� ˼Ĕô&ŭČ 2)&Ĕ§IJĎČ ( Ĕ§TBJMĠ¾ƟĔŕŝ&ĂĤƟĔ ļoĺ &ĂĤ )
� ŘgĨ&ĂĤ
� ŐĔ&yĭ]ğïĪě&ŭČ
� ŘğïĪä&ŭČ
ƜƣƝĵħĪě&ŭČ
ĹŰŦƁ24ŢÁĄƃe% 5 37.5�
p`&ĵħ&ùô"&¬9ŭČ $ Ɵĵħ&¬ŖĢp¶&ıá!
5"û 50&'ĵħùô&@
=\M24ƈ¶
ƜƤƝĎuð
ÊŲ&îÅÚƀŝĞðFHKV ( Y^
GX^ŀƟćjŽeºùąđ 3-2-14) 9ĭ Ĕ§IJ¬ś&ŝğêu{9Ġ¾5 /&Ďu9ð
ƜƥƝŋŤţĉ
,Ɵ«ŭČþ3«ĵħ,!&Ą ƃ9 Kaplan-Meier Ĝ% ţĉƟƣŏƃ&
ĂâÉ5#9 log-rank Ď¾%
ŭ*
3%ƟĵħYHA"ūªàŖĢ%Ƅź 5"ß865ŭČƑķ&Ƅź9ĉ 5/%Ɵ·µƀCJAHėzOE^NW LZ% pa&Ƒķ&ĉ9Ş$
8ƟªaƋÀ&ĂĤƟĔ§IJ¬ś Ɯ A.a śƟ P.g śƟ E.c śƟ P.i śƝŝğêu { ( «ĎČþ ) Ɵ ˼Ĕ&ĂĤ Ɵ Řg Ĩ&ĂĤƟŘB:&¿÷&ĂĤ&Ʀ Ƒķ!Ďť9Ş
$ Ɵŝğêu{&¾²ġ'ùąĔŁ
¸½]sŜĬ&¾²ġ (20 ÌÎŌí]
볦ĀƟ P.31) 9œ% Ɵ A.a śƟ E.c śƟ P.i ś!Ƣp`9 ( ƞ ) Ɵ P.g ś!Ʀp
`9 ( ƞ ) " ĉ9Ş
C. %'(
«ŭČþ&ªaƋÀ&ĂĤ!ŏ
5"Ɵ ( Ơ ) ŏ 42 £ƜįàƦ£Ɵ»à 37 £Ɵ˱Ìƚ 88.5±7.7 ĕƝ Ɵ ( ƞ ) ŏ 23
£ƜįàƦ£Ɵ»à 18 £Ɵ˱Ìƚ 81.7±8.3 ĕƝ!
ĵħ&Īě9,"/0&9şƢ%Ŀ
˱ 3.4±6.1 ù!_ö ( ƞ ) ŏ!' 23 £e 15 £%ĵħ4Ɵ⏠108 ùƟ ˱ 22.0±31.0 ù! Mann-Whitney U Ď¾&ŊĊƟ p=0.016 !ªaƋÀ ( ƞ ) ŏ"
( Ơ ) ŏ"&ƃ%ĂâÉľŪ6 ē%Ɵdŏ9ŢÁĄƃ% 5«ĵħ ,!&ĄƃƜùôƝ9 Kaplan-Meier Ĝ%2 4þƃţĉ9ŞŊĊ9®Ƣ%Ŀ ( Ơ ) ŏ&eº' 365 ùƟ ( ƞ ) ŏ' 202 ù!Ɵ ŢÁĄƃ9Ź ( ƞ ) ŏ ( Ơ ) ŏ9a«
4Ɵ log-rank Ď¾% p=0.048 !Ă â$ÉŪ/36
CJAHėzOE^NWLZ%25ĉ
&ŊĊ9şƣ%ĿOE^NėƜ HR Ɲ!
