本稿を終えるに臨み、本研究の遂行にあたり終始御懇篤なる御指導、ご鞭撻 を賜りました恩師岐阜薬科大学生体機能解析学大講座薬効解析学研究室教授 原英彰博士に深甚なる謝意を表します。
本研究に際して終始御懇切なる御指導ならびに御助言を賜りました岐阜薬科 大学生体機能解析学大講座薬効解析学研究室准教授 嶋澤雅光博士および助教 鶴間一寛博士に深謝いたします。また、諸種の御協力を頂きました薬効解析学 研究室研究室諸氏に心から感謝致します。
本論文の審査にあたり、有益なる御助言を賜りました岐阜薬科大学生体機能 解析学大講座分子生物学研究室教授 古川昭栄博士、岐阜薬科大学医療薬剤学大 講座薬物治療学研究室教授 保住功博士並びに岐阜薬科大学生命薬学大講座生 化学研究室教授 五十里彰博士に深謝致します。
本研究の遂行にあたり、実験材料の御提供、御助言並びに御協力を賜りまし た神戸大学大学院農学研究科生命機能科学専攻教授 白井康仁博士、神戸大学バ イオシグナル研究センター神経情報伝達分野教授 齋藤尚亮博士、岐阜薬科大学 医療薬剤学大講座薬物動態学研究室教授 北市清幸博士に心から感謝の意を表 します。
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引用文献
Adachi, N., Oyasu, M., Taniguchi, T., Yamaguchi, Y., Takenaka, R., Shirai, Y., Saito, N., 2005. Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain. Brain Res Mol Brain Res 139, 288-299.
Ali, H., Nakano, T., Saino-Saito, S., Hozumi, Y., Katagiri, Y., Kamii, H., Sato, S., Kayama, T., Kondo, H., Goto, K., 2004. Selective translocation of diacylglycerol kinase zeta in hippocampal neurons under transient forebrain ischemia. Neuroscience letters 372, 190-195.
Alkam, T., Hiramatsu, M., Mamiya, T., Aoyama, Y., Nitta, A., Yamada, K., Kim, H.C., Nabeshima, T., 2011. Evaluation of object-based attention in mice. Behavioural brain research 220, 185-193.
Andrioli, A., Alonso-Nanclares, L., Arellano, J.I., DeFelipe, J., 2007. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.
Neuroscience 149, 131-143.
Aubry, J.M., Schwald, M., Ballmann, E., Karege, F., 2009. Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation. Psychopharmacology 205, 419-429.
Barbosa, F.J., Hesse, B., de Almeida, R.B., Baretta, I.P., Boerngen-Lacerda, R., Andreatini, R., 2011. Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania. Pharmacol Rep 63, 64-70.
Bari, A., Dalley, J.W., Robbins, T.W., 2008. The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nature protocols 3, 759-767.
Baum, A.E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T.G., Cichon, S., Rietschel, M., Nothen, M.M., Georgi, A., Schumacher, J., Schwarz, M., Abou Jamra, R., Hofels, S., Propping, P., Satagopan, J., Detera-Wadleigh, S.D., Hardy, J., McMahon, F.J., 2008. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
76
Molecular psychiatry 13, 197-207.
Beaulieu, J.M., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G., 2006. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. The Journal of biological chemistry 281, 32072-32080.
Beaulieu, J.M., Sotnikova, T.D., Marion, S., Lefkowitz, R.J., Gainetdinov, R.R., Caron, M.G., 2005. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122, 261-273.
Beaulieu, J.M., Sotnikova, T.D., Yao, W.D., Kockeritz, L., Woodgett, J.R., Gainetdinov, R.R., Caron, M.G., 2004. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proceedings of the National Academy of Sciences of the United States of America 101, 5099-5104.
Caricasole, A., Bettini, E., Sala, C., Roncarati, R., Kobayashi, N., Caldara, F., Goto, K., Terstappen, G.C., 2002. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. The Journal of biological chemistry 277, 4790-4796.
Carlsson, M., Carlsson, A., 1989. The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. Journal of neural transmission 75, 221-226.
Christakis, D.A., Ramirez, J.S., Ramirez, J.M., 2012. Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance. Scientific reports 2, 546.
Craddock, N., Jones, I., 1999. Genetics of bipolar disorder. Journal of medical genetics 36, 585-594.
de Lecea, L., del Rio, J.A., Soriano, E., 1995. Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat. Brain research 32, 1-13.
