Step One Step Two Step Three Step Four Step Five Expression No. Verb phrase .
[‘inthe course of things’] LATER: no t in same time-segment as NOW F1 a
In order to illustrate me, let me take as example the plot ofthe fairy tale ‘Cinderella’. Cinderella is, of course, the beautiful daughter of her father’s first wife; but her mother has died, her father has remarried, and he now has two other daughters by his second wife; and none of these three women is particularly attractive. As they are all jealous of Cinderella’s beauty, they treat her as a mere servant-girl, and prevent her father from giving her any fine clothes, or even a bedroom of her own. (Her nickname comes from the cinders among which she is forced to sleep, down inthe kitchen, in front of its hearth, in order to keep warm.)
CD74 expression is increased with amplified activation of parietal epithelial cells by lipopolysaccharide treatment inthe mouse model of focal segmental glomerulosclerosis.
ボウマン嚢壁側上皮細胞の活性化が増幅され、 CD74 発現が増強する）
It is vital that we aim to achieve growth by increasing sales through further differentiating our products at the same time as developing new products and im- proving existing ones in order to meet today’s spe- cific needs.
お風呂はチャックアウトタイムが可能な時間までご利用いただけます。 Guests may enjoy bathes until the check-out time.
A small towel and a larger bath towel are provided inthe guest room and should be brought with you to the bath.
For each SRP/CS (subsystem) according to Table 5, the maximum value of MTTF D for
each channel is 100 years. For Category 4 SRP/CS (subsystems) the maximum value of
MTTF D for each channel is increased to 2 500 years
（ 6 ） オバマ政権の中東政策の初期の段階での評価・検討の作業を行なったものとしては、三上陽一 「オバマ政権の中東和平政策」 （ 『中東研究』第 504 号〔2009 年 6 月〕 、41―54ページ）などがある。 （ 7 ） Barack Obama, “My Plan for Iraq,” The New York Times, July 14, 2008.
（ 8 ） “Remarks of President Barack Obama—As Prepared for Delivery Responsibly Ending the War in Iraq” （http:// www.whitehouse.gov/the_press_office/Remarks-of-President-Barack-Obama-Responsibly-Ending-the- War-in-Iraq/） ; Peter Baker, “With Pledges to Troops and Iraqis, Obama Details Pullout,” The New York Times, February 27, 2009.
【 Discussion 】
Different from ES cells or NSCs and other types of cancer, SOX2 expressionin breast cancer is dependent on the activity of its promoter region, which has direct correlation with SOX2 transcription and mRNA expression level. The cells with high SOX2 promoter-detecting system can identify and isolate live cells with high SOX2 promoter activity ， detailed analysis ofthe cells with high SOX2 promoter activity reveals that this population has CSC-like characters but with a different mRNA expression profile from other reported bCSCs. This system is useful for detecting and isolating the cell population with CSC-like feature in human breast cancer cells. p54 represses SOX2 expression on mRNA and protein levels, knockdown of p54 can increase SOX2 expression and sphere-forming activity. Profiling of sip54 demonstrates that knockdown of p54 also increases SOX2 downstream genes IGFBP5 and IL1R1 and activates PI3K signaling pathway. Deep investigation reveals that p54 represses SOX2 expressionin breast cancer cells through a unique way that it binds to p227 region in SOX2 promoter by HMG-POU sequence and decreases SOX2 promoter activity by forming complex with pol II to disturb SOX2 transcription process.
11. Abstractor's comments
This study is a controlled clinical trial ofthe effectiveness oftwo brands of maoto and oseltamivir and measured the time required to clear influenza virus from the pharynx of patients with type A influenza virus. It is a quasi-randomized controlled trial in which drug treatments were allocated inthe order of consultation. Oseltamivir reduced fever and improved symptoms faster than maoto. On the other hand, it is very interesting that oseltamivir and maoto had similar effectiveness in clearing influenza virus. The fact that there was no difference between thetwo brands of maoto verifies the homogeneity of Japanese Kampo preparations. 12. Abstractor and date
Sato, Y., and Sakagami, K. (2006). Development of omni- directional stereo vision-based intelligent electric wheelchair. Proceedings ofthe 2006 International Conference of Pattern Recognition ICPR2006, 799-804.
in all animal embryos, early stages of preimplantation development occur inthe absence of transcription (Bogliotti and Ross, 2015). During this period, development relies on maternal proteins and mRNAs stored in cytoplasm of oocyte during oogenesis (Tadros and Lipshitz, 2009). The transition from maternal to embryonic control of development happens in successive waves of increasing intensity until the major activation ofthe embryonic genome occurs. This transition has been known with different names through the literature such as maternal to embryonic transition (MET), zygotic genome activation (ZGA), or embryonic genome activation (EGA). It was found that EGA starts at different time point depending on species such as between the 1- and 2-cell stage in mice (Flach et al., 1982; Schultz, 1993); 4-cell stage in pigs (Jarrell et al., 1991); by 4- to 8-cell stages in humans (Braude et al., 1998); by 8- to 16-cell stage in bovine (Memili and First, 2000). Despite the differences in timing of EGA across species, its major features, such as the degradation of maternal mRNA and proteins and the massive transcriptional activation ofthe embryonic genome are conserved in all metazoan (Schultz, 2002; Schier, 2007; Walser and Lipshitz, 2011).