・圃 - 業績集 : 滋賀医科大学内科学講座呼吸循環器内科 2002～2012

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158

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• Horie M: Bi‑directional ventricular tachycardia revised. J Arrhyth

m .

26: 3‑4，2010

. Itoh H， Shimizu W， Hayashi K， Yamagata K， Sakaguchi T， Ohno S， Makiyama T， Akao M， Ai T， Noda T，恥1iyazakiA， Miyamoto Y， Yamagishi M， Kamakura S， Horie M: Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study. Heart Rhyth

m .

7・1411‑1418，2010

• Matsumoto T， Takashima H， Nakae 1， Yamane T， Hayashi H， Horie M; for th巴SPAIC (Shiga tissue Plasminogen Activator In Coronary circulation) Investigators Angiot巴nsin‑converting enzyme inhibition augments coronary release of tissue plasminogen activator in women but not in men. Hypertension 56(3): 364‑368，2010

• Yoshino T， Nakae 1， Matsumoto T， Mitsunami K， Hori巴M:Relationship between exercise capacity and cardiac diastolic function assessed by time‑volume curve from 16イramegated myocardial perfusion SPECT Ann Nucl Med. 24: 469‑476， 2010.

・

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M， Kawamura M， Matsuura H， Horie M: Atrioventricular block‑induced Torsades de Pointes with clinical and molecular backgrounds similar to ongenital long QT syndrome. Circ J 17: 2535‑2571， 2010.

• Nagaoka 1， Shimizu W， Mizusawa Y， Sakaguchi T， Itoh H， Ohno S， Makiyama T， Yamagata K， Makimoto H， Miyamoto Y， Kamakura S， Horie M: Heart rate‑dependent variability of cardiac巴ventsin type 2 cong巴nitallong‑QTsyndrome. Europace 12: 1623・1629，2010

・

^H^a^y^a^s^h^iH^，^Mi^yamoto A^，^I^s^hⁱ^d^a^K^，^Yoshino T^，^Sugimoto Y^，^l^t^o^M^，^H^o^rⁱ^e^M:^P^r^e^v^a^l^eⁿ^c^e^加^d

QT intervaJ of early repolarization in a hospital‑based population. J Arrhyth

m .

26: 127‑133， 2010

• Nakae 1， Mitsunami K， Yoshino T， Omura T， Tsutamoto T， Matsumoto T，恥10rikawaS Inubushi T，日orieM: Clinical features of myocardial triglyceride in differ巴nttypes of cardiomyopathy assessed by proton magnetic resonance spectroscopy: Comparison with myocardial creatine. J Card Fai .l16: 812‑822，2010.

• Yam勾iM， Tsutamoto T， Kawahara C， Nishiyama K， Yamamoto T， Fujii M， Horie M: Effect of eplerenone versus spironolactone on cortisol and hemoglobin a 1 (c) levels in patients with chronic heart fai lure. A m Heart J 160: 915‑921， 2010

【

2009

】

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^I^k^r^a^r^T^，^H^a^nawa^H^，^Watanabe^H^，^Aiz^a^wa Y^，^Ramadan¹^¥^品¹^，^C^hⁱⁿ^u^s^hⁱ^M^，^H^o^rⁱ^e^M^，^Aizawa

y: Evaluation of channel function after alteration of amino acid residues at the pore center ofKCNQl channel BBRG. 378(3): 589‑594，2009

• Kawamura恥f，Ozawa T， Yao T， Ashihara T， Sugimoto Y， Yagi T， Itoh H， Ito M， Makiyama T， Horie M: Dynamic change in ST‑segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long‑term follow‑up. Circ J 73: 584‑588，2009

• Wu J， Ding W G， Matsuura H， Tsuji K， Zang WJ， Horie M Inhibitory actions of th巴

phosphatidylinositol 3・kinaseinhibitor LY294002 on the human Kv1.5 channel BげtJ Phar

m .

156: 377‑387.2009

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

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• Zankov DP， Yoshida H， Tsuji K， Toyoda F， Ding W G， Matsuura H， Horie M: Adrenergic regulation of th巴 rapidcOl11ponent of delayed rectifier K + current: Implications for arrhythmogenesis in LQT2 patients. Heart Rhyth

m .

6(7): 1038‑1046，2009

・ItohH， Sakaguchi T， Ashihara T， Ding G W， Nagaoka 1， Oka Y， Nakazawa Y， Yao T， Jo H， Ito M， Matsuura H， Horie M: A novel KCNH2 mutation as a modifier for short QT interva .l Int J Cardiol. 137(1): 83・85，2009.

• Nakazawa Y， Ashihara T， Tsutamoto T， Ito M， Horie M: Endothelin‑l as a pr巴dictorof atrial fibrillation recurrence after pulmonary vein isolation. Heart Rhythm. 6(6) 725‑730，2009

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^OhnoS^，^Toyoda F^，^Zankov D^，^Y^o^s^hⁱ^d^a^H^，^Makiyama T^，^T^s^u^jⁱ^K^，^Honda T^ヲ ^O^b^a^y^a^s^h^iK^，

Matsuura H， Shimizu W， Miyal11oto Y， Kal11akura S， Kita T， Horie M: Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome Hum Mutat. 30・557・563，2009.

• Ogawa S， Yamashita T， Yamazaki T， Aizawa Y， Atarashi H， Inoue H， Ohe T， Ohtsu H， Okumura K， Katoh T， Kamakura S， Kumagai K， Kurachi Y， Kodama 1， Koretsune Y， Saikawa T， Sakurai M， Sugi K， Tabuchi T， Nakaya HラNakayal11aT， Hirai M， Fukatani Mラ

Mitamura H; J‑RHYTl也1Investigators: Optil11al treatment strategy for patients with paroxysmal atrial fibrillation: J‑RHYTHM Study. Circ J. 73 242‑248，2009

• Yamashita T， Ogawa S， Sato

工

AizawaY， Atarashi H， Fujiki A， lnoue H， Ito M， Katoh T， Kobayashi Y， Koretsune Y， Kumagai K， Niwano S， Okazaki 0， Okumura K， Saku K， Tanabe T， Origasa H; J‑BAF Investigators: Dose‑response巴ffectsof bepridil in patients with persistent atrial fibrillation monitored with transteJephonic electrocardiograms: a multicenter， randomized， placebo‑controlJed， double‑blind study (J‑BAF Study) Circ J. 73:

1020‑J 027. 2009

• Zankov DP， Toyoda F， Omatsu‑Kanbe M， Matsuura M， Horie M・AngiotensinIl typ巴l receptor l11ediates partially hyposmotic‑induced increase of IKs current in guinea pig atrium. Pflugers Arch. 458: 837^白849，2009

• Nishio Y， Makiyama T， Itoh H， Sakaguchi T， Ohno S， Gong Y‑Z， Yamamoto S， Ozawa T， Ding W‑G， Toyoda F， Kawamura M， Akao M， Matsuura H， Kita T， Horie M: D85N， a KCNEl polymorphism， is a disease‑causing gene variant in long QT syndrome. J A m CoII Cardiol. 54(9): 812・819，2009

・

^TamakiS^，^Nakamura Y^，^T^a^b^a^r^a^Y^，^Okamura T^，^Kanda H^，^Kⁱ^t^a^Y^，^Kadowaki T^，^T^s^u^jⁱ^t^a^Y^，

