2)癌の診断に関する研究
ポジトロンCTによる癌診断研究は,サイクロトロンセンターでPET施設をたち上げたときからの
当分野の研究テーマであり,世界的にも先駆的な仕事がなされている.これらの成果の集大成として,
1985年仙台においてポジトロンCTによる癌診断の国際シンポジウム(PET‑85)が松沢前教授の主催で開催されている.また1994年には第2回のポジトロンCTによる癌診断の国際シンポジウムが福田の
主催で行われた.現在もこの分野では世界をリードしており,学会賞受賞,国際会議への招請,国際誌への多数の論文掲載など対外的にも評価されている.主な研究テーマは,
a) 1〝Cメチオニン, 18F‑FDGによる肺癌の悪性度判定,および治療効果の判定, b)ポジトロン核種によるミクロオートラジオグラム法の開発とその応用, C) 18F‑フルオロデオキシガラクト‑スによる肝癌の分化度診断法の開発,
d)癌集積性ポジトロン標識化合物の開発などである.
3)癌の治療に関する研究
当分野では,腫瘍および正常組織の細胞増殖動態に基づく新しい放射線治療法の開発を目指して基礎
的,臨床的研究を続けている.1)放射線照射中の正常組織(皮膚,小腸など)および腫瘍組織の細胞増殖加速について 2)照射中の腫瘍細胞の増殖加速を考慮した非小細胞肺癌の放射線治療の臨床試行.
3)原子炉熱中性子を用いる悪性黒色腫の中性子捕捉治療の放射線医学的基礎的,臨床的研究(国際 的にもこの治療法に関する感心が高まっているが,基礎的にも臨床的にも世界をリードしてい
る.
2.研究報告
1)著書
1.福田 寛,館野之男. PETの診断への応用.久田欣一編.最新腫瘍核医学: 89‑114, 1993 2. Roland PE, Kawashima R, Gulyas B, 0'Sullivan BT, PET in cognltlVe neurOSCience : Methodologl‑
/.〟
cal constraints, strategleS, and examples五〇m learnlng and memory. In : The cognltlVe Neuroscien‑
ces (ed Gazzaniga M) , pp. 781‑788, MIT press. Massachusetts, 1994
3.伊藤 浩,福田 寛,上村和夫.脳血流のPET一放射線科医の立場から‑.永井輝夫編. MRA と新しい血流診断.東京:朝倉書店; 5, 25: 130‑139, 1994
4. Matsuzawa T, Fukuda H, et al. eds, Clinical PET in Oncology, World Scientinc, 1994.
2)英文論文
1. Kubota K. Kubota R, Yamada S : FDG accumulation in tumortissue. I. NucI Med, 34. 419‑421.
1993
2. Tada M, Iwata R, Sugiyama H, Sato K, Pascali C, Fukuda H, Kubota K, Kubota R, Takahashi H,
Wakui A, Abr Y, F巾iwara T, Sato T, Ido T: A rapid synthesis or (Huoroacety1‑18F)nuor一
melatoninn (N‑ ( 18F) Huoroacety1‑5‑methoxytryptamine) , a potential diagnostic imaging agent. J.
