Studies on the Control and Treatment Measures for Equine Herpesvirus type 1 Infection

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Title

Studies on the Control and Treatment Measures for Equine

_{Herpesvirus type 1 Infection( 内容の要旨(Summary) )}

Author(s)

辻村, 行司

Report No.(Doctoral

Degree)

博士(獣医学) 乙第103号

Issue Date

2010-09-14

Type

博士論文

Version

none

URL

http://hdl.handle.net/20.500.12099/36594

※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

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Studies on the Control _and Treatment Measures for

Equine Herpesvirus type 1 Infection

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J2Xt 8=T) V,_-C , Si4iE314EEi-A-eh*a5Xb5hn&*j(3tj(3tB;i*%iaBhBi3emgei4o)3e6EaTa Xt LT+5>m5A&b5kb 8 _i;#1bJt. B%t i f28 -$1L,l5;r15X 1) Rg E]: i i i.I 3tW##B :

Pathogenicity _and immunogenicity _{of equine} herpesvirus type 1

mutants defective in either gl or _gE _gene in murine _and hamster

models

Tsujimura, K., Yamanaka, T., Rondo, T., Fukushi, _{H. and}

Matsumura, T.

The Journal _{of Veterinary} Medical Science

%. %. /q. #4i4= : _68(10):1029-1038,2006 2) A B: 3j5-.i i: *W##B : *.%.i. 3) 2g B: iE i i: 3tW#3fB :

Equine herpesvirus type 1 mutant defective in glycoprotein E

gene as _candidate

vaccine strain

Tsujimura, K., Shiose, T., Yamanaka, T., Nemoto, M., Rondo, T.

and Matsumura, T.

#4i4= : _71(ll):1439-1448, 2009

Pharmacokinetics _{of penciclovir} _{after oral administration} _{of its}

prodrug famciclovir to horses

Tsujimura, K., Yamada, M., Nagata, S., Yamanaka, T" Nemoto,

M., Rondo, T., Kurosawa, M. _and Matsumura, T.

35. %. i. #1Je-T*'. 72(3):357-361, 2010 B%##3eW3AX 1) i E1'. i i 45: 3em5#33B :

Isolation _and _genetic _analysis _{of Japanese} _encephalitis _virus

from a diseased horse in Japan

Yamanaka, T., _Tsujimura, K., Rondo, T., Yasuda, W., Okada, A.,

Noda, K., Okumura, _{T. and Matsumura,} T.

i. %.

)q. #fi4=

:_68(3):_293-295, ₂₀₀₆

2 ) RE El : _{In uitro efficaciesofoseltamivircarboxylate}

and zanamivir

against equine influenza A viruses

% i _fB : Yamanaka, T., _Tsujimura, K., Rondo, _{T. andMatsumura,} T.

3tn##4; : The Journal _{of Veterinary} Medical Science

%. %. i. #4i* :_68(4):_405-408, ₂₀₀₆

3) i El.I

i i 4;:

3tWu##3B :

Efficacy _{ofoseltamivir} _phosphate to horses inoculated _with

equine influenza A virus

Yamanaka, T" _Tsujimura, K., Rondo, T., Hobo, _{S. and}

Matsumura, T.

The Journal _{of Veterinary} Medical Science _C=##

(5)

4) _,qE % i 4;: t3:ijlr.i+%i-i--.43 : %.-a.f7. 5) Rg E]: a-- % 4;: S.tf/I:i#ani45: *.%.fi. 6) _)qg % i _3B: 32Wg##fB : *.%./q. 7) A B: % i _3B: 3tWJ##3B :

Clinical _{pharmacokinetics} _{of oseltamivir} _and _{its active}

metabolite oseltamivir carboxylate aaer oral administration in

horses

Yamanaka, T., Yamada, M., _Tsujimura, K, Rondo, T., Nagata,

S., Hobo, S., Ku1.OSaWa, M. _and Matsumura, T.

gE4i* :_69(3):293-296, 2007

Evaluation _{of antigen} detection kits for diagnosis _{of equine}

influenza

Yamanaka, T., Tsujimura, K., Rondo, _{T. and Matsumura,} T.

#41* :_70(2):_189-192, ₂₀₀₈

Comparison _{of the} _growth kinetics _{of neuropathogenic} _and

nonneuropathogenic equid herpesvirus type 1 (EHV-1) strains in

cultured murine neuronal cells and the relevance of the D/N752

coding change in DNA polymerase gene (ORF30)

Yamada, S., Matsunura, T., _Tsujimura, K., Yamaguchi, T.,

Ohya, _{K. and Fukushi} H.

#11* : _70(5):_505-511, ₂₀₀₈

Epidemic _{of equine} influenza among vaccinated racehorses in

Japan in 2007

Yamanaka, T., Niwa, H., _Tsujimura, K., Rondo, _{T. and}

Matsumura, T.

%. %. i. #1rT* :_{70(6):623-625,} ₂₀₀₈

8) 2E B:

% i _3B:

3tWq##iB :

Cloning _{of the} genome of equine herpesvirus 4 strain TH20p as

an infectious bacterial _{artificial chromosome}

Azab, W., Kato, K., Arii, I" _Tsujimura, K., Yamane, D" Tohya,

Y., Matsumura, _{T. and Akashi,} H.

Archives _{of Virology} *. %. /i. #4i4= : _{154(5):833-842,} ₂₀₀₉ 9) 2E B: % i 4;: 3aWJ#3f4; : %.%./q. 10)RE a: % i 4;: 3tW#3 _3B

Interspecies transmission _{of equine} influenza _virus (H3N8) to

dogs _{by close} _contact _with _{experimentally} infected horses

Yamanaka, T., Nemoto, M., _Tsujimura, K., Rondo, _{T and}

Matsumura, T.

Veterinary Microbiology

#15* : _139(3-4):_351-355, ₂₀₀₉

Investigation _{of the prevalence} _of _neurologic _equine herpes _virus

type 1 _(EHV-1) in a 23-year _{retrospective} _analysis (1984-2007)

Perking, G. A., Goodman, L. B., _Tsujimura, K, Van de Walle, G.

a., Kin, S. G., Dubovi, _{E. J. and} Osterrieder, N.

Veterinary Microbiology ,

(6)

I _1))Ra % i 4;: 3eWJ##4; : %.%.ff. l2)A i i _fB: 32WJ#33B : %.i.Jq. 13) 2g B: i i _3B: 3ttL/Tg#EE3B:

hop-mediated isothermal _{amplification} assays for detection of

Equid herpesuiT.uS _{1 and} _{4 and} differentiating a _gene-deleted

candidate vaccine strain from wild-type Equid herpesL,irus 1

strains

Nemoto, M., _Tsujimura, K., Yamanaka, T., Rondo, _{T. and}

Matsumura, T.

Journal _{of Veterinary} Diagnostic Investigation

#414= :_22(1):30-36, 2010

Characterization _of a thymidine kinase-deficient mutant of

equine herpesvirus 4 and in vitro susceptibility

_ofth;

virus to

antiviral agents

Azab, W., _Tsujimura, K., Kato, K, Anii, I., Morimoto, T.,

Kawaguchi, Y., Tohya, Y., Matsumura, _{T. and}

AkaShi

H.

Antiviral Research

#4i* :_85(2):_389-395, ₂₀₁₀

Diverse _{pathogenicity} _{of equine} herpesvirus 1 _(EHV-1) isolates

in CBA mouse _model

Yu, M. H., Kasem, S. G., _Tsujimura, K., Matsumura, T, Yanai, T.,

Yamaguchi, T., Ohya, _{K. and Fukushi,} H.