š5" 1.5 p`& HR 9Ŀ&'ªaƋ À!Ɵ 0.7 pa9Ŀ&'ŘB:
!$3Ɵ6&Ƒķ0 ŋŤĶĂâÉ'Ū/36$
D. *
Ĕ§IJ'Ř% 5Ĕ§IJ¬ś&
ãċij!4ƟŇÆIJ$#"¢Đ%Ĭĝő åIJ!05ŸÌƟĔ§IJ¬ś9¥.
ŘňśƙƚŔ&ūªàŖĢ%Ƅź 5"Ļ36 4ƟƙƚŔ1ŠmŰŔ
è5ŒkÏ}÷ŧ% 5Ř B:&žŠàŪů6 5
Ĕ§IJ'ãċij!5"3ƟĔ§IJ
%ōá5"Ĕ§IJ¬ś&ŝe IgG êu {`úƟ&êu{9Ġ¾5"%
24Ĕ§IJ¬śƜ A.a śƟ P.g śƟ E.c śƟ P.i śƝ&ãċĪě9Ļ5"ŗ!5 l«&Ľń!'ƟŢÁĄƃ% 5ĵħ
&Īě"Ĕ§IJ¬śŝğêu{&Ƅź9 Ďť,ƟūªàŖĢ&ĵij%Ƅź 5"ß865ŭČƑķ"&Ƅź0x Ďť9Ş
l«&ŭČ3ƟªaƋÀ&5Ŕ&ĵ ħùôĂâ%·"Ŀ6&
ŊĊ'ƟÒĦ&ŊĊ&2%0ß865Ɵ ªaƋÀ5Ŕ!0ƗiÓä&ȹ ( M [U&oc$# ) %24ūª9ƅ"
ŗ$"³¦6 4ƟªaĒŗ"
ƗiÓä"&fƍĵħùô&É&_Ь
"$ŗàœ365Ɵª aƋÀ$ (42 £ ) !ÿŹƗ' 27 £ƟªaƋ À4 (24 £ ) !ÿŹƗ'Ƣ£!4Ɵ_šƟ óƗªaĒŗ"ƗiÓä&¸$fƍ'$
!5ƟM[U&Ñ$#
&ƗiÓä9ę/5Ɗ%ƟƩƨĎČ$#9 ĭ Ş 58!'$Ɵbƕàū ªĬ 5ŗà0œ365"
3_ď%ªaĒŗ"ƗiÓä"&Ƅź9Ů
5"'Ǝ
5Ŕ'ūªàŖĢ9ųYHAƙ
"ľŪ65ŊĊ"$
CJAHėzOE^NWLZ%25ĉ
!'Ɵ ªaƋÀ %25 HR 1.99 "ƙƟ
ŘB: 0.51 "rŊĊ"$4Ɵn
&³¦"¢Đ&¤9ĿŊĊ!
$3ƟĔ§IJ¬ś&ŝğêu{
!'v3&¤9š"'!$
l«'êu{Ġ¾9ãċ&ĂĤ%Ɩ 5Ɗ%ƟýÌÎ&볦Ā!&ùąĔ ُ½]sŜĬ&¾²ġ (20 ÌÎŌ í]볦ĀƟ P.31) 9œ%Ĕ§
IJ"ūªàŖĢ!'ŝğêu{&¾²ġ
"'İ$5ŗà4ƟūªàŖĢ&Y HA¾%ĭ5"!5¾²ġ9 wç5$#&ϝ܊!5"ß86
l«ƟĎť9Ş $ 1 Ì×&ŝ ğêu{9Ġ¾&' 39 £!
«"ƢÌ×&Ġ¾9ėŶ -5"Ɵ
¾²ġ ( Ơ ) 3 ( ƞ ) ' ( ƞ ) 3 ( Ơ ) %µ
Ŕ66Ƥ£¼¯&
"3ŝğêu{'ŘB:9 5 Ŕ!0µ 5"òÁ65
&2%êu{µ 5"3Ɵ ŝğêu{ĵħYHA9ü5"q¾
´¡%Ɵŝğêu{#63&Ą ƃ&ĵħYHA9ü5"ŗ!
