1. Ohtsubo, K., and Marth, J.D. (2006) Glycosylation in cellular mechanisms of health and di s-ease. Cell 126, 855-867.
2. Cooper, D.N.W. (2002) Galectinomics: finding themes in complexity. Biochim. Bi ophys. Acta 1572, 209-231.
3. Drickamer, K., and Fadden, A.J. (2002) Genomic analysis of C-type lectins. Biochem. Soc.
Symp. 69, 59-72.
4. Nabi, I.R., Shankar, J., and Dennis, J.W. (2015) The galectin la ttice at a glance. J. Cell Sci.
128, 2213-2219.
5. Patnaik, S.K., Potvin, B., Carlsson S., Sturm, D., Leffler, H., and Stanley, P. (2006) Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells.
Glycobiology 16, 305-317.
6. Schachter, H. (1986) Biosynthetic controls that determine the branching and microheterog e-neity of protein-bound oligosaccharides. Biochem. Cell Biol. 64, 163-181.
7. Hirabayashi, J., Hashidate, T., Arata, Y., Nishi, N., Nakamura, T., Hirashima, M., Ura shima, T., Oka, T., Futai, M., Muller, W.E., Yagi, F., and Kasai, K. (2002) Oligosaccharide specifi ci-ty of galectins: a search by frontal affinici-ty chromatography. Biochim. Biophys. Acta. 1572, 232-254.
8. Furtak, V., Hatcher, F., and Ochieng, J. (2001) Galectin-3 mediates the endocytosis of -1 integrins by breast carcinoma cells. Biochem. Biophys. Res. Comm. 289, 845 -850.
- 32 -
9. Guo, H.-B., Lee, I., Kamar, M., and Pierce, M. (2003) N-acetylglucosaminyl-transferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J. Biol. Chem. 278, 52412-52424.
10. Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yosida, A., Takeuchi, M., and Marth, J.D.
(2005) Dietary and genetic control of glucose transporter-2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123, 1307-1321.
11. Ohtsubo, K., Chen, M.Z., Olefsky, J.M., and Marth, J.D. (2011) Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat. Med. 17,
1067-1076.
12. Chen, I.-J., Chen, H.-L., and Demetriou, M. (2007) Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling. J. Biol. Chem. 282, 35361 -35372.
13. Lau, K.S., Partridge, E.A., Grigorian, A., Silvescu, C.I., Reinhold, V.N., Demetriou, M., and Dennis, J.W. (2007) Complex N-glycan number and degree of branching cooper-ate to regulcooper-ate cell proliferation and differentiation. Cell 129, 123 -134.
14. Clark, M.C., Pang, M., Hsu, D.K., Liu, F.-T., de Vos, S., Gascoyne, R.D., Said, J., and Baum, L.G. (2012) Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death. Blood 120, 4635-4644.
15. Johswich, A., Longuet, C., Pawling, J., Rahman, A.A., Ryczko, M., Drucker, D. J., and Den-nis, J.W. (2014) N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway. J. Biol. Chem. 289, 15927 -15941.
16. Ohtsubo, K., Takamatsu, S., Gao, C., Korekane, H., Kurosawa, T.M., and Taniguchi, N.
(2013) N-glycosylation modulates the membrane sub-domain distribution and activity of
- 33 -
glucose transporter 2 in pancreatic beta cells. Biochem. Biophys. Res. Commun. 434, 346-351.
17. Henquin, J.C., and Meissner, H.P. (1986) Cyclic adenosine monophosphate differently af-fects the response of mouse pancreatic -cells to various amino acids. J. Physiol. 381, 77-93.
18. Bahadoran, Z., Mirmiran, P., and Ghasemi, A. (2019) Role of nitric oxide in insulin secretion and glucose metabolism. Trends Endocrinol. Metab. S1043-2760, 30204-30208.
19. Maeda, K., and Ohtsubo, K. (2019) Galectin lattice regulates nutrition sensor fun c-tions in pancreatic cells. Trends Glycosci. Glycotechnol. 31, E27-E29.
20. Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., and Yamamura, K.-I. (1990) Establishment of a pancreatic cell line that retains
glu-cose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127, 126-132.
21. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
22. Silva, F.D., Oliveira, J.E., Freire, R.P., Suzuki, M.F., Soares, C.R., and Bartolini, P. (2019) Expression of glycosylated human prolactin in HEK293 cells and related N-glycan composi-tion analysis. AMB Express. 9, 135.
23. Reeves, P.J., Callewaert, N., Contreras, R., and Khorana, H.G. (2002) Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and
homogene-ous N-glycosylation by a tetracycline-inducible
N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proc Natl Acad Sci U S A. 99, 13419-13424.
- 34 -
24. Shirato, K., Nakajima, K., Korekane, H., Takamatsu, S., Gao, C., Angata , T., Ohtsubo, K., and Taniguchi, N. (2011) Hypoxic regulation of glycosylation via the N -acetylglucosamine cycle. J. Clin. Biochem. Nutr. 48, 20-25.
25. Nakajima, K., Kitazume, S., Angata, T., Fujinawa, R., Ohtsubo, K., Miyoshi, E., and Tan igu-chi, N. (2010) Simultaneous determination of nucleotide sugars with ion -pair
re-versed-phase HPLC. Glycobiology 20, 865-871.
