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㸦2㸧Streptococcus mutans ࡢศ㞳

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㇋࿡ჯࠊⓎ㓝ங㸦࣮ࣚࢢࣝࢺ㸧-

┦ཎ ⱥᏕࠊᱵᮏ ᱻஅ௓ࠊቑᏊ ┤ஓ

ឡ▱ᏛἨ኱Ꮫ

Possibility of the caries prevention with the fermented foods㸦㸰㸧.

㸫Soybean miso and Fermented milk (Yogurt)㸫

Hidetaka Aihara, Shinnosuke Umemoto and Naoya Masuko

࣮࣮࢟࣡ࢻ㸸㱘⼃ caries,Ⓨ㓝㣗ရ Fermented foods,Ⓨ㓝ங Fermented milk,㇋࿡ჯ Soybean miso

1㸬ࡣࡌࡵ࡟

ṑࡢ೺ᗣࡣࠊᰤ㣴ᦤྲྀ࡟ᙳ㡪ࢆཬࡰࡋࠊཌ⏕ປാ

┬ࡣࠊ80ṓ࡛20ᮏࡢṑࢆṧࡍ㸶㸮㸰㸮㸦ࣁࢳ࣐࣭ࣝ

ࢽ࢖࣐ࣝ㸧㐠ືࢆᥦၐ࣭᥎㐍ࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊᐇ 㝿࡟ࡣࠊ80ṓ࡛ᖹᆒ㸲㸬㸴ṑ࡛࠶ࡿࠋṑࡢ႙ኻཎᅉ

࡜ࡋ࡚ࠊ㱘⼃ࠊṑ࿘⑓ࡀ࠶ࡆࡽࢀࡿࠋ㱘⼃࡟ࡘ࠸࡚ࠊ ཌ⏕ປാ┬࡟ࡼࡿ࡜ṑ⛉ಖ೺ᑐ⟇ࡼࡾᑠඣᮇ࡟࠾࠸

࡚ࠊஙṑࡢ㱘⼃㸦ᡤㅝ⹸ṑ㸧ࡣ᫂ࡽ࠿࡟ῶᑡ࠿ࡘ㍍

⑕໬ࡢഴྥࢆ♧ࡋࠊỌஂṑࡢ୍ேᖹᆒ㱘⼃ṑᩘࡶࠊ 20 ṓ㡭ࡲ࡛ῶᑡഴྥࡀㄆࡵࡽࢀࡿ࡞࡝╔ᐇ࡟ᡂᯝ ࡀୖࡀࡗ࡚ࡁ࡚࠸ࡿࠋࡋ࠿ࡋࠊ⌧ᅾ࡛ࡶ 13 ṓ࡛㱘

⼃᭷⑓⪅⋡ࡀ90㸣ࢆ㉺࠼࡚࠸ࡿࡇ࡜ࡶ஦ᐇ࡛࠶ࡿ3) 㸶㸮㸰㸮㸦ࣁࢳ࣐࣭ࣝࢽ࢖࣐ࣝ㸧㐠ືࡢⅭ࡟ࡣࠊᗂ ඣᮇ࡜Ꮫ㱋ᮇࡢ࠺㱘⼃ண㜵࠾ࡼࡧᡂேᮇࡢṑ࿘⑓ண 㜵ࡀ㔜せ࡛࠶ࡿࠋࡇࡇ࡛ࡣࠊ≉࡟㱘⼃࡟ࡘ࠸࡚╔┠

ࡋࡓࠋ

㱘⼃㸦⹸ṑ㸧ࡣࠊཱྀ⭍ෆࡢpHࡀపୗࡍࡿ࡜⣽⳦

ྀ࡟ྵࡲࢀࡿ࢝ࣝࢩ࣒࢘࡜ࣜࣥ㓟ࡀ୙㣬࿴≧ែ࡟࡞

ࡾࠊṑ࡟ྵࡲࢀࡿ࢝ࣝࢩ࣒࢘࡜ࣜࣥ㓟ࡀ⁐ࡅฟࡋ࡚ࠊ

⬺⅊ࡀ㉳ࡇࡿࠋࡋ࠿ࡋࠊࡇࡢ⬺⅊ࡣ୍᫬ⓗ࡞ࡶࡢ࡛ࠊ ၚᾮࡀṑ࡟᥋ゐࡍࡿ࡜ၚᾮ୰ࡢ࢝ࣝࢩ࣒࢘࡜ࣜࣥ㓟 ࡀỿ╔ࡋ࡚ࠊ෌▼⅊໬ࢆᘬࡁ㉳ࡇࡍࠋStreptococcus

mutans ࡟ឤᰁࡍࡿ࡜pHࡢపୗࡀ⥆ࡁࠊ⬺⅊ࡀ⥆

ࡁ㱘⼃ࡀ㉳ࡁࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ1,2)ࠋ⢾ศࡢᦤྲྀࡀ ங㓟ࡢ⏘⏕ࢆᣍࡁࠊpHࡢపୗࢆᣍࡁࠊ⬺⅊ࡀ⥆ࡃࠋ

ࡑࡇ࡛ࠊṑ☻ࡁ࡟ࡼࡾStreptococcus mutans

ྲྀࡾ㝖ࡁࠊ෌▼⅊໬ࢆ㏿ࡸ࠿࡟⾜࠺ࡇ࡜࡛㱘⼃ࢆ㜵

Ṇ ࡍ ࡿ ᪉ ἲ ࡀ ࡜ ࡽ ࢀ ࡚ ࠸ ࡿ ࠋ ṑ ☻ ࡁ ࡟ ࡼ ࡾ ࠊ Streptococcus ⣽⳦ᩘࡢపୗࡀㄆࡵࡽࢀࡿሗ࿌ࡀ࠶

22)ࠋࡋ࠿ࡋࠊStreptococcus mutansࡣ୙⁐ᛶࢢࣝ

࢝ࣥ㸦ᡤㅝṑᇈ㸧ࢆᙧᡂࡋ࡚ࠊṑࡢ⾲㠃࡟ᖖᅾࡋ࡚

࠸ࡿࠋࡑࡇ࡛ࠊࡇࡢ Streptococcus mutansࢆ᰿ᮏ

ⓗ࡟ྲྀࡾ㝖ࡃࡇ࡜ࡀ㱘⼃㜵Ṇ࡟㛵ࡋ࡚᭷ຠ࡞ᡭẁ࡜

⪃ ࠼ ࡽ ࢀ ࡿ ࠋ ࡋ ࠿ ࡋ ࠊ ᚑ ᮶ ࡢ 㱘 ⼃ 㜵 Ṇ ࡣ ࠊ Streptococcus mutans࡟ᑐࡋ࡚࡛ࡣ↓ࡃࠊࣇࢵ⣲࡟

ࡼࡾ࢚ࢼ࣓ࣝ㉁ࡢᙉ໬ࠊங㓟Ⓨ㓝ࡢཎᅉ࡜࡞ࡿ⢾㉁

ࡢᦤྲྀไ㝈➼࡛࠶ࡗࡓࠋ᭱㏆࡛ࡣࠊ㣗ရ⏤᮶ࡢᡂศ

࡟ࡼࡿ㱘⼃㜵Ṇ࡟ᑐࡋ࡚ࡶ㛵ᚰࡀᣢࡓࢀ࠸ࡃࡘ࠿ࡢ ሗ࿌ࡀ࠶ࡿࠋᐩᒣ࡟ࡼࡿ࡜ࠊᰠ῰⏤᮶ࡢ⦰ྜࢱࣥࢽ

ࣥࡣᙉຊ࡞ࢱࣥࣃࢡ㉁จᅛస⏝ࢆᣢࡘࡇ࡜ࡀ▱ࡽࢀࠊ ከࡃࡢ⣽⳦࡬ࡢᢠ⳦ຠᯝࡀᮇᚅ࡛ࡁࡿࡇ࡜࠿ࡽࠊ Streptococcus mutans࡟ᑐࡍࡿᢠ⳦ຠᯝࢆ᳨ウࡋࠊ ࡑࡢ⤖ᯝࠊ῰ᰠ࠿ࡽᢳฟࡋࡓ⦰ྜ᪉ࢱࣥࢽࣥࢆྵ᭷