Turin T C， Horie M， Miki T， Ueshima H Association between polymorphisl11 of the AGTRl and cardiovascular events in a Japanese general sample (The Shigaraki Study). Int J Cardiol. 136(3) 354‑355，2009

・

^Iⁿ^o^u^eH^，^F^u^jⁱ^kⁱ^A^ラ^O^rⁱ^g^a^s^aH^，^Ogawa S^，^Okumura^K^，^Kubota 1^，^Aizawa Y^，Yamashita T， Atarashi H， Horie M， Oh巴T，Doi Y， Shil11izu A， Chishaki A， Saikawa T， Yano K， Kitabatake A， Mital11ura H， Kodal11a 1， Kal11akura S Prevalence of atrial fibrillation in the general population of Japan: An analysis based on p巴riodicheaJth exal11ination. Int J Cardiol. 137 102‑107，2009

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^OkamuraT^，^Sekikawa A^，^Kadowaki T^，^E^J^‑^S^a^e^d^A^，^A^b^b^o^t^t^DR^，^Curb^JD^，^Ed^l¹¹^undowicz D^，

Nakal11ura Y， Murata K， Kashiwagi A， Kil11 ST， Evans R W， Zmuda品1，Maegawa H，

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

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159

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160

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Hozawa A， Mitsunami K， Nisio Y， Iva M G， Horie M， Miyamastu N， Murakami Y， Kuller LH， Ueshima H: Cholesteryl ester transfer protein， coronary calcium and intima‑media thickness of the carotid artery in middle‑aged Japan巴semen. Am J Cardiol. 104(6) 818‑822， 2009

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^NishiyamaK^，Tsutamoto T， Tanaka T， Fujii M， Yamamoto T， Yamaji M， Horie M: Plasma NT・‑proBNPas a more reliable biomarker of endogenous car・diacnatriuretic peptides Than BNP during carperitide infusion. Int Heart J. 50(2) 183‑190，2009

• Yam勾iM， Tsutamoto T， Tanaka T， Kawahara C， Nishiyama K， Yamamoto T， Fujii M， Horie M: Effect of carvedilol on plasma adiponectin concentration in patients with chronic heart failure. Circ J. 73: 1067‑1073，2009.

• Kamakura S， Ohe T， Nakazawa K， Aizawa Y， Shimizu A， Horie M， Ogawa S， Okumura K， TsuchihashiにSugiK， Makita N， Hagiwara N， Inoue H， Atarashi H， Aihara N， Shimizu W， Kurita T， Suyama K， Noda T， Satomi K， Okamura H， Tomoike H: Long‑term prognosis of probands with Brugada‑paロern ST‑Elevation in leads VI‑V3. Circ Arrhythm Electrophysiol. 2(5): 495・503ラ2009

• ltoh H， Sakaguchi

工

DingWS， Watanabe E， Watanabe 1， Nishio Y， Makiyama T， Ohno S， Akao M， Higashi Y， Zenda N， Kubota T， Mori C， Ok句imaK， Haruna T， Miyamoto A， Kawamura M， Ishida K， Nagaoka 1， Oka Y， Nakazawa Y， Yao T， Jo H， Sugimoto Y， Ashihara T， Hayashi H， lto M， Imoto K， Matsuura H， Horie M: Lat巴ntgen巴ticbackgrounds and molecular pathogenesis in drug‑induced long QT syndrome. Circ Arrhythm Electrophysiol. 2(5): 511‑523，2009.

• Tsutamoto T， Kawahara C， Yam句iM， Nishiyama K， Fujii M， Yamamoto T， Horie M Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure. Eur J Heart Fai .l11(7): 653‑658，2009

• Tsutamoto TヲTanakaT， Nishiyama K， Yam句iM， Kawahara CヲFujiiM， Yamamoto T， Horie 恥1:Long‑term effect of efonidipine therapy on plasma aldosterone and left ventricular mass

index in patients with巴ssentialhypertension. Hypertens Res. 32(8): 670‑674，2009

• Yam勾iM， Tsutamoto T， Kawahara C， Nishiyama K， Yamamoto T， Fujii M， Horie恥4 Serum cortisol as a useful predictor of cardiac events in pati巴ntswith chronic heart failure Th巴impactof oxidative stress. Circ Heart Fai .l2: 608・615，2009

• Nishiyama K， Tsutamoto T， Yamaji M， Kawahara C， Yamamoto T， Fujii M， Horie恥1:Dose‑

Dependent prognostic effect of carv巴dilolin patients with chonic heart failure: Special reference to ranscardiac gragient ofnorepinephrine. Circ J. 73: 2270‑2275，2009

• Yam句iM， Tsutamoto T， Tanaka T， Kawahara C， Nishiyama K， Yamamoto T， F吋iiM， Horie M: Effect of carperitide on plasma adiponectin levels in acute decompensated h巴artfailur巴

patients with diabetes mellitus. Circ J. 73: 2264‑2269，2009.

• Tsutamoto T， Yamaji M， Kawahara C， Nishiyama K， Fujii M， Yamamoto T， Horie M: Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A 1 c levels in patients with non‑ischaemic chronic heart failure. Eur J Heart Fai .l11(12): 1195‑1201，2009.

• Fu山lf叫<awaY，日Ehar悶aN， Ta加niguch口iiR， Ha釘印nunaY， Oza出saN， Saito N， Doi T， Hoshino K， Tamura T， Shizuta S， Abe M， Toma M， Morimoto T， Teramukai S， Fukushima M， Kita T，

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

循環器内科 -~ヨ・・院ヨ・・市置臨咽E'__.

Kimura T; CREDO‑Kyoto lnvestigators: Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circ J. 2009: 73(8): 1459‑1465

【

2008 】

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^A^s^hⁱ^h^a^r^aT^，^C^oⁿ^s^t^aⁿ^tⁱⁿ^o^J^，Trayanova NA: Tunnel propagation of postshock activations as a unified hypoth巴sisfor fibrillation induction and isoelectric window. Circ Res. 102(6) 737・745.2008

・

^HaradaM^，^Honjo H^，^Yamazaki M^，^Nakagawa H^，^I^s^hⁱ^g^u^r^o^Y^，^Okuno Y^，^A^s^hⁱ^h^a^r^a^T^，^Sakuma

1， Kamiya K， Kodama 1: Moderate hypothermia increases the chance of spiral wave collision in favor of self termination of ventricular tachycardia/fibrillation. A m J Physiol Heart Circ Physiol. 294(4): HI896・H1905，2008

. Ijiri T， Ashihara T， Yamaguchi T， Takayama K， Igarashi T， Namba T， Shimada T， Haraguchi R， Nakazawa K: A procedural method for modeling the purkinje fibers of the h巴art.J Physiol Sci. 58(7): 481‑486， 2008

・

^TakayamaK^，^A^s^hⁱ^h^a^r^a^T^，^I^jⁱ^rⁱ^T^，^I^g^a^r^a^s^hⁱ^T^，^H^a^r^a^g^u^c^hⁱ^R^，^Nakazawa K^:^A s^k^e^t^c^h^‑^b^a^s^e^d

interface for modeling myocardial fiber orientation that considers the layered structure of the ventricles. J Physiol Sci. 58(7): 487・492，2008

• Matsumoto T， Fujita M， Tarutani Y， Yamane T， Takashima H， Nakae 1， Horie M:

Whole‑body periodic acceleration enhances brachial endothelial function Circ J. 72(1) 139‑143，2008

・

^OhnoS^，^Kubota T^，^Y^o^s^hⁱ^d^a^H^，^T^s^u^jⁱ^K^，^Makiyama T^，^Yamada S^，^Kuga K^，Yamaguchi 1， Kita T， Horie M: A novel mutation associated with Jervell and Lange‑Nielsen syndrome in a Japanese family. Circ J. 72(5): 687・693，2008

• Sakaguchi T， Shimizu W， Itoh H， Noda T， Miyamoto A， Nagaoka 1， Oka Y， Ashihara T， Ito M， Tsuji K， Ohno S， Makiyama T， Kamakura S， Horie M: Age‑and genotype‑specific triggers for Iife‑threatening arrhythmia in the genotyped long‑QT syndrome. J Cardiovasc Electrophysiol. 19(8): 794・799，2008.

