September 2015. The goals include world s urgent issues that should be solved over the next 15 years by the all countries - developed and developing - in a global partnership (146). SDGs are the blueprint to achieve a better and more sustainable future for all.
They address the global challenges we face, including those related to ending poverty, reducing inequality, improving health and education. The WHO also gave commitment to help the world meet the SDGs by championing health across all the goals. WHO core mission is to promote health, alongside keeping the world safe and serving the vulnerable. Beyond fighting disease, they will work to ensure healthy lives and promote
wellbeing for all at all ages, leaving no-one behind. WHO has targeted 1 billion more people to enjoy better health and well-being by 2023.
Tackling noncommunicable diseases like CVDs, cancer, chronic respiratory diseases, diabetes (124), through the reduction of exposure to hazardous environmental and occupational risks is essential in achieving the SDGs, notably, SDG3. The health goal, SDG3 is to ensure healthy lives and promote well-being at all ages. Health target 3.4, related to SDG3, aims to reduce premature mortality from noncommunicable diseases, through prevention and treatment, by one third by 2030.
Effective strategies can be undertaken by the policy makers and associated bodies only when they are able to recognize the effects of environmental factors, e.g. heavy metals, at molecular level (Fig. 3.6). I hope that the review topic discussed in the later part of this thesis will get people to reconsider the strategy to prevent CVDs by improving the environment. As we all know prevention is better than cure.
Acknowledgements
Firstly, I would like to take the opportunity to express the deepest appreciation and my sincere gratitude to my benevolent supervisor Dr. Akio Ebihara, Professor, Laboratory of Biological Chemistry, Faculty of Applied Biological Sciences, Gifu University, Japan for the continuous support of my Ph.D. study and related research, for his patience, motivation, and immense knowledge. His guidance helped me in all the time of research and writing of this thesis. I could not have imagined having a better advisor and mentor for my Ph.D. study.
Besides my supervisor, I would like to thank Dr. Tsutomu Nakagawa, Professor, Laboratory of Biological Chemistry, Faculty of Applied Biological Sciences, Gifu University, Japan and Dr. Akio Morita, Professor, Laboratory of Functional Plant Physiology, Shizuoka University, Japan for not only their insightful comments and encouragement as co-supervisors, but also for the constructive criticism which incented me to widen my research from various perspectives.
I owe a debt of gratitude to Dr. AHM Nurun Nabi, Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh for his motivation and assistance to pursue higher study in a foreign university. He is one of my Ph.D. co-supervisors and was my M.S. thesis supervisor also. Whenever I had faced any difficulties, I directly contacted him. His words inspired me to start my work with new spirit. I will always remain grateful to him.
I must express my gratefulness to Dr. Fumiaki Suzuki, Vice President and Executive Director for International Affairs and Public Relations, Gifu University, Japan who is one of the founders of the Laboratory of Biological Chemistry, Gifu University. He was often present during my midterm presentations in spite of his busy schedule. My Ph.D.
life would become harder without his guideline and valuable advices.
I would like to express my sincere thanks to Dr. Masateru Senge, Professor and Dean, The United Graduate School of Agricultural Science, Gifu University; and Dr. Kohei Nakano, Associate Dean, The United Graduate School of Agricultural Science, Gifu University for allowing me to pursue my doctoral course in their faculty.
I thank Dr. Atsuhiro Shimada, Dr. Misuzu Hashimoto and Dr. Chiharu Nakagawa for
their continuous support and constructive criticism. I also express my thanks to Miss Mayumi Matsui and Ms. Jyunko Mikami for their useful assistance over the study period. I am indebted to my fellow lab mates in the Laboratory of Biological Chemistry for their supports, the stimulating discussions, and for all the fun we have had in the last three years. Few names I must mention are- Miss Maki Kuzuya, Mr. Rui Zhang, Miss Midori Yui, Miss Hiromi Suzuki, Mr. Kota Onoda, Mr. Motoki Sugino, Mr. Seidai Nagai and Mr. Makoto Kousaka.
I would like to convey my gratitude to Dr. Laila N Islam, Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh for allowing me to use the laboratory space and instruments during my M.S. research activities. My sincere gratitude also goes to all the teachers of Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh for sharing their knowledge with the students and making them ambitious.
I would also like to thank all the professors of the United Graduate School of Agricultural Science, Gifu University for their valuable lectures, discussions and suggestions. I wish to thank all the office staffs of the United Graduate School of Agricultural Science for their sincere and unconditional help during my research period.
I also thank Ministry of Education, Science, Sports and Culture, Government of Japan for awarding me Monbukagakusho Scholarship to support my research and daily life in Japan.
My thanks go to Dr. Kazal Boron Biswas, former Postdoc and Ph.D. student of the Laboratory of Biological Chemistry and his wife Swapna Paramanya who was not only my lab mate but also like elder sister for their constant support, providing me homely environment and making my Japan life pleasant. I will miss their son Karnik Biswas a lot. I also thank all of Japanese and Bangladeshi friends who made me feel a pleasant time in Japan.
I humbly extend my thanks to my family: my father, who is not with us but has been always supporting me spiritually, my mother, sisters, brother, all the relatives and in- for supporting me throughout writing this thesis and all the blessings towards me. Last but not the least, I want to thank my beloved husband, Dr. MD. Emon Hossain for his continuous support, inspiration, untiring patience and love in my life.
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