ࡍࡿ㣗ရῧຍ๣࡛࠶ࡿࣃࣝࢩࣥࡣࠊཱྀ⭍㐃㙐⌫⳦ࡢ

௜╔㜼ᐖస⏝࠶ࡿ࠸ࡣࣂ࢖࢜ࣇ࢕࣒ࣝࡢᵓ㐀◚ቯ࡟

ࡼࡿ࡜ᛮࢃࢀࡿከ⳦✀ࢆྵࡴࣂ࢖࢜ࣇ࢕࣒ࣝ࡬ࡢᢠ

⳦స⏝ࡀሗ࿌ࡉࢀࡓ17)ࠋࡲࡓࠊ኱ཎࡽ࡟ࡼࡿ࡜ࠊᮏ᮶ 㣧㣗⏝࡛࠶ࡾᏳ඲ᛶ࡟ၥ㢟ࡀ࡞࠸ࣈࢻ࢘ࡢࣈࢻ࢘㓇ᦢ

ࡾ⢑㸦ࣃ࣑ࢫ㸧࠿ࡽᢳฟࡋࡓ⏕⌮άᛶ≀㉁ࡀࠊGTase ᐖάᛶ࠾ࡼࡧStreptococcus mutans ࡢቑṪᢚไຠᯝ

ࢆ᭷ࡋࠊࣃ࣑ࢫᢳฟ≀ࡢ㱘⼃ᢚไ≀㉁࡜ࡋ࡚ࡢྍ⬟ᛶ

ࢆ♧၀ࡋࡓ18) ࠋ㕥ᮌࡽ࡟ࡼࡿ࡜ᢠ㓟໬స⏝ᢠ⫢㞀ᐖ స⏝ど⚄⤒ᶵ⬟ᨵၿస⏝ᢠ⅖⑕స⏝ື⬦◳໬ᨵၿ స⏝࡞࡝ࢆ᭷ࡍࡿ஦ࡀ▱ࡽࢀ࡚࠸ࡿࢼࢫࡢ⓶࡟ྵࡲࢀ

ࡿ࣏ࣜࣇ࢙ࣀ࣮ࣝࡢ 1✀࡛࠶ࡿࡀ㱘⼃ཎᅉ⳦࡟ᑐࡋ࡚

(2)

in vitro ᐇ㦂࡟࠾࠸࡚ࠊ㢧ⴭ࡞ẅ⳦స⏝ࡀㄆࡵࡽࢀ,ᢠ 㱘⼃స⏝ࢆ᭷ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀࡓࠋ19)ᑠすࡽ࡟ࡼ

ࡿ࡜᪥ᮏྂ᮶ࡼࡾᯝᐇ࡜ࡋ࡚࡞ࡌࡳࡢ῝࠸㣗ရ࡛࠶ࡿ

࡜࡜ࡶ࡟⏕⸆࡜ࡋ࡚ࡶ⏝࠸ࡽࢀࠊᢠ㓟໬స⏝ࠊᢠ⅖⑕స

⏝ࠊᢠ⳦స⏝࡞࡝ࡢ࠸ࡃࡘ࠿ࡢ⏕≀Ꮫⓗάᛶࢆ᭷ࡍࡿ

ᰠࡢ⶟(࡬ࡓ)ࢆ஝⇱ࡋࡓᰠ⶟ᢳฟᡂศ࡛࠶ࡿ࢘ࣝࢯ࣮

ࣝ㓟࠾ࡼࡧ࢜ࣞ࢔ࣀ࣮ࣝ㓟ࡀ㱘⼃ཎᅉ⳦࡟ᑐࡋ࡚㢧ⴭ

࡞ẅ⳦స⏝ࡀㄆࡵࠊᢠ㱘⼃స⏝ࢆ᭷ࡍࡿࡇ࡜ࡀሗ࿌ࡉ

ࢀࡓ20)

ࡇࡢࡼ࠺࡟㣗ရࠊ࠾ࡼࡧ㣗ရ⏤᮶ᡂศ࡟ࡼࡿ✚ᴟⓗ

࡞㱘⼃㜵Ṇ࡟ࡘ࠸࡚ὀ┠ࢆ㞟ࡵጞࡵ࡚࠸ࡿࠋ

ࡑࡇ࡛ࠊᮏ◊✲࡛ࡣࠊ㣗ရ࡜ࡋ࡚㠀ᖖ࡟㌟㏆࡞࿡ჯࠊ

Ⓨ㓝ங㸦࣮ࣚࢢࣝࢺ㸧ࢆ⏝࠸࡚Streptococcus mutans ࡢቑṪᢚไ࡟ࡘ࠸᳨࡚ウࡍࡿࠋ

ࡇࡢStreptococcus mutans ࡢቑṪࢆᢚ࠼ࡿ✚ᴟⓗ

࡞᪉ἲࡀࠊ2012ᖺ࡟஑ᕞ኱Ꮫ኱Ꮫ㝔㎰Ꮫ◊✲㝔࡜㮵ඣ ᓥ኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉ࠊᅜ❧㛗ᑑ་⒪◊✲ࢭ

ࣥࢱཱྀ࣮⭍⑌ᝈ◊✲㒊࡜ࣂ࢖࢜࣋ࣥࢳ࣮ࣕ࡜ࡢඹྠ◊

✲࡟ࡼࡾ᪥ᮏ࡛㛤Ⓨࡉࢀࠊ20121219᪥஑ᕞ኱Ꮫ グ⪅ࢡࣛࣈ࡟࡚Ⓨ⾲ࡉࢀࡓࢿ࢜ࢼ࢖ࢩࣥࢆྵࡴ࣮࢜ࣛ

ࣝࣆ࣮ࢫ࡛࠶ࡿ4)ࡋ࠿ࡋࠊࡲࡔࠊᗈࡃᬑཬࡋ࡚࠸࡞࠸ࠋ ࡇࢀࡣࠊங㓟⳦ࡀ⏘⏕ࡍࡿᢠ⳦ᛶ≀㉁ࡢࣂࢡࢸࣜ࢜ࢩ

ࣥࡢࢿ࢜ࢼ࢖ࢩࣥࢆ฼⏝ࡋࡓࡶࡢ࡛࠶ࡿࠋ

ࣂࢡࢸࣜ࢜ࢩࣥ࡜ࡣࠊங㓟⳦ࡀ⏘⏕ࡍࡿᢠ⳦ᛶ࣌ࣉ

ࢳࢻ࡛࠶ࡿ5)ࠋࡇࢀࡣࠊ⏕⏘⳦ࡢ㢮⦕✀࡟ᑐࡋ࡚ᢠ⳦ᛶ

ࢆ♧ࡋࠊ୍⯡ⓗ࡟↓࿡↓⮯ࠊప pH ࡛Ᏻᐃࠊ121Υࠊ 10ศ௨ୖࡢ⪏⇕ᛶࢆ᭷ࡋࠊᚤ㔞㸦nM⃰ᗘ㸧࡛ᢠ⳦

ᛶࢆ♧ࡍࠋࡉࡽ࡟ࠊ࣌ࣉࢳࢻࡢࡓࡵࠊ⭠⟶ෆ࡛ᾘ໬

㓝⣲࡟ࡼࡾศゎࡉࢀࠊ⪏ᛶ⳦ࡢฟ⌧ࡣ㉳ࡇࡾ㞴ࡃࠊ Ᏻ඲ᛶࡢ㧗࠸ᢠ⳦≀㉁࡜ࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿࠋ

ࣂࢡࢸࣜ࢜ࢩࣥࡢࢼ࢖ࢩࣥAࡣࠊ1928ᖺ࡟Ⓨぢࡉ

ࢀࠊᗈࡃୡ⏺୰࡛㣗ရಖᏑᩱ࡜ࡋ࡚౑⏝ࡉࢀ࡚࠸ࡿ

)ࠋࡋ࠿ࡋࠊ᪥ᮏ࡛ࡣࠊ200932᪥࡟㣗ရಖᏑ

ᩱ࡜ࡋ࡚ㄆྍࡉࢀࡓ)ၿ⸨ ጾྐࡽ࡟ࡼࡾࠊங㓟⳦ࣂ

ࢡࢸࣜ࢜ࢩࣥࡢ᳨⣴࡜฼⏝࡟ࡘ࠸࡚⧳ࡵࡽࢀࡓ⥲ㄝࡀ

࠶ࡿ21)ࠋࡑࡢ⥲ㄝ࡟ࡼࡿ࡜ࠊࣂࢡࢸࣜ࢜ࢩࣥ࡟ࡣࠊங 㓟⳦ࢆࡣࡌࡵ࡜ࡍࡿࢢ࣒ࣛ㝧ᛶ⣽⳦ࡀ⏕⏘ࡍࡿࣂࢡࢸ

ࣜ࢜ࢩࣥࡣࠊ⩻ヂᚋಟ㣭࡟ࡼࡗ࡚⏕ࡌࡿ␗ᖖ࢔࣑ࣀ㓟

ࢆྵࡴࢡࣛࢫI ࡜ࠊྵࡲ࡞࠸ࢡࣛࢫII ࡟኱ูࡉࢀࡿࠋ

ࡲࡓࠊࢼ࢖ࢩࣥࡢస⏝ᶵసࡣࠊ⣽⳦⣽⬊ࡢ⾲㠃࡟Ꮡᅾࡍ

ࡿ࣌ࣉࢳࢻࢢࣜ࢝ࣥ๓㥑య࡛࠶ࡿࣜࣆࢻ II ࢆᶆⓗ࡜

ࡋ࡚స⏝ࡋࠊࣜࣆࢻϩࢆ㊊᥃࠿ࡾ࡜ࡋ࡚⣽⬊⭷࡟Ꮝࢆ

ᙧᡂࡋࠊATPࡸ࢖࢜ࣥ࡞࡝ࡢ⣽⬊ෆᐜ≀ࢆ⁐ฟࡉࡏࡿ

ࡇ࡜࡛ẅ⳦ⓗ࡞ຠᯝࢆ♧ࡍࠋࡇࡢ୍㐃ࡢ㐣⛬ࡣ▐᫬࡟

㉳ࡇࡾࠊࣜࣆࢻIIࡀࢢ࣒ࣛ㝧ᛶ⣽⳦ࡢ⾲㠃࡟ᬑ㐢ⓗ

࡟Ꮡᅾࡍࡿࡇ࡜࠿ࡽࠊࢼ࢖ࢩࣥ࡟ᑐࡍࡿ⪏ᛶࡣ⏕ࡌ

࡟ࡃ࠸࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋࡋ࠿ࡋࠊ⣽⬊ࡢ᭱ࡶእഃ

࡟እ⭷ࢆࡶࡘࢢ࣒ࣛ㝜ᛶ⣽⳦࡟ᑐࡋ࡚ࡣࠊࢼ࢖ࢩࣥ

ࡣ⣽⬊⭷ୖࡢࣜࣆࢻ II ࡟฿㐩ࡍࡿࡇ࡜ࡀ࡛ࡁࡎࠊ ᢠ⳦స⏝ࢆཬࡰࡍࡇ࡜ࡀ࡛ࡁ࡞࠸ࡀࠊእ⭷ࢆ✺◚ࡋ ࡉ࠼ࡍࢀࡤࠊࢼ࢖ࢩࣥࡶࢢ࣒ࣛ㝜ᛶ⣽⳦࡟ᑐࡋ࡚ࠊ ᢠ⳦άᛶࢆ♧ࡍࠋ౛࠼ࡤࠊእ⭷ࡢᵓ㐀ࢆኚ໬ࡉࡏࡿ

