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Studies on the Clinical Application of Kisspeptin Analog and Neurokinin B Receptor Agonist to Improve Reproductive Performance in Goats

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Title Studies on the Clinical Application of Kisspeptin Analog andNeurokinin B Receptor Agonist to Improve Reproductive Performance in Goats( 内容と審査の要旨(Summary) ) Author(s) LARASATI PUJI RAHAYU

Report No.(Doctoral Degree) 博士(獣医学) 甲第506号 Issue Date 2018-03-13 Type 博士論文 Version ETD URL http://hdl.handle.net/20.500.12099/75289 ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

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                             Ặྡ㸦ᮏ㸦ᅜ㸧⡠㸧   /$5$6$7,38-,5$+$<8㸦࢖ࣥࢻࢿࢩ࢔ඹ࿴ᅜ㸧 ୺ ᣦ ᑟ ᩍ ဨ Ặ ྡ   ᮾி㎰ᕤ኱Ꮫ ᩍᤵ ⏣ ୰ ▱ ᕫ Ꮫ ఩ ࡢ ✀ 㢮   ༤ኈ㸦⋇་Ꮫ㸧 Ꮫ ఩ グ ␒ ྕ   ⋇་༤⏥➨㸳㸮㸴ྕ Ꮫ ఩ ᤵ ୚ ᖺ ᭶ ᪥  ᖹᡂ㸱㸮ᖺ㸱᭶㸯㸱᪥      Ꮫ ఩ ᤵ ୚ ࡢ せ ௳   Ꮫ఩つ๎➨㸲᮲➨㸯㡯ヱᙜ   ◊ ✲ ⛉ ཬ ࡧ ᑓ ᨷ   