医療薬学研究室
Medical Pharmaceutics
教 授 赤尾 光昭 Teruaki Akao 准教授 今村 理佐 Lisa Imamura
◆ 原 著
1) Jin J.S., Zhao Y.F., Nakamura N., Akao T., Kakiuchi N., Min B.S., and Hattori M.: Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria. Biol. Pharm. Bull., 30: 2113-2119, 2007.
2) Nagai H.*, He J.-X., Tani T., and Akao T.: Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots. J. Pharm. Pharmacol., 59: 1421-1426, 2007.
3) Tang J., Akao T., Nakamura N., Wang Z.-T., Takagawa K., Sasahara M., and Hattori M.: In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. Drug. Metab. Dispos., 35: 1832-1839, 2007.
4) Jin J.S., Zhao Y.F., Nakamura N., Akao T., Kakiuchi N., and Hattori M.: Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.
Biol. Pharm. Bull., 30: 904-911, 2007.
5) He J.-X., Goto E., Akao T., and Tani, T.: Interaction between Shaoyao-Gancao-Tang and a laxative with respect to alteration of paeoniflorin metabolism by intestinal bacteria in rats. Phytomedicine, 14: 452-459, 2007.
6) Akao T., Hanada M., Sakashita Y., Sato K., Morita M., and Imanaka T.: Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. J. Pham. Pharmacol., 59: 87-93, 2007.
7) Sato Y.*, He J.-X., Nagai H., Tani T., and Akao T.: Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol. Pharm. Bull., 30: 145-149, 2007.
◆ 学会報告
1)
佐藤圭亮*, 花田匡人, 赤尾光昭：オウゴン成分バイカリンはMRP2
の基質である．日本薬学会第127
回年会, 2007, 3,28-30,
富山．2)
今村理佐，永野康己，西尾公秀，渡邊 彦．富山大学薬学部薬局実習の現状把握と今後の課題，日本薬学会第127
年会，2007
，3
，28-30
，富山3)
長澤美佳*, 永井秀昌, 赤尾光昭, 谿 忠人：安中散料とその配合生薬の腸管収縮抑制作用．第24
回和漢医薬学会大 会, 2007, 9, 8-9, 富山．◆ その他