• Nagaoka 1， Shimizu W， Itoh H， Yamamoto S， Sakaguchi T， Ashihara T， 1to M， Yoshida H， Ohno S， Miyamoto Y， Kamakura S， Akao M， Horie M: Mutation site dependent variability of cardiac events in LQT2 form of congenital long‑QT syndrom. Circ J. 72(5): 694‑699， 2008

• Makiyama T， Akao M， Shizuta S， Doi T， Nishiyama K， Oka Y， Ohno S， Nishio Y， Tsuji K， Itoh H， Kimura T， Kita T， Horie M: A novel SCN5Again‑of‑function mutation M1875T associated with familial atrial fibrillation. J Am ColI Cardiol. 52(16): 1326‑1334，2008

• Yasue H，恥1izunoY， Harada E， Itoh T， Nakagawa H， Nakayama M， Ogawa H， Tayama S， Honda T， Hokimoto S， Ohshima S， Hokamura Y， Kugiyama K， Horie M， Yoshimura M， Harada M， Uemura S， Saito Y: Effects of 3・hydroxy‑3・methylglutarylcoenzyme A reductase inhibition on coronary spasm after withdrawal of Ca‑channel blockers. J A m ColI Cardiol. 51(18): 1742ー1748，2008

• Tsutamoto T， Tanaka T， Sakai H， Nishiyama K， Fujii M， Yamamoto T， Nakae 1， Ohnishi M，

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

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Wada A， Horie M: Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic Peptid巴inpatients with chronic heart failure. Circ J. 72(5)・740‑746， 2008

• Nakae J，ν[atsuo S， Matsumoto T， Mitsunami K， Horie M: Augmentation Index and Pulse Wave Velocity as lndicators of Cardiovascular Stiffness. Angiolog

y .

59 421‑426，2008.

• Matsuo S， Nak句imaK， Horie M， Nakae 1， Nishimura T; The J‑ACCESS lnvestigators Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population Circ J. 72(4): 611・617，2008.

• Tanaka T， Tsutamoto T， Nishiyama K， Sakai H， Fujii M， Yamamoto T， Horie M: lmpact of oxidative stress on plasma adiponectin in patients with chronic heart failure. Circ J. 72(4) 563‑568， 2008

・ TanakaT， Tsutamoto T， Sakai H， Nishiyama K， Fujii I¥孔 YamamotoT， Horie M・Effectof atrial natriuretic peptide on adiponectin in patients with heart failure. Eur J Heart Fail. 10(4): 360・366，2008

• Tamaki S， Nakamura Y， Teramura恥1，Sakai I¥孔 1，Takayama T， Okabayashi T， Kawashima T， Horie M: The factors contributing to whether or not hypertensive patients bring their hom巴bloodpressure record to the outpatient exam. Intern Med. 47(18): 156ト1565，2008

・ MakiyamaT， Akao M， Haruna Y， Tsuji K， Doi T， Ohno S， Nishio Y， Kita T， Horie M:

Mutation analysis of the glycerol‑3 phosphate dehydrogenase‑l Iike (GPDIL) gene in Japanese patients with Brugada syndrome. Circ J. 72: 1705‑1706，2008

・恥1akitaN， Behr E， Shimizu W， Horie M， Sunami A， Crotti L， Schulze‑Bahr E， Fukuhara S， Mochizuki N， Makiyama T， Itoh H， Christiansen M， McKeown P， Miyamoto K， Kamakura S， Tsutsui H， Schwartz P J， Georg巴J.rA，Roden D: The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest.

118(6):2219‑2229，2008

• Yamada H， Yoshida恥1，Nakano Y， Suganami

工

SatohN，恥1itaT， Azuma K， Itohルl， Yamamoto Y， Kamei Y， Horie M， Watada H， Ogawa y: ln vivo and in vitro inhibition of monocyte adhesion to endotheilal cells and endotheilal adhesion molecules by eicosapentaenoic acid. Arteroisc/er Thromb Vasc Bio .l28: 2173‑2179，2008

• Gong YZ， Ding W G， Wu J， Tsuji K， Horie M， Matsuura H Cinnamyl‑3， 4・dihydroxy‑alpha‑cyanocinnamateand nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase Eur J Pharmaco .l600(ト3):18‑25，2008

• Takayama T， Teramura M， Sakai H， Tamaki S， Okabayashi T， Kawashima T， Yamamoto T， Horie恥1，Suzuki T， Asai T: Perforated mitral valve aneurysl11 associated with Libman‑Sacks endocarditis. Intern Med. 47(18): 1605‑1608，2008

• Nakae 1， Matsuo S， Matsumoto T， Horie恥1:Clinical significance of diastolic function as an indicator of myocardial ischemia assessed by 16‑frame gated myocardial perfusion SPECT Ann Nuc/ Med. 22: 677‑683，2008

• Inoue T， Eguchi Y， Matsumoto T， Kijima Y， Kato ，YOzaki Y， Waseda K， Oda H， Seiki K， Node K， Urade Y: Lipocalin‑type prostaglandin D synthase is a power向1biomark巴rfor severity of stable coronary a口erydis巴ase.Atherosclerosis. 201(2): 385‑391，2008.

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

循環器内科 .長..ョ・E吾薗・町・断酒園屋書

1 . ‑

• Sakaguchi T， Itoh H， Ding W G， Tsuji K， Nagaoka J， Oka Y， Ashihara T， Ito M， Yumoto Y， Zenda N， Higashi Y， Takeyama Y， Matsuura H， Horie M: Hydroxyzine， a first generation H1・receptorantagonist， inhibits human ether‑a‑go‑go related gene (田RG)current and causes syncope in a patient with the田 RGmutation. J Pharmacol Sci. 108(4): 462‑471， 2008

• Tsutamoto T， Nishiyama K， Sakai H， Tanaka T， Fujii M， Yamamoto T， Yam句iM， Horie M:

Transcardiac increase in norepinephrine and prognosis in patients with chronic heart failure. Eur J Heart Fail. 10(12): 1208司1214，2008

• Horie M， Ishida K， Nishio Y， Nagaoka 1， Matsui K: Genetic background of arrhythmogenic right v巴ntriculardysplasialCardiomyopathy: Time to start asian r巴gistry.J Arrhythm 24 195‑199，2008

