࣟ ࢥ ࣔ 25 ࠊ2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࠊ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ 㸧 ࡢ ᐃ ࢆ ࠾ ࡇ ࡞ ࡗ ࡓ ࠋ ศ ᯒ ⤖ ᯝ
ࡽ ࠊ ⏨ ᛶ ࡢ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ヱ ᙜ ⪅ ࡣ ᭷ ព ㄆ ▱ ᶵ ⬟ ࡀ ప ࡃ ࠊ ヱ ᙜ 㡯
┠ ᩘ ࡀ ቑ ࠼ ࡿ ࡋ ࡓ ࡀ ࡗ ࡚ ࡑ ࡢ ഴ ྥ ࡣ 㢧 ⴭ ࡛ ࠶ ࡗ ࡓ ࠋ ୍ ᪉ ࠊ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ
ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ ࠾ ࠸ ࡚ ࡣ ࠊ ⏨ ዪ ࡶ ㄆ ▱ ᶵ ⬟ ࡢ 㛵 㐃 ࡣ ぢ ࡽ ࢀ ࡞ ࡗ ࡓ ࠋ ௨
ୖ ࡼ ࡾ ࠊ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ ࡣ ࠊ ⏨ ᛶ ࠾ ࠸ ࡚ ㄆ ▱ ᶵ ⬟ ప ୗ ண ᅉ Ꮚ ࡢ ᭷ ⏝ ᛶ ࡀ ♧ ၀ ࡉ ࢀ ࡓ ࠋ
࢟ ࣮ ࣡ ࣮ ࢻ : ୰ 㧗 㱋 ⪅ ࠊ ㄆ ▱ ᶵ ⬟ ࠊ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࠊ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ
ࣥ ࢻ ࣟ ࣮ ࣒ ࠊ ࣟ ࢥ ࣔ ᗘ ࢸ ࢫ ࢺ
2
Abstract
The purpose of this study was to examine how cognitive function is related to metabolic syndrome and locomotive syndrome in a Japanese general population over the age of 60. The subjects were 101 males and 167 females living in the Iwaki area, Hirosaki city in Aomori Prefecture. The survey parameters were as follows:: cognitive function test (Mini-Mental State Examination, MMSE), metabolic syndrome index (abdominal girth, blood pressure, serum lipid and serum glucose level) and the locomotive syndrome index (the 25-question geriatric locomotive function scale, two-step test and stand-up test). As a result, males with locomotive syndrome had significantly lower cognitive function, and the tendency was remarkable as the number of relevant items increased. On the other hand, in the metabolic syndrome index, associations with neither gender nor cognitive function were observed. From the above, it was found that the locomotive syndrome evaluation index was considered useful as a tool for screening cognitive decline in males.
Keywords: Middle-aged and elderly people, Cognitive function, Metabolic
syndrome, Locomotive syndrome, Locomotive syndrome index
3
⥴ ゝ
㉸ 㧗 㱋 ♫ ࡢ ᡃ ࡀ ᅜ ࠾ ࠸ ࡚ ࠊ ㄆ ▱ ࡣ ῝ ้ ࡞ ♫ ၥ 㢟 ࡛ ࠶ ࡿ ࠋ ᪥ ࡛ ࡣ ࠊ ୡ
⏺ ୰ ࡛ 4,600 ே ࢆ ㉸ ࠼ ࡿ ே ࠎ ࡀ ㄆ ▱ 㸦 Alzheimer ̓ s disease: AD㸧 ⨯ ᝈ ࡋ ࡚ ࠾ ࡾ ࠊࡇ ࡢ ᩘ ࡣ 2050 ᖺ ࡲ ࡛ 1 ൨ 3,150 ே ቑ ຍ ࡍ ࡿ ᥎ ᐃ ࡉ ࢀ ࡚ ࠸ ࡿ
1)
ࠋᡃ ࡀ ᅜ ࠾ ࠸ ࡚ ࡣ ࠊ 2012 ᖺ ࡢ 65 ṓ ௨ ୖ ࠾ ࡅ ࡿ ㄆ ▱ ࡢ ᭷ ⋡ ࡣ 15.0㸣 ࡛ ࠊ
⣙ 462 ே ࡶ ࡢ ࡰ ࡿ ࡇ ࡀ බ ⾲ ࡉ ࢀ ࡓ
2)ࠋ ࡲ ࡓ ࠊ ᅋ ሢ ࡢ ୡ ௦ ࡢ ࢇ ࡀ ᚋ ᮇ 㧗 㱋 ⪅ ࡞ ࡿ 2025 ᖺ ࡣ ࠊ᭷ ⋡ ࡣ 20%௨ ୖ ࡞ ࡾ ࠊ740 ே ௨ ୖ ࡀ ㄆ ▱ ࡞
ࡿ ᥎ ィ ࡉ ࢀ ࡚ ࠸ ࡿ
2)ࠋ ㄆ ▱ ࡣ ᪩ ᮇ ධ ࢆ ⾜ ࠺ ࡇ ࡛ 㐍 ⾜ ࢆ 㐜 ࡽ ࡏ ࡿ ࡇ ࡀ ࡛ ࡁ ࡿ ゝ ࢃ ࢀ ࡚ ࠸ ࡿ ࡓ ࡵ
3)ࠊ ㄆ ▱ ᶵ ⬟ ప ୗ ࢆ ᪩ ᮇ Ⓨ ぢ ࡛ ࡁ ࡿ ࡼ ࠺ ࡞ ࢫ ࢡ ࣜ ࣮ ࢽ
ࣥ ࢢ ࢶ ࣮ ࣝ ࡢ 㛤 Ⓨ ࡀ ᛴ ົ ࡛ ࠶ ࡿ ࠸ ࠼ ࡿ ࠋ
ㄆ ▱ ࡢ ༴ 㝤 ᅉ Ꮚ ࡣ ᵝ ࠎ ࡛ ࠶ ࡿ ࡀ ࠊ ࡑ ࡢ 1 ࡘ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ 㸦 ௨