59Ďť5ÜŠ5"ß865ũ
%«ĎČ3 100 ùƃ&ĵħ%Ƅ
&-9ţĉ -5"Ɵ P.g śŝğêu{
& HR 2.42 Ɯ 95% ~Ɠƃ 0.49 Ơ 11.90 Ɵ P=0.278 Ɲ Ɵ ŘB: HR=0.22 Ɯ 95% ~ Ɠƃ 0.04 Ơ 1.39 Ɵ P=0.108 Ɲ"$
ŖĢ%25ĵħ"&ƄźĿ61
ŗà9Ŀ© 50&"œ365
E. (/
l«&@ZKŭČ9ĉ"7Ɵª aƋÀ&5Ŕ&ĵħĂâ%·"
ľŪ6ƟªaƋÀ&5Ŕ%Â5Ř B:&žŠà9Ūů3650&!
,ƟĔ§IJ¬śŝğêu{" 1 Ìƃ
!&ĵħùô%'ĸñ&Ƅź'š36$
Ɵêu{Ġ¾3ƢÌƃ"
ƂĄƃ!$Ɵ_¾&Ąƃ9ŧ¾5
"!Ĕ§IJ¬śĵħYHA%ÕƐ 5ŗà5"&ŊĊ9Ø36
F. ,
ĩ%ŦŷiƑ$
G. %' +
ĩ%ŦŷiƑ$
H. $"05!3
ĩ%ŦŷiƑ$
%'
śÇƐƱnj(Ǒŵ IgG ġŒŏ#ÌūƇ®ìnƱnjŒŏ(ȎǼđȬ 6+ÌūŒŏ({ƛđ&Ȏ9ƞƦ
Ǐ «
ĺņśƣäìʼnƜŅäìśƣǓƇìƣ
%'.8<Ó(Ĝ&9śÇƐńƐſ)Ȭ 70 Ⱥ 80 Ȩ#Ŕ2!Ȥ/ǸþȬ Njþ÷"(ńƐƿ3ß©Â&9śÇƐ)śǀƷs^hoG&ƇĒ9śÇƐƱnj
&6!ƓƑnǽǒ9ƱnjėōđƏĔ"9ǸþȬºDŽƱnj#dzđƏĔ#(Ȏ<
8ĥİ:!8ȬśÇƐ& !3ÀŖ%ÛÆ07:96&%!
!ȬśÇƐ{ȏ)²&ºDŽöĞ&ƍ/7ȬÓŠ(dzƕ%Ă(Ĥnßǽ&Ŕ 2!Ȇǘ%Ǫȟ#%!9Ž&DZȤȦƢ=1 <Ó")ȬȤȦƿ&9 śÇƐƱnj=Ä1ºDŽƱnj&69ėōƑóƫĐ#%!"ņƞƦ)ȬǑ ū9)Ìū=Œ#9śÇƐŒŏ=îĹȬŒŏƴŋ#džĀXhdoP#(ȎǼ đ6+Œŏȍ(ȎǼđ& !ŒǠ7&Ȭ CPI (á®#¾ƥŒŏƴŋ#(
ȎǼ& !3ŒǠóǯ)Ōœ&!îĹ:íŅĂǣ͹ǣƿ 690 Áȩƌ đȹ 493 ÁȬýÖþȦ 46.4 8.7 ŜȬæđȹ 197 ÁȬýÖþȦȹ 38.8 7.6 ŜȪ"9 ŒŏƉ(Œ#!Ȭ¹ǣŁ&ĥõǑŵ#¥ŷÌū=ĩ¸ǑūŒŏȚƘ)ȬśÇ ƐƱnj&ó9Ǒŵ IgG ġȩ P.g P.i A.a E.c Ȫ=ŰíÌūŒŏ)ȬƇ®ì Œŏ#!Ȭ_eHlZmȩ Hb ȪȈȬ LDH ȩ lactate dehydrogenase ȪŨđȬ AST ȩ aspartate amino transferase ȪŨđȬ ALT ȩ alanine amino transferase ȪŨđ6+ ALP ȩ alkaline phosphatase ȪŨđ=ȬƱnjŒŏ#!ȬƵnjijȬ P.g ij6+Ƶnjij&³29 P,g ij(