・恥1atsuoS， Nakajima K， Kinuya S， Sato Y， Matsumoto N， Horie M: Cardiac scintigraphic findings of mitochondrial myopathy， encephalopathy， lactic acidosis and stroke‑like episod巴s:A case repo口ExpClin Cardio .l13: 93θ5，2008

• Furukawa Y， Taniguchi R， Ehara N， Ozasa N， Haruna Y， Saito N， Doi T， Hoshino K， Shizuta S， Morimoto T， Imai Y， Teramukai S， Fukushima M， Kita T， Kimura T; CREDO‑Kyoto Investigators: Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease: perspectives from the CREDO‑Kyoto registry. Circ J. 73: 1937・1945，2009

【 2007 】

・ OhnoS， Zankov D， Yoshida H， Tsuji K，恥1akiyamaT， Itoh H， Akao恥1，Hancox JC， Kita T， Horie M: N‑and C‑t巳rminalKCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm. 4(3): 332‑340， 2007

・ TsujiK， Akao M， Tshii T， Ohno S，恥1akiyamaT， Doi T， Haruna Y， Yoshida H， Nakashima T， Kita T， Horie M: Mechanistic basis for the pathogenesis of long QT syndrome caused by a splicing mutation in KCNQ1 gene. J Mol Cell Cardiol. 42(3) 662‑669，2007.

• Tsujita Y， Nakamura Y， Zhang Q， Tamaki S， Nozaki A， Amamoto K， Kadowaki T， Kita Y， Okamura T， Horie M， Ueshima H: The association between high‑density lipoprotein cholesterol level and cholesteryl est巴rtransfer protein taqIB gene polymorphism is influenced by aIcohol drinking in a population‑based sample. Atherosclerosis. 191(1) 199‑205， 2007

・ NagataniY， Takahashi M， Takazakura R， Nitta N， Murata K， Ushio N， Matsuo S， Yamamoto T， Horie M: Multidetectorィowcomputed tomography coronary angiography optimization of image reconstruction phase according to the heart rate. Circ J. 71(1) 112・121，2007

・ TodaH， Ding W G， Yasuda Y.Toyoda F， Ito M， Matsuura H， Horie M: Stimulatory action of protein kinase Cvarepsilon isoform on th巴 slowcomponent of delayed rectifier K(+) current in guinea‑pig atrial myocytes. Br J Pharmacol. 150: 1011‑1021， 2007

• Sakai H， Tsutamoto T， Ishikawa C， Tanaka T， Fujii M， Yamamoto T， Takashima H， Horie M: Direct comparison of brain natriuretic peptid巴(BNP)and N‑terminal pro‑BNP secretion

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

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163

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and extent of coronary a同erystenosis in patients with stable coronary artery disease. Circ J. 71(4): 499‑505，2007

• Matsuo S， Nakae 1， Tsutamoto T， Okamoto N， Horie M: A novel clinical indicator using Tc‑99m sestamibi for evaluating cardiac mitochondrial function in patients with cardiomyopathies. J Nucl Cardiol. 14(2): 215‑220，2007

・

^I^t^o^hH^，^T^s^u^jⁱ^K^，^S^a^k^a^g^u^c^hⁱ^T^，^Nagaoka¹^，^Oka Y^，^Nakazawa Y^，^Yao T^，^J^o^H^，^A^s^hⁱ^h^a^r^a^T^，^I^t^o

M，Hori巴M，Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardio .l121(3): 249‑252，2007

・

^TakashimaH^，Matsumoto T， Nakae 1， Yamane T， Horie M・Cigarettesmoking impairs bradykinin・stimulatedtissue plasminogen activator release in human coronary circulation. Thrombo Res. 120: 791‑796. 2007.

・

^TodoT^，^H^a^r^a^g^u^c^hⁱ^R^，^Namba T^，^Yao T^，^A^s^hⁱ^h^a^r^a^T^，^Hⁱ^g^a^s^hⁱ^恥¹^，^Iⁿ^a^d^a^H^，Nakazawa K Development of Cardiac Arrhythmia Risk Evaluation" system based on computer simulation. Proc IEEE/ICME Int Conf Complex Med Eng 182・185，2007

・

^H^a^r^a^g^u^c^h^iR^，^I^g^a^r^a^s^hⁱ^T^，^Owada S^，^Yao T^，^Namba T^，^A^s^hⁱ^h^a^r^a^T^，^I^k^e^d^a^T^，Nakazawa K Electrophysiological heart simulator equipped with sketchy 3・D modeling. Complex Medical Engineering Springer‑Verlag， 107‑116，2007

• Tsutamoto T， Tanaka T， Sakai H， Ishikawa C， Fujii M， Yamamoto T， Horie M: Total and high molecular weight adiponectin， haemodynamics， and mortality in patients with chronic heart failure. Eur Heart J 28: 1723‑1730. 2007

• Nakae 1， Mitsunami K， Matsuo S， Horie M: Creatine Depletion and Altered Fa町 Acid Metabolism in Diseased Human Hearts Clinical Investigation Using (I)H Magnetic Resonance Spectroscopy and (123)1 BMIPP Myocardial Scintigraphy. Acta Radio .l48(4) 436‑443，2007

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M， Wada Aラ Horie M: Direct comparison of transcardiac difference between brain natnuretlc p巴ptide(BNP) and N‑terminal pro‑BNP in patients with chronic heart failure Eur J Heart Fai .l9(6・7):667嗣673，2007

• Tsutamoto T， Sakai H， Tanaka T， Fujii M， Yamamoto T， Wada A， Ohnishi恥1，Horie M Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure. Circ J. 71: 915‑921，2007

• Horie M， Ito H: Disord巴rsof cardiac repolarization: Long QT and ShOlt QT syndromes Circ J. 71: A50‑A53. 2007

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^Lu^J^，^Zhu SM^，^Zang WJ^，^Xu XL^，^Luo HL^，^Yu XJ^，^Wang SP^，^Kong SS^，^Wu^J^，^H^o^rⁱ^e^M^，^Sun

L: Protective mechanism of adenosine to the rat arterial巴ndothelialdysfunction induced by hydrogen peroxide. 8iol Pharm 8ull. 30(7): 1206‑1211，2007

• Tanaka T， Tsutamoto T， Sakai H， Fujii M， Yamamoto T， Horie M: Effect of efonidipine versus amlodipine on aldosterone in patients with hypertension. Hypertens Res. 30(8) 691‑697， 2007

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^T^s^u^t^a^m^o^t^oT^，^A^s^aⁱ^S^，^Tanaka T^，^S^a^k^aⁱ^H^，Nishiyama K， Fujii M， Yamamoto T， Ohnishi M， Wada A， Saito Y， Horie M: Plasma level of cardiotrophin‑l as a prognostic predictor in

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patients with chronic hemt failure. Eur J Heart Fai .l9(10): 1032‑1037，2007

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^TanakaT^，^T^s^u^t^a^m^o^t^o^T^，^S^a^k^aⁱ^H^，^F^u^jⁱⁱ^M^，^Yamamoto T^，^H^o^rⁱ^巴M:Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertens Res. 30(8): 691・697，2007

• Crotti L， Spazzolini C， Schwartz P， Shimizu W， Denjoy 1， Schulze‑Bahr E， Zaklyazminskaya E， Swan H， Ackerman M， Moss A， Wilde A， Horie M， Brink P， Insolia R， Ferrari G， Crimi G: Th巴 commonlong QT syndrome mutation KCNQ 1/ A341 V causes unusually severe clinical manifestations in patients with different ethnic backgrounds Toward a mutation‑specific risk stratification. Circulation. 116: 2366・2375，2007