ୗ ࠊ ࣓ ࢱ ࣎ 㸧 ࡀ ࠶ ࡿ ࠋ ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡋ ࡚ ࠊ ෆ ⮚ ⬡ ⫫ 㠃 ✚ ࠊ ⾑ ᅽ ࠊ ⾑ ୰ ⬡ ㉁ ࠊ
⾑ Ύ ⾑ ⢾ ࡀ ᣲ ࡆ ࡽ ࢀ ࡿ ࡀ ࠊ ࡑ ࢀ ࡒ ࢀ ㄆ ▱ ࠾ ࡼ ࡧ ㄆ ▱ ᶵ ⬟ ࠊ ⬻ ࡢ ჾ ㉁ ⓗ ኚ ࡢ 㛵 㐃 ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ ࠋ ෆ ⮚ ⬡ ⫫ ࡢ ✚ ࡘ ࠸ ࡚ ࡣ ࠊ ㏆ ᖺ ࠊ ⬻ ࡢ ⴎ ⦰ ࠊ ⬻ ⓑ ㉁
ኚ ࠾ ࡼ ࡧ ࣛ ࢡ ࢼ ᱾ ሰ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ࡇ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ
4,5)ࠋ⾑ ᅽ ࡘ ࠸ ࡚ ࡣ ࠊ
⦰ ᮇ ⾑ ᅽ ࡢ 㧗 ࠸ ⪅ ࡲ ࡓ ࡣ ᣑ ᙇ ᮇ ⾑ ᅽ ࡢ ప ࠸ ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ࡣ ప ࡃ ࡞ ࡿ ࡇ ࡀ ࢩ ࢫ ࢸ ࣐ ࢸ ࢵ ࢡ ࣞ ࣅ ࣗ ࣮ ࡛ ♧ ࡉ ࢀ ࡚ ࠸ ࡿ
6) ࠊ ⾑ ᅽ ࡢ ࢥ ࣥ ࢺ ࣟ ࣮ ࣝ ࡼ ࡗ ࡚ ㄆ ▱
ࡢ ࣜ ࢫ ࢡ ࡀ ప ୗ ࡍ ࡿ ࡇ ࡀ ♧ ࡉ ࢀ ࡚ ࠸ ࡿ
7)ࠋ⬡ ㉁ ␗ ᖖ 㛵 ࡋ ࡚ ࡣ ࠊప HDL ࢥ
4
ࣞ ࢫ ࢸ ࣟ ࣮ ࣝ ࡀ ప ࠸ ࠊMini-Mental State Examination㸦MMSE㸧ᚓ Ⅼ 㛵 㐃 ࡋ ࡚
࠸ ࡿ ࡇ ࡀ ♧ ࡉ ࢀ ࡚ ࠸ ࡿ
8)ࠋ ࡲ ࡓ ࠊ ⾑ ୰ ⬡ ㉁ ࡣ ㄆ ▱ ᶵ ⬟ ࡢ ୰ ࡛ ࡶ ࠊ ᐇ ⾜ ᶵ ⬟ ࠊ ὀ ព ᶵ ⬟ ࠊฎ ⌮ ㏿ ᗘ ࡢ 20 ᖺ ᚋ ࡢ ప ୗ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ
9)ࠋ୍ ᪉ ࠊ⾑
⢾ ࡘ ࠸ ࡚ ࡣ ࠊ ⢾ ᒀ ࡀ ㄆ ▱ ࡢ ࣜ ࢫ ࢡ ࢆ ྥ ୖ ࡉ ࡏ ࡿ ࡇ ࡣ ከ ࡃ ࡢ ◊ ✲ ࡛ ♧ ࡉ ࢀ
࡚ ࠸ ࡿ ࡶ ࡢ ࡢ
10)ࠊ ゝ ㄒ ࠊ ど ぬ ⓗ ࢚ ࣆ ࢯ ࣮ ࢻ グ ᠈ ࠾ ࡼ ࡧ ゝ ㄒ ⓗ ᥎ ㄽ ࡢ 㛵 㐃 ࡣ ぢ ࡽ
ࢀ ࡞ ࡗ ࡓ ࡋ ࡚ ࠸ ࡿ
11)ࠋ ௨ ୖ ࡢ ࡼ ࠺ ࠊ ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡣ ⬻ ࡢ ჾ ㉁ ⓗ ኚ ࢆ ಁ 㐍 ࡋ ࠊ ㄆ ▱ ᶵ ⬟ ప ୗ 㛵 㐃 ࡍ ࡿ ࡇ ࡀ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ
㌟ య ᶵ ⬟ ప ୗ ࡶ ࡲ ࡓ ㄆ ▱ ᶵ ⬟ ࡢ ప ୗ 㛵 㐃 ࡍ ࡿ ࡇ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ ࡀ
12)ࠊ ㏆ ᖺ ᮏ 㑥 ࢆ ୰ ᚰ ㌟ య ᶵ ⬟ ప ୗ ࡦ ࠸ ࡚ ࡣ ᐷ ࡓ ࡁ ࡾ ࡢ ண 㜵 ࡢ ࡓ ࡵ ࡢ ᴫ ᛕ ࡋ ࡚ ࠊ ࣟ ࢥ
ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒㸦 ௨ ୗ ࠊࣟ ࢥ ࣔ 㸧ࡢ ⪃ ࠼ ᪉ ࡀ ᗈ ࡀ ࡗ ࡚ ࡁ ࡚ ࠸ ࡿ ࠋࡇ ࢀ ࡣ ࠊ ࠕ ➽
⫗ ࠊ 㦵 ࠊ 㛵 ⠇ ࠊ ㌾ 㦵 ࠊ ᳝ 㛫 ᯈ ࠸ ࡗ ࡓ 㐠 ື ჾ ࡢ ࠸ ࡎ ࢀ ࠊ ࠶ ࡿ ࠸ ࡣ 」 ᩘ 㞀 ᐖ ࡀ
㉳ ࡇ ࡾ ࠊ ࠕ ❧ ࡘ ࠖ ࠕ Ṍ ࡃ ࠖ ࠸ ࡗ ࡓ ᶵ ⬟ ࡀ ప ୗ ࡋ ࡚ ࠸ ࡿ ≧ ែ ࠖ ᐃ ⩏ ࡉ ࢀ ࡚ ࠸ ࡿ
13)ࠋ
ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ 㛵 ࡋ ࡚ ࡣ ࠊ ࣟ ࢥ ࣔ 25 ࠊ 2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࠾ ࡼ ࡧ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࡢ 3 ࡘ ࡢ ᳨ ᰝ ࡀ ⏝ ࠸ ࡽ ࢀ ࡚ ࠸ ࡿ
14-16)ࠋ ࡞ ࡛ ࡶ ࠊ ࣟ ࢥ ࣔ 25 ࡢ ࢫ ࢥ ࡀ 6 ௨ ୖ ࡢ ⪅ ࡣ ࠊ 6 ᮍ ‶ ࡢ ⪅ ࡼ ࡾ ࡶ ㄆ ▱ ᶵ ⬟ 㞀 ᐖ ࡛ ࠶ ࡿ ྜ ࡀ 㧗 ࡗ ࡓ ࡇ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠾
ࡾ
17)ࠊ ᑗ ᮶ ⓗ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࢆ ㄆ ▱ ᶵ ⬟ ప ୗ ࡢ ᪩ ᮇ Ⓨ ぢ ࡢ ࢶ ࣮ ࣝ ࡋ ࡚ ά ⏝ ࡛ ࡁ ࡿ ࡇ ࡀ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ ࡋ ࡋ ࡞ ࡀ ࡽ ࠊ ࣟ ࢥ ࣔ ㄆ ▱ ᶵ ⬟ ࡢ 㛵 㐃 ࢆ ᳨ ウ ࡋ ࡓ ሗ
࿌ ࡣ ᑡ ࡞ ࠸ ࡢ ࡀ ⌧ ≧ ࡛ ࠶ ࡾ ࠊ ࡼ ࡾ ከ ࡃ ࡢ ◊ ✲ ࡀ ᚲ せ ࡉ ࢀ ࡿ ࠋ ࡲ ࡓ ࠊ ࣟ ࢥ ࣔ ࣓
ࢱ ࣎ ࡣ ే Ⓨ ࡍ ࡿ ࡀ ከ ࡃ
18)ࠊ ࡕ ࡽ ࡢ ᙳ 㡪 ࡀ ᙉ ࠸ ࡣ ᫂ ࡽ ࡞ ࡗ ࡚ ࠸ ࡞ ࠸ ࠋ
5
ࡑ ࡇ ࡛ ᮏ ◊ ✲ ࡣ ࠊ 60 ṓ ௨ ୖ ࡢ ᆅ ᇦ ᅾ ఫ ࢆ ᑐ ㇟ ࡋ ࡚ ࠊ ㄆ ▱ ᶵ ⬟ ࣓ ࢱ ࣎ ࠾ ࡼ ࡧ
ࣟ ࢥ ࣔ ࡢ 㛵 㐃 ࢆ ᳨ ウ ࡍ ࡿ ࡇ ࢆ ┠ ⓗ ࡋ ࡚ ᐇ ࡋ ࡓ ࠋ
᪉ ἲ
◊ ✲ ཧ ຍ ⪅
◊ ✲ ཧ ຍ ⪅ ࡣ ࠊ 2005 ᖺ ࡼ ࡾ 㟷 ᳃ ┴ ᘯ ๓ ᕷ ᒾ ᮌ ᆅ ༊ ࠾ ࠸ ࡚ ᐇ ࡉ ࢀ ࡓ ᒾ ᮌ ᗣ ቑ 㐍 ࣉ ࣟ ࢪ ࢙ ࢡ ࢺ ࣭ ࣉ ࣟ ࢪ ࢙ ࢡ ࢺ デ ཧ ຍ ࡋ ࡓ ⪅ ࡢ ࠺ ࡕ ࠊ ࣟ ࢥ ࣔ 㛵 ࡍ ࡿ ㄪ ᰝ