26. Nakajima, K., Ito, E., Ohtsubo, K., Shirato, K., Takamiya, R., Kitazume, S., Angata, T., and Taniguchi, N. (2013) Mass isotopomer analysis of metabolically labeled nucleotide sug-ars and N- and O-glycans for tracing nucleotide sugar metabolisms. Mol. Cell. Proteomics 12, 2468-2480.
27. Chen, R., Gong, P., Tao, T., Gao, Y., Shen, J., Yan, Y., Duan, C., Wang, J., and Liu, X. (2017) O-GlcNAc glycosylation of nNOS promotes neuronal apoptosis following glutamate exci-totoxicity. Cell Mol. Neurobiol. 37, 1465-1475.
28. Feng, L., Wang, J., and Ma, X. (2018) Exogenous SERP1 attenuates restenosis by restoring GLP-1 receptor activity in diabetic rats following vascul ar injury. Biomed. Pharmacother.
103, 290-300.
29. Gellai, R., Hodrea, J., Lenart, L., Hosszu, A., Koszegi, S., Balogh, D., Ver, A., Banki, N.F., Fulop, N., Molnar, A., Wagner, L., Vannay, A., Szabo, A.J., and Fekete, A. (2016) Role of O-linked N-acetylglucosamine modification in diabetic nephropathy. Am. J. Physiol. Renal.
Physiol. 311, F1172-F1181.
30. Kim, S.Y., Hwang, J.S., and Han, I.O. (2013) Tunicamycin inhibits Toll -like recep-tor-activated inflammation in RAW264.7 cells by suppression of NF -B and c-Jun activi-ty via a mechanism that is independent of ER-stress and N-glycosylation. Eur. J. Pharmacol.
721, 294-300.
- 35 -
31. Lynch, K., Treacy, O., Gerlach, J.Q., Annuk, H., Lohan, P., Cabral, J., Joshi, L., Ryan, A.E., and Ritter, T. (2017) Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment.
Front. Immunol. 8, 1427.
32. Zaborska, K.E., Edwards, G., Austin, C., and Wareing, M. (2017) The role of
O-GlcNAcylation in perivascular adipose tissue dysfunction of offspring of high -fat di-et-fed rats. J. Vasc. Res. 54, 79-91.
33. Moncada, S., Palmer, R.M., and Higgs, E.A. (1991) Nitric oxide: physiology, pathophysio lo-gy, and pharmacology. Pharmacol. Rev. 43, 109-142.
34. Lajoix, A.D., Reggio, H., Chardès, T., Péraldi-Roux, S., Tribillac, F., Roye, M., Dietz, S., Broca, C., Manteghetti, M., Ribes, G., Wollheim, C.B., and Gross, R. (2001) A neuronal isoform of nitric oxide synthase expressed in pancreatic -cells controls insulin secre-tion. Diabetes 50, 1311-1323.
35. Nakada, S., Ishikawa, T., Yamamoto, Y., Kaneko, Y., and Nakayama, K. (2003) Constit u-tive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose -induced nitric oxide production in -cells. Pflügers Arch. Eur. J. Physiol. 447, 305-311.
36. Rizzo, M.A., and Piston, D.W. (2003) Regulation of cell glucokinase by S-nitrosylation and association with nitric oxide synthase. J. Cell Biol. 161, 243 -248.
37. Cahuana, G.M., Tejedo, J.R., Hmadcha, A., Ramírez, R., Cuesta, A.L., Soria, B., Martin, F., and Bedoya, F.J. (2008) Nitric oxide mediates the survival action of IGF -1 and insulin in pancreatic cells. Cell Signal. 20, 301-310.
- 36 -
38. Sunouchi, T., Suzuki, K., Nakayama, K., and Ishikawa, T. (2008) Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic cells. Pflügers Arch. Eur. J. Physiol. 456, 573-579.
39. Closs, E.I. (1996) CATs, a family of three distinct mammalian cationic amino acid transpor t-ers. Amino Acids 11, 193-208.
40. Ito, K., and Groudine, M. (1997) A new member of the cationic amino acid transporter f ami-ly is preferentialami-ly expressed in adult mouse brain. J. Biol. Chem. 272, 26780 -26786
41. McCarthy, M.I. (2003) Growing evidence for diabetes susceptibility genes from genome scan data. Curr. Diab. Rep. 3, 159-167.
42. van Tilburg, J.H., Sandkuijl, L.A., Strengman, E., van Someren, H., Rigters -Aris, C.A., Pear-son, P.L., van Haeften, T.W., and Wijmenga, C. (2003) A genome -wide scan in type 2 diabe-tes mellitus provides independent replication of a susce ptibility locus on 18p11 and sug-gests the existence of novel loci on 2q12 and 19q13. J. Clin. Endocrinol. Metab. 88, 2223-2230.
43. Gunton, J.E., Kulkarni, R.N., Yim, S., Okada, T., Hawthorne, W.J., Tseng, Y.H., Roberson, R.S., Ricordi, C., O'Connell, P.J., Gonzalez, F.J., and Kahn, C.R. (2005)
Loss of ARNT/HIF1 mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122, 337-349.
44. Rotmann, A., Strand, D., Martiné, U., and Closs, E.I. (2004) Protein kinase C activ ation pro-motes the internalization of the human cationic amino acid transporter hCAT-1. A new regu-latory mechanism for hCAT-1 activity. J. Biol. Chem. 279, 54185-54192.