• Tsutamoto T， Sakai H， Nishiyama K， Tanaka T， Fujii 1¥久 YamamotoT， Horie M: Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and N‑terminal proBNP and prognosis in patients with chronic heart failure. Circ J. 71(12): 1873‑1878， 2007

• Sumitomo N， Sakurada HラTaniguchiK， Matsumura恥1，Abe 0， Miyashita M， Kanamaru H， Karasawa K， Ayusawa M， Fakamizu S， Nagaoka 1， Horie M， Harada K， Hiraoka M Association of atrial arrhythmia and sinus node dys乱lI1ction in patients with catecholaminergic polymorphic ventricular tachycardia. Circ J. 71(10): 1606‑1609，2007

• Sugimoto T， Hajiro Tフ Flリimoto Tヲ K句yo N， Horie M， Kashiwagi A: Thrombotic microangiopathy in an adult patient with clinically amyopathic dermatomyositis complicated with interstitiallung disease. Lupus. 16(12): 1004‑1005.2007

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^H^a^y^a^s^h^iH^，^S^hⁱ^f^e^r^a^w^Y^，^S^a^t^o^D^，^Nⁱ^h^eⁱ^M^，^Lⁱⁿ^S^，^Chen P^，^G^a^r^fⁱⁿ^k^e^l^A^，^Weiss^N J^，^Qu^Z^:

Dynamic origin of spatially discordant alternans in cardiac tissu巴 BiophysJ. 92 448‑460， 2007

• Namba T， Haraguchi R， Igarashi T， Owada S， Yao T， Ashihara T， Todo T， Ikeda T， Nakazawa K: Developm巴ntof graphical interface for modeling excitation map in the electrophysiological heart simulato. rProc IEEEIICME Int Conf Complex Med Eng 168‑171， 2007

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^TodoT^，^Yao T^，^A^s^hⁱ^h^a^r^a^T^，^H^a^r^a^g^u^c^hⁱ^R^，^Nakazawa K^，^I^k^巴^daT^，^Ohe T

Tdentification of local myocardial repolarization time by bipolar electrode potentiaL J Electrocardiol. 40(SuppL6): S97‑S102， 2007

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^T^a^k^a^g^iM^，^Yokoyama Y^，^Aonuma K^，^Aⁱ^h^a^r^a^N^，^Hⁱ^r^a^o^k^a^M;^f^o^r^t^h^e^J^a^p^aⁿ^I^dⁱ^o^p^a^t^hⁱ^c

ventricular fibrillation study (J‑IVFS) investigators: Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with Brugada syndrome. J Cardiovasc Electrophysiol. 18(12): 1244‑1251，2007

• Nakae 1， Matsuo S， Tsutamoto T， Matsumoto T， Mitsunami K， Horie M: Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT Ann Nucl Med. 21: 315^幽323，2007

【 2006

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^Dohke^，^Wada A^，^I^s^oⁿ^o^T^，^F^u^jⁱⁱ^M^，^Yamamoto T^，Tsutamoto T， Horie M: Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive

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^HatadaK^，Washizuka T， Horie M， Watanabe H， Yamashita F， Chinushi M， Aizawa Y Tumor necrosis factor‑alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway. Biochem Biophys Res Commu

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• Ishikawa C， Tsutamoto T， Fujii恥1，Sakai H， Tanaka T， Horie M: Prediction of mo目alityby high‑sensitivity C‑reactive protein and brain natriuretic Peptide in patients with dilated cardiomyopatby. Circ J. 70: 857‑863，2006

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^LuJ^，^Nishⁱ^T^，^A^s^hⁱ^h^a^r^a^T^，^S^c^hⁿⁱ^d^e^r^N^，^Amano A^，^恥¹^a^t^s^u^d^a^T^，^K^o^t^e^r^a^H^:^Theⁱⁿ^f^l^u^eⁿ^c^e^o^f

activation tim巴onthe contraction force of myocardial tissue: A simulation study. Conf Proc IEEE Eng Med Biol Soc. 1: 2900‑2903，2006.

・ItohH， Horie M， Ito恥1，Imoto K: Arrhythmogenesis in the short‑QT syndrome associated with combined HERG channel gating defl巴ctsA simulation study Circ J. 70(4): 502‑508， 2006.

• Matsuo S， Nakae 1， Matsumoto T， Horie M: Impact of巴ndothelialdysfunction on left ventricular rernodeling a白ersuccessful primary coronary angioplasty for acute l11yocardial infarction: Analysis by quantitative ECG‑gated SPECT. Ann Nucl Med. 20: 57‑62，2006

• Matsuo S， Sato Y， Nakae 1， Masuda D， Matsumoto N， Horie M: Evaluation of cardiac resynchronization therapy in drug‑resistant dilated‑phase hypertrophic cardiomyopathy by

l11eans ofTc‑99m sestamibi ECG‑gat巴dSPECT. Ann Nucl Med. 20(9): 643‑647，2006

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^Nakae¹^，^Matsuo S^，^Koh T^，^Mitsuna^l¹¹ⁱ^K^，^H^o^rⁱ^e^M:^l^o^dⁱⁿ^e^‑¹²³^BMIPP s^cⁱⁿ^tⁱ^g^r^a^p^h^yⁱⁿ^t^h^e

evaluation of patients with heart failure. Acta Radiol. 47: 810・816，2006

• Ozawa T， Ito M， Tal11aki S， Yao T， Ashihara T， Kita Y， Okamura T， Ueshima H， Horie恥4 Gender and age effects on ventricular repolarization abnormality in Japanese g巴neral carriers of G643S common single nucleotide polymorphisl11 of KCNQl gene. Circ J 70(6) 645‑650，2006

• Sakai H， Tsutamoto T， Tsutsui T， Tanaka T， Ishikawa C， Horie M: Serum Level of Uric Acid， Partly Secreted From the Failing Heart， is a Prognostic Marker in Patients With Congestive Heart Failure. Circ J. 70・1006・1011，2006

• Schwartz PJ， Spazzolini C， Crotti L， Bathen J， Denjoy 1， Schulze‑Bahr E， Amlie JP， Timothy K， Shkolnikova M， Berul C， Bitner‑Glindzicz M， Toivonen L， Horie M: Th巴

Jervell and Lange‑Nielsen Syndrome. Molecular basis， natural history， and clinical outcome. Circulation. 113: 783‑790，2006

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^TamakiS^，^Nakamura Y^，^T^a^b^a^r^a^Y^，^Okamura T^，^Kⁱ^t^a^Y^，^Kadowaki T^，^T^s^u^jⁱ^t^a^Y^，^H^o^rⁱ^e^恥¹^，

Miki T， Ueshima H: Relationship between metabolic syndrome and Trp64Arg polymorphism ofthe s3‑Adrenergic receptor gene in a general sample: the Shigaraki study. Hype

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^TamakiS^，^Nakamura Y^，^Y^o^s^hⁱⁿ^o^T^，^Matsumoto^Y^，^T^a^r^u^t^aⁿⁱ^Y^，Okabayashi T， Kawashima T， Horie M: The association between morning hypertension and metabolic syndrome in hypertensive patients. Hypertens Res. 29: 783‑788，2006.