࣮࢟ࣞࢺ๣ࢆే⏝ࡍࡿࡇ࡜࡛ࠊࢼ࢖ࢩࣥࡣእ⭷ࢆ㏱

㐣ࡍࡿࡇ࡜ࡀ࡛ࡁࠊࢢ࣒ࣛ㝜ᛶ⣽⳦࡟ࡶᢠ⳦άᛶࢆ

♧ࡍࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋࡲࡓࠊ㣗ရࠊ㠀㣗ရ࡬ࡢ

฼⏝࡟ࡘ࠸࡚ࡶ㏙࡭ࡽࢀ࡚࠸ࡿࠋ1920ᖺ௦࡟Ⓨぢࡉ

ࢀࡓࢼ࢖ࢩࣥࡣࠊ1950ᖺ௦࡟WHOࠊFAO࡟ࡼࡾ

ㄆྍࡉࢀࠊFDA࡛ࡶᏳ඲ᛶࡀㄆࡵࡽࢀ࡚⌧ᅾ࡛ࡣࠊ 50࢝ᅜ௨ୖ࡛㣗ရಖᏑᩱ࡜ࡋ࡚฼⏝ࡉࢀ࡚࠸ࡿࠋ๓

㏙ࡢࡼ࠺࡟᪥ᮏ࡛ࡣࠊ2009ᖺ࡟ㄆྍࡉࢀࡓࠋࢼ࢖ࢩࣥ

ࡣࢢ࣒ࣛ㝧ᛶ⣽⳦࡟ᙉ࠸ᢠ⳦άᛶࢆ♧ࡍࡓࡵࠊBacillus ᒓࠊClostridium ᒓࠊStaphylococcus ᒓࠊListeria

࡞࡝ࡢ㣗ရಖᏑୖၥ㢟࡟࡞ࡿ⣽⳦࡟ᑐࡋ࡚ຠᯝࢆ♧ࡍ

஦ࡀ▱ࡽࢀ࡚࠸ࡿࠋ≉࡟ࠊప ࡛ࡢಖᏑࡀ࡛ࡁ࡞࠸㣗ရ

ࡸࠊప ࡛ቑṪࡍࡿᚤ⏕≀ࡀၥ㢟࡜࡞ࡿ㣗ရࠊຍ⇕ฎ⌮

ࡀ࡛ࡁ࡞࠸㣗ရࡀ౑⏝ᑐ㇟࡜࡞ࡾࠊࡲࡓࠊ࿡ჯࡀࡑࡢ౑

⏝ᑐ㇟࡜࡞ࡗ࡚࠸ࡿࡢࡶ≉ᚩ࡛࠶ࡿࠋ㠀㣗ရ⏝㏵࡬ࡢ

฼⏝࡟ࡘ࠸࡚ࠊձࢼ࢖ࢩࣥࢆ୺๣࡜ࡋࡓᡭᣦ⏝ẅ⳦Ὑ ί๣ࡀ㝧࢖࢜ࣥ⏺㠃άᛶ๣࡜ࢼ࢖ࢩࣥࢆే⏝ࡍࡿࡇ࡜

࡛㺂ࢢ࣒ࣛ㝜ᛶ⳦࡟ᑐࡋ࡚ࡶ༑ศ࡞ẅ⳦ຠᯝࢆ♧ࡍ஦

ࡀ♧ࡉࢀࡓࠋղ∵ஙᡣ⅖ࡢண㜵๣࣭἞⒪๣࡜ࡋ࡚ࠊ⌮᝿

ⓗ࡞≀࡜ࡋ࡚ᮇᚅࡉࢀ࡚࠸ࡿࠋճࣂࢡࢸࣜ࢜ࢩࣥࡢ㧗

⣧ᗘࠊప౯᱁໬ࡀồࡵࡽࢀ࡚࠸ࡿࠋմ๓㏙ࡢࢿ࢜ࢼ࢖ࢩ

ࣥࢆ฼⏝ࡋࡓ࣮࢜ࣛࣝࣆ࣮ࢫࡣࠊᱵ࢚࢟ࢫ࡜ࢼ࢖ࢩࣥ

ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡟ࡼࡾࠊᱵ࢚࢟ࢫ࡟ྵࡲࢀࡿ࢟ࣞ

࣮ࢺస⏝ࢆᣢࡘࢡ࢚ࣥ㓟࡟ࡼࡾࢢ࣒ࣛ㝜ᛶ⳦࡟ᑐࡋ࡚

ࡶຠᯝࢆ♧ࡍࠋࡇࢀࡣ㺂ࢢ࣒ࣛ㝧ᛶ⳦࡛࠶ࡿ㱘⼃⳦ࡢ Streptococcus mutansࡔࡅ࡛↓ࡃࠊࢢ࣒ࣛ㝜ᛶࡢṑ࿘

⑓⳦㸦Porphyromonas gingivalis 㸧࡟ࡶ㧗࠸ᢠ⳦άᛶ

ࢆ♧ࡍࡇ࡜࡛ࠊཱྀ⭍ෆࡢ⾨⏕⎔ቃࢆዲࡲࡋࡃࡍࡿࡢ࡟

ᙺ❧ࡗ࡚࠸ࡿࠋᰴᘧ఍♫㹋㸤㹎࠿ࡽࡣࠊ࠾ཱྀࢣ࢔ங㓟⳦

ࣂࢡࢸࣜ࢜ࢩࣥࡀཱྀ⭍ࢣ࢔ၟရ࡜ࡋ࡚ࠊ2014ᖺࡼࡾ㈍

኎ࡉࢀ࡚࠸ࡿ23)ࠋࡇࡢࡼ࠺࡟ᡃࡀᅜ࡟࠾࠸࡚ࡶࠊࣂࢡ ࢸࣜ࢜ࢩࣥࡢ㣗ရࠊ㠀㣗ရศ㔝࡛ࡢ฼⏝ࡶ┒ࢇ࡟࡞ࡗ

࡚ࡁ࡚࠸ࡿࠋ

ங㓟⳦ࢆ฼⏝ࡋࡓⓎ㓝㣗ရࡢࣂࢡࢸࣜ࢜ࢩࣥ࡟

ࡘ࠸࡚ࠊከࡃࡢሗ࿌ࡀ࠶ࡿࠋᜠ⏣࡟ࡼࡿ࡜ࠊங࣭⫗

〇ရࢆ୺࡜ࡋࡓ㣗ရ࠿ࡽከࡃࡢࣂࢡࢸࣜ࢜ࢩࣥ⏘⏕

(3)

ங㓟⳦ࡀⓎぢࡉࢀࠊࡲࡓࠊ᪥ᮏࡢ௦⾲ⓗ࡞Ⓨ㓝㣗ရ

࡛᭷ࡿ࿡ჯ࠿ࡽࡶࣂࢡࢸࣜ࢜ࢩࣥ⏘⏕ங㓟⳦ࡀぢࡘ ࡅࡽࢀ࡚࠸ࡿࠋࡑࡢᛂ⏝࡟ࡘ࠸࡚ࡶሗ࿌ࡀ࠶ࡿ7,8,9

ࡲࡓࠊࣇࢼᑑྖ࡞࡝ࡢ㛗࠸ᮇ㛫ಖᏑࡍࡿⓎ㓝㣗ရ ࡢಖᏑᛶ࡟ࣂࢡࢸࣜ࢜ࢩࣥࡀ㛵୚ࡋ࡚࠸ࡿྍ⬟ᛶࡶ

♧၀ࡉࢀ࡚࠸ࡿ10)

ࡇࡢࡼ࠺࡟ࠊⓎ㓝㣗ရ࡟ྵࡲࢀ࡚࠸ࡿࣂࢡࢸࣜ࢜

ࢩࣥࡣࠊᵝࠎ࡞ᙧ࡛㣗ရࡢಖᏑᛶྥୖ࡟ᙺ❧ࡕࠊࡑ ࡢᛂ⏝࡟ࡘ࠸࡚ࡶ᳨ウࡉࢀ࡚࠸ࡿࠋⓎ㓝⫗〇ရࡢở ᰁ⣽⳦ࡢቑṪᢚไࢆ┠ⓗ࡜ࡋ࡚ࠊᕷ㈍㣗⫗ࡼࡾࠊศ 㞳ࡋࡓங㓟⳦ࡢࣂࢡࢸࣜ࢜ࢩࣥࡢᢠ⳦ᛶ࡟ࡘ࠸࡚ࠊ 㜿㒊㔜ேࡽ࡟ࡼࡾሗ࿌ࡉࢀ࡚࠸ࡿ24)