Labelkd Compds. Radiopham, 33, 601‑600, 1993
3. Ishiwata K, Kubota K, Murakami M, Kubota R, Senda M: A comprative study on protein
incorporation or L‑ (methy1‑3H)methioninc, L‑ (口4C) 1eucine and L‑2(18F) Huorotyrosine in
tumor bearlng mice. NucL Med. Biol, 20, 895‑899, 1993
4. Som P, Wang GJ, Osier ZH, Knapp FR, Yonekura Y, F山ibayashi Y, Yamamoto K, Kubota K :
Myocardial uptake of cocaine and erects or cocaine on myocardial substrate utilization and perfusion in hypertensive rats. Ann. NucI Med, 7, S 219‑S 226, 1993
5. Mishima Y, Honda C, Ichihashi M, Shiono M, Wadabayashi N, Obara H, Hiratsuka ∫, Fukuda H, Karashima H, Kanda K, Kobayashi T, Yoshino K : Sel∞tive melanoma themal neutron capture
therapy for lymphnode metastasis. KURRI‑ TR‑374, I 1‑16, 1993
6･ Mishima Y, Ichihashi M, Honda C, Shiono M, Nakagawa T, Obara H, Shirakawa ∫, Hiratsuka H,
Kanda K, Kobayashi T, Nozaki T, Aizawa 0, Yoshino K, Fukuda H : Treatment of metastatic melanoma by neutron capture therapy. KURRI‑ TR‑374, 19‑23, 1993
7. Yokoi T, Iida H, Itch H, Kanno I. A new graphic plot analysis for cerebral blood How and
pa正tion coe鯖cient with iodine‑ 123‑10doamphetamine and dynamic SPECT validation studies
uslng oxygen‑15‑water and PET. J NucI Med 34. 498‑505. 1993
8･ Fukuda H, Hiratsuka ∫, Honda C, Kobayashi T, Yoshino K, Abe Y, Takahashi ∫, Shiono M,
Karashima H, Kanda K, Ichihashi M, Mishima Y : Optimization or neutron Huence and timing Or irradiation for the treatment or malignant melanoma by boron neutron capture therapy uslng lOB‑
150 加齢脳･神経研究部門
paraboronophenylalanine. KURRI‑ TR‑374, 1923, 212‑220, 1993
9･ Kawashima R, Yamada K, Kinomura S, Yamaguchi T, Matsui H, Yoshioka S, Fukuda H:
RegiQnal cerebral blood How changes ofco証cal motor areas and pr誼ontal areas in humans related
to IPSilateral and contralateral hand movement. Brain Resear･ch 623, 33‑40, 1993
10･ Kawashima R, Itch M, Hatazawa ∫, Miyazawa H, Yamada K, Matsuzawa T, Fukuda H∴ Change
of reg10nal cerebral blood now during listenlng tO an unfamiliar spoke language･ Neurosci Left
/･■●
le1, 69‑72, 1993
11･ Kubota K, Yamada S, Ishiwata K, Ilo M, F可iwara T, Fukuda H, Tada M, Ido T : Evaluation or the treatment response or lung cancer with positron emission tomography and L‑ [methy1‑1 1C]
methionine : a preliminary study. Ear I. NucL Med 20(6), 495‑501, 1993
12･ Fukuda H, Takahashi J, F申wara T, Yamaguchi K, Abe Y, Kubota K, Sato T, Miyazawa H, Hatazawa ∫, Tada M, Ishiwata K, Ido T : High A∝umulation of 2‑Deoxy‑2‑nuorine‑18‑Huoro‑
D‑galactose by well‑diHerentiated hepatomas or mice and rats. I NucL Med. 34(5) , 780‑786, 1993
13･ Itch M, M Jeong, F巾iwara T, Watanabe H, Okamura N, Seo S, Watanuki S, Fukuda H, IdoT:
Instability or subj∞t's psychological state during PET activation study monitored with EEC.
Uemura T･ (ed) quantmcation or brain mnction tracer kinetics and imageanalysis in brain PET.
EIsevier, Amsterdam, 627‑632, 1993.
14･ Iyo M, Nishio M, Itch T, Fukuda H, Suzuki K, Yamasaki T, Fukui S, Tateno Y : Dopamine D2
and Serotonin S2 R∞eptors in Susceptibility to Methamphetamine Psychosis Det∞ted by Positron
Emission Tomography. Psychiat Res Neuroimaging. 50, 217‑231, 1993
15･ Roland PE, Levin B, Kawashima R, Akeman S : Thr∞‑dimensional analysュs Of clustered voxels
in 150‑butanol brain activation images･ Human Brain Mapplng I, 3‑19, 1993.
16. Kubota R, Yamada S, Ishiwata K, Tada M, Ido T, Kubota K: Cellular a∞umulation or 18F‑
labeled boronophenylalanine depending on DNA synthesis and melanin incorporation : a double‑
tracer microautoradiographic study of B‑16 melanoma in vivo. Br J Cdnαr e7, 701‑705, 1993.
