図 15. 移植部位では移植後早期に STAT3 の活性化が誘導される
5. 脱細胞化組織移植技術を用いたさらなる研究により子宮再生機序の解明が進み、
子宮再生医療の発展が期待されるだけでなく、異所性子宮内膜増殖を本態とする 子宮腺筋症や子宮内膜症の病態解明につながる可能性がある。
55
おわりに
本研究では、子宮再生を評価する実験モデル、マウス脱細胞化組織移植モデルを確
立し、
STAT3
が子宮の再生に重要な役割を果たしていることを確認した。子宮内膜や子宮の先天的・後天的な欠損は不妊治療における克服困難な課題の一つであり、子宮 再生医療はこの難題に革新的な解決策を見出す可能性がある。月経ごとに脱落と再生 を繰り返し高い再生能を有すると考えられる子宮内膜においてもその再生機序や幹 細胞の存在は不明であり、それらを解明する有力な実験系が確立されていないのが子 宮再生研究の現状といえる。この点において、子宮内膜や子宮の再生を生体内で人工 的に誘導し、遺伝子改変技術も組み合わせて再生過程を検証する本モデルは、画期的 な実験手法であると考えられる。将来的には再生を促進する物質の同定や、それと脱 細胞化組織移植を組み合わせることによる臨床応用などへの発展が期待される。また、
子宮内膜の再構築に関わっていると推定される分子経路は、子宮内膜症や子宮腺筋症 の発症や増悪とも関連している可能性があり、これらの疾患の病態解明という点につ いても今後さらに研究を発展させてゆきたいと考えている。
謝辞
本研究を遂行するにあたり、終始ご指導いただきました廣田泰講師、藤井知行教授、
大須賀穣教授に心よりお礼を申し上げます。
56
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