Kanai， A. and N atori， S.(1989) Cloning of gene cluster for sarcotoxin 1，
antibacterial proteins of Sarcophaga peregrina. FEBS Lett.， 258，
199-202.
Kanost， M. R.， Dai， W. and Dunn， E. (1988) Peptidoglycan fragments elicit antibacterial protein synthesis in larvae of Manduca sexta.
Arch. Insect Biochem. Physiol.， 8， 147-164.
Kappler， C.， Meister， M.， Lagueux， M.， Gateff， E.， Hoffmann， A and
ReichhartヲJ-M. (1993) Insect immunity. Two 17 bp repeats nesting a B-related sequence confer inducibility to the diptericin gene andbind a polypeptide in bacteria-challenged Drosophila. EMBO J.ヲ12，
Drosophila compact gene cluster involved in the response to infection. EMBO J.， 9， 217-224.
Kyte， J. and Doolitle， R. F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol.， 157， 105-132.
Lackie， A. M. (1988) Haemocyte behaviour. Adv. Insect Physiol.ヲ21，85-178.
LambertヲJ.，Keppi，E.， DimarcqヲJ.-L.，Wicker， C.， ReichhartヲJ.-M.，
Dunbar， B.， Lepage， P.， Dorsselaer， A. V.， HoffmarしJ.ヲFothergillラJ.and Hoffman， D. (1989) Insect immunity: isolation from immune blood of the
dipteran
Phormia terranova e
of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proc Natl. Acad. Sci. USA， 86，262-26.Lee， J.-Y， Boman， A.， Chuanxin， S.， Andersson， M.フJrnvall，H.ヲMutt， V.
and Lenardo， M. and Baltimore， D. (1989) Antibacterial peptides from pig intestine: Isolation of a mammalian cecropin. Proc. N atl. Acad. Sci. USA，
86，9159-9162.
Lehrer， R. I.， Ga回，T. and Selsted， M. E. (1991) Defensins: Endogenous antibiotic peptides of animal cells. Cell， 64， 229-230.
Lenardo， M. and Baltimore， D. (1989) NF- KB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell， 58， 227-229.
Lidhol肌D.-A.，Gudmundsson， G. H. and BomanヲH. G. (1991) A highly repetitive， mariner-like element in the genome of均Jalophora
cecropia. J. Biol. Chem.， 266， 11518-11521.
Low， B. (1968) Formation of merodiploids in matings with a class of rec
recipient strains of Escherichia coli K12. Proc. Natl. Acad.
Sci. U.S.A， 60， 160-167.
Maniatis， T.， Fritsch， E. F. and Sambrook， J. (1982) Molecular Cloning: A Laboratory Manual， Cold Spring Harbor Laboratory， Cold Spring Harbor， New York.
松尾 寿之・水野 健作・児島将康(1988)神経ペプチド. タンパク質11
-構造 と 機能編- (勝部・京極・崎山・高木・中川編
)
pp. 393-411.東京化学同人，東京.
Matsuyama， K. and N atori， S. (1988) Molecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrÍlza. J. Biol. Chem.ヲ263，17117-17121.
Miyata， T.， Tokunaga， F.， Yoneya， T.， Yoshikawa， K.ヲ1wanaga，SヲNiwa，
M.， TakaoヲT. and Shimonisi， Y. (1989) Antimicrobial peptides，
isolated from horseshoe crab hemocytes， tachyplesin 11ヲand
polyphemusins 1 and 11: Chemical structures and biological activity
.
J.Biochem.， 106， 663-:668.
Mori， S.， 1zumi， S. and Tomino， S. (1991) Structures and organization of major plasma protein genes of the silkworm Bombyx mori. J. Mol.
Biol.， 218，7-12.
Morishima， 1.， Suginaka， S.， Ueno， T and Hirano， H. (1990) 1solation and structure of cecropins， inducible antibacterial peptides， from the silkworm， Bombyx mori. Comp. Biochem. Physiol.， 95B， 551-554.
Murray， S. E.， Brammar， W. J. and Murray， K. (1977) Lambdoid phages that simplify the recovery of in vitro recombinants. Molec. Gen.
Genet.， 150，53-61.
Nakajima， Y.， Qu， X.- m. and Natori， S. (1987) Interaction between liposomes and Sarcotoxin IA， a potent antibacterial protein of
Sarcophaga peregrina (flesh fly). J. Biol. Chem.， 262ヲ1665-1669.