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Targeting of Akt Antagonizes Aspects of Cardiomyocyte Hypertrophy. Proc Natl Acad Sci

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

循環器内科

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S A. 103(32): 11946‑11951，2006.

• Tsutamoto T， Wada A， Sakai H， Ishikawa C， TanalくaT， Hayashi M， Fujii M， Yamamoto T， Dohke T， Ohnishi M， Takashima H， Kinoshita M， Horie M: Relationsbip between renal function and plasma brain natriuretic Peptide in patients with heart failure. J Am ColI Cardiol. 47: 582‑586，2006

• Yaman巴T，Matsumoto T， Nakae 1， Takashima H， Tarutani Y， Tamaki S， Horie M: Impact of paraoxonase polymorphism (QI92R) on endothelial function in intact coronary circulation Hypertens Res. 29(6): 417‑422， 2006

• Zhang CT， Yasuno S， Kuwahara K， Zankov D， Kobori A， Makiyama T， Horie M: Blockade of Angiotensin II type 1 rec巴ptorimproves the arrhythmia morbidity in mice with left ventricular hypelirophy. Circ J. 70(3): 335‑341， 2006

• Zankov DP， Toyoda F， Ding W G， Matsuura H， Horie M: Angiotensin II potentiates IKs potassium current via ATl receptors in guinea‑pig atrial myocytes. Circulation. 113(10) 1278‑1286，2006.

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^Z^ankovDP^，Omatsu‑Kanbe M， Toyoda F， Ding W G， Matsuura H， Isono T， Horie M Response to letter regarding article， "Angiotensin II potentiates the slow component of delayed rectifier K + Current via the ATl receptor in guinea pig atrial myocytes"

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【

2005

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^AibaT^，^S^hⁱ^z^imu W^，^Iⁿ^a^g^a^kⁱ^恥¹^，^Noda T^，^Miyoshi S^，^Ding W‑G^，^Zankov DP^，^Toyoda F^，

恥1atuuraH， Horie M， Sunagawa K: Cellular and ionic mechanism for drug^司inducedlong QT syndrome and effectiveness of verapami .lJ Am ColI Cardiol. 45 300‑307，2005

• Ashihara T， Trayanova NA: Cell and tissue responses to electric shocks. Europace. 7 155・165，2005

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^HamamotoT^，^Tanaka H^，^Mani H^，^Tanabe T^，^F^u^jⁱ^w^a^r^a^K^，^Nakagami T^，^H^o^rⁱ^e^M^，^Oyamada

M， Takamatsu T: 1n situ Ca2+ dynamics of Purkiinje fibers and its interconnection with subjacent ventricular myocytes. J Mol Cell Cardio .l38: 561‑569，2005.

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^H^a^r^a^g^u^c^h^iR^，^I^g^a^r^a^s^hⁱ^T^，^Owada S^，^Yao T^，^Namba T^，^A^s^hⁱ^h^a^r^a^T^，^I^k^e^d^a^T^，^Nakazaw^a^K

Electrophysiological heart simulator equipped with sketchy 3‑D modeling. Proc IEEE/ICME Int Conf Complex Med Eng. 293‑296， 2005

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^I^sⁱ^k^a^w^aC^，Tsutamoto T， Wada A， Fujii M， Ohno K， Sakai H， Yamamoto T， Horie恥f Inhibition of aldosterone and endothelin‑l by carp巴ritidewas attenuated more than one week Infusion in patients with congestive heart failure J Cardiovasc Pharmacol. 46: 513‑518，2005

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^KatoT^，^Muraski^J^，^Chen Y^，^T^s^u^jⁱ^t^a^Y^，^W^a^l^l^J^，^G^l^e^m^b^o^t^s^kⁱ^CC^，^S^c^h^a^e^f^e^r^E^，^B^e^c^k^e^r^l^e^M^，

Sussman 恥1A:Atrial natriur巴tic peptide promotes cardiomyocyte survival by cG恥1P‑dependentnuclear accumulation of zyxin and Akt. J Clin Invest. 115: 2716‑2730， 2005

• Makiyama T， Akao M， Tsuji K， Doi T， Ohno S， Takenaka K， Kobori A， Ninomiya T， Yoshida H， Takano T， Makita N， Yanagisawa F， Higashi Y， Takeyama Y， Kita T， Horie M:

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・恥1atsuoS， Nakamura 1， Yamada T， Uchida 1， Nakae 1， Horie M: EffI巴ctof statin therapy on arterial stiffness in patients with hyperl ipidemia: Shiga pravastatin atherosclerosis study (SHIPAS) group. J Appl Res. 5 397‑401，2005

• Nakae 1， Mitsunami K， Matsuo S， Inubushi T， Morikawa S， Tsutamoto T， Koh T， Horie M Myocardial cr巴atineconcentration in various nonisch巴mich巴artdiseases assessed by 1 H magnetic resonance spectroscopy. Circ J 69・711‑716，2005

• Nakae 1， Mitsunami K， Matsuo S， Inubushi T， Morikawa S， Koh T， Horie M: Detection of calf muscle alterations in patients with chronic heart failure by 31 P magnetic resonance spectroscopy: Impaired adaptation to continuous exercise. Exp Clin Cardio .l10: 4‑8， 2005

・ Nakae1， Matsuo S， Koh T， Mitsunami K， Horie M: Left ventricular systolic/diastolic function evaLuated by quantitative ECG‑gated SPECT: comparison with echocardiography and plasma BNP analysis Ann Nucl Med. 19: 447‑454，2005

• Nakae 1， Matsuo S， Koh T， Mitsunami K， Horie M: Clinical significance of plasma BNP measurement in patients with psychiatric disease. International Med J 12 181‑184，2005.

・ TamakiS， Nakamura Y， Tabara Y， Okamura T， Kita Y， Kadowaki T， Tsujita Y， Horie恥

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Miki T， Ueshima H: Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effect on hypertension in a Japanese population (The Shigaraki study) Hypertens Res. 28: 645‑650，2005

• Tanaka H， Hamamoto T， Takamatsu T: Toward an integrated understandi時 ofthe Purkinje fibers in the heart: the functional and morphological interconnection between the purkinje fibers and ventricular muscle. Acta Histochem Cytoc 38 257・265，2005

• Tarutani Y，恥fatsumotoT， Takashima H， Yal11ane T， Horie M: Brachial artery tlow‑mediated vasodilation is correlated with coronary vasomotor and fibrinolytic responses induced by bradykinin. Hypertens Res. 28: 59‑66， 2005

• Tsujita Y， Kato T， Sussl11an MA: Evaluation of left ventricular function in cardiomyopathic mice by tissue Doppler and color M‑mode Doppler echocardiograph

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• Yao T， Ashihara T， Ito M， Nakazawa K， Horie恥4^・Refractorygradient is responsible for the increase in ventricular vulnerability under sodium channel blockade. Circ J 69: 345・353， 2005

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muscarinic K channel by extracellular ATP through membrane phosphatidylinositol 4， 5‑biphsopahte in guinea‑pig atrial myocytes. Br J Pharmaco .l145: 156‑165，2005

・ ZankovDP， Ding W‑G，恥1atsuuraH， Horie恥1: Open‑state unblock characterizes acute inhibition of IKS potassium current by amiodarone in guinea‑pig ventricular myocytes. J Cardiovasc Electrophysio .l16: 314‑322，2005

• Zhang L， B巴nsonD W， Tristani‑Firouzi M， Ptacek LJ， Tawil R， Schwartz PJ， George AL， Horie M， Andelfinger G， Snow GL， Fu 下Ackerman MJ， Vincent GM:

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-H・.~.~j.闘畢ヨ_.-mutations: characteristic T‑U‑wav巴pa仕ernspredict the KCNJ2 genotype. Circulation. 111 2720‑2726. 2005

【 2004 】

• Ashihara T， Trayanova NA: Asymmetry in membrane responses to electric shocks: 1nsights from bidomain simulations. Biophys J 87(4): 2271‑2282，2004.