㐃ྜ⋇་Ꮫ◊✲⛉             ⋇་Ꮫᑓᨷ ◊✲ᣦᑟࢆཷࡅࡓ኱Ꮫ   ᮾி㎰ᕤ኱Ꮫ Ꮫ ఩ ㄽ ᩥ 㢟 ┠6WXGLHVRQWKH&OLQLFDO$SSOLFDWLRQRI.LVVSHSWLQ $QDORJDQG1HXURNLQLQ%5HFHSWRU$JRQLVWWR,PSURYH 5HSURGXFWLYH3HUIRUPDQFHLQ*RDWV 㸦ࣖࢠ࡟࠾ࡅࡿ⦾Ṫᛶྥୖࡢࡓࡵࡢ࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀ ㉁࠾ࡼࡧࢽ࣮ࣗࣟ࢟ࢽࣥ % ཷᐜయసື⸆ࡢ⮫ᗋᛂ⏝࡟㛵 ࡍࡿ◊✲㸧 ᑂ ᰝ ጤ ဨ   ୺ᰝ  ᮾி㎰ᕤ኱Ꮫ  ᩍ ᤵ  Ώ ㎶   ඖ             ๪ᰝ  ᖏᗈ␆⏘኱Ꮫ  ᩍ ᤵ  ᯇ ஭ ᇶ ⣧             ๪ᰝ  ᒾ ᡭ ኱ Ꮫ  ᩍ ᤵ  㧗 ᶫ   ㏱             ๪ᰝ  ᮾி㎰ᕤ኱Ꮫ  ᩍ ᤵ  ⏣ ୰ ▱ ᕫ             ๪ᰝ  ᒱ 㜧 ኱ Ꮫ  ᩍ ᤵ  ᮧ ℩ ဴ ☻   Ꮫ఩ㄽᩥࡢෆᐜࡢせ᪨  ㏆ᖺ㸪⚄⤒ෆศἪᶵᵓࡢゎᯒࡀ㐍ࡳ㸪⦾Ṫᶵ⬟ࢆ୰ᯡᛶ࡟⤫ᚚࡍࡿᛶ⭢่⃭࣍ࣝࣔࣥᨺ ฟ࣍ࣝࣔࣥ㸦*Q5+㸧ศἪㄪ⠇ᶵᵓ࡟࢟ࢫ࣌ࣉࢳࣥ࠾ࡼࡧࢽ࣮ࣗࣟ࢟ࢽࣥ %㸦1.%㸧ࡀ㔜せ࡞ ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࡢ஧ࡘࡢ࣍ࣝࣔࣥస⏝ࢆ᭷ࡍࡿ᪂つ࣍ࣝࣔ ࣥ๣ࡣ㸪*Q5+ ࠾ࡼࡧ㯤యᙧᡂ࣍ࣝࣔࣥ㸦/+㸧ศἪࢆ่⃭ࡍࡿ⸆๣࡜ࡋ࡚ࡑࡢά⏝ࡀᮇᚅࡉ ࢀ࡚࠸ࡿࠋࡇࢀࡽࡢ࣍ࣝࣔࣥࡢຠ⬟ࢆㄪ࡭ࡿࡓࡵ㸪ᮏᏛ఩ㄽᩥ࡛ࡣ㸪࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀ ㉁࡛࠶ࡿ 7$. ࠾ࡼࡧ 1.