Okada， M. and N atori， S. (1983) Purification and characterization of an antibacterial protein from haemolymph of Sarcophaga peregrina (fresh fly) larvae. Biochem. J.ラ211 ，727-734.
Okada， M and Natori， S. (1985) Primary structure of Sarcotoxin 1， an antibacterial protein induced in hemolymph of Sarcophaga peregrina
(flesh fly) larvae. J. Biol. Chem.， 260， 7174-7177.
Powning， R. F. and Davidson， W. J. (1973) Studies on insect bacteriolytic enzymes. 1. Lysozymes in haemolymph of Galleria mellonella and Bombyx nlori. Comp. Biochem. Physiol.， 45Bヲ669-68 1.
Qu， X.-m.， Steiner， H.， Engstrom， A.， Bennich， H and Boman， H. G.
(1982) Insect immunity: Isolation and structure of cecropin B and D from pupae of the chinese oak silk moth， Antheraea pernyi. Eur. J.
Biochem.， 127， 2 19-224.
Reichhart， J -M汁Meister，M.， Dimarcq， J.-L.， Zachary， D.， Hoffman， D.，
RuizヲC.，RichardsヲG and Hoffman， J. A. (1992) Insect immunity:
developmental and inducible activity of the
Drosophila
diptericinpromoter. EMBO J.， 11， 1469-1477.
Rogers， J.， Goedert， M. and Wilson， P. W. (1988) An extra sequence in the lambda EMBL3 p o lyl i
nk e
r.Nucl. Acids Res.， 16ラ1633.
Samakovlis， C.， Kimbrell， D. A.， Kylsten， P .， Engstromヲ入. and
Hultmark， D. (1990) The immune response in Drosophila: pattern of cecropin expression and biological activity . EMBO J.ヲ9，2969-2976.
Samakov lis， C.，λsling， B.ヲBoman，H. G.， Gateff， E. and HultmarkラD.
(1992)
In vitro
induction of cecropin genes-an immune response in aDrosophila
blood cell line. Biochem. Biopys. Res. Commun.ラ188，1169- 1175.
Sa時er，F.， Nicklen， S. and CoulsonヲA. R. (1977) DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A.， 74，5463-5467.
Seeger， M. A.ヲHaffley，L. and Kaufman， T. C. (1988) Characterization of amalgam: a member of the immunoglobulin superfamily from
Drosophila. Cell， 55， 589-600.
Sen， R. and Baltimore， D. (1986) Inducibility of immunoglobulin enhancer-binding protein NF-B by a posttranslational mechanism.
Cell， 47， 921-928.
Shiba， T.， Ueki， Y.， Kubota， 1.， Teshima， T.， Sugiyama， Y.， Oba， Y. and
KikωhiヲM. (1983) Structure of Lepidopteran， a self- defense substance produced by silkworm. Peptide Chem. (E. Munekata， ed.)， pp.209-214.
Protein Research Foundation， Osaka.
Shiraishi， A. and N atori， S. (1988) Humoral mediator-dependent activation of the Sarcophaga lectin gene. FEBS Lett.， 232， 163-166.
Shiraishi， A. and N atori， S.(1989) Humoral factor activating the
Sarcophaga
lectin gene in cultured fat body. Insect Biochem.，19ヲ261-267.
Shaw， G. and Kamen， R. (1986) A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell， 46，.659-667・.
Southern， E. M. (1975 ) Detection of specific sequen∞s among DNA fragments separated by gel electrophoresis. J. Mol. Biol.， 98， 503-517.
Steiner， H.， Hultmark， D.， Engström， A.， Bennich， H. and Boman， H. G.
(1981) Sequence and specificity of two antibacterial proteins
involved in insect immunity. N atureヲ292ヲ246-248.Steiner， H.， Andreu， D. and Merrifield， R. B. (1988) Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects. Biochim. Biophys. Acta， 939， 260-266.
Sumida， M.ヲIchimori， H.， Yuhki， T.， Mori， H and Matsubara， F. (1992) Induction of antibacterial activity in the haemolymph of the
silkwormヲBombyx
mori
by injection of formalin-treatedEscherichia coli
K-12 in the anterior and posterior body part of the ligated larvae. Comp. Biochem. Physiol. 101B， 173-178.Sun， S.-C.， Lindstめm， 1.， Boman， H. G.， Faye， I. and Schmidt， O. (1990) Hemolin: an insect-immune protein belonging to the immunoglobulin superfamily. Science， 250， 1729-1732.