¨¿=Űí/pȂ(óǯƿ& !Ȭ CPI (á®(ńź#¾Œŏƴŋ#(ȎǼ đ=ǫ,śÇƲƸŒŏ)Ȭ CPI Ŧ&69ºDŽǣŏ&!ǒóǯƿ&9ƴ ŋ) s(ǻ8"Ǒŵ IgG ġ(Ȭ P.g &ó9ġ)Ȭ CPI ä ƿ-$ńĖ&Ȥ=ơÌūƇ®ìŒŏ")Ȭ LDH Ũđ# Hb Ȉ CPI (
äƿ"Ȥ=ơÂ& Ǒŵ IgG ġ#ÌūŒŏƴŋ(ȎǼ& !)Ȭ P.g ġ# LDH Ũđ#(ȍ&ńĖ%ȎǼǧ27:/pȂ(óǯƿ& !Ȭ 2004 þ# 2008 n 2009 þ(ĂǣĶŁ( CPI 7Ȭ CPI á®%ƻ#ǽǒ ƻ&ȠȬ¾Œŏƴŋ#(ȎǼ=ǫ,(ƴŋȬ P.g ġ)Ȭá®%
ƻ")ńĖ%á¬07:%Ȭǽǒƻ") P.g ġ(ńĖ%ß©ǧ 27: r(ƴŋ7ȬǑŵ P.g ġȬÌū Hb # LDH )śÇƏĔŒŏ#!ń
P.g
ºDŽ(}äƏĔ"9ȧǐ#śÇƐ)Ȭ
&ºDŽċƇż(Ñėō&6!ƓƇ 9ėōƑ"9/Ȭ:7(ƓƑ4ǽ ǒ&)ȬŖ%ƇŨƽĚȎu9#
7ȬƇŨƽĚƐ#!ħ 7:!9<
Ó(ȧǐńƐſ)ȬþȦ÷=ǻ!
1'ŮôÂ&9ȬśÇƐ(:) 70 Ⱥ 80 Ȩ=DZ 9Ȥơ:!9©
!ȬśÇƐ)²&ºDŽöĞ&#$/7Ȭ
dzƕ%Ă&3ćș=¶.#Ľ7
&%!!8Ȭ(óƫ)ÓŠ(
Ă(Ĥßǽ&Ŕ2!Ȇǘ%Ǫȟ#%!
7&ȬśÇƐƱnj=Ä1ºDŽƱnj
&6!ăǰ:9ÎsđǁŸȩǨÎ đǁŸȪóƫ3ȬDZȤȦƢ&Ƨ<
Ó")Đ#%!9
ƂÕȬśÇƐ&ó9ţƒŦ)Ùņţƒ
&è/8ȬǎżƒŦȬâƣţƒ6+Ƈ ƒŦƪƠƨ:!8ȬĔƿ(ƐĘ&Ď óĎ%:!9ȬśÇƐ {ȏ&Ȏ!)Ȭ^hoGKmUloj â(ªŋƕ%ĸŦơ:!%(
6%žŤs")ȬśÇƐóƫ#!ĻŅ ƓǙnĻŅţƒ=Ƙƕ#9Ʃ}ř{ȏ ńƉ%{ȏğŞ#%9ȬƂž(ś ÇƐŒǣ(ã)ȬĪȉ=Ɖ<59
case finding (ğŦĩƉ:!9
%<ȬśÇƐ(iNG={ŰȬ(
(iNG=Ȑµ9(")%Ȭ"&
śÇƐ&%!9Ã=Īȉ"09 case finding (ğŦ"Ʃ}ř{ȏîDz :!9(6%ĸŦ")ȬLJǛƑž
%ęđƕ&ǽǒ9śÇƐ&!)Ȭ č3ĻŅƓǙ& %7%Ü¿3ã
!ȬśÇƐ(ƓƑ4ǽǒ={
