MPPH
230 230 230 230 220 230 230
20%Methano1:80%0.01MNaH2P04 25%Methano1:75%0.01MNa㌧P04 40%Methan0160%O.01MNaH2P04 35%Methan0165%0.01MNa叫P04 55%Methan0145%0.01MNa叫P04 55%Methan0145%O.01M NaH2P04 60%Methan0140%0−01MNaH2P04
a;MPPH:5一⑫一methy1−phenyl)一5−ph㎝ylhydantoin
一99一 策VII編
引用文献
1 Sheiner,L.B.,Rosenberg,B.and M肛athe,V−V.,∫戸物rmoco々fm〃。帥〃m,5,
445_79(1977).
2 Sheiner,L.B.,Beal,S.and Rosenberg,B.,CZ加戸んαrmαcoZ r々er,26,294−305 (1979).
3 Mi1sap,R.L.,Hi11,M.R.and Szef1er,S.J.∫ρec5oZρ伽m〃。oた加eれ。 co㎜腕7oガ。n加
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4 Lietman,P.S.,α加Pん。グmoooZ,6.1551−62(1979).
5 Diamond,I.and Schmid,R.,ノαj〃舳e∫r,45,678−89(1966).
6 0ie,S.and Lcvy,G.,ノ戸々〃㎜∫cj,68,6−9(1979).
7 0ie,S.and Levy,G.,∫Pん〃m∫cゴ,68,1−6(1979).
8 Koshida,R.,Nakashima,E.,Ichimura,F.,N瓜ano,O.,Watanabe,R.,Taniguchi,N.
andTsuji,A.,ノPん〃mocoわjo4ソn,10,436−42(1987)・
9 Koshida,R.,Nakashima,E.,Taniguchi,N.,Tsuji,A.,Benet,L−Z.and Ichimura,F.,
戸乃αグm Re∫,6,486_91(1989).
10 Deguchi,Y.,Koshida,R.,Nakashima,E.,Watanabe,R.,Taniguchi,N.,Ichimura,P.
andTsuji,A.,ノ戸々。グm∫d,77,674−8(1988)・
l1 堀下平,奥村勝彦,斎藤一文字,安原真人,越川富雄,橋田亨,奥野武彦,中川照
真,山岡清,臨床薬理,15,535−44(1984).
一100一 引用文献
12 家入一郎,樋口駿,吉川学,青山敏信,堀岡正義,薬剤学,47,224−32(1987).
13 Buれ。n,M−E.,Brater,D,C.,Chen,P.S。,Day,R.B.,Huber,P.J−and Vasko,M.R.,α加 戸ん。グ〃一〇coZτんer,37,349−57(1985).
14 Bumn,M.E.,Chow,M−S.S.,Platt,D.R.,Day,R.B.,Brater,D.C.and Vasko,M.R.,
C〃n戸ん。グ〃一,5,143−9(1986).
15 Ke1man,A.W.,Thomson,A.H.,Whiting,B.,Brys㎝,S.M.,Steedman,D.A.,
Mower,G.E.and Samba−Donga,L.A.,〃∫α加〃〃mocoZ,18,685−92(1984).
16 Scatchard,G.,^舳〃γ^cod∫cゴ,51,660−72(1949).
17 Metz1er,C.M.,F1fhng,G.L.and McEwen,A.J.^〃∫e{mo舳。Zヵr〃0ML〃伽a
o∬ocjαed〃。8γo舳.(The Upjohn Co.Kalamazoo,Mich,1974).
18 Bhand,C.,Samzin,M.,Peyrot,V.,Gi11i,R.,Bourdeaux,M.andSa㎡,J.C.,〃。Z
P/20グη一〇coZ,21,92−9(1982).19 Kragh Hansen,U.,戸加グmocoZ Rev,33,17−53(1981).
20 Jacobsen,C.,Bfocんem∫,171,453−9(1978).
21 加藤昌太良,中原佐和子,足立公一,小児科蘇床,31,689−92(1978).
22 Beal,S−L.and Sheincr,L.B.σ∫er∫Bo∫jc G〃ae,(The Techinica1Report of the Div.
ofc1inica1Phamaco1ogy,UniversityofCa1ifomia,SanFranciscoCA,1980).
23 Yamaoka,K.,Nakagawa,T.,Tanaka,H.,Yasuhara,M.,Okumura,K.andHoh,R.,ノ
戸ん。グ〃一〇c()わjo−Dy〃,8,246−56(1985).