ங㓟⳦ࡀ⏘⏕ࡍࡿࣂࢡࢸࣜ࢜ࢩࣥࡣࠊ㏆⦕ࡢங㓟

⳦࡟ᑐࡋ࡚ᢠ⳦ᛶࢆ♧ࡍࡇ࡜ࡀࡑࡢ≉ᚩ࡛࠶ࡿࡇ࡜

࠿ࡽࠊ㱘⼃ࡢཎᅉ⣽⳦࡟ᑐࡋ࡚ࡶᢠ⳦ᛶࢆ♧ࡍྍ⬟

ᛶࡀ㧗࠸ࠋStreptococcus mutansࡢ⏘⏕ࡍࡿࣂࢡࢸ

ࣜ࢜ࢩࣥ㸦࣑࣮ࣗࢱࢩࣥ㸧ࡀ㱘⼃ࢆ㜵ࡄྍ⬟ᛶࡶሗ

࿌ࡉࢀ࡚࠸ࡿ11

ឡ▱┴ࢆ୰ᚰ࡟ᮾᾏᆅ᪉࡛฼⏝ࡉࢀ࡚࠸ࡿ㇋࿡

ჯ㸦㉥࿡ჯࠊ㉥ࡔࡋ㸧≉࡟ඵ୎࿡ჯࡣࠊ኱㇋ࠊ኱㇋

㯜࡜㣗ሷࡔࡅ࡛ࡘࡃࡽࢀࠊ஧ኟ஧෤ࡢ㛗࠸⇍ᡂᮇ㛫

ࢆ⤒࡚ฟⲴࡉࢀࡿࠋ࿡ჯ〇㐀࡟ࠊ㯜࡜ྠᵝࠊங㓟⳦

ࡶ㔜せ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࡇ࡜ࡣࠊࡼࡃ▱ࡽࢀ࡚࠸

ࡿࠋࡑࡇ࡛ࠊ㇋࿡ჯ࡜ඵ୎࿡ჯࠊⓎ㓝㣗ရ࡜ࡋ࡚ࡼ

ࡃ ▱ ࡽ ࢀ ࡚ ࠸ ࡿ ࣚ ࣮ ࢢ ࣝ ࢺ ࡢ Streptococcus

mutans࡟ᑐࡍࡿᢠ⳦ᛶࡢྍ⬟ᛶࢆ᳨ウࡍࡿࠋ

2㸬ᮦᩱ࡜᪉ἲ

㸦1㸧ཱྀ⭍ෆࡢ

Streptococcus mutans

ࡢ᳨ฟ࡜ศ㞳

ࢹࣥࢺ࢝ࣝࢺSM࢟ࢵࢺࢆ౑⏝ࡋࡓࠋࢹࣥࢺ࢝

ࣝࢺSM࢟ࢵࢺࡢ୰࡟ࡣࠊࢫࢺࣜࢵࣉ࣑࣮ࣗࢱࣥࢫࠊ ࢧ࢖ࢺࢫࢺࣜࢵࣉࠊヨ㦂⟶ࠊࣂࢩࢺࣛࢩࣥ㘄ࠊ࣒࢞

࣌ࣞࢵࢺࠊࢿ࣮࣒ࢩ࣮ࣝࡀධࡗ࡚࠸ࡿࠋࣂࢩࢺࣛࢩ

ࣥ㘄ࡣࠊ࣑࣮ࣗࢱࣥࢫࣞࣥࢧ⌫⳦௨እࡢ⣽⳦ࡢⓎ⫱

ࢆᢚไࡍࡿᢠ⏕≀㉁࡛࠶ࡿࠋ

᳨ᰝࡢᡭ㡰࡜ࡋ࡚ࡣࠊ

1) ᳨ᰝࡢ15ศ௨ୖ๓࡟ࠊࢹࣥࢺ࢝ࣝࢺSM࢟ࢵ

ࢺࡢヨ㦂⟶࡟ࣂࢩࢺࣛࢩࣥ㘄ࢆ1㘄ධࢀࡿࠋ 2) ࣒࢞࣌ࣞࢵࢺࢆ1ศ㛫࿪ᄮࡋࠊࡑࡢ㝿࡟ฟࡓၚ

ᾮࡣ㣧ࡳ㎸ࡴࠋ

3) ࣒࢞࣌ࣞࢵࢺࢆᤞ࡚ࠊࢫࢺࣜࢵࣉ࣑࣮ࣗࢱࣥࢫ ࡢ᳨ᰝ㠃ࢆࠊ⯉⾲㠃࡟5 ᚟ࡉࡏࡿࠋཱྀ၁࡛వ ศ࡞ၚᾮࢆᣔࡁ࡞ࡀࡽᘬࡁฟࡍࠋ

4) ࢧ࢖ࢺࢫࢺࣜࢵࣉࡢ᳨ᰝ㠃࡟ࣇࣟࢫ࡞࡝࡛᥇

ྲྀࡋࡓࣉ࣮ࣛࢡࢆῧ௜ࡍࡿࠋ

5) ࢫࢺࣜࢵࣉ࣑࣮ࣗࢱࣥࢫ࡜ࢧ࢖ࢺࢫࢺࣜࢵࣉ

ࢆ⫼㠃࡛ྜࢃࡏࠊ࢟ࣕࢵࣉ࡟ᕪࡋ㎸ࡴࠋ 6) ヨ㦂⟶࡟ᆶ┤࡟ᤄධࡋ࡚ࠊ࢟ࣕࢵࣉࢆ㛢ࡵࠊ

37Υ࡛48᫬ᇵ㣴ࡍࡿࠋ

7) 48 ᫬㛫ᚋ࡟ࠊ࢚࢝ࣜࢫࣜࢫࢡࣔࢹࣝࢳ࣮ࣕࢺ

࡜ẚ㍑ࡋࠊ ᐃࢆ⾜࠺ࠋ

㸦2㸧Streptococcus mutans ࡢศ㞳

SM࢟ࢵࢺ࡛ᚓࡽࢀࡓStreptococcus mutansࡢࢥࣟ

ࢽ࣮ࢆᾮయᇵᆅ࡟᥋✀ࡋࠊ༢୍ࡢࢥࣟࢽ࣮࡜ࡋ࡚ᇵ㣴 ࡋࡓࠋ

㸦3㸧౑⏝ᇵᆅ

ᇵᆅࡣࠊ࣌ࣉࢺࣥ15gࠊࢲ࢖ࢬ࣌ࣉࢺࣥ5gࠊሷ໬ࢼࢺ

࣒ࣜ࢘5gࢆ1Łࡢ⵨␃Ỉ࡟⁐ゎࡋࠊpH7.2࡟ㄪ〇ࡋࠊ

121Υࠊ15ศࡢ᮲௳࡛㧗ᅽ⵨Ẽ⁛⳦ࡋ࡚౑⏝ࡋࡓࠋᚲせ

࡟ᛂࡌ࡚ࠊ15gࡢᐮኳࢆຍ࠼࡚ࠊᐮኳᇵᆅ࡜ࡋ࡚౑⏝ࡋ ࡓࠋ

㸦4㸧ヨᩱ

࿡ჯ

ඵ୎࿡ჯ ᰴᘧ఍♫ࡲࡿࡸඵ୎࿡ჯ ឡ▱┴ᒸᓮᕷඵᖂ⏫ 㑏㏻52

ᒸᓮᇛࡼࡾඵ୎㞳ࢀࡓඵᖂ⏫࡛సࡽࢀࡿ㇋࿡ჯࡢ 1

✀࡛㣗ሷࠊỈࠊ኱㇋㺂኱㇋㯜ࡢࡳࢆཎᩱ࡜ࡋࠊ஧ᖺ௨ୖ

⇍ᡂࡉࡏ࡚ฟⲴࡉࢀࡿࠋ

㇋࿡ჯ ᱝሯ࿡ჯ ྜ㈨఍♫㔝⏣࿡ჯၟᗑ ឡ▱┴㇏⏣ᕷᱝሯす⏫༡ᒣ6␒ᆅ

ឡ▱┴ࢆ୰ᚰ࡟㣗࡭ࡽࢀࡿ㇋࿡ჯࢆኳ↛㔊㐀࡟ࡼࡾ

〇㐀ࡋ࡚࠸ࡿࠋ

࣮ࣚࢢࣝࢺ

᫂἞ࣈࣝ࢞ࣜ࢔࣮ࣚࢢࣝࢺ 450g ᰴᘧ఍♫᫂἞

᳃Ọࣅࣇ࢕ࢲࢫ࣮ࣚࢢࣝࢺ 400g ᳃Ọஙᴗᰴᘧ

఍♫

ࡇࢀࡽࡢ࣮ࣚࢢࣝࢺࡣࠊ㠀ຍ⇕ฎ⌮ࣉ࣮࣮ࣞࣥࣚࢢࣝ

ࢺ࡛࠶ࡾࠊங㓟⳦㺂∵ஙࡢࡳ࡛సࡽࢀ࡚࠸ࡿࠋங㓟⳦ࡀ

⏕ࡁࡓ≧ែ࡛ྵࡲࢀࡿࠋ ヨᩱࡣᕷ㈍ࡢࡶࡢࢆ౑⏝ࡋࡓࠋ

㸦5㸧ᢠ⳦ᛶࡢ᳨ウ

࿡ჯࡣࠊ㔜㔞ࡢ2ಸࡢ⵨␃Ỉࢆຍ࠼⁐ゎࡉࡏ3ಸ࡟

ᕼ㔘ࡋࠊ࣮ࣚࢢࣝࢺࡣࠊࡑࡢࡲࡲࠊ10000rpm™20min ࡢ㐲ᚰศ㞳࡟ࡼࡾୖ⃈ࡳࢆ࡜ࡾࠊ࣐࢞ࣥ⥺⁛⳦῭ࡳࡢ 5 ml ࢸࣝࣔࢩࣜࣥࢪ࡜ ADVANTEC ♫〇 DISMIC-