Ű9ķ%ŒŏŦ(ȌƓ)ȬŔ2!Ȇǘ
#ƾ 7:9© !ȬȤȦƿ(dzƕ%
9#&ȬƏƐ(žĘ(Ǥ&3Ɖ7:
9#7ȬdžĀŒŏ)ƏƐ(NGioV mHȬǣĶ6+ţƒªŋ(£íƪ&
!čǘt»Ř#%!9¦ǹ(#Ȭ ĉňǒ<:!9śÇƐŒŏ)Ȭśƣ¯ú
&69ǚǣnǝǣ׌ŏ-#>$"ȬǕ Œƿ7ĩ¸Ƈǥĵ=Œ#9 Œŏ)-#>$ǒ<:!%"Ȭ ĝ)ºDŽÒń(Ƈǥĵ"9Ìū&
ƚƘȬ:=Œ#9śÇƐŒŏŦ=
ŒǠ!Ìū)¾ÌūDž7ť :®ìĜ(-&ȬśǀŲŴūȬƔ ǑƃȬ§ȕrƖƱǂ%$(ƇĜ4Ȭċ Ƈż#(ǭƈżƪ=Ä1#7Ǘ Ȕ%Ŗƙ=Å!9Ȭ(pĸ"ºDŽ (žĘ=6·Ŀ!93(#ƾ 9 Ìū=Œ#9śÇƐŒŏ#!)ȬŶ Ǒǥȣ4ȄưŨđ=Űí9Ƈ®ìŒŏȬ 6+śÇƐ´Ʊnj=PoJQU&
ƱnjŒŏŒǠnȌƓ:!9:7 (ȬƇ®ìŒŏ#!)Ȭ_eHlZ mȩ Hb ȪȈ4 LDH =)2#9ijƥȠ (ȄưśÇƐ(NGioVmHŒŏŦ
#!ńƉ"9#ÛÆ:!9
%<Ȭ::(Œŏ&!ȬDQ UC\=ƬȬIJėā#ŽƎāşǵ ƕljç%Œŏ"9#Ơǧ:!
9/ȬƱnjŒŏ& !)ȬśÇƐ´
Ʊ nj Ȭ Ž & Porphyromonas gingivalis ȩ P.g Ȫ(íȈŒŏśÇƐ(ƺĔžŤ=
Ǥ9r"ńƉ"9#3ÛÆ:
!97&Ȭ P.g ij(Űí)ȬśÇƐ (ƓƑ4ǽǒ(Ƥā=Ǥ9r"ńƉ
"9#3ơ:!9Ìū)Ȭśƣ țØ&!şǵƕĩ¸4Ƈǥ ĵ"9!ȬśÇƐ(džĀŒŏ
#!ÌūŒŏƠƨ:Ȭ:7(ƴŋ
Į4ƭƄ&3ńƉ%Œŏ&%9#ď<:
9
ǻûȬėōƑ&ó9Œŏ#!)Ȭ¾ ƥŒŏ7(Ɛ´Ʊnj(ŒnÀí4Ǒū x(ġŰíǒ<:9śÇƐ)ėō Ƒ"9#7ȬƐ´nj&ó9Ǒūġ
Űí)ńƉ#ď<:9Ž&ċȈ(Ǒ ūǥĵ"Űí»ǃ%Œŏ)ȬśƣțØ"
3°&ŨƉň9#ƾ 9ņƞƦƁ(
ȤŎ7(Hjo^)ȬĥõǑŵ=Œ#
9śÇƐ´Ʊnj&ó9 IgG ġŰí ȬśÇƐNGioVmH&ńƉ"9
#=ÛÆ!9
"ņƞƦ")ȬÌū=Œ#9Ƈ®
ìnƱnjŒŏ#Ǒū=Œ#9śÇƐ´
Ʊnj&ó9 IgG ġŰí=ǒȬ¾Œ ŏƴŋ(ȎǼđ4:7(śÇƐŒŏ#
!ńƉđ& !ŒǠ
B. %'
ȰȮóǯƿ
óǯ)Ōœ&!îĹ:íŅĂǣ ͹ǣƿ 690 Áȩƌđȹ 493 ÁȬýÖþȦ 46.4 8.7 ŜȬæđȹ 197 ÁȬýÖþȦȹ 38.8 7.6 ŜȪ"9Ȭóǯƿ&6!