17･ Yamaguchi S, Meguro K, Itch M, Aoki T, Kinomura S, Yamaguchi T, Matsui H, Doュ C, Yamada T, Yamazaki H, Fukuda H, Sasaki H : De∞reased comcal glucose metabolism correlatred with
hippocampal atrophy in dementia patients･ I CBF Metab, 13, suppl 1, s 10, 1993
18･ Kinomura S, Fukuda H, Yamada K, Yoshka S, Ono S, Miyazawa H, Kawashima R, Ilo H, Itoh M, Watanuki S. Seo S : High order gustatory projections in human brain studied 150‑CO2 continuous inhalation method･ I CBF Metab, 13, suppl 1, S 708, 1993
19･ Ono S, Yoshioka S, Miyazawa H, Kinomura S, Ilo H, Fukuda H: The canes of brain glucose
metabolism during visual stimulation det∞ted by the weighted integration method･ I CBF
Metab, 13, suppl 1, S700, 1993
20･ Miyazawa H･ Kinomura S, One s, Ilo H, Fukuda H : Brain blood volume measured with x‑ray
compted tomography･ I CBF Metab, 13, suppl 1, S8調, 1003
21･ Mishima Y, Honda C, Ichihashi M, Shiono M, Wadabayashi N, Obara H, Hiratsuka ∫, Fukuda H, Karashima H･ Kanda K, Kobayashi T, Yoshino K : Sel∞tivel melanoma thermal neutorn capture
therapy for lymphonode metastasis. In Advances in Neutron Capture Therapy. Soloway AH, Banh RF, Carpenter DE eds, Plenum Press, New York, 705‑710, 1993
22. Matsumoto M, Nakamura T, Watabe H, Itch M, Hatazawa : Estimation or organ biodistribution and absorbed dose from external measurement with TLDs in PET studies. Med Bio Eng Comput,
31, 151‑156, 1993
23. Iinuma K, Yokoyama H, Otsuki T, Yanai K, Watanabe T, Itch M: Histamine Hl r∞eptors in
/.〟
complex partial seizures. Lancet, 341, 238, 1993
24. Muraishi K, Kameyama K, Sato K, Shirane R, Ogawa A, Yoshoto T, Hatazawa ∫, Itoh M:
Cerebral circulatory and metabolic changes following EC/Ic bypass surgery in cerebral occlusive diseases. Neurolog Res, 15. 97‑103, 1993
25. Watabe H, Nakamura T, Takahashi H, Itch M, Matsumoto M, Yamadera A : Development or a miniature gemma‑ray endoscoplC probe fbi tumor localization in nuclear medicine. IEEE
Tr･ansact NucI Sos. 40, 88‑94. 1993 ,
26. Nagasawa W, Iimura T, Nomura H, Itoh M, Ido T : A case ofco証cobasal degeneration studied
with positron emission tomography. Behavioral Neurol, 6, 59‑64, 1993
27. Nagasawa H, Saito H, Kogure k, Hatazawa ∫, Itch M, F巾iwara T, Watanuki S, Seo S, Iwata R, Ido T : 6‑ [18F]Huorodopa metabolism in patients with hemiparkinsonism studied by positron emis‑
sion tomography. J Neurolog Sci. 115, 136‑143, 1993
28. Fares Y, Itoh M, Watabe H, Ghista D.N : 18‑FDG in diabetes mellitus, Nucl hstmm Method Phy Res. 79. 936‑941, 1993
29. Sato K, Kameyama M, Ishata K, Takamasa K, Yoshimoto T, Itch M : Multicentic glioma studied with positron emission tomography. A case report Surg Neurlo 42, 14‑18, 1994
30. Nagasawa H, Kogure k, Itoh M, Ido T : Multi‑fTocal metabolic disturbances in human brain after cerebral imf:arction studied with 18FDG and positron emission tomography. Neurvreport 5, 961‑
964, 1994
3). Nagasawa H, Kogure K, Fujiwara T, ltoh M. Tdo T : Metabolic disturbances in nxo‑local brain areas after cortical stroke studied by positron emission tomography. J Neurolog Sci, 123, 147‑ 153, 1994