ࢆ ᐇ ࡋ ࡓ 2014㹼2016 ᖺ ᗘ ࡢ ཧ ຍ ⪅ ࡛ ࠶ ࡗ ࡓ ࠋ 3 ᖺ 㛫 ࡢ ཧ ຍ ⪅ ࡢ ᘏ ே ᩘ ࡣ 3,428
ྡ ࡛ ࠶ ࡗ ࡓ ࠋ ࡑ ࡢ ࠺ ࡕ ࠊ 60 ṓ ᮍ ‶ ࡢ ⪅ ࠊ ࢹ ࣮ ࢱ 㔜 」 ⪅ ࠊ ࡀ ࢇ ࣭ ᚰ ᝈ ࣭ ⬻ ⾑ ⟶ ᝈ ࣭ ኚ ᙧ ᛶ ⭸ 㛵 ⠇ ࣭ ே ᕤ 㛵 ⠇ ࣭ ㄆ ▱ ࣭ ⢭ ⚄ ᝈ ࡢ ᪤ Ṕ ࡢ ࠶ ࡿ ⪅ ࠊ ⢾ ᒀ
⒪ ⸆࣭ᢠ ࠺ ࡘ ⸆ ࠊᢠ ⢭ ⚄ ⸆࣭ㄆ ▱ ⒪ ⸆ ࡢ ᭹ ⸆ ࡢ ࠶ ࡿ ⪅ ࠊMMSE ࡀ 24 Ⅼ ᮍ ‶ ࡢ ⪅ ࠊ ศ ᯒ ࢹ ࣮ ࢱ Ḟ ᦆ ࡢ ࠶ ࡿ ⪅ ࢆ 㝖 እ ࡋ ࡓ 268 ྡ ࢆ ᭱ ⤊ ⓗ ࡞ ศ ᯒ ᑐ ㇟ ⪅ ࡋ ࡓ 㸦 Figure 1㸧ࠋᮏ ◊ ✲ ࡣ ᘯ ๓ Ꮫ Ꮫ 㝔 ་ Ꮫ ◊ ✲ ⛉ ⌮ ጤ ဨ ࡢ ᢎ ㄆ ࢆ ᚓ ࡚㸦 ␒ ྕ㸸 2014-014 ࠊ2014-377ࠊ2016-028㸧ᐇ ࡉ ࢀ ࠊཧ ຍ ⪅ ࡣ ๓ ◊ ✲ ࡢ ┠ ⓗ ෆ ᐜ
ࢆ ཱྀ 㢌 ࠾ ࡼ ࡧ ᩥ ᭩ ࡚ ㄝ ᫂ ࢆ ⾜ ࠸ ࠊ ᭩ 㠃 ࡼ ࡿ ྠ ព ࢆ ᚓ ࡓ ࠋ
(ࡇ ࡇ Figure 1 ࢆ ᤄ ධ)6
ㄪ ᰝ 㡯 ┠
1 㸧 ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ
࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡋ ࡚ ࠊ ⭡ ᅖ ࠊ ⦰ ᮇ ࣭ ᣑ ᙇ ᮇ ⾑ ᅽ ࠊ ⾑ ୰ ⬡ ㉁ ࠊ ⾑ Ύ ⾑ ⢾ ࢆ ᐃ ࡋ ࡓ ࠋ ⭡ ᅖ ࡣ ࠊ ࠾ ࡅ ࡿ ࿘ ᅖ 㛗 ࢆ 0.1 cm ༢ ࡛ ㍍ ࠸ Ẽ ࡢ ࿘ ᮇ ィ ࡋ ࠊ
⏨ ᛶ ࡣ 85 cmࠊ ዪ ᛶ ࡣ 90 cm ௨ ୖ ࢆ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ ⾑ ᅽ ࡣ ࠊ ⦰ ᮇ ᣑ ᙇ ᮇ ࡢ
ୖ ⭎ 㒊 ศ ࡢ ⾑ ᅽ ࢆ ᐃ ࡋ ࠊ ⏨ ዪ ࡶ ⦰ ᮇ ⾑ ᅽ 130mmHg ௨ ୖ ࠊ ᣑ ᙇ ᮇ ⾑ ᅽ 85 mmHg ௨ ୖ ࢆ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ ⾑ ୰ ⬡ ㉁ ࡣ ࠊ 㟼 ⬦ ࡽ ᥇ ⾑ ࡋ ࡓ ⾑ ᾮ ୰ ࡢ ࢺ ࣜ ࢢ ࣜ ࢭ ࣛ ࢻ ್ HDL ࢥ ࣞ ࢫ ࢸ ࣟ ࣮ ࣝ ್ ࢆ ᐃ ࡋ ࠊ ⏨ ዪ ࡶ ࡑ ࢀ ࡒ ࢀ 150 mg / dL ௨ ୖ ࠊ 40 mg / dL ᮍ ‶ ࢆ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ ⾑ Ύ ⾑ ⢾ 㛵 ࡋ ࡚ ࡣ ࠊ ✵ ⭡ ⾑ ⢾ ࢆ ᐃ ࡋ ࠊ 110 mg / dL ௨ ୖ ࢆ ヱ ᙜ ᇶ ‽ ࡋ ࡓ
19)ࠋ
2 㸧 ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ
ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡋ ࡚ ࠊࣟ ࢥ ࣔ 25
14)ࠊ2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ
15)ࠊ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ
16)
ࢆ ᐃ ࡋ ࡓ ࠋ
ࣟ ࢥ ࣔ 25 ࡘ ࠸ ࡚ ࡣ ࠊ Seichi ࡽ 㸦 2012㸧 ࡢ 25 ࡢ 㡯 ┠ ࡽ ࡞ ࡿ ㄪ ᰝ ⚊ ⮬ ᕫ グ ධ ࡍ ࡿ ໟ ᣓ ⓗ ᑻ ᗘ ࡛ ࠶ ࡿ
14)ࠋ ┤ ㏆ 1 ࣨ ᭶ 㛫 ࡢ ࠊ య ࡢ ③ ࡳ ࡸ ά ື ࡢ ㎞ ࡉ 㛵 ࡍ ࡿ 4 㡯 ┠ ࠊ᪥ ᖖ ⏕ ά ࡢ ά ື 㛵 ࡍ ࡿ 16 㡯 ┠ ࠊ♫ ⓗ ᶵ ⬟ 㛵 ࡍ ࡿ 3 㡯 ┠ ࠊ㌿ ಽ ࡸ ⛣ ື
⬟ ຊ ᑐ ࡍ ࡿ Ᏻ 㛵 ࡍ ࡿ 2 㡯 ┠ ࢆ ࠊࡑ ࢀ ࡒ ࢀ 㞀 ᐖ ࡞ ࡋ㸦 0 Ⅼ 㸧 ࡽ 㔜 ᗘ ࡢ 㞀 ᐖ㸦 4
Ⅼ 㸧ࡲ ࡛ ࡢ 5 ẁ 㝵 ࡛ ホ ౯ ࡋ ࠊྜ ィ ᚓ Ⅼ㸦 0㹼 100 Ⅼ 㸧ࢆ ⟬ ฟ ࡍ ࡿ ࠋᚓ Ⅼ ࡀ 㧗 ࠸ ࠊ
7
ࣟ ࢥ ࣔ ࡣ ᝏ ࡋ ࡚ ࠸ ࡿ ุ ᐃ ࡉ ࢀ ࡿ ࠋ ⏨ ዪ ࡶ 7 Ⅼ ௨ ୖ ࢆ ࣟ ࢥ ࣔ ࡢ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ
2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࡣ ࠊୗ ⫥ ࡢ ➽ ຊ ࠊࣂ ࣛ ࣥ ࢫ ࠊᰂ ㌾ ᛶ ࡞ Ṍ ⾜ ⬟ ຊ ࢆ ホ ౯ ࡍ ࡿ ᐃ ࡛ ࠶ ࡿ
15)ࠋ ᐃ ᡭ 㡰 ࡣ ඛ ⾜ ◊ ✲ ᚑ ࠸ ࠊ㸦 1 㸧 㛤 ጞ ࣛ ࣥ ୧ ㊊ ࡢ ࡘ ࡲ ඛ ࢆ ྜ ࢃ ࡏ ࡚ ❧ ࡘ ࠊ㸦 2㸧 ᭱ ດ ຊ ࡛ 2 Ṍ ⫤ ࡛ ๓ 㐍 ࡋ ࠊ ฿ 㐩 ᆅ Ⅼ ࡛ ࡧ ୧ ㊊ ࡢ ࡘ ࡲ ඛ ࢆ ࡑ
ࢁ ࠼ ࡚ ❧ ࡘ ࠊ 㸦3㸧㛤 ጞ ࣛ ࣥ ࡽ ㊊ ᣦ ࡢ ඛ ➃ ࡲ ࡛ ࡢ ㊥ 㞳 ࢆ cm ༢ ࡛ ᐃ ࡍ ࡿ ࠊ
ࡋ ࠊ 2 ᅇ ᐇ ࡋ ࡓ ࠋࡇ ࡢ ᡭ 㡰 ࡼ ࡗ ࡚ ᚓ ࡽ ࢀ ࡓ ㊥ 㞳 ࡢ ࠺ ࡕ ࠊ㊥ 㞳 ࡢ 㛗 ࠸ ᪉ ࢆ ㌟ 㛗㸦 cm㸧
࡛ 㝖 ࡋ ࡓ ್ ࢆ 2 ࢫ ࢸ ࢵ ࣉ ್ ࡋ ࡚ ࣟ ࢥ ࣔ ࢆ ุ ᐃ ࡋ ࡓ ࠋ⏨ ዪ ࡶ 1.3 ᮍ ‶ ࢆ ࣟ ࢥ ࣔ ࡢ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ
❧ ࡕ ୖ ࡾ ࢸ ࢫ ࢺ ࡣ ࠊ ୗ ⫥ ࡢ ➽ ຊ ࢆ ホ ౯ ࡍ ࡿ ᐃ ࡛ ࠶ ࡿ ࠋ 40cmࠊ 30cmࠊ 20cm ࠊ 10cm ࡢ ␗ ࡞ ࡿ 㧗 ࡉ ࡢ 4 ࡘ ࡢ ྎ ࢆ ⏝ ࠸ ࠊ㧗 ࠸ ྎ ࡽ ୧ ⬮ ࡛ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࠊḟ
∦ ⬮ ࡛ ❧ ࡕ ୖ ࡀ ࡗ ࡓ ࠋ ㉳ ❧ ጼ ໃ ࢆ 3 ⛊ ಖ ᣢ ࡛ ࡁ ࢀ ࡤ ࠊ ヨ ᢏ ࡀ ᡂ ຌ ࡋ ࡓ ุ ᐃ ࡉ ࢀ ࡓ
16)ࠋ40cm ࡢ ྎ ࡽ ୧ ⬮ ࡛ ❧ ࡕ ୖ ࡀ ࢀ ࡞ ࠸ ሙ ྜ ࢆ 0 Ⅼ ࠊ10cm ࡢ ྎ ࡽ ∦ ⬮ ࡛ ❧ ࡕ ୖ ࡀ ࢀ ࡓ ሙ ྜ ࢆ 8 Ⅼ ࡋ ࡓ ࠋ⏨ ዪ ࡶ 5 Ⅼ ᮍ ‶ ࡢ ⪅㸦 40cm ࡢ ྎ ࡽ ∦ ⬮ ࡛ ❧ ࡕ
ୖ ࡀ ࢀ ࡞ ࠸ ሙ ྜ 㸧 ࢆ ࣟ ࢥ ࣔ ࡢ ヱ ᙜ ᇶ ‽ ࡋ ࡓ ࠋ
3 㸧 ㄆ ▱ ᶵ ⬟ ホ ౯ ᣦ ᶆ
⯡ ⓗ ㄆ ▱ ᶵ ⬟ ࡣ ࠊ MMSE ࢆ ⏝ ࠸ ࡚ ホ ౯ ࡋ ࡓ
20㸧ࠋ MMSE ࡣ ࠊ ಶ ู 㠃 ㄯ ࡼ ࡿ
ㄆ ▱ ᶵ ⬟ ホ ౯ ࡢ ࢸ ࢫ ࢺ ࣂ ࢵ ࢸ ࣜ ࣮ ࡛ ࠶ ࡾ ࠊ 11 ࡢ タ ၥ 㸦 㛫 ࡢ ぢ ᙜ ㆑ ࠊ ሙ ᡤ ࡢ ぢ ᙜ
8
㆑ ࠊ ༢ ㄒ ࡢ ༶ ㉳ ࠊ ィ ⟬ ࠊ ༢ ㄒ ࡢ 㐜 ᘏ ⏕ ࠊ ≀ ရ ⛠ ࠊ ᩥ ࡢ ၐ ࠊ ཱྀ 㢌 ᥦ ♧ ࠊ
⮬ Ⓨ ᭩ Ꮠ ࠊ ᅗ ᙧ ᶍ 㸧 ࡼ ࡾ ᵓ ᡂ ࡉ ࢀ ࡚ ࠸ ࡿ ࠋ ᚓ Ⅼ ⠊ ᅖ ࡣ 0㹼 30 Ⅼ ࡛ ࠶ ࡿ ࠋ
ㄽ ⌮ ⓗ グ ᠈ ࡣ ࠊ ᪥ ᮏ ㄒ ∧ ࢘ ࢙ ࢡ ࢫ ࣛ ࣮ グ ᠈ ᳨ ᰝ ࡢ ࠺ ࡕ ࠊ ゝ ㄒ ᛶ ࡢ ࢚ ࣆ ࢯ ࣮ ࢻ グ
᠈ ⬟ ຊ ࢆ ᐃ ࡍ ࡿ ࠕ ㄽ ⌮ ⓗ グ ᠈ ϩ ࠖ ࢆ ᐇ ࡋ ࡓ
21)ࠋ ཧ ຍ ⪅ ࡣ 150 Ꮠ ⛬ ᗘ ࡢ ▷ ࠸ ≀ ㄒ ࢆ ⫈ ࠸ ࡓ ᚋ ࠊ⣙ 30 ศ ࡢ 㛫 㝸 ࢆ ✵ ࡅ ࡚ ࠊࡑ ࡢ ≀ ㄒ ࡘ ࠸ ࡚ ぬ ࠼ ࡚ ࠸ ࡿ ࡇ ࢆ ཧ ຍ
⪅ ⏕ ࡉ ࡏ ࡿ ࠋ ᚓ Ⅼ ⠊ ᅖ ࡣ 0 㹼50 Ⅼ ࡛ ࠶ ࡿ ࠋ
⤫ ィ ゎ ᯒ
⏨ ዪ 㛫 ࡢ ≉ ᚩ ࡢ ẚ ㍑ ࡣ ࠊt ᳨ ᐃ ࠾ ࡼ ࡧ ࢝ ᳨ ᐃ ࢆ ⏝ ࠸ ࡚ ᳨ ウ ࡋ ࡓ ࠋࡲ ࡓ ࠊ࣓
ࢱ ࣎ ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࠊ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ ࠾ ࡼ ࡧ ㄽ ⌮ ⓗ グ ᠈ ࡢ 㛵 㐃 ࢆ ᳨ ウ ࡍ ࡿ ࡓ ࡵ ࠊᚑ ᒓ ኚ ᩘ ࢆ MMSE ࠾ ࡼ ࡧ ㄽ ⌮ ⓗ グ ᠈ ϩ ࡢ ᚓ Ⅼ ࠊᅛ ᐃ ᅉ Ꮚ ࢆ ⭡ ᅖ ࠊ⾑ ᅽ ࠊ
⾑ ୰ ⬡ ㉁ ࠊ ⾑ Ύ ⾑ ⢾ ࠊ ࣟ ࢥ ࣔ 25 ࠊ2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࠊ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࡢ ヱ ᙜ ≧ ἣ ࡋ ࡓ ࠊ ඹ ศ ᩓ ศ ᯒ ࢆ ⾜ ࡗ ࡓ ࠋ ࡲ ࡓ ࠊ ࣓ ࢱ ࣎ ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡢ ヱ ᙜ ᩘ ࡶ ᅛ ᐃ ᅉ Ꮚ ຍ ࠼ ࠊㄆ ▱ ᶵ ⬟ ホ ౯ ᣦ ᶆ ࡢ ᚓ Ⅼ ᑐ ࡍ ࡿ ഴ ྥ ᛶ ࡢ ᳨ ᐃ ࡶ ⾜ ࡗ ࡓ ࠋ3 ⩌ 㛫 ࡢ ᳨ ᐃ ࡘ ࠸ ࡚ ࡣ ࠊ ᚋ ᳨ ᐃ Bonferroni ࡢ ᪉ ἲ ࢆ ⏝ ࠸ ࡓ ࠋ ୖ グ ࡍ ࡚ ࡢ ศ ᯒ
࠾ ࠸ ࡚ ࠊ ᖺ 㱋 ࠊ ᩍ ⫱ ᖺ ᩘ ࠊ ⌧ ᅾ ࡢ ႚ ↮ ⩦ ័ ࠊ ⌧ ᅾ ࡢ 㣧 㓇 ⩦ ័ ࠊ ⌧ ᅾ ࡢ 㐠 ື ⩦ ័ ࢆ
ඹ ኚ 㔞 ࡋ ࡓ ࠋ⤫ ィ ゎ ᯒ ࡣ SPSS ver 23 ࢆ ⏝ ࠸ ࠊ᭷ ព Ỉ ‽ ࡣ ༴ 㝤 ⋡ 5% ᮍ ‶ ࡋ
ࡓ ࠋ
9
⤖ ᯝ
◊ ✲ ཧ ຍ ⪅ ࡢ ≉ ᚩ
◊ ✲ ཧ ຍ ⪅ ࡢ ≉ ᚩ ࢆ Table 1 ♧ ࡋ ࡓ ࠋᖹ ᆒ ᖺ 㱋 ࡣ ࠊ⏨ ᛶ 67.6 s 5.9 ṓ ࠊዪ ᛶ 65.9 s 5.2 ṓ ࡛ ࠶ ࡗ ࡓ ࠋ ᇶ ᮏ ᒓ ᛶ ࡘ ࠸ ࡚ ࡣ ࠊMMSE 㐠 ື ⩦ ័ ௨ እ ࡢ ࡍ ࡚ ࡢ 㡯 ┠ ࡛ ᭷ ព ᕪ ࡀ ㄆ ࡵ ࡽ ࢀ ࡓ ࠋ ㄆ ▱ ᶵ ⬟ 㛵 ࡍ ࡿ 㡯 ┠ ࡛ ࡣ ࠊ ዪ ᛶ ࡢ ᪉ ࡀ ㄽ ⌮ ⓗ グ
᠈ ϩ ࠾ ࠸ ࡚ ᭷ ព Ⰻ ዲ ࡛ ࠶ ࡗ ࡓ ࠋ
࣓ ࢱ ࣎ ཬ ࡧ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡘ ࠸ ࡚ ࠊ Table2 ♧ ࡋ ࡓ ࠋ ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡘ ࠸
࡚ ࡣ ࠊ ࡍ ࡚ ࡢ 㡯 ┠ ࠾ ࠸ ࡚ ዪ ᛶ ࡢ ᪉ ࡀ ᭷ ព Ⰻ ዲ ࡛ ࠶ ࡗ ࡓ ࠋ ࡋ ࡋ ࡞ ࡀ ࡽ ࠊ ⾑ Ύ ⾑ ⢾ ࡢ ᇶ ‽ ヱ ᙜ ⪅ ࡣ ⏨ ዪ 㛫 ᭷ ព ᕪ ࡣ ㄆ ࡵ ࡽ ࢀ ࡞ ࡗ ࡓ ࠋ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡘ
࠸ ࡚ ࡣ ࠊ2 ࢫ ࢸ ࢵ ࣉ ್ ࡢ ࡳ ⏨ ᛶ ࡢ ᪉ ࡀ ᭷ ព Ⰻ ዲ ࡛ ࠶ ࡾ ࠊᇶ ‽ ヱ ᙜ ⪅ ࡣ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࠾ ࠸ ࡚ ዪ ᛶ ࡢ ᪉ ࡀ ᭷ ព ከ ࡗ ࡓ ࠋ
ㄆ ▱ ᶵ ⬟ ホ ౯ ᣦ ᶆ ࣓ ࢱ ࣎ ཬ ࡧ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡢ 㛵 㐃
ㄆ ▱ ᶵ ⬟ ホ ౯ ᣦ ᶆ ࣓ ࢱ ࣎ ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡢ 㛵 㐃 ࡘ ࠸ ࡚ Table 3
♧ ࡋ ࡓ ࠋ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡢ ヱ ᙜ ྜ ィ ᩘ ࡛ ࠊዪ ᛶ ࡢ ࡳ ヱ ᙜ ᩘ ࡀ 1 ࡢ ⪅ ࡀ ࠊヱ ᙜ ᩘ ࡀ 0 ࡢ ⪅ ࡼ ࡾ ࡶ MMSE ࡀ ప ࡗ ࡓ ࠋ
ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡛ ࡣ ࠊ⏨ ᛶ ࡛ ࡣ ࣟ ࢥ ࣔ 25 ࠾ ࡼ ࡧ 2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࡛ ࠊࣟ ࢥ ࣔ ヱ ᙜ ࡍ ࡿ ⪅ ࡢ ᪉ ࡀ ᭷ ព MMSE ࡀ ప ࡗ ࡓ ࠋࡲ ࡓ ࠊㄽ ⌮ ⓗ グ ᠈ ϩ ࠾ ࠸ ࡚ ࠊ⏨ ᛶ
(ࡇ ࡇ Table 2 ࢆ ᤄ ධ) (ࡇ ࡇ Table 1 ࢆ ᤄ ධ)
10
ࡣ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࠾ ࠸ ࡚ ᭷ ព ᕪ ࡀ ㄆ ࡵ ࡽ ࢀ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ࡍ ࡿ ⪅ ࡢ ᚓ Ⅼ ࡣ ప
ࡗ ࡓ ࠋ MMSEࠊ ㄽ ⌮ ⓗ グ ᠈ ࡶ ࣟ ࢥ ࣔ ヱ ᙜ ᩘ ࡛ ᭷ ព ࡞ ⩌ 㛫 ᕪ ࡀ ㄆ ࡵ ࡽ ࢀ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ᩘ 2 ௨ ୖ ࡢ ⪅ ࡣ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ᩘ 0 1 ࡢ ⪅ ẚ ࡚ ᭷ ព ᚓ Ⅼ ࡀ ప ࡃ ࠊ ヱ ᙜ ᩘ ࡢ ከ ࠸ ⪅ ࡣ ᚓ Ⅼ ࡀ ప ࠸ ഴ ྥ ࠶ ࡗ ࡓ ࠋ
⪃ ᐹ ㄆ ▱ ᶵ ⬟ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ
ᮏ ◊ ✲ ࡛ ࡣ ࠊ ⏨ ᛶ ࠾ ࠸ ࡚ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡣ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ ࠾ ࡼ ࡧ ㄽ ⌮ ⓗ グ ᠈
㛵 㐃 ᛶ ࡀ ㄆ ࡵ ࡽ ࢀ ࠊ≉ ヱ ᙜ ᩘ ࡀ ከ ࠸ ⪅ ㄆ ▱ ᶵ ⬟ ࡀ ప ࡃ ࡞ ࡿ ഴ ྥ ࡀ ࠶ ࡗ ࡓ ࠋ
㌟ య ᶵ ⬟ ࡣ ㄆ ▱ ᶵ ⬟ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ࡇ ࡀ ඛ ⾜ ◊ ✲ ࡼ ࡗ ࡚ ᫂ ࡽ ࡞ ࡗ ࡚ ࠾ ࡾ
12)
ࠊ ࣃ ࣇ ࢛ ࣮ ࣐ ࣥ ࢫ ࡢ ప ࠸ ⪅ ࡣ ⥲ ࡌ ࡚ ㄆ ▱ ᶵ ⬟ ࡶ ప ࠸ ഴ ྥ ࠶ ࡗ ࡓ ࠋ ࣟ ࢥ ࣔ ࡘ
࠸ ࡚ ࡶ ࠊ Nakamura et al.(2017)ࡢ ዪ ᛶ ࢆ ᑐ ㇟ ࡋ ࡓ ◊ ✲ ࠾ ࠸ ࡚ ࠊ ࣟ ࢥ ࣔ 25 ࡢ ࢫ ࢥ ࡀ 6 Ⅼ ௨ ୖ ࡢ ཧ ຍ ⪅ ࡣ ࠊࢫ ࢥ 6 Ⅼ ᮍ ‶ ࡢ ⪅ ࡼ ࡾ ࡶ 4.12 ಸ ㄆ ▱ 㞀 ᐖ ࡢ ⪅ ࡀ ከ ࡗ ࡓ
20)ࠋ ࡇ ࡢ ሗ ࿌ ࡣ ࠊ ᮏ ◊ ✲ ࠾ ࠸ ࡚ ࣟ ࢥ ࣔ ࡢ ヱ ᙜ ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ࡀ ప ࠸ ࠸
࠺ ⤖ ᯝ ࢆ ᨭ ᣢ ࡍ ࡿ ࡶ ࡢ ࡛ ࠶ ࡿ ࠋࡲ ࡓ ࠊ2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࠊ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࡘ ࠸
࡚ ಶ ࠎ ࡢ ᳨ ᰝ ㄆ ▱ ᶵ ⬟ 㛵 㐃 ࡍ ࡿ ඛ ⾜ ◊ ✲ ࡣ ࡇ ࢀ ࡲ ࡛ ぢ ࡽ ࢀ ࡚ ࠸ ࡞ ࠸ ࡀ ࠊ ᮏ ◊
✲ ࠾ ࠸ ࡚ ࡣ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ 2 ࢫ ࢸ ࢵ ࣉ ࢸ ࢫ ࢺ ࠊ ㄽ ⌮ ⓗ グ ᠈ ❧ ࡕ ୖ ࡀ ࡾ ࢸ ࢫ ࢺ ࡛ ᭷ ព ᕪ ࡀ ㄆ ࡵ ࡽ ࢀ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ࡣ ప ࡗ ࡓ ࠋ ≉ ࠊ ࣟ ࢥ ࣔ ࡢ ヱ
(ࡇ ࡇ Table 3 ࢆ ᤄ ධ)
11
ᙜ ᩘ ࡀ ከ ࠸ ࠊ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ ㄽ ⌮ ⓗ グ ᠈ ࡢ ୧ ⪅ ࡢ ᚓ Ⅼ ࡀ ୗ ࡀ ࡗ ࡚ ࠸ ࡃ ഴ ྥ ࡀ ࠶ ࡾ ࠊ ⤡ ᅉ Ꮚ ࢆ ㄪ ᩚ ࡋ ࡓ ศ ᯒ ࠾ ࠸ ࡚ ࡶ ᭷ ព ࡞ ഴ ྥ ᛶ ࡀ ☜ ㄆ ࡉ ࢀ ࠊ ≉ 2 㡯
┠ ௨ ୖ ࡢ ⪅ ࡢ ࢫ ࢥ ࡀ ࡁ ࡃ ప ୗ ࡋ ࡚ ࠸ ࡓ ࠋ ௨ ୖ ࡼ ࡾ ࠊ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡣ ⏨ ᛶ
࠾ ࠸ ࡚ ㄆ ▱ ᶵ ⬟ ప ୗ ࡢ ண ᅉ Ꮚ ࡋ ࡚ ά ⏝ ࡛ ࡁ ࡿ ࡇ ࡀ ♧ ၀ ࡉ ࢀ ࡓ ࠋ
ࣟ ࢥ ࣔ ࡀ ㄆ ▱ ᶵ ⬟ 㛵 㐃 ࡍ ࡿ ࣓ ࢝ ࢽ ࢬ ࣒ ࡋ ࡚ ࠊ ⬻ ࡢ ჾ ㉁ ⓗ ࡞ ኚ ࡀ ᣲ ࡆ ࡽ ࢀ
ࡿ ࠋDum et al.(2016) ࡣ ⬻ ⓶ ㉁ ࡢ ᦆ യ ࡀ ⮬ ᚊ ᶵ ⬟ ࢆ ྠ ࡋ ࠊ㐠 ື ࠾ ࡼ ࡧ ㄆ ▱ ᶵ ⬟ ᙳ 㡪 ࢆ ࠼ ࡿ ࡇ ࢆ ሗ ࿌ ࡋ ࡚ ࠸ ࡿ
22)ࠋ ࡇ ࡢ ◊ ✲ ⤖ ᯝ ࡣ ࠊ 㐠 ື ࠊ ㄆ ▱ ࠊ ࠾ ࡼ ࡧ ឤ ࢆ ឤ ⚄ ⤒ ࡢ ฟ ຊ ⤖ ࡧ ࡘ ࡅ ࡿ ≉ ᐃ ࡢ ࣐ ࣝ ࢳ ࢩ ࢼ ࣉ ࢫ ᅇ ㊰ ࡀ Ꮡ ᅾ ࡋ ࠊ ࡑ ࢀ ࡀ ࣟ ࢥ ࣔ ㄆ ▱ ᶵ ⬟ ࡢ 㛵 㐃 ࢆ ♧ ࡍ ࡅ ࡛ ࠶ ࡿ ࡇ ࡀ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ ࡘ ࡲ ࡾ ࠊ ⬻ ჾ ㉁ ⓗ ࡞ 㞀 ᐖ ࡀ Ⓨ ⏕ ࡍ ࡿ ࠊ ㄆ ▱ ᶵ ⬟ 㐠 ື ᶵ ⬟ ࡢ ᪉ ᙳ 㡪 ࡀ ཬ ࡪ ࡇ ࡀ ♧ ၀ ࡉ ࢀ ࡿ ࠋᮏ ◊ ✲ ࠾ ࠸ ࡚ ࠊㄆ ▱ ᶵ ⬟ ࣓ ࢱ ࣎ ࡢ ホ ౯ ᣦ ᶆ ᭷ ព ࡞ 㛵 㐃 ࡣ ࡳ ࡽ ࢀ ࡎ ࠊ
ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ᭷ ព ࡞ 㛵 㐃 ࡀ ㄆ ࡵ ࡽ ࢀ ࡓ ⌮ ⏤ ࡶ ࡇ ࡢ ࡼ ࠺ ࡞ ᙳ 㡪 ࡀ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ
⏨ ᛶ ࡢ ࡳ ㄆ ▱ ᶵ ⬟ ࣟ ࢥ ࣔ ホ ౯ ᣦ ᶆ ࡢ 㛫 㛵 㐃 ࡀ ㄆ ࡵ ࡽ ࢀ ࡓ せ ᅉ ࡋ ࡚ ࡣ ࠊ ᮏ ◊ ✲ ࡢ ཧ ຍ ⪅ ࡣ 60 ᡯ ௨ ୖ ࡢ ⪅ ࡀ ᑐ ㇟ ࡛ ࠶ ࡾ ࠊ⏨ ᛶ ࡣ ㏥ ⫋ ࢆ ㏄ ࠼ ࡓ ⪅ ࡀ ከ ࡗ ࡓ ࡓ ࡵ ࡛ ࠶ ࡿ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ ᪥ ᖖ ࡛ ⾜ ࢃ ࢀ ࡚ ࠸ ࡓ ά ື ࡀ ప ୗ ࡍ ࡿ ࠊ ㄆ ▱ ᶵ ⬟ ࠾ ࡼ ࡧ 㐠 ື ᶵ ⬟ ࡣ ప ୗ ࡍ ࡿ ࡇ ࡀ ඛ ⾜ ◊ ✲ ࡛ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ
23,24)ࠋ ୍ ᪉ ዪ ᛶ ࡣ ࠊ ⏨ ᛶ
ྠ ᵝ 60 ṓ ࠾ ࡅ ࡿ ㏥ ⫋ ࡣ ࠶ ࡿ ࡶ ࡢ ࡢ ࠊᐙ ࡸ ே 㛵 ಀ ࡞ ㄆ ▱ ᶵ ⬟ ࡢ ⥔ ᣢ ᭷
ຠ ࡛ ࠶ ࡿ ⪃ ࠼ ࡽ ࢀ ࡿ ά ື ࢆ ⥅ ⥆ ࡍ ࡿ ഴ ྥ ࡀ ࠶ ࡿ
25,26)ࠋ ࡲ ࡓ ࠊ ዪ ᛶ ࡣ ⏨ ᛶ ẚ
࡚ ㌟ య ᶵ ⬟ ࡀ ప ࠸
27)ࠋ ௨ ୖ ࡢ ࡼ ࠺ ࠊ ⏨ ᛶ ዪ ᛶ ࡛ ࡣ ㄆ ▱ ᶵ ⬟ ㌟ య ᶵ ⬟ ࡀ ప ୗ
12
ࡋ ࡚ ࠸ ࡃ 㐣 ⛬ ࡀ ␗ ࡞ ࡗ ࡚ ࠸ ࡿ ࡇ ࡼ ࡾ ࠊ ⏨ ዪ ࡢ 㐪 ࠸ ࡀ ⏕ ࡌ ࡓ ࡢ ࡛ ࡣ ࡞ ࠸ ⪃ ࠼
ࡽ ࢀ ࡿ ࠋ
ㄆ ▱ ᶵ ⬟ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ
ᮏ ◊ ✲ ࡢ ⤖ ᯝ ࡽ ࠊ ዪ ᛶ ࠾ ࠸ ࡚ ࣓ ࢱ ࣎ ヱ ᙜ ᩘ ࡛ ࡢ ࡳ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ ࡢ 㛫
᭷ ព ᕪ ࡀ ㄆ ࡵ ࡽ ࢀ ࡓ ࡶ ࡢ ࡢ ࠊ ⏨ ዪ ࡶ ヱ ᙜ ᩘ ࡀ ከ ࠸ ࢫ ࢥ ࡀ ప ࠸ ࡞ ୍ ᐃ ࡢ ഴ ྥ ࡣ ☜ ㄆ ࡉ ࢀ ࡞ ࡗ ࡓ ࠋ ࡇ ࡢ ࡇ ࡣ ࠊ ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ㄆ ▱ ᶵ ⬟ ࡢ 㛵 㐃 ᛶ ࡣ ᑠ ࡉ ࠸ ࡇ ࢆ ♧ ၀ ࡋ ࡚ ࠸ ࡿ ࠋ
ඛ ⾜ ◊ ✲ ࠾ ࠸ ࡚ ࠊ ࣓ ࢱ ࣎ ホ ౯ ᣦ ᶆ ࡣ ࠊ ㄆ ▱ ᶵ ⬟ ࡶ ࡋ ࡃ ࡣ ⬻ ࡢ ჾ ㉁ ⓗ ኚ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ࡇ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ ࠋ Debette et al.(2010)ࡢ ᖖ ࡞ ୰ 㧗 ᖺ ࢆ ᑐ ㇟
⾜ ࡗ ࡓ ◊ ✲ ࡛ ࡣ ࠊ ෆ ⮚ ⬡ ⫫ ࡢ య ✚ ࡀ ࡁ ࠸ ⬻ య ࡢ య ✚ ࡀ ᑠ ࡉ ࠸ ࡇ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ
5)ࠋ ࡲ ࡓ ࠊKim et al.(2017)ࡣ ࠊ ෆ ⮚ ⬡ ⫫ ᆺ ⫧ ‶ ࡣ ⬻ ⓑ ㉁ ኚ ࠾ ࡼ ࡧ
ࣛ ࢡ ࢼ ᱾ ሰ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ࡇ ࢆ ሗ ࿌ ࡋ ࡚ ࠸ ࡿ
4)ࠋ ࡋ ࡋ ࡞ ࡀ ࡽ ࠊ ୧ ⪅ ࡢ ◊ ✲
࠾ ࠸ ࡚ ࡣ ࠊ ㄆ ▱ ᶵ ⬟ ࠊ ෆ ⮚ ⬡ ⫫ 㔞 ࠾ ࡼ ࡧ ⬻ ࡢ ჾ ㉁ ⓗ ኚ ࡢ 㛵 㐃 ᛶ ࢆ ᳨ ウ ࡍ ࡿ
ࡣ ⮳ ࡗ ࡚ ࠾ ࡽ ࡎ ࠊ ෆ ⮚ ⬡ ⫫ ࡀ ㄆ ▱ ᶵ ⬟ ཬ ࡰ ࡍ ᙳ 㡪 ࡣ ౫ ↛ ᫂ ࡽ ࡣ ࡞ ࡗ ࡚ ࠸
࡞ ࠸ ࠋ ᮏ ◊ ✲ ࠾ ࠸ ࡚ ࡶ ࠊ ㄆ ▱ ᶵ ⬟ ࡣ ⭡ ᅖ 㛵 㐃 ࡋ ࡚ ࠾ ࡽ ࡎ ࠊ ࡇ ࢀ ࡽ ࡢ ሗ ࿌ ྠ ᵝ ࡢ ⤖ ᯝ ࡞ ࡗ ࡓ ࠸ ࠼ ࡿ ࠋ
⾑ ᅽ 㛵 ࡋ ࡚ ࡣ ࠊ ⦰ ᮇ ⾑ ᅽ ࡢ 㧗 ࠸ ⪅ ࡲ ࡓ ࡣ ᣑ ᙇ ᮇ ⾑ ᅽ ࡢ ప ࠸ ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ࡣ
ప ࡃ ࡞ ࡿ
6)ࠊAD ࡣ 㧗 ⾑ ᅽ ㈇ ࡢ 㛵 㐃 ᛶ ࡀ ࠶ ࡿ
28)ࠊ ୰ ᖺ ࡢ 㧗 ⾑ ᅽ ࢆ ࢥ ࣥ ࢺ ࣟ ࣮
13
ࣝ ࡍ ࡿ ࡇ ࡼ ࡾ ㄆ ▱ ࡢ ࣜ ࢫ ࢡ ࢆ ప ୗ ࡉ ࡏ ࡽ ࢀ ࡿ ࡞
7)ࠊ ぢ ゎ ࡣ ୍ ⮴ ࡋ ࡚ ࠸ ࡞
࠸ ࠋ ࡲ ࡓ ࠊ ⬡ ㉁ ␗ ᖖ 㛵 ࡋ ࡚ ࡣ ࠊ ⥲ ࢥ ࣞ ࢫ ࢸ ࣟ ࣮ ࣝ ࠊ ࢺ ࣜ ࢢ ࣜ ࢭ ࣛ ࢻ ್ ࠊ LDL ࡢ ୖ ᪼ ࡣ ࠊᐇ ⾜ ᶵ ⬟ ࠊὀ ព ᶵ ⬟ ࠊ࠾ ࡼ ࡧ ฎ ⌮ ㏿ ᗘ 㛵 㐃 ࡋ ࡚ ࠸ ࡿ ሗ ࿌ ࡋ ࡚ ࠸ ࡿ
9)ࠋ ⢾ ᒀ ࡘ ࠸ ࡚ ࡣ ࠊ ㄆ ▱ ࡢ 㛵 㐃 ࢆ ♧ ࡋ ࡚ ࠸ ࡿ ሗ ࿌ ࡀ ࠶ ࡿ ୍ ᪉ ࡛
10)ࠊDos et al.(2017) ࡢ ๗ ᳨ ࢆ ᐇ ࡋ ࡓ ㄪ ᰝ ࡛ ࡣ ࠊ ⏕ ๓ ⢾ ᒀ ࡢ デ ᩿ ࢆ ཷ ࡅ ࡓ ⪅ ࠾ ࡼ ࡧ ⢾ ᒀ
ࡢ ⸆ ≀ ⒪ ࢆ ཷ ࡅ ࡚ ࠸ ࡓ ⪅ ࡘ ࠸ ࡚ ࡣ ࠊ AD ⢾ ᒀ 㛵 㐃 ࡀ ぢ ࡽ ࢀ ࡞ ࡗ ࡓ ࡋ ࡚ ࠸ ࡿ
29)ࠋ Huntley et al.(2017)ࡢ ◊ ✲ ࡛ ࡶ ㄆ ▱ ࡢ デ ᩿ ࢆ ཷ ࡅ ࡚ ࠸ ࡞ ࠸ 50 ṓ ௨ ୖ ࡢ ᑐ ㇟ ⪅ ࡣ ࠊ ⢾ ᒀ ゝ ㄒ ࠊ ど ぬ ⓗ ࢚ ࣆ ࢯ ࣮ ࢻ グ ᠈ ࠾ ࡼ ࡧ ゝ ㄒ ⓗ ᥎ ㄽ ࡢ 㛵 㐃 ࡣ ぢ ࡽ ࢀ ࡞ ࡗ ࡓ ࡋ ࡚ ࠸ ࡿ
11)ࠋ ⾑ Ύ ⾑ ⢾ ㄆ ▱ ᶵ ⬟ ࡢ 㛵 㐃 ࡣ ᫂ ☜ ࡞ ࡗ ࡚ ࠾