)Ȭ,!(ŒŏȚƘ=¹!%ƿ3
ǣîĹŅȍ)Ȭ 2008 þȸŃ7 2009 þ 10 Ń"/Ȭóǯƿ(p Ȃ& !)Ȭ 2004 þŁ&îĹŒŏƴ ŋ& !3Ð(ŒǠóǯ#ņƞ Ʀ=îĹ9&8Ȭóǯƿ&óĴł
#ºȝ&!ƞƦð&Ȏ9°%ǩĽ=
ǒĈȬÀĖ=Ċ
WHO ^lo]ȩ TPS ^lo]ȬZWTm UƢȬiYSmLgPAmȪ=ƉȬƯ 20g (ĦÔ"śÇaIQU&ĦȬǴĢ ġŁŹ"(śǀǷƷȂ(ƘƗ8=
mm ²"ŰíņƞƦ")ȬȜȘ ǸČȬȜȘxåȬȜȘǿČ( 3 Ź6 +LjnºǍ(xå 1 ŹȬ¿ǟ 4 Ź=Ű í
ȲȮÌūƇ®ìŒŏ
ȡ|į¸ȱȺȲŁȍƳǾĈ&ȬȢĵ 6+ƆÈĵ%$=Ä/%Ec`oNȩ 1 g Ȫ= 5 ȍÉÏȬ(ȍ&ũÌ ū=ųnjN[QRƭ&ĩ¸ĩ¸
Ìū)Űí/"šs&êŰí) ȩŐȪZonBcnBjŒŏOmPoȩÚ ƀȪ&!ǒƇ®ìŒŏ#!Ȭ LDH ȩ lactate dehydrogenase Ȫ Ũ đ Ȭ AST ȩ aspartate amino transferase ȪŨđȬ ALT ȩ alanine amino transferase ȪŨđ6+
ALP ȩ alkaline phosphatase ȪŨđ# Hb Ȉ=îĹ
ȳȮÌūx(śÇƐƱnjŒŏ
¦ǹ(ĸŦ&!ĩ¸Ìū=Œ#
!Ȭ P.g ij#ÀŁ&ŰíƵƱnjij&ó 9 P.g ¨¿ȩȪ=ƬŰí&)Ȭ Lyons 7 & 6 9 TaqMan L N S c ȩ ABIPRISM 7700 Ȭ TaqMan ȬƮÓȪ=Ɖ íȈi@jPAc PCR Ŧ=ĎƉƱ nj DNA (ģ)ȬÌū 200 l & 1/10 Ȉ(
DNA ģǥǎȩ FastBreak Ȭ Promega ȬƮÓȪ
=© ĈȬLJ¬őȅģǖƹȩ ACE-96 Ȭ
Bio Tec ȬʼnȪ=Ɖ!ǒƵnjij(
Ƭí& !)Ȭőȅ( 16srRNA )Ʊ
nj(ƥȠ&<7şǵƕ(ÝÙȃ¡
Prevotella intermedia ȩ P.i ȪȬ Actinobacillus actinomycetemcomitans ȩ A.a ȪȬ Eikenella corrodens ȩ E.c Ȫ =ƉȬ::&ó 9 IgG ġ=ŰíŰí) Murayama 7&68ÛÆ: ELISA Ŧ(áŦ&!