一101一 引用文献
24 Sheiner,L,B.and Beal,S.L一,∫戸ん。rmoooれ〃eτ〃。ρん07m,9,503−12(1981).
25 Friis−Hansen,B.,戸e〃αrた∫,28,169−181(1961).
26 Mun・ay,K.M.,Bauer,L.A.and Koup,J.R.,α加肋。舳,5,411−4(1986).
27 Morse,W.I.and S㏄1dner,J.S.,〃e励。〃∫m,12,99−107(1963).
28 Row1and,M.andBenet,L.Z.,∫〃〃moco〃〃er〃。帥。グm,1,123−35(1973).
29 加藤隆一,臨床薬物動態学,pp197(南江堂,東京,1992).
30 Tozer,T.N.andWinter,M.E.〃enγojn,25−1−25−44(AppliedTherapeutics Inc.,
Spokane,WA,1992).
31 Richens,A.and Dunlop,A.,L伽。er,2,247−8(1975).
32 Lund,L.andA1van,G.,L伽。er,2.1305−6(1975).
33 Ludd㎝,T.M.,Hawkins,D.W.,Allen,J.P.andHoffman,S.F.,L伽。α,1,307−8
(1976).34 Martin,E.,Tozer,T.N.,Sheiner,L.B.and Riege1man,S.,∫〃〃mocoたfner
Bfoρん。rm,5,579−96(1977).35 Rambcck,B.,Bo㎝igk,H.E.,Dun1op,A.,Mullen,P.W.,Wadsworth,J.具nd
Richens,A.,τ加7D用g〃。η〃,1,325−33(1979).36 Mull㎝,P.W.,αjn〃。伽。coげんぴ,23,228−32(1978).
37 Chiba,K.,Ishizaki,T.,Miura,H.andMinagawa,K.,∫Ped1αr,96,479−84(1980).
一102一 引用文献
38 Robinson,F.C.,Wamer,R.N.andGonzalez,M.A.,〃e〃。Zo8y,31,761−3(1981).
39 Robinson,F.C.and Mayer,P.R.,rんe7D用g〃。〃,4,225−8(1982).
40 Amijo,J.A.andCavada,E.,肋e7D用8〃。〃,13,507−10(1991).
41 Sheincr,L.B.and Bea1,S.L.,∫戸乃07moco〃mc Bfoρ乃。rm,8,553−71(1980).
42 Aoyama,T.,Yukawa,T.,Higuchi,S.,Nakao,Y.andHorioka,M.,γo々〃。f8o々〃,47,
49_55(1987).
43 Grasela,T.H.,Sheiner,L.B.,Rambeck,B.,Boenigk,H.E.,Dunlop,A.,Mullen,P.
W.,Wadsworth,J.,Richens,A.,Ishizaki,T.,Chiba,K.andet,a.1.,α〃
戸んαグ〃一〇co々f〃eτ,8,355−64(1983).
ψ Mi11er,R.,Rheeders,M.,Klein,C.and Suchet,I.,∫λ〃r,72,188−190(1987).
45 堀下平,奥村勝彦,北澤式文,神代昭,斉藤侑也,樋口駿,水柿道直,山路昭,力久
忠昭,谷川原祐介,薬効学,50,292−9(1990).
46 Y・k・w・,E.,Hig・・hi,S.・・dA・y・m・,T.,Cん・m肋・グm肋〃吻・,37,全363−6
(1989).47 Leppik,I.E.,Eρ〃eρ∫jo,33,S32−S40(1992).
48 Kato,Y.,Hirate,J.,Sakaguchi,M.,Ueno,I.andHo㎡koshi,I.,∫肋。伽。coわゴ。−D〃,
10,166_72(1987).
49 Tsuji,A.,Yoshikawa,T.,Nishide,K一,Minami,H.,Kimura,M、,Nakasima,E一,
Terasaki,T.,Miyamoto,E.and Nightingale,C.H.,D用8〃e肋Dゆ。∫,13,729−39
−103一 引用文献
50
51
52
53
54
55
56
57
58
59
60
61
(1985).
Yokogawa,K、,Nakashima,E.andIchimura,F.,D川g〃eωわDj∫ρos,18,258−63
(1990).
Gcrbcr,N.andWagner,J.G.,Re∫Comm〃nαem戸。伽Z戸畑舳。coZ,3,455(1972)・
AshIey,J,J.andLevy,G.,∫戸加グmoco〃〃α〃。ρん〃m,1,99−102(1973).
Itoh,T.,Sawada,Y.,Lin,T.H.,Iga,T.andHanano,M.,∫肋〃mocoわjo−D〃.。11,
289_308(1988).
Higgins,G.M.and Anderson,R.M.,ル。んPαん。Z.,12,186−200(1931).
Monks,A.,Boobis,S.,Wadsworth,J.and Rich㎝s,A.,〃Jαfn肋。mocoZ,6,
487_92(1978).