El-Mallakh, R.S., Decker, S., Morris, M., Li, X.P., Huff, M.O., El-Masri, M.A., Levy, R.S., 2006. Efficacy of olanzapine and haloperidol in an animal model of mania.
Progress in neuro-psychopharmacology & biological psychiatry 30, 1261-1264.
77
Fienberg, A.A., Hiroi, N., Mermelstein, P.G., Song, W., Snyder, G.L., Nishi, A., Cheramy, A., O'Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N., Cooper, D.C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.J., Hyman, S.E., Surmeier, D.J., Girault, J., Nestler, E.J., Greengard, P., 1998. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science (New York, N.Y 281, 838-842.
Freund, T.F., Buzsaki, G., 1996. Interneurons of the hippocampus. Hippocampus 6, 347-470.
Frey, B.N., Andreazza, A.C., Cereser, K.M., Martins, M.R., Valvassori, S.S., Reus, G.Z., Quevedo, J., Kapczinski, F., 2006. Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life sciences 79, 281-286.
Gainetdinov, R.R., Mohn, A.R., Bohn, L.M., Caron, M.G., 2001. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America 98, 11047-11054.
Gant, J.C., Thibault, O., Blalock, E.M., Yang, J., Bachstetter, A., Kotick, J., Schauwecker, P.E., Hauser, K.F., Smith, G.M., Mervis, R., Li, Y., Barnes, G.N., 2009.
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice:
implications for autism and epilepsy. Epilepsia 50, 629-645.
Ghosh, S., Strum, J.C., Sciorra, V.A., Daniel, L., Bell, R.M., 1996. Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid.
Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells.
The Journal of biological chemistry 271, 8472-8480.
Goto, K., Hozumi, Y., Nakano, T., Saino, S.S., Kondo, H., 2007. Cell biology and pathophysiology of the diacylglycerol kinase family: morphological aspects in tissues and organs. International review of cytology 264, 25-63.
Goto, K., Kondo, H., 1993. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Proceedings of the National Academy of Sciences of the United States of America 90, 7598-7602.
Greengard, P., Allen, P.B., Nairn, A.C., 1999. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23, 435-447.
78
Guggenhuber, S., Monory, K., Lutz, B., Klugmann, M., 2010. AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. PLoS one 5, e15707.
Han, K., Holder, J.L., Jr., Schaaf, C.P., Lu, H., Chen, H., Kang, H., Tang, J., Wu, Z., Hao, S., Cheung, S.W., Yu, P., Sun, H., Breman, A.M., Patel, A., Lu, H.C., Zoghbi, H.Y., 2013. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503, 72-77.
Hoertel, N., de Maricourt, P., Gorwood, P., 2013. Novel routes to bipolar disorder drug discovery. Expert opinion on drug discovery 8, 907-918.
Hozumi, Y., Fukaya, M., Adachi, N., Saito, N., Otani, K., Kondo, H., Watanabe, M., Goto, K., 2008. Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. The European journal of neuroscience 28, 2409-2422.
Hozumi, Y., Watanabe, M., Otani, K., Goto, K., 2009. Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons.
BMC neuroscience 10, 99.
Huang, M., Li, Z., Ichikawa, J., Dai, J., Meltzer, H.Y., 2006. Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex. Brain research 1099, 44-55.
Ishisaka, M., Hara, H., 2014. The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice. Journal of pharmacological sciences 124, 336-343.
Itoh, K., Watanabe, M., 2009. Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. Neuroscience 159, 735-743.
Kakefuda, K., Oyagi, A., Ishisaka, M., Tsuruma, K., Shimazawa, M., Yokota, K., Shirai, Y., Horie, K., Saito, N., Takeda, J., Hara, H., 2010. Diacylglycerol kinase beta knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS one 5, e13447.
Kanoh, H., Yamada, K., Sakane, F., 1990. Diacylglycerol kinase: a key modulator of signal transduction? Trends in biochemical sciences 15, 47-50.
79
Kiguchi, M., Fujita, S., Oki, H., Shimizu, N., Cools, A.R., Koshikawa, N., 2008.
Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder. Journal of neural transmission 115, 1079-1085.
Kirshenbaum, G.S., Clapcote, S.J., Duffy, S., Burgess, C.R., Petersen, J., Jarowek, K.J., Yucel, Y.H., Cortez, M.A., Snead, O.C., 3rd, Vilsen, B., Peever, J.H., Ralph, M.R., Roder, J.C., 2012. Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha3 sodium pump. Proceedings of the National Academy of Sciences of the United States of America 108, 18144-18149.