Sun， S.-C.， Asling， B. and Faye， I. (1991a) Organization and expression of
the immunoresponsive lysozyme gene in the giant silk moth，
めlalophora cecropia.
J. Biol. Chem.， 266， 6644-6649.
Sun， S-C.， Lindström， 1.， Lee， Y. and Faye， 1. (1991b) Structure and expression of the attacin genes
on的alophora cecropia.Eur. J.
Biochem.， 196. 247-254.
Sun， S.-C. and Faye， 1 (1992) Cecropia immuno代sponsive facto巳an insect immunoresponsive factor with DNA-binding properties similar to nuclesr-factor B. Eur. J. Biochem.， 204， 885-892.
Takahashi， H.， Komano， H. and N atori ，S. (1986) Expression of the lectin gene in Sarcophaga p ereg rina during normal development and under conditions where the defence mechanism is activated. J. Insect
Physiol.， 32， 771-779.
Taniai， K.， Kato， Y.， Hirochika， H. and Yamakawa， M. (1992) Isolation and nucleotide sequence of cecropin B cDNA clones from the silkworm， Bombyx mori. Biochim. Biophys. Acta， 1132， 203-206.
Teshima， T.， Ueki， Y.， Nakai， T and Shiba， T.， KikuchiヲM. (1986)
Structure determination of Lepidopteran， self-defence substance produced by silkworm. Tetrahedron， 42， 829-834.
Teshima， T.， Nakai， T.， Ueki， Y.， Shiba， T. (1987) Structure
determination of Lepidopteran Cヲself-defence substance produced by silkworm
(Bombyx mori).
Tetrahedron， 43ヲ4513-4518.Trenczek， T. and Faye， 1. (1988) Synthesis of immune proteins in primary cultures of fat body from
局lalophora cecropia.Insect Biochem.， 18，
299-312.
Tryselius， Y.ヲSamakovlis， C汁Kimbrell， D. A. and HultmarkヲD. (1992) CecC， a cecropin gene expressed during metamorphosis in
Drosophi la pupae. Eur. J. Biochem.， 204， 395-399.
Tu， Y-Z.， Qu， X.-M. and Xu， T.-S. (1989) Purification， characterization
and structure of CM2Ph1， an antibacterial peptide from Bombyx
n10rÍ. Sci. in China. 32， 1072-1081.
Wade， D.， Boman， A.， Waohlin， B.， Drain， C. M.， Andreu， D.， Boman， H.
G. and Me凶field，R. B. (1990) All-D amino acid-containing
channel-forming antibiotic peptides. Proc. Natl. Acad. Sci. USA， 87，
4761-4765.
Wago， H. (1983) Cellular recognition of foreign materials by Bon1byx morÍ phagocytes: 11. Roleof hemolymph and phagocyte filopodia in the cellular reactions. Dev. Comp. lmmunol.， 7， 199-208.
和合 治久 (1983) 昆虫の生体防御1. 海鳴社. 東京・
Wago， H. (1990) Phagocytic recognition in BOn'lbyx 1110rÍ. Immunology of insects .and other anthropods (Gupta， A. P. ed.) pp. 216-235. CRC
press， Boca Raton， FL.
Yamakawa， M.， Shirata， A.， Taniai， K. and Miyamoto， K. (1990) Effects of the hemolymph from Bon1byx morÍ， immunized with
Escherichia coli， on the proliferation of plant pathognic bacteria.
Agric. Biol. Chem.， 54， 2175-2176.
Yoshida， H.， Ochiai， M. and Ashida， M. (1986)β-1，3-gIucan receptor and peptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system. Biochem. Biophys. Res.
Commun.， 141，1177-1184.
Xanthopoulos， K. G.， Lee， J.-Y， Gan， R.， Kockum， K.， Faye， 1. and Boman， H. G. (1988) The structure of the gene for cecropin B， an antibacterial immune protein
from同Jalophora cecropia.Eur. J.
Biochem.， 172， 371-376.
Zasloff， M. (1987) Magainins， a class of antimicrobial peptides from
Xenopus
skin: Isolation， Characterization of two active formsフand partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA，84， 5449-5453.