25CS PORESIZE0.45ȣm࡛㝖⳦ࢆ⾜࠸ᢠ⳦ᛶ ᐃヨ

ᩱ࡜ࡋࡓࠋ

(4)

ୖグࡢ⁛⳦ᐮኳᇵᆅࢆࢩ࣮ࣕࣞ࡟ศὀ◳໬ᚋࠊศ㞳 ࡋࡓ Streptococcus mutans ࡢ๓ᇵ㣴ᾮࢆ⏕⌮㣗ሷỈ

10ಸᕼ㔘ࡋࠊ1.0mlࢆᐮኳᇵᆅ⾲㠃࡟ࢥ࣮ࣥࣛࢪᲬ

࡛ᆒ➼࡟ఙࡤࡋࠊࢡ࣮ࣜࣥ࣋ࣥࢳෆ࡛ᨺ⨨ࡋࡓࠋ⁛⳦ࡋ ࡓ࣮࣌ࣃ࣮ࢹ࢕ࢫࢡ࡟ࡑࢀࡒࢀࡢヨᩱࢆຍ࠼ࠊᐮኳᇵ ᆅୖ࡟⨨ࡁࠊ37Υ࡛48᫬㛫ᇵ㣴ᚋࠊ࣮࣌ࣃ࣮ࢹ࢕ࢫࢡ ࡢ࿘ࡾ࡟ Streptococcus mutans ࡢ⏕⫱ࡋ࡚࠸࡞࠸㜼 Ṇ෇ࡢᙧᡂࡢ᭷↓࡟ࡼࡾࠊᢠ⳦ᛶࢆุᐃࡋࡓࠋ

3㸬⤖ᯝ࡜⪃ᐹ

㸦1㸧ཱྀ⭍ෆࡢ

Streptococcus mutans

ࡢ᳨ฟ࡜ศ㞳

10 ௦ࡢ⏨Ꮚ኱Ꮫ⏕ࠊ50 ௦ࡢ⏨ᛶ࠿ࡽࢹࣥࢺ࢝ࣝࢺ SM࢟ࢵࢺࢆ⏝࠸࡚ࠊStreptococcus mutansศ㞳ࡋࡓࠋ ᢠ ⳦ ᛶ ࡢ ᳨ ウ ࡟ ࡣ ࠊ ࡇ ࡢ ศ 㞳 ࡋ ࡓ Streptococcus mutansࢆ౑⏝ࡋࡓࠋ2ᰴࡢStreptococcus mutans

