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BRCA BRCA

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BRCA BRCA cDNA

BRCA BRCA

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RAD cDNA . kb ,

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BRC repeats RAD a : BRC repeats RAD

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CHIAI OSHIKAWA OSHIMATSU ONUMA OMIOKA AKEDA RIKAWA OMINOKI

MI ASHIZUME ORIMATSU

CHIAI OSHIKAWA ONUMA OMIOKA ASHIZUME ORIMATSU

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CHIAI ORIMATSU OMIZAWA

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YUTO

UMBS ICKLEM

CHIAI ORIMATSU OSHIKAWA YUTO

OSHIKAWA ORIMATSU CHIAI AGANO ASHIZUME

OMIOKA ASAKI ASHIZUME WANAGA

O , K., Y , Y., Y , K., O ,

T., T , Y., T , E., A , J., M ,

K., O , T., H , K. and M , M. ( a). Valine of human BRC repeat plays an important role in the interaction between BRCA

and RAD . ., , .

O , K., Y , Y., O , T., T , Y.,

H , K. and M , M. ( b). Interac- tions between canine RAD and full length or truncated BRCA BRC repeats. ., in press.

P , L., Y , D. S., L , T., A , S., L , M.,

B , T. L. and V , A. R. ( ).

Insights into DNA recombination from the struc- ture of a RAD -BRCA complex. , , C , C. F., C , P. L., Z , Q., S , Z. D. and .

R , T. C., B , K. A., R , B. A., R , S.

L , W. H. ( ). Expression of BRC repeats in

C. and B , J. ( ). Germline mutations of the breast cancer cells disrupts the BRCA -Rad

BRCA and BRCA genes in a breast and ovari- complex and leads to radiation hypersensitivity

an cancer patient. ., , .

and loss of G( )/M checkpoint control.

R , C., S , J. M., O , M. and

., , .

J , M. ( ). Rad overexpression promotes D , C. R., T , D. O., F , F. L. and H ,

alternative double-strand break repair pathways H. H. ( ). Survey of animal neoplasms in Ala-

and genome instability. , , .

meda and Contra Costa Counties, California. I.

R , P., M , M., B , T., F , T., H , Methodology and description of cases.

J., L -T , K. and V E , H. ( ). Mam-

., , .

mary tumor development in dogs is associated H , W. L., H , Y. H., C , T. J., W , M. L.

with BRCA and BRCA . ., ,

and C , S. C. ( ). Single nucleotide varia- tion in exon of canine BRCA in healthy and .

R , G. R., C , C. J., D , N.

cancerous mammary tissue. ., , .

J., P , J. and M , W. ( ). Flow

M , Y., S , J., S -E , D.,

cytometric analysis of DNA ploidy in canine

F , P. A., H , K., T , S., L ,

mammary tumors. ., , .

Q., C , C., B , L. M., D , W. and .

T , M., T , S., F , A., T , L.

( ). A strong candidate for the breast and

H., M , Y., H , M., T , S. and Y , ovarian cancer susceptibility gene BRCA .

M. ( ). Conserved domains in the chicken

, , .

homologue of BRCA . , , .

M , L. ( ). Population-based incidence of

T , G. N., S , L., W , J., M ,

mammary tumours in some dog breeds.

C. W., A , W. and M , S. ( ). Mam-

., , .

mary neoplasia in a closed beagle colony.

M , J. E., T , D. O., D , C. R. and

, , .

A , A. C. ( ). Canine mammary tumors.

W , A. K., P , R., O , P. A., T , S.

, , .

V. and B , P. L. ( ). RAD interacts with M , M. E. and J , M. ( ). Mitotic

the evolutionarily conserved BRC motifs in the homologous recombination maintains genomic

human breast cancer susceptibility gene brca . stability and suppresses tumorigenesis.

., , .

., , .

W , R., B , G., L , J., S , S.,

O , K., M , M., T , N. and

S , S., M , J., C , N., G , S.,

S , B. ( ). Cloning and sequencing full

G , C. and M , G. ( ). Identification of length of canine Brca and Rad cDNA.

the breast cancer susceptibility gene BRCA .

., , .

, , .

O , K., M , M., Y , Y., S ,

Y , Y., M , M., O , K., N ,

B. and H , K. ( ). IBrca C-terminus

M., T , Y., S , N., H , K. and

interacts with Rad and contributes to nuclear

I , T. ( ). Novel variations and loss of focus formation in double-strand repair of DNA.

heterozygosity of BRCA identified in a dog with

., , .

mammary tumors. ., , .

FEBS Lett

Vet. J

Nature

Gynecol. Oncol J. Biol.

Chem

Oncogene J. Natl.

Cancer Inst

Cancer Res

Vet. J

Cancer Res et al

Sci-

ence Oncogene

J.

Reprod. Fertil. Suppl

Cancer Res

Pathol. Vet.

Nat. Rev.

J. Biol. Chem Mol. Cell. Biol

J. Vet.

Med. Sci

Nature

Biomed. Res

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参照

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