Klausberger, T., Marton, L.F., O'Neill, J., Huck, J.H., Dalezios, Y., Fuentealba, P., Suen, W.Y., Papp, E., Kaneko, T., Watanabe, M., Csicsvari, J., Somogyi, P., 2005.
Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. J Neurosci 25, 9782-9793.
Konradi, C., Zimmerman, E.I., Yang, C.K., Lohmann, K.M., Gresch, P., Pantazopoulos, H., Berretta, S., Heckers, S., 2011. Hippocampal interneurons in bipolar disorder.
Archives of general psychiatry 68, 340-350.
Krapacher, F.A., Mlewski, E.C., Ferreras, S., Pisano, V., Paolorossi, M., Hansen, C., Paglini, G., 2010. Mice lacking p35 display hyperactivity and paradoxical response to psychostimulants. Journal of neurochemistry 114, 203-214.
Kuruba, R., Hattiangady, B., Parihar, V.K., Shuai, B., Shetty, A.K., 2011. Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity. PLoS one 6, e24493.
Li, X., Bijur, G.N., Jope, R.S., 2002. Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. Bipolar disorders 4, 137-144.
Machado-Vieira, R., Kapczinski, F., Soares, J.C., 2004. Perspectives for the development of animal models of bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry 28, 209-224.
Marco, P., Sola, R.G., Ramon y Cajal, S., DeFelipe, J., 1997. Loss of inhibitory synapses on the soma and axon initial segment of pyramidal cells in human epileptic peritumoural neocortex: implications for epilepsy. Brain research bulletin 44, 47-66.
80
McOmish, C.E., Lira, A., Hanks, J.B., Gingrich, J.A., 2012. Clozapine-induced locomotor suppression is mediated by 5-HT2A receptors in the forebrain.
Neuropsychopharmacology 37, 2747-2755.
Merida, I., Avila-Flores, A., Merino, E., 2008. Diacylglycerol kinases: at the hub of cell signalling. The Biochemical journal 409, 1-18.
Moya, P.R., Murphy, D.L., McMahon, F.J., Wendland, J.R., 2010. Increased gene expression of diacylglycerol kinase eta in bipolar disorder. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 13, 1127-1128.
Musto, A., Bazan, N.G., 2006. Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. Epilepsia 47, 267-276.
Nierenberg, A.A., Miyahara, S., Spencer, T., Wisniewski, S.R., Otto, M.W., Simon, N., Pollack, M.H., Ostacher, M.J., Yan, L., Siegel, R., Sachs, G.S., 2005. Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants.
Biological psychiatry 57, 1467-1473.
Nishizuka, Y., 1995. Protein kinase C and lipid signaling for sustained cellular responses. Faseb J 9, 484-496.
O'Brien, W.T., Harper, A.D., Jove, F., Woodgett, J.R., Maretto, S., Piccolo, S., Klein, P.S., 2004. Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24, 6791-6798.
O'Brien, W.T., Huang, J., Buccafusca, R., Garskof, J., Valvezan, A.J., Berry, G.T., Klein, P.S., 2011. Glycogen synthase kinase-3 is essential for beta-arrestin-2 complex formation and lithium-sensitive behaviors in mice. The Journal of clinical investigation 121, 3756-3762.
Okada, M., Hozumi, Y., Tanaka, T., Suzuki, Y., Yanagida, M., Araki, Y., Evangelisti, C., Yagisawa, H., Topham, M.K., Martelli, A.M., Goto, K., 2012. DGKzeta is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cellular signalling 24, 1573-1582.
81
Ong, J.C., Brody, S.A., Large, C.H., Geyer, M.A., 2005. An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition. The Journal of pharmacology and experimental therapeutics 315, 1163-1171.
Oyagi, A., Oida, Y., Kakefuda, K., Shimazawa, M., Shioda, N., Moriguchi, S., Kitaichi, K., Nanba, D., Yamaguchi, K., Furuta, Y., Fukunaga, K., Higashiyama, S., Hara, H., 2009. Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice. PLoS one 4, e7461.
Pantazopoulos, H., Lange, N., Baldessarini, R.J., Berretta, S., 2007. Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia. Biological psychiatry 61, 640-652.
Park, S.W., Shen, X., Tien, L.T., Roman, R., Ma, T., 2011. Methamphetamine-induced changes in the striatal dopamine pathway in mu-opioid receptor knockout mice. Journal of biomedical science 18, 83.