ࡽ ࡎ ࠊ ᚋ ࡢ ◊ ✲ ࡀ ᚅ ࡓ ࢀ ࡿ ࡇ ࢁ ࡛ ࠶ ࡿ ࠋ
௨ ୖ ࡢ ࡼ ࠺ ࠊ ᮏ ◊ ✲ ⤖ ᯝ ඛ ⾜ ◊ ✲ ࡢ ⤖ ᯝ ࡢ ┦ 㐪 ࡣ ࠊ ඛ ⾜ ◊ ✲ ࡛ ࡣ ࠊ ㄆ ▱
㧗 ⾑ ᅽ ࠊ ⢾ ᒀ ࠸ ࡗ ࡓ ⓗ ≧ ែ ࠶ ࡿ ᑐ ㇟ ↔ Ⅼ ࢆ ᙜ ࡚ ࡚ ࠸ ࡿ ୍ ᪉ ࡛ ࠊ ᮏ ◊
✲ ࡣ 3 ᝈ 㸦 ᝏ ᛶ ᪂ ⏕ ≀ ࣭ ᚰ ᝈ ࣭ ⬻ ⾑ ⟶ ᝈ 㸧ࠊ ᩚ ᙧ እ ⛉ ⓗ ᝈ ࠊ ⢾ ᒀ ⒪
୰ ࡢ ⪅ ࡞ ࡢ ᪤ Ṕ ࡲ ࡓ ࡣ ࡑ ࡢ ࠸ ࡢ ࠶ ࡿ ⪅ ࢆ 㝖 እ ࡋ ࡓ ࠊ ẚ ㍑ ⓗ ᖖ ࡞ ⪅ ࡢ ከ ࠸ 㞟 ᅋ ࢆ ◊ ✲ ᑐ ㇟ ࡋ ࡚ ࠸ ࡿ ࡇ ㉳ ᅉ ࡍ ࡿ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ
ຍ ࠼ ࡚ ࠊ ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡣ ࠊ ࡑ ࡢ ᮏ ㉁ ࡀ ᚠ ⎔ ჾ ᝈ 㸦 ື ⬦ ◳ ࡽ
ᚰ ➽ ᱾ ሰ ࠊ ⬻ ༞ ୰ ࡞ 㸧 ண 㜵 ࡢ ࡓ ࡵ ࡢ ண ഛ ⓗ ែ ࡋ ࡚ タ ᐃ ࡉ ࢀ ࡚ ࠾ ࡾ ࠊ ⓗ ࡞
ᇶ ‽ ࡼ ࡾ ࡶ ప ࠸ ್ タ ᐃ ࡉ ࢀ ࡚ ࠸ ࡿ ࠋ ࡑ ࡢ ࡓ ࡵ ⾑ ᅽ ࠊ ⾑ ୰ ⬡ ㉁ ࠾ ࡼ ࡧ ⾑ Ύ ⾑ ⢾
ㄆ ▱ ᶵ ⬟ ࡢ 㛫 㛵 㐃 ࡀ ㄆ ࡵ ࡽ ࢀ ࡞ ࡗ ࡓ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ
14
ᮏ ◊ ✲ ᑐ ㇟ ⪅ ࡣ ࡢ ㄪ ᰝ ࡼ ࡾ ࠊ ࣟ ࢥ ࣔ ࣭ ࣓ ࢱ ࣎ ࡢ ヱ ᙜ ⪅ ࡀ ᑡ ࡞ ࡃ ࠊ low risk population ࡛ ࡢ ᳨ ウ ࡛ ࠶ ࡗ ࡓ ゝ ࠼ ࡿ ࠋ ᮏ ◊ ✲ ࡢ ཧ ຍ ⪅ ࠊ ࡼ ࡾ ୍ ⯡ ⓗ ࡞ ఫ Ẹ ࢆ ᑐ ㇟ ㄪ ᰝ ࡋ ࡓ ⪃ ࠼ ࡽ ࢀ ࡿ ROAD ࢫ ࢱ ࢹ ࡢ ㄪ ᰝ ẚ ㍑ ࡍ ࡿ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ⪅ ࡣ 60 ṓ ௦ ࡢ ⏨ ᛶ ࡛ ࡑ ࢀ ࡒ ࢀ 41.6% 49.3%௨ ୖ ࠊ 70 ṓ ௦ ࡢ ⏨ ᛶ ࡛ ࡣ ࡑ ࢀ ࡒ ࢀ 64.5% 71.7%௨ ୖ ࡛ ࠶ ࡾ ࠊᮏ ◊ ✲ ࡢ ཧ ຍ ⪅ ࡢ ࣟ ࢥ ࣔ ヱ ᙜ ⪅ ࡣ ᑡ ࡞ ࠸ ഴ ྥ ࠶ ࡗ ࡓ
30)
ࠋࡇ ࡢ ഴ ྥ ࡣ ዪ ᛶ ࡛ ࡶ ☜ ㄆ ࡉ ࢀ ࡓ ࠋ୍ ᪉ ࠊᮏ ◊ ✲ ࡢ ཧ ຍ ⪅ ࡢ ࠺ ࡕ 60㹼 74 ṓ ࡢ ࣓ ࢱ ࣎ ヱ ᙜ ⪅ ࡣ ⏨ ᛶ 14.㸯 %ࠊዪ ᛶ 2.3% ࡛ ࠶ ࡾ ࠊࡇ ࢀ ࡣ ཌ ⏕ ປ ാ ┬ ࡢ ≉ ᐃ ᗣ デ ᰝ ࣭
≉ ᐃ ಖ ᣦ ᑟ࣭࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ ≧ ἣ ࡛ ♧ ࡉ ࢀ ࡚ ࠸ ࡿ ࣓ ࢱ ࣎ ヱ ᙜ ⪅㸦 ⏨ ᛶ 27.8%ࠊዪ ᛶ 9.8%㸧ࡼ ࡾ ప ࡗ ࡓ
31)ࡇ ࡢ ⌮ ⏤ ࡋ ࡚ ᒾ ᮌ ᗣ ቑ 㐍 ࣉ ࣟ ࢪ ࢙ ࢡ ࢺ 㺃
ࣉ ࣟ ࢪ ࢙ ࢡ ࢺ デ ࡣ ⣙ 2,000 㡯 ┠ ࡢ ㄪ ᰝ 㡯 ┠ ࢆ ᭷ ࡋ ࠊ ᑐ ㇟ ⪅ ୍ ே ࡿ ㄪ ᰝ 㛫 ࡣ 4-7 㛫 ࢆ ᭷ ࡍ ࡿ ࡓ ࡵ ᚲ ↛ ⓗ ࡼ ࡾ ᗣ ே ࡀ ㄪ ᰝ ཧ ຍ ࡋ ࡓ ࡇ ࡀ ⪃ ࠼ ࡽ ࢀ
ࡿ ࠋ
ࡇ ࡢ ࡼ ࠺ ࡞ ࣟ ࢥ ࣔ ࣭ ࣓ ࢱ ࣎ ࡢ low risk population ࠾ ࠸ ࡚ ࠊ ࣟ ࢥ ࣔ ᗘ ㄆ ▱ ᶵ
⬟ 㛵 㐃 ࡀ ぢ ࡽ ࢀ ࡓ ࡇ ࡣ ࠊ ࣟ ࢥ ࣔ ᗘ ࡼ ࡾ ᪩ ࡃ ㄆ ▱ ࢆ ឤ ▱ ࡛ ࡁ ࡿ ᇶ ‽ ࡞ ࡾ ࠺
ࡿ ྍ ⬟ ᛶ ࢆ ♧ ࡋ ࡓ ࠸ ࠼ ࡿ ࠋ ᮏ ◊ ✲ ࡢ ᭱ ࡢ ព ⩏ ⪃ ࠼ ࡿ ࠋ
ᮏ ◊ ✲ ࡢ 㝈 ⏺
ᮏ ◊ ✲ ࡣ ᶓ ᩿ ◊ ✲ ࡛ ࠶ ࡿ ࡇ ࡽ ࠊ ㄆ ▱ ᶵ ⬟ ࣟ ࢥ ࣔ ࡢ ᅉ ᯝ 㛵 ಀ ࢆ ♧ ࡍ ࡇ
ࡀ ࡛ ࡁ ࡚ ࠸ ࡞ ࠸ ࠋ ࡲ ࡓ ࠊ ㄆ ▱ ᶵ ⬟ ప ୗ 㛵 㐃 ࡍ ࡿ ⪃ ࠼ ࡽ ࢀ ࡿ ㏥ ⫋ ࣭ ᑵ ປ ≧ ἣ
15
ࡘ ࠸ ࡚ ࡣ ࠊ ᮏ ◊ ✲ ࡛ ࡣ ⪃ ៖ ࡛ ࡁ ࡚ ࠸ ࡞ ࠸ ࠋ ᚑ ࡗ ࡚ ࠊ ᚋ ࡣ ᑐ ㇟ ⪅ ࡢ ㏥ ⫋ ࣭ ᑵ ປ ≧ ἣ ࢆ ⪃ ៖ ࡋ ࡓ ୖ ࡛ ࠊ ࣟ ࢥ ࣔ ヱ ᙜ ࡋ ࡓ ⪅ ࡑ ࠺ ࡛ ࡞ ࠸ ⪅ ࢆ ㏣ ㊧ ࡋ ࡚ ㄆ ▱ ᶵ ⬟ ࡢ ኚ
ࢆ ẚ ㍑ ࡍ ࡿ ⦪ ᩿ ◊ ✲ ࢆ ᐇ ࡍ ࡿ ᚲ せ ࡀ ࠶ ࡿ ࠸ ࠼ ࡿ ࠋࡇ ࡢ ࡼ ࠺ ࡞ 㝈 ⏺ ࡣ ࠶ ࡿ ࡀ ࠊ ᮏ ◊ ✲ ࡣ ㄆ ▱ ᶵ ⬟ ࣟ ࢥ ࣔ ࡢ 㛵 㐃 ࢆ ᫂ ࡽ ࡋ ࡓ ᩘ ᑡ ࡞ ࠸ ሗ ࿌ ࡛ ࠶ ࡾ ࠊ ㄆ ▱ ᶵ
⬟ ప ୗ ࡢ ࢫ ࢡ ࣜ ࣮ ࢽ ࣥ ࢢ ᡭ ἲ ࡢ 㛤 Ⓨ ㈉ ⊩ ࡛ ࡁ ࡿ ࡶ ࡢ ⪃ ࠼ ࡽ ࢀ ࡿ ࠋ
⥲ ᣓ
ᮏ ◊ ✲ ࡣ ࠊᆅ ᇦ ᅾ ఫ ࡢ 60 ṓ ௨ ୖ ࡢ ⪅ ࢆ ᑐ ㇟ ࠊㄆ ▱ ᶵ ⬟ ࠊ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࠾ ࡼ ࡧ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ 㛵 㐃 ࢆ ᳨ ウ ࡋ ࡓ ࠋ ࡑ ࡢ ⤖ ᯝ ࠊ ⏨ ᛶ
࠾ ࠸ ࡚ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ ⪅ ࡣ ࠊ ⯡ ⓗ ㄆ ▱ ᶵ ⬟ ࠾ ࡼ ࡧ ㄽ ⌮ ⓗ グ ᠈ ࡀ ప ୗ ࡋ ࡚ ࠸ ࡿ ࡇ ࡀ ᫂ ࡽ ࡞ ࡾ ࠊ ヱ ᙜ 㡯 ┠ ᩘ ࡀ ከ ࡃ ࡞ ࡿ ࡑ ࡢ ప ୗ ࡢ ⛬ ᗘ ࡣ
ࡁ ࡗ ࡓ ࠋ ௨ ୖ ࡼ ࡾ ࠊ ࣟ ࢥ ࣔ ࢸ ࣈ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ホ ౯ ᣦ ᶆ ࡣ ࠊ ⏨ ᛶ ࠾ ࠸ ࡚ ㄆ