⏝࠸࡚ࠊ࿡ჯࠊ࣮ࣚࢢࣝࢺ࡟ࡼࡿᢠ⳦ᛶࡢ᳨ウࢆ⾜ࡗࡓ ࡀࠊ10௦ࡢ⏨Ꮚ኱Ꮫ⏕ࡢᰴࡣ࠸ࡎࢀࡢヨᩱ࡟ᑐࡋ࡚ࡶࠊ ឤཷᛶࡀㄆࡵࡽࢀ࡞࠿ࡗࡓࠋ

㸦2㸧ᢠ⳦ᛶࡢ᳨ウ

ᅗ㸯 ㇋࿡ჯ࡜࣮ࣚࢢࣝࢺࡢ Streptococcus mutans ࡢቑṪ࡟ᑐࡍࡿᙳ㡪

A:᫂἞ࣈࣝ࢞ࣜ࢔࣮ࣚࢢࣝࢺ B㸸ඵ୎࿡ჯ

C㸸ᱝሯ࿡ჯ

D㸸᳃Ọࣅࣇ࢕ࢲࢫ࣮ࣚࢢࣝࢺ

ᢠ⏕≀㉁ࡢຊ౯ ᐃ࡟⏝࠸ࡽࢀࡿ᪉ἲࢆᛂ⏝ࡋࡓࠋ ࡑࡢ⤖ᯝࠊᱝሯ࿡ჯࡢ࣮࣌ࣃ࣮ࢹ࢕ࢫࢡࡢ࿘ࡾ࡟᫂ࡽ

࠿࡟Streptococcus mutansࡢቑṪࡀぢࡽࢀࡎࠊ㜼Ṇ෇

ࡀㄆࡵࡽࢀࡓࠋⴭ⪅ࡽࡣࠊ௨๓ࠊᕷ㈍ࡢ࣮ࣚࢢࣝࢺ࡟

Streptococcus mutansࡢቑṪࢆᢚ࠼ࡿྍ⬟ᛶࡢ࠶ࡿ〇 ရࢆሗ࿌ࡋࡓ16

࿡ჯ࡟ࡣࠊከࡃࡢங㓟⳦ࡀྵࡲࢀࠊ㯜ࡀቑṪࡋࡸࡍ࠸

㓟ᛶ≧ែࢆసࡾୖࡆࡿࡢ࡟㈉⊩ࡋ࡚࠸ࡿ 7,8,9ࠋࡲࡓࠊ

ࣂࢡࢸࣜ࢜ࢩࣥࡀ࿡ჯ〇㐀୰࡟ቑṪฟ᮶ࡿங㓟⳦ࡢ✀

㢮ࢆ㝈ᐃࡍࡿࡇ࡜࡛ࠊࡑࢀࡒࢀࡢ࿡ჯࡢ≉ᚩࡀ⏕ࡲࢀ

࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋඵ୎࿡ჯࡣ22෤ࡢ⇍

ᡂᮇ㛫ࠊ௒ᅇ౑⏝ࡋࡓ㇋࿡ჯࡣ18ࣨ᭶ࡢ⇍ᡂᮇ㛫ࢆ⤒

࡚ฟⲴࡉࢀࡿࠋ㇋࿡ჯࡣ௚ࡢ࿡ჯ࡟ẚ࡭࡚⇍ᡂᮇ㛫ࡀ 㛗ࡃࠊங㓟⳦ࡢ〇㐀㐣⛬࡟࠾ࡅࡿᙺ๭ࡣ኱ࡁ࠸࡜࠸࠼

ࡿࠋ

᪥ᮏ࡛ࡣࠊྛ✀ࡢₕࡅ≀࡛௦⾲ࡉࢀࡿங㓟⳦ࢆ฼⏝

ࡋࡓⓎ㓝㣗ရࡀྂࡃ࠿ࡽᦤྲྀࡉࢀ࡚ࡁ࡚࠸ࡿ 7,8,9ࠋከ ࡃࡢₕࡅ≀ࡣࠊங㓟Ⓨ㓝࡟ࡼࡾ⨾࿡ࡋࡃࠊಖᏑᛶࡀྥୖ

ࡍࡿࠋ௚࡟ࡣࠊᑑྖࡢཎᆺࡢ୍ࡘ࡜ゝࢃࢀࡿᩘᖺᚚ㣤࡟

ࡘࡅ㎸ࡲࢀࡿ࡞ࢀᑑྖࡀ࠶ࡿࠋ࡞ࢀᑑྖࡣࠊ࢔ࢪ࢔ࡢ ᅜࠎ࡛ࡶసࡽࢀ࡚࠸ࡿࠋᚚ㣤࡛ࡘࡅ㎸ࢇࡔ≀ࡀከࡃࠊ≉

࡟㣗୰ẘࡢ༴㝤ᛶࡢ㧗࠸㧗 ከ‵ࡢࣔࣥࢫ࣮ࣥᆅᇦ࡛

฼⏝ࡉࢀ࡚ࡁࡓࡢࡣࠊࣂࢡࢸࣜ࢜ࢩࣥࢆࡣࡌࡵ࡜ࡍࡿ

ᢠ⳦ᛶ≀㉁ࡢᏑᅾࡀ㈉⊩ࡋ࡚࠸ࡿ஦ࡀ᥎ᐹࡉࢀࡿࠋ

௒ᅇࠊ౑⏝ࡋࡓStreptococcus mutansࡣேࡢཱྀ⭍

ࡼࡾศ㞳ࡋࡓᰴࢆ౑⏝ࡋࡓࡓࡵࠊᢠ⳦ᛶࡢឤཷᛶࡣࠊᰴ

࡟ࡼࡾ␗࡞ࡾࠊࡼࡾᢠ⳦ࢫ࣌ࢡࢺࣝࡢᗈ࠸ࣂࢡࢸࣜ࢜

ࢩࣥࢆࢫࢡ࣮ࣜࢽࣥࢢࡍࡿᚲせࡀ࠶ࡿࠋ

ࣂࢡࢸࣜ࢜ࢩࣥࢆ฼⏝ࡋࡓཱྀ⭍ࢣ࢔┠ⓗࡢ⸆๣ࡀ⣽

⳦ከࡃᕷ㈍ࡉࢀ࡚ࡁ࡚࠸ࡿࠋࡇࢀࡽࡢၟရࡣࠊ୺࡟㺂㧗 㱋⪅ࠊṑ☻ࡁ࡞࡝ࡢࢣ࢔ࡢ㞴ࡋ࠸㞀ࡀ࠸⪅ேࡀ౑⏝ࡍ

ࡿࡇ࡜ࢆ๓ᥦ࡜ࡋ࡚࠸ࡿࠋ୍⯡ⓗ࡟ᗂඣᮇ࠿ࡽࠊ⏑࠸≀

ࢆ㛫㣗࡟ከࡃ㣗࡭࡞࠸㺂ཱྀ⭍ෆ࡟⢾ศࢆṧࡉ࡞࠸ࠊ㓟ᛶ

࡟ಖࡓ࡞࠸࡜࠸࠺㱘⼃(⹸ṑ)ࡢཎᅉࢆྲྀࡾ㝖ࡃᾘᴟⓗ

࡞᪉ἲࡀྲྀࡽࢀ࡚ࡁࡓࠋࡑࡢ᪉ἲ࡟ຍ࠼ࠊཎᅉ⳦࡛࠶ࡿ

Streptococcus mutansࡢቑṪࢆ┤᥋ᢲࡉ࠼ࡿ✚ᴟⓗ࡞

᪉ἲࢆ࡜ࡿࡇ࡜࡛᭦࡟ࠊ㱘⼃㜵Ṇࡀྍ⬟࡟࡞ࡿ࡜⪃࠼

ࡽࢀࡿࠋࡑࡢࡓࡵ࡟ఏ⤫ⓗ࡟㣗࡭ࡽࢀ࡚ࡁࡓከࡃࡢங 㓟⳦ࢆ฼⏝ࡋࡓⓎ㓝㣗ရࡢ Streptococcus mutans ᑐࡍࡿቑṪᢚไຠᯝࢆฟ᮶ࡿࡔࡅࠊᦤྲྀࡍࡿ᮲௳࡟㏆

࠸ᙧ᳨࡛ウࡍࡿࠋ

㣗ရࡣ㺂༢⊂࡛ᦤྲྀࡉࢀࡿࡇ࡜ࡣ↓ࡃࠊᬑ㏻ࡣࠊ୍ᗘ ࡢ㣗஦࡛」ᩘྠ᫬࡟ᦤྲྀࡉࢀ࡚࠸ࡿࠋ1 ᪥ࡢᦤྲྀရ┠

࡟㛵ࡋ࡚ࡣ᭦࡟ከࡃ࡞ࡿࠋཌ⏕ປാ┬ࡀ1985ᖺ࡟୍᪥

(5)

30ရ┠ࡢ㣗ရᦤྲྀࢆ᥎ዡࡋࡓࡇ࡜ࡣࠊᰤ㣴㠃࡟ࡘ࠸࡚

࡛ࡣ࡞ࡃࠊ㣗ရ┦஫స⏝࡟ࡼࡿ༴㝤ᛶࢆపୗࡉࡏࡿⅭ

࡛࠶ࡗࡓࠋࡇࡢࡼ࠺࡟༢⊂࡟ᦤྲྀࡉࢀࡿࡇ࡜ࢆ๓ᥦ࡜

ࡋࡓ᮲௳࡛↓ࡃࠊ」ᩘࡢ㣗ရࢆ⤌ࡳྜࢃࡏࡓᐇ㝿ࡢ㣗

⏕ά࡟ἢࡗ࡚ࠊ௒ᚋࠊ᳨ウࢆຍ࠼ࡿࠋຠᯝࡢቑ኱ࡍࡿ⤌

ࡳྜࢃࡏࠊຠᯝࡀῶᑡࡍࡿ⤌ࡳྜࢃࡏ࡞࡝ࠊከࡃࡢྍ⬟

ᛶࡀ⪃࠼ࡽࢀࡿࠋ௒ᚋࠊ✚ᴟⓗ࡟㱘⼃ࢆ㜵ࡄ㣗⏕άࢆ᳨

ウࡍࡿࠋࡲࡎࡑࡢࡓࡵ࡟㺂ከࡃࡢఏ⤫ⓗ࡞Ⓨ㓝㣗ရࠊཬ ࡧ ࠊ ᭱ ㏆ ὀ ┠ ࡉ ࢀ ࡚ ࠸ ࡿ ᶵ ⬟ ᛶ ࢆ ㅻ ࠺ Ⓨ 㓝 ங ࡢ Streptococcus mutans࡟ᑐࡍࡿቑṪᢚไຠᯝࢆ᳨ウࡍ

ࡿࠋࡲࡓࠊ㣗⏕ά࡜㱘⼃⳦Streptococcus mutansࡢཱྀ

⭍ෆࡢ⳦ᩘ࡟㛵ࡋ࡚ࡶ᳨ウࡋࠊ㣗⏕ά࡜㱘⼃⳦ࡢ㛵ಀ

࡟ࡘ᳨࡚ウࡋࠊStreptococcus mutans ࡢቑṪࢆᢚ࠼ࡿ

ྍ⬟ᛶࡢ࠶ࡿ㣗ရ㸦ࣂࢡࢸࣜ࢜ࢩࣥࢆྵࡴྍ⬟ᛶ㸧ࢆぢ

࠸ࡔࡋࠊ᭦࡟⤌ࡳྜࢃࡏ࡟ࡼࡿᢠ⳦స⏝ࡢຠᯝࡢኚ໬

ࢆ᳨ウࡍࡿࠋ

ᘬ⏝ᩥ⊩

㸧Hamada, S.and Slade, H. D.: Biology,

immunology, and cariogenicity of Streptococcus mutans, Microbiol. Rev., 44, 331-384,(1980).