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J.A., Steckler, T., 2006. Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J Neurosci 26, 9022-9029.
Regier, D.S., Higbee, J., Lund, K.M., Sakane, F., Prescott, S.M., Topham, M.K., 2005.
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proceedings of the National Academy of Sciences of the United States of America 102, 7595-7600.
Reich, W., Neuman, R.J., Volk, H.E., Joyner, C.A., Todd, R.D., 2005. Comorbidity between ADHD and symptoms of bipolar disorder in a community sample of children and adolescents. Twin Res Hum Genet 8, 459-466.
Reid, C.A., Berkovic, S.F., Petrou, S., 2009. Mechanisms of human inherited epilepsies.
Progress in neurobiology 87, 41-57.
Rezin, G.T., Furlanetto, C.B., Scaini, G., Valvassori, S.S., Goncalves, C.L., Ferreira, G.K., Jeremias, I.C., Resende, W.R., Cardoso, M.R., Varela, R.B., Quevedo, J., Streck, E.L., 2014. Fenproporex increases locomotor activity and alters energy metabolism, and mood stabilizers reverse these changes: a proposal for a new animal model of mania.
Molecular neurobiology 49, 877-892.
82
Rhee, S.G., Bae, Y.S., 1997. Regulation of phosphoinositide-specific phospholipase C isozymes. The Journal of biological chemistry 272, 15045-15048.
Roybal, K., Theobold, D., Graham, A., DiNieri, J.A., Russo, S.J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M.H., Orsulak, P., Takahashi, J.S., Nestler, E.J., Carlezon, W.A., Jr., McClung, C.A., 2007. Mania-like behavior induced by disruption of CLOCK. Proceedings of the National Academy of Sciences of the United States of America 104, 6406-6411.
Sakane, F., Imai, S., Kai, M., Yasuda, S., Kanoh, H., 2007. Diacylglycerol kinases: why so many of them? Biochimica et biophysica acta 1771, 793-806.
Salkovic-Petrisic, M., Tribl, F., Schmidt, M., Hoyer, S., Riederer, P., 2006.
Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. Journal of neurochemistry 96, 1005-1015.
Sanjuan, M.A., Pradet-Balade, B., Jones, D.R., Martinez, A.C., Stone, J.C., Garcia-Sanz, J.A., Merida, I., 2003. T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation. J Immunol 170, 2877-2883.
Schwaller, B., Tetko, I.V., Tandon, P., Silveira, D.C., Vreugdenhil, M., Henzi, T., Potier, M.C., Celio, M.R., Villa, A.E., 2004. Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures. Molecular and cellular neurosciences 25, 650-663.
Scotti, M.A., Lee, G., Stevenson, S.A., Ostromecki, A.M., Wied, T.J., Kula, D.J., Gessay, G.M., Gammie, S.C., 2011. Behavioral and pharmacological assessment of a potential new mouse model for mania. Physiology & behavior 103, 376-383.
Shioda, N., Yamamoto, Y., Watanabe, M., Binas, B., Owada, Y., Fukunaga, K., 2009.
Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain. J Neurosci 30, 3146-3155.
Shirai, Y., Kouzuki, T., Kakefuda, K., Moriguchi, S., Oyagi, A., Horie, K., Morita, S.Y., Shimazawa, M., Fukunaga, K., Takeda, J., Saito, N., Hara, H., 2010. Essential role of neuron-enriched diacylglycerol kinase (DGK), DGK beta in neurite spine formation, contributing to cognitive function. PLoS one 5, e11602.
83
Siegel, A.M., 2004. Presurgical evaluation and surgical treatment of medically refractory epilepsy. Neurosurgical review 27, 1-18; discussion 19-21.
Stertz, L., Fries, G.R., Aguiar, B.W., Pfaffenseller, B., Valvassori, S.S., Gubert, C., Ferreira, C.L., Moretti, M., Cereser, K.M., Kauer-Sant'anna, M., Quevedo, J., Kapczinski, F., 2013. Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania. Rev Bras Psiquiatr 36, 39-46.
Sutton, L.P., Rushlow, W.J., 2011. The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling. Neuroscience 199, 116-124.
Topham, M.K., 2006. Signaling roles of diacylglycerol kinases. Journal of cellular biochemistry 97, 474-484.
Topham, M.K., Prescott, S.M., 2001. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. The Journal of cell biology 152, 1135-1143.
Valjent, E., Corvol, J.C., Pages, C., Besson, M.J., Maldonado, R., Caboche, J., 2000.