▱ ᶵ ⬟ ప ୗ ࡢ ண ᅉ Ꮚ ࡢ ᭷ ⏝ ᛶ ࡀ ♧ ၀ ࡉ ࢀ ࡓ ࠋ
16
Reference
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2)ཌ ⏕ ປ ാ ┬ , ᖹ ᡂ 29 ᖺ ∧ 㧗 㱋 ♫ ⓑ ᭩ 㸦 య ∧ 㸧 .
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10) ᶓ 㔝 ᾈ ୍ 㸬 ⢾ ᒀ ྜ ే ࡋ ࡚ ࡢ ࣝ ࢶ ࣁ ࣐ ࣮ . ᪥ ⪁ ་ ㄅ .
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to walk, using a two-step test. J Showa Med Assoc 2003;63(3):301-308.
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16) Muranaga S. Evaluation of the muscular strength of the lower extremities using the standing movement and clinical application. J Showa Med Assoc 2001;61(3):362-327.
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19) ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ デ ᩿ ᇶ ‽ ᳨ ウ ጤ ဨ . ࣓ ࢱ ࣎ ࣜ ࢵ ࢡ ࢩ ࣥ ࢻ ࣟ ࣮ ࣒ ࡢ ᐃ ⩏ デ ᩿ ᇶ ‽ . ᪥ ᮏ ෆ ⛉ Ꮫ 㞧 ㄅ 2005;94(4):794-809
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21) Wechsler, D. Wechsler Memory Scale-Revised manual. The Psychological Corporation, San Antonio 1987.
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23) ⏕ ෆ ⏤ ె , ᮏ ⏣ ㈗ ⣖ , 㝞 ᾧ , . ᆅ ᇦ ᅾ ఫ 㧗 㱋 ⪅ ࠾ ࡅ ࡿ ♫ ⓗ ά ື ࡢ ཧ ຍ
య ຊ ࡢ 㛵 㐃 . ᪥ ᮏ බ ⾗ ⾨ ⏕ 㞧 ㄅ 2016; 63(12): 727-737.
24) ᑠ 㛗 ㇂ 㝧 Ꮚ 㸪Ώ 㑓 ᬛ அ 㸪ᑠ 㛗 ㇂ ṇ ᫂ . ᆅ ᇦ ᅾ ఫ 㧗 㱋 ⪅ ࡢ ㄆ ▱ ᶵ ⬟ ♫ ཧ ຍ ࡢ 㛵 㐃 ᛶ - ♫ ά ື ࠾ ࡼ ࡧ ♫ ࢿ ࢵ ࢺ ࣡ ࣮ ࢡ ࢆ ୰ ᚰ ࡋ ࡚ -. Dementia Japan 2013;27: 81-91,
25) ┦ 㤿 ඃ ᶞ , ゅ ⏣ ᠇ , ⃰ ᡂ ᶞ , 㸬 ㆤ ண 㜵 㐠 ື ࡢ ㄆ ▱ 㛵 㐃 ࡍ ࡿ せ ᅉ ࡢ ᳨ ウ ά ື ᣐ Ⅼ ࡲ ࡛ ࡢ ≀ ⌮ ⓗ ㊥ 㞳 ♫ ὶ ≧ ἣ ╔ ┠ ࡋ ࡚ 㸬 ᪥ ᮏ බ ⾗ ⾨ ⏕ 㞧 ㄅ 2015;62: 651-661.
26) Tsunoda K, Soma Y, Kitano N, et al. Age and gender differences in
21
correlations of leisure-time, household, and work-related physical activity with physical performance in older Japanese adults. Geriatr Gerontol Int 2013;13:919-927
27) ᒾ ℩ ᘯ ᫂ , ᮧ ⏣ ఙ , ஂ ಖ Ꮚ , . ᆅ ᇦ ᅾ ఫ 㧗 㱋 ⪅ ࡢ ⫼ ➽ ຊ ࡞ ࡽ ࡧ ㌟ య ᶵ ⬟ ࡢ ᛶ ᕪ . Japanese Journal of Health Promotion and Physical Therapy 2013;3(3):97-101.
28) Kuyumcu ME, Yesil Y, Oztürk ZA, et al. Alzheimer’s disease is associated with a low prevalence of hypertension. Dement Geriatr Cogn Disord 2012;33:6-10.
29) Dos Santos Matioli MNP, Suemoto CK, Rodriguez RD, et al. Diabetes is Not Associated with Alzheimer's Disease Neuropathology. J Alzheimers Dis 2017;60(3):1035-1043.
30) Yoshimura N, Muraki S, Oka H, et al. Association between new indices in
the locomotive syndrome risk test and decline in mobility: third survey of the
ROAD study. J Orthop Sci 2015 ;20(5):896-905.
22
31) ཌ ⏕ ປ ാ ┬ . ࠕ ≉ ᐃ ᗣ デ ᰝ࣭≉ ᐃ ಖ ᣦ ᑟ ࡢ ᐇ ≧ ἣ 㛵 ࡍ ࡿ ࢹ ࣮ ࢱ (ᖹ ᡂ 27
ᖺ ᗘ )ࠖ . http://www.mhlw.go.jp/bunya/shakaihosho/iryouseido01/info02a-2.html
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Figure 1 ◊ ✲ ཧ ຍ ⪅ ࡢ 㑅 ฟ