Kober,A.,Olsson,Y.and Sjδho1m,I.,〃。Z戸畑グmocoZ,18,237−42(1980).
Cramer,J.A.and Mattson,R,H.,rんerD用8〃。〃,1,105−16(1979).
Dahlqvist,R.,Borg邑,O.,Rane,A一,Walsh,Z−and Sjoqvist,F・,B〃α加Pん〃mocoZ,
8,547_52(1979).
Solomon,H.M.,Schrogie,J.J.andWi11iams,D一,肋。んem肋。mocol,17,143−51
(1968).
Rudman,D.,Bixler,T.J.d and De1Rio,A.E.,∫P伽グmocoZ Exρ〃ぴ,176,261−72
(1971).
Spector,A.A.,Santos,E.C.,Ashbrook,J.D.andFle正。her,J.E.,AηnNγAcod∫cj,
一104一 引用文献
226,247_58(1973).
62 Wi1ding,G。,Fe1dhoff,R.C.and Vesell,E.S.,別。伽m〃αグmocoZ,26.1143−6
(1977).63 Pate1,I.H.andLevy,R.H.,助〃eρ∫fo,20,85−90(1979).
ω Monks,A.andRichens,A.,B7ノα加〃。㎜ocoZ,8,187−9(1979).
65 Zimmeman,C.L.,PateI,I.H.,Levy,R.H.,Edwards,D.,Nelson,S.D.and
Hutchinson,M.,Eρ〃eρ∫ゴ。,22,11−7(1981).66 A1bani,F.,Riva,R.,Pr㏄accianti,G.,Bamzzi,A.andPerucca,E.,Eρ〃e庫α,24,
65_73(1983).
67 Bowd1e,T.A.,Patel,I.H.,Lcvy,R.H.and Wilensky,A.J.,E〃∫α加〃。mocoZ,
23,343_7(1982).
68 Box,GEP.andMu11er,ME.,λ舳〃αん∫吻舳,29,610−1(1958).
69 Toscano,J.P.andJameson,J.P.,C〃n戸畑グm,5,396−402(1986).
70 Higuchi,S。,Aoyama,T,andHohoka,M.,∫〃〃㎜oco〃。ψn,10,703−18(1987).
71 Vozeh,S.,Muir,K.T.,Sheiner,L.B.andFo11ath,F.,ノ肋。グmoco〃mc別。ρ肋m,9,
131_46(1981).
72 Mu叩hy,J.E.,Bmni,J.and Stewai,R.B.,^mノ〃。∫ρ肋〃m,38,348−54(1981).
73 Blake,D.A.,Collins,J−M.,Miyasaki,B.C.and Cohen,F.,D用8me肋〃sρo∫,6,
246_250(1978).
一105一 引用文献
74 Hansen,B.A.and Poulsen,H.E.,∫o伽∫α加Loわ7〃e∫c,46,233−7(1986).
75 Pou1sen,H.E.and Pi1sgaard,H.,L〜e7,5,196−9(1985).
76 Fouts,J.R一,7〃P乃。グmocoZル7eeれ〃9,6,257(1962).
77 Borg至,O.,JuhIin Damfeldt,A.and DahIqvist,R.,P物グmocoZo8y,16,37−43(1978).
78 Sj6ho1m,I.,Ekman,B.,Kober,A.,Ljungstedt Pahlman,I.,Seiving,B.and Sjodin,
T、,〃。Z戸々。グmαcoZ,16,767−77(1979).
79 Mamyama,K.,Awazu,S.,Nishigori,H.andIwatsuru,M.,αem肋。舳肋〃τoり。,
34.3394_402 (1986).
80 Nadai,M.,Yoshizumi,H.,Kuzuya,T.,Hasegawa,T.,Johno,I.and,Kitazawa,S.,
」つr〃8ハ4e吻わDj∫ρo。∫,18,565−70(1990).
81 Podolsky,S.C〃〃。oZ Dfoわαe∫,〃。de用〃。〃。geme〃,xvii(App1eton−Centuフー
Crofts,New York,1980).
82 Popovich,R.P.,Monchcf,J.W.,Dccherd,J.F.,Bomar,J.J.B.andPy1c,W,K.,Am
∫oc^灯ゲ∫〃e用0rgoη∫,64,Abstracts(1976).83 Popovich,R,P.,Moncrief,J.W.,Nolph,K.D.,Ghods,A.J一,Twardowski,Z.J.and Pyle,W.K.,ル〃〃e用〃ed,88,449(1978).
84 Schneider,J.G.,0わ∫fα一G〃ecoZ−CZ加一〃。グ沽一^m,21,195−212(1994).
85 F1essner,M.F.,Deωck,R.L.and Schu1tz,J.S.,Am∫P伽∫joZ,246,r597−607
(1984).一106一 引用文献
86
87
88
89
90
91
92
93
94
95
96
97
98
99
円essner,M.F.,De砒。k,R.L.and Schultz,J,S.,λm∫戸柳∫foZ,248,f413−24(1985).