32. Kubota K, Ishata K, Kubota R, Yamada S : Investigation or tumor invasion with (lllIn)anti‑
myosine. NucI Med. Biol, 21 : 239‑244, 1994
33. Tada M, Iwata R, Sugiyama H, Sato K, Fukuda H, Kubota K, Kubota R, F山iwara T, Takahashi H, Wakui A, Ido T : An e億cient synthesis of N‑[18F]nuoroacetylserotonin (N‑[18F]‑Huor‑
oacety1‑5‑hydroxytryptamine). J Labelkd Compds and Radiopham 741‑746, 1994
34. 0'Sullivan BT, Roland PE, Kawashima R : A PET study orsomatosensory discrimination in man一
microgeometry versus macrogeometry. Ear J Neurosci 6, 137‑148, 1994
35. Kawashima R, Roland PE, 0'Sullivan BT : Fields in human motor area involved in preparation for
reaching, actual reaching and visuomotor leamlng : A positron emission to齢ography study･ J
Neurosci 512. 382‑413. 1994
152 加齢脳･神経研究部門
36･ Fukuda H, Hiratsuka J, Honda C, Kobayashi T, YoshinoK, Karashima H, Takahashi J, Abe Y, Kanda K･ Ichihashi M, Mishima Y : Boron neutron capture therapy of malignant melanoma uslng
10B‑paraboronophenylalanine with sp∝ial re筒ence to evaluation of radiation dose and damage to
the nomal skin. Radial Res l38, 435‑442, 1994
37･ Kubota 良, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N : Microautoradiographic study for
the diHerentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics
/■′
of Huorine‑18‑Huorodeoxyglucose uptake. J Nud Med 35, 100･一日2, 1994.
38･ Kubota R, Kubota K, Yamada S, Tada M, ldo T, Tamahashi N : Active and passive o千田uorine‑
18] Huorodeoxyglucose uptake by pren∝rotic cancer cess in vivo : A microautoradio一graphic
study. J NucI Med 35, 1007‑1075, 1994.
39･ Kubota K, Kubota 良, Yamada S, Ishiwata K : Feasibility of llC‑L一methionine and 18F‑Huor一
〇deoxyglucose fbi the treatment evaluation of cancer with PET･ In Clinical PET in Oncology, Matsuzawa T et all eds, Wo′〟 Sc壷ntljk, 47‑53, 1994. ,
00: Ishiwata K, Kubota K, Murakami M, Kubota R, Sasaki T, Ishii S, Senda M: Comparison or
[methy1‑3H], [1‑14C]leucine and [2‑18F]肌Orotyrosine in the mouse metastasis medel, in which
protein synthesis is inhibited by cycloheximide･ In Clinical PET in Oncology, Matsuzawa T et al.
eds, World Sc壷ntljk, 59‑61, 1994.
41･ Abe Y, Yamaguchi T, Matui H, Takahashi ∫, Sato T, Fukuda H, Tada M, Hatazawa I, Ilo M, Iwata
R, Ido T, Watanuki S, Seo S and Watabe H･ Assessment of tumor blood How using positron emission tomography and H2150: Erect or hydralazine and niredipine･ ln Clinical PET in
Oncology, Matsuzawa T et all eds, World Sc壷ntljk, 83‑85, 1994
42･ Kubota K, Yamada S, F山iwara T, Tada M, Yamada K, Matsuzawa T, Fukuda H, Ilo M, Ido T:
Lung tumor imaglng With PET using 18F一触uorodeoxyglucose and 1 lC‑methionine. In Clinical PET in Oncology, Matsuzawa T et al. eds, World Sc壷nttjb, 131‑139, 1994.
43. F巾iwara T, Kubota K, Abe Y, Itch M, Fukuda H, Takahashi T, Iwata R, Ido T, Matsuzawa T:
PET study of lung cancer uslng F‑18 FDG and C‑ll methionine･ In Clinical PET in Oncology, Matsuzawa T et ale eds, World Scbntljb, 141‑146, 1994.
44 Fukuda H : Liver tumor imaglng With F‑18 Huorodeoxyglucose‑review: In Clinical PET in Oncology, Matsuzawa T et all eds, World Sc壷ntljk, 147‑151, 1994.