• Ashihara T， Namba T， 1to M， 1keda T， Nakazawa K， Trayanova N: Spiral wave control by a localized stimulus: A bidomain model stud

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• Ashihara T， Trayanova NA: Shock‑induced changes in transmembrane potentia :lWhat is the asymmetry due to? 1nsights from bidomain simulations. Advances in Electrocardiolog

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• Ashihara T， Trayanova NA: Mechanisms of shock^帽inducedarrhythmogenesis: Role of tissue discontinuity and electroporation in the initiation of focal repetitive postshock activations. Advances in Electrocardiolog

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^F^u^jⁱ^iM^，^Wada A^，^O^hⁿⁱ^s^hⁱ^M^，Tsutamoto T， Matsumoto T， Yamamoto T， Takayama T， Dohke T， 1sono T， Eguchi Y， Horie M: Endogenous bradykinin suppresses myocardial fibrosis though the cardiac‑genetated endothelin system under chronic angiotensin‑converting enzyme inhibition in heart failure. J Cardiovasc Pharmacol.

44(Supp.ll): S346・S349，2004.

• Kobori A， Sarai N， Shimizu W， Nakamura Y， Murakami Y， Makiyama T， Ohno S， Takenaka K， Ninomiya T， Fujiwara Y， Matsuoka S， Takano M， Noma A， Kita T， Horie M: Additional gene variants reduce effectiveness of beta‑blockers in the LQT 1 form of long QT syndrom巴

J Cardiovasc Electrophysiol. 15: 1^開10，2004

• Matsumoto T， Takashil11a H， Ohira N， Tarutani Y， Yasuda Y， Yal11ane T， Matsuo S， Horie M Plasma level of oxidized LDL is an independent determinant of coronary macro‑and microvasol11otor responses induced by bradykinin. J Am ColI Cardio .l44: 45ト457，2004

• Matsuo S， Matsul11oto T， Nakae 1， 1to M， Nakamura Y， Takada M， Murata K， Horie M Evaluation of cardiac resynchronization therapy in drug‑resistant idiopathic dilated cardiomyopathy by means of technetium‑99m tetrofoSl11in electrocardiography‑gated single‑photon emmision cOl11puted tomograph

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• Matsuo S， Matsumoto T， Takashil11a H， Ohira N， Yamane T， Yasuda Y， Tarutani Y， Horie M The relationship between f1ow‑mediated brachial artery vasodilation and coronary vasomotor responses to bradykinin: comparison with those to acetylchoJine. J Cardiovasc Pharmaco .l44: 164‑170，2004

• Matsuo S， Nakamura Y， Matsumoto T， Nakae 1， Nagatani H， Takazakura R， Takahashi M， Murata K， Horie M: Visual assessment of coronary aはery stenosis with

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• Matsuo S，恥1atsumotoT， Nakae 1， Koh T， Masuda D， Takada恥1，Murata K， Horie恥4 Prognostic value of ECG‑gated thallium‑201 single‑photon emission tomography in patients with coronary artery disease. Ann Nucl Med. 18 617‑622，2004

• Nakae 1，恥1itsunamiK， Yabe T， Inubushi T， Morikawa S， Matsuo S， Koh T， Horie M D^巴tectionof metabolic abnormality in asynergic regions of ischemic human myocardium using 31P and 1H magnetic resonance spectroscopy. J Cardiovasc Magn Reso

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^N^a^k^a^e1^，^Mⁱ^t^s^uⁿ^a^mⁱ^K^，^M^a^t^s^u^o^S^，^M^a^t^s^u^m^o^t^o^T^，^Morikawa S^，^Iⁿ^u^b^u^s^hⁱ^T^，^Koh T^，^H^o^rⁱ^e^M:

Assessment of myocardial creatine concentration in dysfunctional human heart by proton magnetic resonance spectroscopy. Magn Reson Med Sci. 3・19‑25，2004

• Nakamura Y， Tamaki S， Uchida Y， Ohmichi N， Yamaoka 0，恥1iyauchiN， Fukuhara T， Sayama H， Yamada T， Matsuo S， Yamada Y: Angiot^巴nsmconve巾ngenzyme genotype influences the response to th^巴angiotensinII receptor antagonist losartan in patients with hypertension. Hypertens Res. 27: 137‑140，2004

• Niimi A， Matsumoto H， Takemura M， Ueda T， Nakano Y， Mishima M: Clinical assessm^巴nt of airway remodeling in asthma: utility of computed tomograph

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• Ohira N， Matsumoto T， Tamaki S， Takashima H， Tarutani Y， Yall1ane T， Yasuda Y， Horie恥f Angiotensin‑converting enzyll1e insertion / deletion polymorphisll1 modulates coronary release of tissue plasminogen activator in response to bradykinin. Hypertens Res. 27: 39‑45，2004

• Ozawa T， Ito M， Tamaki S， Yao T， Ashihara T， Kita Y， Ueshill1a H， Horie M: Ventricular repolarization abnorll1ality in Japanese carriers of G643S single nucleotide polYll1orphisll1

ofKCNQl gene. Advances in Electrocardiolog

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• Shimizu W， Horie M， Ohno S， Takenaka K， Yamaguchi M， Shill1izu M， Washizuka T， Aizawa Y， Nakamura K， Ohe T， Aiba T， Miyall1oto Y， Yoshimasa Y， Towbin J， Priori S^ヲ Kall1akura S: Mutation site‑specific differences in arrhythmic risk and sensitivity to syll1path^巴ticstimulaion in the LQT1 Form of congenital long QT syndrome. J Am CoII Cardio .l44: 117・125，2004

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^T^a^k^a^y^a^l^l¹^aT^，^Wada A^，^T^s^u^t^a^m^o^t^o^T^，^O^hⁿⁱ^s^hⁱ^M^，^F^u^jⁱⁱ^M^，^I^s^oⁿ^o^T^，^H^o^rⁱ^巴^M:C^oⁿ^t^rⁱ^b^u^tⁱ^oⁿ^o^f

vascular NAD(P)H oxidase to^巴ndothelialdysfunction in heart failure and the therapeutic effects ofHMG‑CoA reductase inhibito C.rirc J 68 1067‑1075，2004

• Tsutamoto T， Sakai H， Wada A， Ishikawa C， Ohno K， Fujii M， Yamamoto T， Takayama T， Dohk巴T，Horie M: Torasemide inhibits transcardiac extraction of aldosterone in patients with congestive heart failure. J Am CoII Cardio .l44 2252‑2253，2004

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Yamall1oto T， Takayama T， Dohke T，日one恥1:Transcardiac increase in tumor necrosis factor‑alpha and left ventricular end‑diastolic volume in patients with dilated

