本研究を遂行するにあたり、GLUT5 安定発現系 CHO-K1 細胞を分与いただきました、
前橋工科大学工学部生物工学科食品生理機能工学研究室の薩 秀夫 准教授に深甚た る感謝の意を表します。
本研究を遂行するにあたり、幾多の御助言、御指導を賜りました名古屋市立大学大学院 薬学研究科薬物動態制御学分野 井上 勝央 准教授に深く感謝致します。
本研究を遂行するにあたり、幾多の有益な御助言、御指導を賜りました本学大学院薬 学研究科生薬学分野 寺坂 和祥 講師、石内 勘一郎 助教に深く感謝致します。
本研究を遂行するにあたり、RI 施設での実験をサポート頂きました RI 管理室の皆様 に深く感謝致します。
本研究を遂行するにあたり、様々な御助言、御討論、ご協力をして頂きした本学大学 院薬学研究科生薬学分野の皆様に深く感謝致します。
本研究を遂行するにあたり、幾多の御懇篤な御指導、御鞭撻を賜りました名古屋市立大 学大学院薬学研究科生薬学分野 水上 元 名誉教授(現高知県立牧野植物園園長)に深甚 たる感謝の意を表します。
最後に、本研究を遂行するにあたり、終始詳細な御助言、御指導をして頂きした本学 大学院薬学研究科生薬学分野 牧野 利明 教授に心底より感謝致します。
参考文献
1) 一般財団法人医薬品医療機器レギュラトリーサイエンス財団編 (2016) 第十七改正 日本薬局方. じほう, 東京.
2) 神戸中医学研究会編 (2011) 中医臨床のための中薬学. 東洋学術出版社, 東京.
3) De Souza LR, Jenkins AL, Sievenpiper JL, Jovanovski E, Rahelic D, and Vuksan V (2011) Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: differential effects on postprandial glycemia in healthy individuals. J Ethnopharmacol 137:245250.
4) Shishtar, E, Sievenpiper, JL, Djedovic, V, Cozma, AI, Ha, V, Jayalath, VH, Jenkins, DJ, Meija, SB, de Souza, RJ, Jovanovski, E, Vuksan, V (2014) The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLOS One 9: e107391.
5) 田代眞一 (2000) 漢方薬の正しい使い方〜漢方薬の薬理作用.Pharma Medica 18:
1317, 2000.
6) Akao T, Kida H, Kanaoka M, Hattori M, and Kobashi K (1998) Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 50:11551160.
7) Akao T, Kanaoka M, and Kobashi K (1998) Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration–measurement of compound K by enzyme immunoassay. Biol Pharm Bull 21:245249.
8) Lee J, Lee E, Kim D, Yoo J, and Koh B (2009) Studies on absorption, distribution and metabolism of ginseng in humans after oral administration. J Ethnopharmacol 122:143148.
9) Tawab MA, Bahr U, Karas M, Wurglics M, and Schubert-Zsilavecz M (2003) Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31:10651071.
10) Munekage M, Kitagawa H, Ichikawa K, Watanabe J, Aoki K, Kono T, and Hanazaki K (2011) Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers.
Drug Metab Dispos 39:17841788.
11) Liu H, Yang J, Du F, Gao X, Ma X, Huang Y, Xu F, Niu W, Wang F, Mao Y, Sun Y, Lu T, Liu C, Zhang B, and Li C (2009) Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metab Dispos 37:22902298.
12) Han M and Fang XL (2006) Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 27:499505.
13) Han M, Sha X, Wu Y, and Fang X (2006) Oral absorption of ginsenoside Rb1 using in vitro and in vivo models. Planta Med 72:398404.
absorption in rats. J Pharm Pharmacol 61:347352.
15) Xiong J, Sun M, Guo J, Huang L, Wang S, Meng B, and Ping Q (2009) Active absorption of ginsenoside Rg1 in vitro and in vivo: the role of sodium-dependent glucose co-transporter 1. J Pharm Pharmacol 61:381386.
16) Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, and Wright EM (2011) Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol 300:C1421.
17) Yang Z, Wang JR, Niu T, Gao S, Yin T, You M, Jiang ZH, and Hu M (2012) Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora. Drug Metab Dispos 40:15381544.
18) Chang TC, Huang SF, Yang TC, Chan FN, Lin HC, Chang WL. (2007) Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression. J Agric Food Chem 55:1993-1998.
19) Han, M, Fang, XL (2006) Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 27: 499505.
20) Brunet, JL, Maresca, M, Fantini, J, Belzunces, LP (2004) Human intestinal absorption of imidacloprid with Caco-2 cells as enterocyte model. Toxicol Appl Pharmacol 194: 19.
21) Jiang, S, Ren, D, Li, J, Yuan, G, Li, H, Xu, G, Han, X, Du, P, An, L (2014) Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus. Fitoterapia 95: 5864.
22) Wang, CW, Su, SC, Huang, SF, Huang, YC, Chan, FN, Kuo, YH, Hung, MW, Lin, HC, Chang, WL, Chang, TC (2015) An essential role of cAMP response element binding protein in ginsenoside Rg1-mediated inhibition of Na+/glucose cotransporter 1 gene expression. Mol Pharmacol 88: 10721083.
23) 高山宏世 (2013) 腹証図解 漢方常用処方解説. 泰晋堂, 東京 24) 合田幸弘,袴塚高志 (2013) 新一般用漢方の手引き. じほう, 東京.
25) Lin, CH, Kuo, YH, Shih, CC (2014) Effects of bofu-tsusho-san on diabetes and hyperlipidemia associated with AMP-activated protein kinase and glucose transporter 4 in high-fat-fed mice. Int J Mol Sci 15:2002220044.
26) Qian, W, Hasegawa, J, Tsuno, S, Endo, Y, Matsuda, A, Miura, N. (2014) Effects of kampo formulas on the progression of hypercholesterolemia and Fatty liver induced by high-cholesterol diet in rats. Yonago Acta Med 57: 147158.
27) Azushima, K, Tamura, K, Wakui, H, Maeda, A, Ohsawa, M, Uneda, K, Kobayashi, R, Kanaoka, T, Dejima, T, Fujikawa, T, Yamashita, A, Toya, Y, Umemura, S (2013) Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity. PLoS One 8: e75560.
28) Park, J, Bose, S, Hong, SW, Lee, DK, Yoo, JW, Lim, CY, Lee, M, Kim, H (2014)