45･ Yamaguchi K, Itch M, Fukuda H, Abe Y, F申wara T, Takahashi H, Matsuzawa T: A simple
quantitative measurement or liver blood volume on liver disease with 1 leo labeled red boo° cell
uslng POSitrom emission tomography･ In Clinical PET in Oncology. Matsuzawa T et al. eds. World
Sc壷ntljb, 163‑ 166, 1994.
46･ Fukuda H: Evaluation of tissue speeinc character or cancer uslng PET･ In Clinical PET in
Oncology, Matsuzawa T et all eds, Wo′〟 Sc壷nt絢, 229‑235, 1994.
47･ Takahashi ∫, Fukuda H, F巾iwara T, Itoh M, Abe Y, Yamaguchi K, Kubota K, Sato T, Iwata R,
Takahashi T, Ido T, Tada M : Tissue characterization or hepatocellular carcinomas by positron
emission tomography using 18F一皿uorodeoxy‑galactose and 18F‑Huoro‑deoxy‑glucose. In Clini‑
cal PET in Oncology, Matsuzawa T et al. eds, World Sc壷ntljk, 237‑242, 1994.
48･ Yamaguchi K, Fukuda H, Itoh M, Tada M, Abe Y, F巾iwara T, Takahashi H, Matsuzawa T:
Di鮪rential diagnosis betw∞n hepatocellular carcinoma and metastatic liver tumor using 2‑deoxy‑
2‑ (18F)nuoro‑D一galactose using positron emission tomography. In Clinical PET in Oncology, Matsuzawa T et al. eds, World Sc壷ntljb, 243‑245, 1994.
49. Tada M, lwata R, Sugiyama H, Sato K, Pascali C, Fukuda H, Kubota K, Kubota R, Takahashi H,
Wakui A, Abe Y, F串wara T, Sate T, Ido T: A rapid synthesis or担uoroacety1‑18F] Huor‑
omelatonin･ In Clinical PET in Oncology, Matsuzawa T et al. eds, World Scbntljk, 343‑347, 1994.
50･ Kawashima R, Roland PE, 0'Sullivan T : Activity ln the human prlmary motor COHex related to IPSilateral hand movements. Brain Res 663. 251‑256. 1994
51･ Kinomura S, Kawashima 良, Yamada K, One S, Itch M, Yoshoka S, Yamaguchi T, Matsui H, Miyazawa H, Itoh H, Goto R, F巾iwara T, Satoh K, Fukuda H : Functional anatomy of taste perceptlOn in the human brain studied with positron emission tomography. Brain Res 659, 263‑
266, 1994
52･ Hatazawa I, Itoh H, Shimosegawa 良, Kanno I, Murakami M, Miura S, Iida H, Okudera T, Inugami A, Ogawa T, F両ta H, Satoh Y, Nagata K, Hirata Y, Uemura K. A∝umulation ofL‑[2‑(F‑18)]‑
Huorophenylalanine in peri‑inrarct area in a patient with acute cerebral inrarction. Ann Nuc/
Med, 8, 213‑217, 1994
53･ Iida H, Ttoh H, Bloomneld PM, Munaka M. Higano S, Murakami M, [nugami A, Eberl S, Aizawa Y, Kanno I, Uemura K･ A method to quantitate cerebral blood How uslng a rOtatlng gamma
camera and iodine‑123 iodoamphetamine with one blood sampling. E〟r J NucI Med, 21, 1072‑
1084, 1994.
54･ Iida H, Itch H, Nakazawa M, Hatazawa I, Nishimura H, Onishi Y, Uemura K. Quantitative mapplng Or regional cerebral blood How using Iodine‑123‑IMP and SPECT. J NucI Med 35, 2019‑2030, 1994.
55･ Murakami F, Araki T, Yanai Y, Kato H, Fujiwara T, Kogure K: EHects on vinconate and
pentobarbital against pOStischemic alterations in spirod∞anone binding sites in the gerbil brain･
Phamacobgy, 49, 286‑295. 1994
56･ Abe Y, Matsui H, Yamaguchi T, Yoshioka S, Yamada K, Fukuda H : Chest wall destruction as a result or late radiation damage : 20‑year rollow‑up or an irradiated lung tumor. Radial. Med, 12,
79‑81, 1994.