% ࣞࢭࣉࢱ࣮㸦1. ࣞࢭࣉࢱ࣮㸧సື⸆࡛࠶ࡿࢭࣥࢡࢱ࢖ࢻ࠾ ࡼࡧ % ࢆⓎ᝟࿘ᮇࡢ␗࡞ࡿࢫࢸ࣮ࢪ࡟ᢞ୚ࡋ㸪ࣖࢠࡢ⦾Ṫᶵ⬟࡟ཬࡰࡍᙳ㡪ࢆㄪ࡭ ࡓࠋ ᐇ㦂Ϩ࡛ࡣ㸪ࣖࢠࡢ㯤యึᮇ㸦᤼༸ᚋ  ᪥㸪(/3 ⩌㸧࠾ࡼࡧ㯤య㛤ⰼᮇ㸦᤼༸ᚋ ࠥ ᪥㸪0/3 ⩌㸧࡟ 7$. ࢆ㟼⬦ෆᢞ୚ࡋ㸪7$. ᢞ୚ࡀ⦾Ṫᶵ⬟࡟ཬࡰࡍᙳ㡪ࢆㄪ࡭ࡓࠋ (/3 ⩌࡟࠾࠸࡚㸪7$. ᢞ୚ᚋ㸪⾑୰ /+ ࠾ࡼࡧ࢚ࢫࢺࣛࢪ࣮࢜ࣝ⃰ᗘࡣ᭷ព࡟ୖ᪼ࡋ㸪 㢌୰  㢌࡟࠾࠸࡚ᢞ୚ᚋ  ᫬㛫௨ෆ࡟᫂░࡞ /+ ࢧ࣮ࢪ࠾ࡼࡧ᤼༸ࡀㄏ㉳ࡉࢀࡓࠋ୍᪉㸪(/3 ⩌ࡢ  㢌࠾ࡼࡧ 0/3 ⩌ࡢ඲㢌࡟࠾࠸࡚㸪7$. ᢞ୚࡟ࡼࡿ⾑୰ /+ ⃰ᗘࡢୖ᪼ࡀㄆࡵࡽࢀ ࡓࡶࡢࡢ㸪/+ ࢧ࣮ࢪ࠾ࡼࡧ᤼༸ࡣほᐹࡉࢀ࡞࠿ࡗࡓࠋ7$. ฎ⨨ࡢ /+ ศἪ࡟ᑐࡍࡿ่⃭ స⏝ࡣ (/3 ⩌࡟ẚ࡭࡚ 0/3 ⩌࡟࠾࠸࡚ῶᑡࡋࡓࠋࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪7$. ฎ⨨࡟ᑐࡍ ࡿ /+ ศἪࡢ཯ᛂᛶࡣ㸪㯤యᮇࡢࢫࢸ࣮ࢪ࡟ᕥྑࡉࢀࡿࡇ࡜ࡀ♧ࡉࢀ㸪7$. ࡢ /+ ศἪ ่⃭స⏝ࡣ༸⬊ᮇ࠿ࡽ㯤యᮇࡢ⛣⾜㐣⛬࡟࠾࠸࡚ῶᙅࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ ᐇ㦂ϩ࡛ࡣ஧ࡘࡢᐇ㦂ࢆ⾜ࡗࡓࠋᐇ㦂ϩ ࡛ࡣ㸪༸ᕢ㟼Ṇ࡟⨯ᝈࡋࡓࣖࢠ⭐ෆ࡟⸆๣ᢞ ୚ࢳ࣮ࣗࣈࢆ␃⨨ࡋ㸪ࢭࣥࢡࢱ࢖ࢻࢆ  ᫬㛫⭐ෆ࡟ᣢ⥆ᢞ୚ࡋࡓࠋࡑࡢ⤖ᯝ㸪ᢞ୚┤ᚋ࡟ ˄㸯㸱˅

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   ᫂░࡞ࣃࣝࢫ≧ /+ ศἪࡢಁ㐍ࡀほᐹࡉࢀࡓࠋ୍᪉㸪ࡑࡢᚋࡢ᳨ᰝ࡟࠾࠸࡚㸪Ⓨ᝟࠾ࡼࡧ /+ ࢧ࣮ࢪࡣほᐹࡉࢀࡎ㸪᤼༸ࡶㄏ㉳ࡉࢀ࡞࠿ࡗࡓࠋࢭࣥࢡࢱ࢖ࢻࡢ⭐ෆᣢ⥆ᢞ୚ࡣ㸪༸ᕢ 㟼Ṇࢆ἞⒪ࡍࡿᡭẁ࡜࡞ࡾᚓࡿࡇ࡜ࡀ᥎ ࡉࢀࡓࡀ㸪ᮏᐇ㦂࡛㐺⏝ࡋࡓࢭࣥࢡࢱ࢖ࢻࡢᢞ ୚㔞ࡣ /+ ࡢࣃࣝࢫ≧ศἪࢆಁ㐍ࡍࡿࡶࡢࡢ㸪᤼༸༸⬊ࡢᡂ⇍ࢆಁࡍ࡟ࡣ୙༑ศ࡛࠶ࡿ࡜⪃ ࠼ࡽࢀࡓࠋᐇ㦂ϩ ࡛ࡣ㛗᫬㛫ࡢ⸆⌮స⏝ࡀ௜ຍࡉࢀࡓ᪂つ 1. ࣞࢭࣉࢱ࣮సື⸆㸪 % ࢆ༸⬊ᮇ࠾ࡼࡧ㯤యᮇࡢࣖࢠ࡟ᢞ୚ࡋ㸪⏕ṪෆศἪ⣔ࡸ༸ᕢᶵ⬟࡟ཬࡰࡍᙳ㡪ࢆ ㄪ࡭ࡓࠋࡑࡢ⤖ᯝ㸪୧⩌࡜ࡶ࡟㸪ᢞ୚ᚋ  ᫬㛫ࡢᮇ㛫࡟࠾࠸࡚᭷ព࡟ /+ ศἪࡀ่⃭ࡉࢀࡓࠋ ࡋ࠿ࡋ࡞ࡀࡽ㸪ࡑࡢᚋࡢほᐹᮇ㛫࡟࠾࠸࡚ /+ ࢧ࣮ࢪࡸ༸⬊࡜㯤యࡢ่⃭స⏝ࡣㄆࡵࡽࢀ࡞ ࠿ࡗࡓࠋࡇࡢ⤖ᯝ࠿ࡽ㸪௒ᅇ⏝࠸ࡓ % ࡢ༢ᅇᢞ୚ἲ࡛ࡣ༸⬊Ⓨ⫱࡜༸ᕢࢫࢸࣟ࢖ࢻ ࣍ࣝࣔࣥࢆ่⃭ࡍࡿࡓࡵ࡟ᚲせ࡞ /+ ศἪಁ㐍ࢆㄏⓎࡍࡿ࡟ࡣ୙༑ศ࡛࠶ࡿࡇ࡜ࡀ᥎ ࡉ ࢀࡓࠋ ᐇ㦂Ϫ࡛ࡣ㸪7$. ࡜ % ࡢྠ᫬ᢞ୚ࡀ⦾Ṫᶵ⬟࡟ཬࡰࡍᙳ㡪ࢆ᳨ウࡋࡓࠋᐇ㦂 ϩ ࡜ྠᵝ࡟༸⬊ᮇ࠾ࡼࡧ㯤యᮇࡢࣖࢠ࡟ 7$. ࠾ࡼࡧ % ࢆྠ᫬࡟༢ᅇ㟼⬦ෆᢞ ୚ࡋࡓࠋ༸⬊ᮇ⩌࠾ࡼࡧ㯤యᮇ⩌ࡢ୧⩌࡟࠾࠸࡚㸪ᢞ୚ᚋ  ᫬㛫ࡢ㛫࡟᭷ព࡞ /+ ศἪࡢୖ ᪼ࡣ☜ㄆࡉࢀࡎ㸪ᢞ୚ᚋࡢ⾑୰ /+ ⃰ᗘࡣ㸪7$.㸦ᐇ㦂Ϩ㸧࠾ࡼࡧ %㸦ᐇ㦂ϩ㸧 ࡢ༢⊂ᢞ୚ࡢ⤖ᯝ࡟ẚ࡭࡚ప್࡛࠶ࡗࡓࠋࡇࡢ⤖ᯝ࠿ࡽ㸪༸⬊ᮇ࠾ࡼࡧ㯤యᮇࡢ୧ᮇ࡟࠾ ࠸࡚㸪࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀㉁࡜ 1. ࣞࢭࣉࢱ࣮సື⸆࡟ࡼࡿ /+ ศἪ่⃭స⏝ࡀྠ᫬ᢞ୚࡟ ࡼࡾῶ㏥ࡍࡿࡇ࡜ࡀ᥎ ࡉࢀࡓࠋ ⤖ㄽ࡜ࡋ࡚㸪௒ᅇ᳨ドࡋࡓ࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀㉁㸦7$.㸧࠾ࡼࡧ 1. ࣞࢭࣉࢱ࣮సື ⸆㸦ࢭࣥࢡࢱ࢖ࢻ࠾ࡼࡧ %㸧ࡣ /+ ศἪ่⃭స⏝ࢆ᭷ࡍࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋࡲࡓ㸪 ࡑࢀࡒࢀࡢ⸆๣ࡀ␗࡞ࡿస⏝ᵝᘧ࡛ /+ ศἪࡸ༸ᕢࢫࢸࣟ࢖ࢻ࣍ࣝࣔࣥศἪ࡟స⏝ࡍࡿࡇ ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾ㸪/+ ศἪ࡟ᑐࡍࡿࡇࢀࡽࡢ࣍ࣝࣔࣥࡢຠ⬟ࡣ㸪Ⓨ᝟࿘ᮇࡢ᫬ᮇ࡟࠾ࡅࡿ ༸ᕢࡢ⏕⌮≧ែࡀ㛵୚ࡋ࡚࠸ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡓࠋࡉࡽ࡟㸪% ࡣ༢ᅇᢞ୚࡟ࡼࡗ࡚ ࡶ /+ ศἪ࡟ᑐࡋ࡚ᣢ⥆ⓗ่⃭స⏝ࢆ᭷ࡍࡿ⸆๣࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽ㸪༸⬊ Ⓨ⫱࡜㯤యᶵ⬟ࡢಁ㐍ࢆࡶࡓࡽࡍ /+ ศἪࢆㄏᑟࡍࡿࡓࡵ࡟ࡣ㸪% ࡢᢞ୚㔞ࡸᢞ୚㢖 ᗘ࡞࡝ᢞ୚᪉ἲ࡟ࡘ࠸࡚᭦࡟᳨ウࡀᚲせ࡛࠶ࡿ࡜ᛮࢃࢀࡿࠋ     ⏦ㄳ⪅࡟Ꮫ఩ㄽᩥ◊✲ෆᐜࢆⓎ⾲ࡉࡏ㸪ᮏ◊✲ࡀ㸪᪂つ⸆๣࡜ࡋ࡚๰⸆ࡉࢀࡓ࢟ࢫ࣌ࣉ ࢳࣥ㢮⦕≀㉁㸦7$.