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

循環器内科 -民・・I~.市園陸別E語._.

cardiomyopathy. Eur J Heart Fail. 6: 173・180，2004

• Yamamoto T， Wada A， Tsutamoto T， Ohnishi M， Horie M: Long‑term treatment with a phosphodiest巴rasetype 5 inhibitor improves pulmonary hypertension secondary to heart failure through enhancing the natriuretic peptides‑cG恥1p pathwa

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J Cardiovasc Pharmacol. 44: 596‑600，2004

• Yasumllra Y， Miyatake K， Okamoto H， Miyauchi T， Kawana M， Tsutamoto T， Kitakaze M， Matsllbara H， Takaoka H， Anzai T， Himeno H， Yokoyama H， Yokoya K， Shintani U， Hashimoto K， Koretsune Y， Nakamura Y， lmai K， Maruyama S， Masaoka Y， Sekiya M， Shiraki T， Shinohara H， Ozono K， Matsuoka T， Miyao Y， Nomura F: Rationale for the lIse of combination angiotensin‑converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure. Circ J. 68: 361‑366，2004

• Yumoto Y， Horie M， Kubota T， Ninomiya T， Kobori A， Takenaka K， Takano M， Niwano S， Izumi T: Bepridil block of recombinant hllman cardiac IKs current shows a time‑dependent unblock. J Cardiovasc Pharmaco .l43: 178‑182， 2004

【2003】

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cordis as a mechanism of postshock activation Arrhythmia induction stlldy lIsing a bidomain mode .lJ Cardiovasc Electrophysiol. 14(3) 295‑302，2003.

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Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria. Circulatio

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107(6) 905‑910，2003

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Hamatani T， Nozato Y， Kataoka K， Morigami N， Ohnishi M， Kinoshita M， Horie M:

lmmediate administration of mineralocorticoid receptor antagonist spironolactone prevents post‑infarct left ventriclllar remod巴Iingassociated with suppr巴ssion of a mark巳rof myocardial collag巴nsynthesis in patients with first anterior acute myocardial infarction Circulation. 107: 2559‑2565， 2003

• Horie M， Takenaka K， Ai T， Haruna T， Kono Y， Yoshida H， KlIbota T， Ninomiya TラKobori A， Ono S， Makiyama S， Otani and Takano M， Takaki H， Kamakura S， Shimizu W Potassium Channe/s and Channelopathy‑Clinical Cardiac Pacinc and EIθctroph ysiology恥10nduzziEditore， 347‑349， 2003

• Katsuta H， Ozawa S， Ninomiya TヲShimoyamaT， lto E， Tanaka T， Yamaguchi S， Katahira H， Nagamatsll S， Horie M， lshida H: Insulinotropic action of gllltamate is dependent on the

inhibition of ATP‑sensitive potassium channel activities in }，狙N6beta cells. 8iochem 8iophys Res Commun. 311: 660‑664， 2003

• Konishi H， Nishio S， TSlltamoto T， Minouchi T， Yam勾iA: Serum carvediol concentation and its relation to change in plasma brain natriuretic peptide level in the treatment of h巴a口 failure: a pr巴liminarystudy. Int J Clin Pharmol Ther 41: 578‑586，2003

・

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Takemura G， Horie M， Miyamoto Y，恥1.orisakiT， Kuratomi S， Noma A， Fujiwara H， Yoshimasa Y， Kinoshita H， Kawakami R， Kishimoto 1， Nakanishi M， Usami S， Saito Y， Harada M， Nakao K: NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J. 22: 6310‑6321，2003

• Matsumoto T， Minai K， Horie H， Ohira N， Takashima H， Tarutani Y， Yasuda Y， Ozawa T， Matsuo S， Kinoshita M， Horie M: Angiotensin‑conve山ngenzyme inhibition but not angiotensin Il type 1 receptor antagonism augments coronaηrelease oftissue plasminogen activator in hypertensive patients. J Am ColI Cardiol. 41(8): 1373‑1379，2003

• Matsumoto T， Wada A， Tsutamoto T， Ohnishi M， Isono T， Kinoshita M・Chymaseinhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure Circulatio

n .

107(20): 2555‑2558，2003

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• Matsuo S， Nakamura Y， Kinoshita M， Horie M: Plasma B・typenatriuretic peptide measurement in asymptomatic population. International Med J. 10・105‑108，2003

• Matsuo S， Nakamura Y， Matsumoto T， Nakae 1， Murata K， Horie M: Prognostic value of iodine‑123 metaiodobenzylguanidine imaging in patients with heart failure Exp Clin Cardio .l8 95‑98，2003.

• Nakae 1， Matsumoto T， Omura T， Takashima H， Ohira N， Tarutani Y， Yasuda Y， Matsuo S， Koh T， Nakamura Y， Kinoshita M， Horie M: Endothelial modulation and tolerance dev巴lopmentin the vasorelaxant responses to nitrate of rabbit aorta. Life Science. 73 3083‑3094，2003

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S， Inubushi T， Nakamura Y， Kinoshita M， Horie M: Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy. J Am ColI Cardiol. 42: 1587・1593，2003.

• Ninomiya T， Takano M， Haruna T， Kono Y， Horie恥1:Verapamil， a Ca2+ entry blockerヲ

targets th巴pore‑formingsubunit of cardiac type KATP channel (Kir62). J Cardiovasc Pharmaco .l42: 161‑168，2003

• Sekikawa A， Horiuchi BH， Edmundowicz D， Ueshima H， Curb DJ， Kim ST， Okamura T， Kadowaki T， Kashiwagi A， Mitsunami K，トJakamuraY， Murata K， Ku1ler LH， Okamura T A "natural experiment" in cardiovascular epidemiology in the early・21stcentur

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Heart. 89: 255‑257，2003

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Kamakura S， Horie M: Exercise stress test amplifi巴sgenotype‑phenotype correlation in the LQT1 and LQT2 forms ofthe long QT syndrome. Circulatio

n .

107: 838‑844，2003

• Tsutamoto T， Tsutsui T， Maeda K， Hayashi M， Wada A， Ohnishi M， Fujii M， Ishii C: Effects of long‑acting calcium channel antagonists on neurohumoral factors: comparison of nifedipine coat‑core with amlodipine. J Cardiovasc Pharmaco .l4177・81，2003

• Tsutamoto T， Wada A， Hayashi M， Tsutsui T， Maeda K， Ohnishi M， Sawaki M， Fujii M，

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

循環器内科 E望・.~.市置闘E主._.

Matsumoto T， Yamatoto T， Takayama T， Ishii C， Kinoshita M: Relationship between transcardiac gradient of endothelin‑l and le仕ventricularremodelling in patients with first anterior myocardial infarction. Eur Heart J. 24 346‑355，2003

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【2011 】

• Horie M: 108th Scientific Meeting of the Japanese Society of Internal Medicine: Educational lecture: 3. Diagnosis and treatment of Japanese patients with Brugada syndrome Nihon Naika Gakkai Zasshi. 100(9): 2599‑2604，2011

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fJlJ~;;"守押. 70:42ト422，2011.

堀江稔教授就任・呼吸循環器内科設立 10周年記念誌

ドキュメント内業績集 : 滋賀医科大学内科学講座呼吸循環器内科 2002～2012 (ページ 32-83)

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