57. Kubota R, Kubota K, Yamada S, Tada M, Takahashi T, Iwata R, Tamahashi N : Methionine uptake by tumor tissue : a Microautoradiograhphic compasrison with FDG. I NucL Med, 35,
1994 (in press)
58･ Kubota K, Kubota R, Yamada S, Tada M: Effects of radiotherapy on the cellular uptake or carbon‑14 labeled L‑methionine in tumor tissue. NucL Med. Biol, 21, 1994(in press)
59･ Kawashima R and Fukuda H : Functional organization of the human primary motor area: An update on current concepts. Rev Neurosci, 1994(in press)
154 加齢脳･神経研究部門
00･ Kawashima R, Roland PE, 0'Sullivan BT : Functional anatomy of re00hing and visiomotor earning : A positron emission tomography study. Cerieb Cortex, 1994(in press)
61･ Ito H, lida H, Bloomneld PM, Murakami M. Tnugami A. Kanno I. Fukuda H, Uemura K･ Rapid calculation or regional CBF and distribution volume using N‑isopropyl‑p‑[1231] iodoam‑
phetamine (123HMP) and dynamic SPE〔T. J NucI Med 1995 (in press).
62. Ito H. Hatazawa I. Murakami M, Miura S, Iida H, Bloomneld PM, Kanno I, Fukuda H, Uemura K. Measurement of neutral amino acid transpon at the blood brain barrier using L‑(2‑18F)‑
nuorophenylalanine and PET : Aging EHects in Man. J NucI Med 1995(in press).
63. Ito H, Ishii K, Atsumi H, Kinoshita T, Kawashima R, Oho S, Yoshioka S, Iida H, Uemura K, Fukuda H･ Error analysts Or Table look‑up method for cerebral blood How measurement by 123
1‑IMP brain SPE〔T : Comparison with conventional microspherc model method. Ann NucI
Med 1995(in press).
eA Kawashima R, Itoh H, Ono S, Satoh K, Furumoto S, Gotoh 良, Koyama M, Yoshka S, Takahashi
T: YanaglSaWa T, Fukuda H : Activity in the human primary motor COneX related to arm and nnger movements. Neur10rlePOrt 1995 (in press)
65･ Kawashima R, 0'Sullivan BT, Roland PE: Closlng the minds eye. Doc Na〟 Acad S°i USA 1995(in press)
〈CYRIC Annual Remrt)
1. Kubota K., lshiwata K., Kubota R., Yamada S., Abe Y., Takahashi I., Fukuda H., Ido T. ; Tissue
distribution or ( 18F) nuorophenylalanine and L‑ (methy1‑14C) methionine. 〔YRIC Ann. Rep∴
100‑102, 1993
2･ Kubota K･, Kubota R., Yamada S., Tada M. ; Microautoradiography study or L‑methionine distribution on tumor tissue : effects or radiotherapy. CYRlC Ann. Rep. 153‑155. 1993
3･ Kubota R･, Kubota K., Yamada S., Tada M., Ido T., Tamahashi N. ; Time course study of3H‑DG uptake by tumors at cellular level. CYRIC Ann. Rep. 100‑142, 1993
4. Kubota R., Kubota K., Yamada S., Tada M., Takahashi T., Iwata R., Tamahashi N言Di範rence in distribution ormethionine and FDG in tumor tissues in vivo. 〔YRIC Ann. Rep. 143‑145, 1993 5･ Tada M･, Iwata R., Sugiyama H., Sato K., Fukuda H., Kubota K., Kubota 良., Takahashi H,, Wakui
A･. Fujiwara L Sato T., ldo T. ; Synthesis or Nw‑ ( 18F) Huoroacety1‑5‑hydroxytryptamine from
ethyl p‑tosyloxyacetate. 〔YRIC Ann. Rep. 96‑99, 1993
6･ Kubota R･, Kubota K･, Yamada S･, Tada M･, Ido T･, Tamahashi N･; Cell cycle dependency or
(18F)FDG uptake by cancer cells in vivo. 〔YRIC Ann. Rep. 146‑149, 1993
7･ Yamada S･, Kubota K･, Kubota R., Tamahashi N., Ido T. ; Quantitative microautoradiographic
study or 18F‑FDG in experimental inHammatory tissue. 〔YRIC Ann. Rep. 150‑152, 1993.