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J Neurosci 20, 8701-8709.
Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.C., Stipanovich, A., Caboche, J., Lombroso, P.J., Nairn, A.C., Greengard, P., Herve, D., Girault, J.A., 2005. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proceedings of the National Academy of Sciences of the United States of America 102, 491-496.
van Enkhuizen, J., Geyer, M.A., Kooistra, K., Young, J.W., 2013. Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 16, 1021-1031.
Verebey, K., Kogan, M.J., Mule, S.J., 1981. Phencyclidine-induced stereotype in rats:
effects of methadone, apomorphine, and naloxone. Psychopharmacology 75, 44-47.
Volkow, N.D., Wang, G.J., Fowler, J.S., Gatley, S.J., Logan, J., Ding, Y.S., Hitzemann, R., Pappas, N., 1998. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 155, 1325-1331.
84
Wallace, H., Shorvon, S., Tallis, R., 1998. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 352, 1970-1973.
Wang, A.Y., Lohmann, K.M., Yang, C.K., Zimmerman, E.I., Pantazopoulos, H., Herring, N., Berretta, S., Heckers, S., Konradi, C., 2011. Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region. Acta neuropathologica 122, 615-626.
Weber, H., Kittel-Schneider, S., Gessner, A., Domschke, K., Neuner, M., Jacob, C.P., Buttenschon, H.N., Boreatti-Hummer, A., Volkert, J., Herterich, S., Baune, B.T., Gross-Lesch, S., Kopf, J., Kreiker, S., Nguyen, T.T., Weissflog, L., Arolt, V., Mors, O., Deckert, J., Lesch, K.P., Reif, A., 2011. Cross-disorder analysis of bipolar risk genes:
further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacology 36, 2076-2085.
Willner, P., 1984. The validity of animal models of depression. Psychopharmacology 83, 1-16.
Yan, Z., Feng, J., Fienberg, A.A., Greengard, P., 1999. D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proceedings of the National Academy of Sciences of the United States of America 96, 11607-11612.
Yasuda, S., Kai, M., Imai, S., Takeishi, K., Taketomi, A., Toyota, M., Kanoh, H., Sakane, F., 2009. Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. The Journal of biological chemistry 284, 29559-29570.
Zhang, L., Lou, D., Jiao, H., Zhang, D., Wang, X., Xia, Y., Zhang, J., Xu, M., 2004.
Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 24, 3344-3354.
Zhou, M., Rebholz, H., Brocia, C., Warner-Schmidt, J.L., Fienberg, A.A., Nairn, A.C., Greengard, P., Flajolet, M., 2010. Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proceedings of the National Academy of Sciences of the United States of America 107, 4401-4406.
85
Zhu, Z.Q., Armstrong, D.L., Hamilton, W.J., Grossman, R.G., 1997. Disproportionate loss of CA4 parvalbumin-immunoreactive interneurons in patients with Ammon's horn sclerosis. Journal of neuropathology and experimental neurology 56, 988-998.
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略語一覧表
5-HIAA ： 5-hydroxy indol-3-acetic acid 5-HT ： 5-hydroxytryptamine hydrochloride ABC ： Avidin Biotinylated Enzyme complex ADHD ： attention deficit hyperactie disorder
AMPA ： α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid DA ： 3,4-dihydroxyphenylethylamine
DAB ： diaminobenzidine DAT ： dopamine transporter DG ： diacylglycerol DG ： dentate gyrus
DGK ： diacylglycerol kinase DMSO ： dimethyl sulfoxide
DOPAC ： 3,4-dihydroxyphenyl acetic acid EDTA ： ethylenedinitrilotetraacetic acid ERK ： extracellular signal-regulated kinase GABA ： γ-animobutyric acid
GluR1 ： glutamate receptor 1 GPCR ： G-protein-coupled receptor GSK-3 ： glycogen synthase kinase-3 IP3 ： inositol trisphosphate
IS ： internal standard
MARCKS ： myristoylated alanine-rich protein kinase C substrate
MEK ： mitogen-activated protein kinase/extracellular signal-regulated kinase kinase MPH ： methylphenidate
NMDA ： N-methyl-D-aspartate
Ola ： olanzapine
PA ： phosphatidic acid PB ： phosphate buffer PBS ： phosphate buffer saline PH ： pleckstrin homology
PI4P5-kinase ： phosphatidylinositol 4-phosphate 5-kinase PIP2 ： phosphatidylinositol 4,5-bisphosphate PKC ： protein kinase C
PLC ： phospholipase C