ǒġ(Ǥ&!)Ȭ ȩȭȪ Ȭ ȩȪȬȩȫȪ(ȲŞȒ(ǤÙű=Ǣí :7Ùű& !)ǔȰ&ơ
%ȬŰí)ȩŐȪioMfȩȋùȪ&â ŧ
ǔȱ&óǯƿ( CPI ¤&0Ǒŵ IgG ġ#ÌūŒŏƴŋ(ȎǼ& !ơ
%ȬÌūƇ®ìŒŏƴŋ& !)Ȭ pȂóǯƿ( 2004 þǣŁ(ƴŋ3ơ
!9/Ȭ CPI Ȱ(ƿ)Ȭ 2004 þȬ 2008 n 2009 þ#3&ȰÁ 2Ȭ ǜŊToP7ȐâǑŵġ&Ȏ
!Ȭ P.g ġ) CPI Ȥƿ"Ȥ=
ơÂ&Ȭ A.a Ȭ E.c 6+ P.i
&ó9ġ):3 CPI #(Ľ7
%ȎǼ)07:%ÌūƇ®ìŒŏ
&Ȏ!Ȭ Hb ȈȬ LDH ŨđȬ AST ŨđȬ ALT Ũđ) CPI Ȥƿ"Ȥ=ơÂ
&ÀŖ& P.g ij3 CPI Ȥƿ
"ãÂ& 2008 n 2009 þ(
óǯƿ& !ȬǔȰ&ơǑŵ IgG ġ
£íÙű"Ƞƴŋ# CPI #(Ȏ
Ǽ=ǔȲ&ơ
%<Ȭ CPI ȯ")ȩȭȪãȬ CPI Ȥƿ-$ȑđ·Ďƿã
ǔȳ&!(Œŏƴŋȍ(Ŋƴŋ=ơ Ǒŵ IgG ġȍ")Ȭ A.a # E.c Ȭ A.a # E.c Ȭ P.i # E.c Ȭ P.i # P.g Ȭ P.g # P.i ȍ"::ńĖ%ȎǼǧ27:
7& P.g ġ# P.g ijȬ P.i ġ#
LDH2008 n 2009 ȍ"::ńĖ%ȎǼ ǧ27:Ƈ®ìŒŏ")Ȭ ALT2004 þȬ AST2004 þȬ LDH2008 n 2009 þȬ Hb2004 þȬ Hb2008 n 2009 þ#::
ńĖ%ȎǼǧ27:/Ȭ ALP2004 þ) LDH2004 þȬ Hb2004 þ#::
ńĖ%ȎǼǧ27: Hb & !)Ȭ 2004 þ" ALT2004 þȬ AST2004 þȬ LDH2004 þ Ȭ LDH2008 n 2009 þ Ȭ Hb2008 n 2009 þ#Ȭ 2008 n 2009 þ"
ALT2004 þȬ AST2004 þȬ LDH2004 þȬ
LDH2008 n 2009 þ#Ȭ::ńĖ%Ȏ
Ǽǧ27:ƱnjŒŏ")Ȭ P.g ij#
E.c ġȬ P.g ij# P.g ¨¿ȍ"::
ńĖ%ȎǼǧ27:
ǔȴ&Ǒŵ IgG ġȩǔȲ(£íÙű
&69Ȫ#ÌūŒŏƴŋ#(ȎǼ=ơ A.a Ȭ E.c 6+ P.i & !)ȬÌūƇ®
ìnƱnjŒŏƴŋ#(ȍ"ńĖ%ȎǼ)0
%:%
óǯƿ(Ȭ 2004 þ# 2008 n 2009 þ(
Œŏƴŋ9ƿ& !Ȭ CPI (ǽǒ(
ńź#Œŏƴŋ#(ȎǼ=ŒǠȩǔȵȪ
(ƴŋȬ 2008 n 2009 þ& CPI ǽǒ
ƻ")Ȭǽǒ%ƻ&ş,ȬǑŵ
P.g ġńĖ&Ȥ"
ドキュメント内
H21総括・分担.indd
(ページ 42-49)