8･ Susumu Yamada, Kazuo Kubota, Roko Kubota, Nobuaki Tamahashi and Tatsuo ldo : Quantita‑
tive microautoradiographic study or 18F‑FDG in experimental inHammaroty tissue. CYRIC Ann
Rep 150‑152, 1993.
9･ Roko Kubota, Kazuo Kubota, Susumu Yamada, Masao Tada, Tatsuo ldo and Nobuaki Tamaha‑
shi : Time course study of 3H‑DG uptake by tumor at cellular level･ CYRIC An Rep 100‑142,
1993.
10･ Roko Kubota･ Kazuo Kubota, Susumu Yamada, Masao Tada, Tooru Takahashi, Ken lwata and
Nobuaki Tamahashi･Di飾rence in distribution or methionine and FDG in tumor tisues in vivo.
i各=i
CYRIC Ann Rep 143‑145, 1993.
1 1･ Roko Kubota, Kazuo Kubota, Susumu Yamada, Masao Tada, Tatsuo ldo and Nobuaki Tamaha‑
shi : Cell cycle dependency o=18F]FDG uptake by cancer cells in vivo. CYRIC Ann Rep 146‑
149, 1993.
12･ Kazuo Kubota･ Kjichi lshiwata･ Roko Kubota, Susumu Yamada, Yoshinao Abe, Jutaro Takahashi,
Hiroshi Fukuda and Tatsuo ldo : Tissue distribution o= 18F] Huorophenylalanine and I‑ [methy1‑
14C]methionine. CY剛C Ann Rep 100‑102, 1993. ノ
13･ Kazuo Kubota･ Kiichi lshiwata･ Roko Kubota, Susumu Yamada, Yoshinao Abe, Jutaro Takahashi,
Hiroshi Fukuda and Tatsuo Idol Tissue distribution oH 18F] Huorophenylalanine and 1‑ [methy1‑
14C]methionine･ CYRIC Ann Rep 100‑102, 1993.
14･ Ono S, Kawashima R･ Kinomura S･･ Ilo H, Goto R, Fukuda H : Simpined method or blood sampling for CMRglc measurement･ CYRIC Annual Repon･ 218‑223, 1993
3)和文論文
1･畑沢 順,伊藤 浩,上村和夫:痴呆診断のための補助検査 C) SPECT,PET.老年医学Ger‑
iatrid Med00: 927‑929
2･平塚純一,福田 寛,古林 徹,神田啓治,市橋正光,三嶋 豊:ヒト悪性黒色腫膵癌型のそれ
ぞれに対応した最適熱中性子捕捉療法の確立Establishment or Optimal Themal Neutron Capture Therapy for 5 Types of Human Malignant Melanoma･ KURRI‑TR‑374 : 235‑244, 1993
3･横井孝司,飯田秀博,伊藤 浩,菅野 巌.線形グラフプロット法による局所脳血流量の定量解
析法の開発: "231‑IMPダイナミックSPECTへの応用.核医学00: 1451‑1457, 1993.
4･伊藤 浩,飯田秀博,村上松太郎, Bloom触dPM,三浦修一,奥寺利男,犬上 篤,小川敏英, 畑澤 順,藤田英明,下瀬川恵久,菅野 巌,福田 寛,上村和夫. N‑isopropyl‑p‑[1231]iodoam phetamine(1231‑IMP)およびダイナミックSPECTを用いた局所脳血流量画像および局所脳血液 分配定数画像の高速計算法の開発.核医学00: 13‑23, 1993
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7･須原哲也,古川重夫,宍戸文男,福田 寛‥ポジトロンCT用頭部固定装置の試作核医学00(10),