F1essner,M.F.,Ded二dck,R.L.and Schu1tz,J.S.,λmノ戸佃sゴ。Z,248,h15−25(1985).
Toπes,I.J.,Litterst,C.L.andGu㎞no,A.M.,P肋舳。coZo8γ,17,330−40(1978).
Sato,H.,Ishikawa,F.,Okezaki,E.,Nagata,O.,Nakashima,E一,Deguchi,Y.,
Ichimura,F.and Tsuji,A.,C加m P加舳8〃τoり。,36.3180−5(1988).
Toon,S.andRow1and,M.,∫〃〃mocoZ政ρ〃e7,225,752−63(1983).
Steiner,S.H.,Moor,M.J.and Bicke1,M.H.,D川g〃e励〃sρo∫,19,8−14(1991).
Tsuji,A.,Takanaga,H.,Tamai,I.and Terasaki,T.,戸畑m Re∫,11,30−7(1994).
Hessner,M.F.andDe砒。k,R.L.,ノ^m∫oc〃eρ加。Z,5,116−20(1994).
Nishida,K.,Sato,N.,Sasaki,H.and Nakamura,J.,ノP伽グm Pん。mocoZ,46,867−870
(1994).
Watkins m,J.B.andDyks庁a,T.P.,D用8〃e肋Dゆ。∫,15,177−83(1987).
Ichimura,F.,Deguchi,Y.,Yokogawa,K.and Nakashima,E一,Cんem P加ηn B〃〃
7ro々yo,35.2030−7(1987).
Tamai,I.,Maekawa,T.andTsuji,A.,∫.〃。舳.故ρ.τ加r.,253,537−5ψ(1990).
Watkins m,J.B.andNoda,H.,∫.肋。舳.Exρ.肋ぴ.,239,467−473(1986).
Mehva,R.,∫肋〃m∫cご,80,207−11(1991).
一107一 引用文献
100 Ilstrup,K.M.,Keane,W.F.and Michels,L.D.,L牝∫d,29,717−24(1981).
101 Saikawa,I.,Takai,A.,Na上ashima,Y一,Ikegami,T.,Hayakawa,H.,丁吐agi,T.㎝d
Yamauchi,H。,ノ。ρ∫A〃伽。比∫,33.1084−96(1980).102 Kedem,O.and Katcha1sky,A.,別。c〃m別。ρ伽∫λαo,27,229−46(1958).
103 Rippe,B,Perry,M.A.andGranger,D.N.,〃jぴ。w∫cRes,29,89−102(1985).
104 K㎞no,A.,Hayashi,M.,Awazu,S.andHanano,M.,ノ〃。舳。coωo−Dyn,5,670−7
(1982).
105 Lau,A.H.,Chow−Tung,E.,Assadi,F.K.,Fomell,L.and John,E.,戸々〃moc0708ツ,
31,284_8(1985).
106 De㎞ck,R.L.,Hcssner,M.F.,Co11ins,J.M.andSchultz.J.S.,λm∫ocルケ〃e用。Z
Or8o〃s,5,1−5(1982).107 Randerson,D.H.andFa∬e1I,P.C.,Am∫ocA灯ゲ/〃e用αZ0グgo〃s,3,140−6(1980).
108 Jacobs㎝,J.andWemberg,R.P.,α加αem,20,783(1974).
109 市村藤雄,椥11弘一,山名月中,辻彰,倉田孝一,木戸日出喜,伊藤達彦,山口成
良,薬剤学,43,50−60(1983).
110 Kamata』(i,T.and Kitagawa,H.,ノρ〃∫戸ん〃mαcoZ,24,195−203(1974).
111 0mura,T.and Sato.R.,ノ別。Z C加m,239.2370−8(1964).
112 Lowry,O.H.,Roseberough,N.J.,Farr,A.L.and Randa11,R.J.,∫〃。Z C加㎜,193,
一108一 引用文献
113
114
115
116
265_75(1951).
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Subcr,R.L.,Lce,C.,Torosian,G.andEdds,G.T.,ノ戸畑グm∫cj,70,981(1981).
Tsuji,A.,Kubo,O.,Miyamoto,E.and Yamana,T.,ノ肋伽n∫cゴ,66.1675−9(1977).
Okez荻i,E.,Terasaki,T.,Na』(amura,M。,Nagata,O.,Kato,H.and Tsuji,A.,D用8 ハ e吻わ10 .∫ρos,16,865−74(1988).
一109一 引用文献