2)

㬞 ஭㻌 ஂ୍䠄䜋䛛䠅䠖 䛄ṑ⛉་ᖌ䞉ṑ⛉⾨⏕ኈ 䛾䛯䜑䛾ၚᾮ᳨ᰝ䝝䞁䝗䝤䝑䜽䛅䠈㧗ὠᚁ⏨䠈118-119 䠄2008䠅

3㸧ཌ⏕ປാ┬㸸

http://www1.mhlw.go.jp/topics/kenko21_11/b6.ht ml

4) ࣮࢜ࣛࣝࣆ࣮ࢫ㸸http://oralpeace.com/oralpeace 5) ┈⏣᫬ග㸦࡯࠿㸧㸸ࢼ࢖ࢩࣥ-㢮ᕼ࡞ᢠ⳦≀㉁-࣑

ࣝࢡࢧ࢖࢚ࣥࢫ 6) ཌ⏕ປാ┬㸸

http://www.ffcr.or.jp/zaidan/MHWinfo.nsf/0/8aa11 687a2aaf0c4492570650018d5ba?OpenDocument 7) ᜠ⏣໶㸸࿡ჯ㔊㐀࡟Ꮡᅾࡍࡿࣂࢡࢸࣜ࢜ࢩࣥ⏘

⏕ங㓟⌫⳦᪥ᮏ㔊㐀༠఍ㄅ

8) ຍ⸨ ୔㞝㸸 ᢠ⳦ᛶங㓟⳦ࢫࢱ࣮ࢱ࣮࢝ࣝࢳࣕ

࣮ࢆ฼⏝ࡋࡓ࿡ჯ㔊㐀

᪥ᮏ㣗ရ⛉ᏛᕤᏛ఍ㄅ,47,752-759, (2000) 9) ᳃ᆅᩄᶞ㸸㣗ရಖⶶ࡟࠾ࡅࡿங㓟⳦ࡢ฼⏝, ᪥ᮏ㣗

ရ⛉ᏛᕤᏛ఍ㄅ,49,207-219,(2002)

10)ᇼ㉺ᫀᏊ㸸㏆Ụࡢ࡞ࢀࡎࡋ,᪥ᮏ㣗ရᚤ⏕≀Ꮫ఍㞧 ㄅ,28,9-15,(2011)

11)Ᏻ⚟⨾᫛㸸㱘⼃ཎᛶ⣽⳦Streptococcus mutans

⏘⏕ࡍࡿࣂࢡࢸࣜ࢜ࢩࣥ(࣑࣮ࣗࢩࣥ)ࡢ㱘⼃ᢚไస

⏝࡟㛵ࡍࡿ◊✲ 2࣑࣮ࣗࢱࢩࣥࡢᢠ⳦స⏝ࢆጉࡆ

ࡿᅉᏊ࡟ࡘ࠸࡚,ᑠඣṑ⛉Ꮫ㞧ㄅ,25,395-403,(1987)

12)஭ୖ࿴᫓㸦࡯࠿㸧㸸ᚤ⏕≀฼⏝ᢏ⾡࡟㛵ࡍࡿ◊✲

㸦㸯㸧Ѹࣃࣥ✀ࡢங㓟⳦࡜㓝ẕࡢ฼⏝Ѹ,ᇸ⋢┴⏘ᴗᢏ

⾡⥲ྜࢭࣥࢱ࣮◊✲ሗ࿌,4,

13)㐍㈡▱ຍᏊ㸦࡯࠿㸧㸸ዷ፬࡟࠾ࡅࡿ㱘⼃ཎᛶ⣽⳦ᩘ࡜

ႚ↮࠾ࡼࡧ㣗஦࡟㛵ࡍࡿᐇែㄪᰝ,ᑠඣṑ⛉Ꮫ㞧 ㄅ,45,584-592,(2007)

14)⣽㔝᫂⩏⦅㸸ࠗⓎ㓝ஙࡢ⛉ᏛѸங㓟⳦ࡢᶵ⬟࡜ಖ೺ຠ

ᯝѸ࠘᳃⏣ᐩᏊ,58,(2002)

15)Shah, Nagendra, Ly Linh:  Streptococcus thermophilus࡟ࡼࡗ࡚⏘⏕ࡉࢀࡿBifidobacterium spp.࡟ ᑐᑐ ࡍ ࡿ ࣂ ࢡ ࢸ ࣜ ࢜ ࢩ ࣥ Bioscience and Microflora,1342-1441Vol.18,1999

16)┦ཎ ⱥᏕ㸸Ⓨ㓝㣗ရ࡟ࡼࡿ㱘⼃ண㜵ࡢྍ⬟ᛶ-Ⓨ

㓝ங㸦࣮ࣚࢢࣝࢺ㸧-ឡ▱ᏛἨ኱Ꮫ࣭▷ᮇ኱Ꮫ⣖

せ,(50),1-4 (2015)

17)ᐩᒣ ₩㸸࣏࣐ࣜ࢖ࢡࣟࣂ࢖࢔ࣝࣂ࢖࢜ࣇ࢕࣒ࣝࡢ

㏥♫άᛶ࡟ᑐࡍࡿ᪂つᢠ⳦๣ࡢᢠ⳦ຠᯝ,⚄ዉᕝṑ

⛉,51(1),56-60(2016)

18)኱ཎ ⣸㸦࡯࠿㸧Streptococcus mutans࡟ᑐࡍࡿ

ࣈࢻ࢘㓇ᦢࡾ⢑ᢳฟᡂศࡢᢚไຠᯝ,ᑠඣṑ⛉Ꮫ㞧 ㄅ,49(3),251-258(2011)

19)㕥ᮌ ⚽᫂㸦࡯࠿㸧㸸ࢼࢫࢽࣥࡢ㱘⼃ཎᅉ⳦࡟ᑐࡍࡿ

ᢠ ⳦ ຠ ᯝ, ᪥ ᮏ ṑ ⛉ ಖ Ꮡ Ꮫ 㞧 ㄅ,53(3),296- 303(2010)

20)ᑠす ⨾ᚨ㸸㱘⼃ཎᅉ⳦࡟ᑐࡍࡿᰠ⶟ᢳฟᡂศࡢᢠ

⳦ຠᯝ ᪥ᮏṑ⛉ಖᏑᏛ㞧ㄅ,51(3),299-307(2008)

21)ᩧ⸨ ጾྐ㸦࡯࠿㸧㸸ங㓟⳦ࣂࢡࢸࣜ࢜ࢩࣥࡢ᥈⣴࡜

฼⏝ Japanese Journal of Lactic Acid Bacteria, 25(1),1-10(2014)

22)Hohashi, N and Nakagami,G :Result of oral bacteria among infants brushing their own teeth : using the Ș-hemolytic Streptococcus count on the tooth surface as the indicator, japan journal Health & Human Ecology, 73(5),183-192(2007) 23) ᰴᘧ఍♫㹋㸤㹎㸸࠾ཱྀࢣ࢔ங㓟⳦ࣂࢡࢸࣜ࢜ࢩࣥࠊ

http://www.mandp.tokyo/wp- content/uploads/2015/02/PDF-4.pdf

24)ᒸ㒊 㔜ே㸦࡯࠿㸧㣗⫗ࡼࡾศ㞳ࡋࡓங㓟⌫⳦ࡀ⏘

⏕ࡍࡿࣂࢡࢸࣜ࢜ࢩࣥࡢᢠ⳦≉ᛶ,ᒸᒣ኱Ꮫ㎰Ꮫ㒊 Ꮫ⾡ሗ࿌,89,39-44(2000)

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