㸧࠾ࡼࡧ 1. ࣞࢭࣉࢱ࣮సື⸆㸦ࢭࣥࢡࢱ࢖ࢻ࠾ࡼࡧ %㸧ࡢ ⦾Ṫᶵ⬟่⃭స⏝࡟ࡘ࠸࡚ࣖࢠࢆ⏝࠸᳨࡚ドࡋࡓࡶࡢ࡛࠶ࡿࡇ࡜ࢆ☜ㄆࡋࡓࠋ ᐇ㦂Ϩ࡛ࡣ㸪ࣖࢠࡢ㯤యึᮇ㸦᤼༸ᚋ  ᪥㸪(/3 ⩌㸧࠾ࡼࡧ㯤య㛤ⰼᮇ㸦᤼༸ᚋ ࠥ ᪥㸪0/3 ⩌㸧࡟ 7$. ࢆ㟼⬦ෆᢞ୚ࡋࡓ࡜ࡇࢁ㸪(/3 ⩌࡟࠾࠸࡚㸪7$. ᢞ୚ᚋ㸪⾑୰ /+ ⃰ᗘࡣ᭷ព࡟ୖ᪼ࡋ㸪 㢌୰  㢌࡟࠾࠸࡚᫂░࡞ /+ ࢧ࣮ࢪ࠾ࡼࡧ᤼༸ࡀㄏ㉳ࡉࢀࡓࠋ୍ ᪉㸪(/3 ⩌ࡢ  㢌࠾ࡼࡧ 0/3 ⩌ࡢ඲㢌࡟࠾࠸࡚ࡣ㸪⾑୰ /+ ⃰ᗘࡢୖ᪼ࡣㄆࡵࡽࢀࡓࡶࡢࡢ㸪 /+ ࢧ࣮ࢪ࠾ࡼࡧ᤼༸ࡣほᐹࡉࢀ࡞࠿ࡗࡓࠋࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪7$. ࡢ /+ ศἪ่⃭స⏝ ࡣ༸⬊ᮇ࠿ࡽ㯤యᮇࡢ⛣⾜㐣⛬࡟࠾࠸࡚ῶᙅࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ ᐇ㦂ϩ ࡛ࡣ㸪༸ᕢ㟼Ṇࡢࣖࢠ⭐ෆ࡟ࢭࣥࢡࢱ࢖ࢻࢆ  ᫬㛫ᣢ⥆ᢞ୚ࡋࡓ࡜ࡇࢁ㸪ᢞ ୚┤ᚋ࡟᫂░࡞ࣃࣝࢫ≧ /+ ศἪࡢಁ㐍ࡀほᐹࡉࢀࡓࠋࢭࣥࢡࢱ࢖ࢻࡢ⭐ෆᣢ⥆ᢞ୚ࡣ㸪/+ ࡢࣃࣝࢫ≧ศἪࢆಁ㐍ࡉࡏࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋᐇ㦂ϩ ࡛ࡣ㛗᫬㛫ࡢ⸆⌮స⏝ࡀ௜ ຍࡉࢀࡓ 1.% ࣞࢭࣉࢱ࣮సື⸆㸪% ࢆࣖࢠ࡟ᢞ୚ࡋࡓ࡜ࡇࢁ㸪༸⬊ᮇ࠾ࡼࡧ㯤యᮇ ࡟࠾࠸࡚㸪ᢞ୚ᚋ᭷ព࡞ /+ ศἪࡢୖ᪼ࡀほᐹࡉࢀࡓࠋࡋ࠿ࡋ࡞ࡀࡽ㸪ࡑࡢᚋࡢほᐹᮇ㛫࡟ ᑂ ᰝ ⤖ ᯝ ࡢ せ ᪨

(4)

   ࠾࠸࡚༸⬊࡜㯤యࡢ่⃭స⏝ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࠋ௒ᅇ⏝࠸ࡓ % ࡢ༢ᅇᢞ୚ἲ࡛ࡣ ༸⬊Ⓨ⫱࡜༸ᕢࢫࢸࣟ࢖ࢻ࣍ࣝࣔࣥࢆ่⃭ࡍࡿࡓࡵ࡟ᚲせ࡞ /+ ศἪಁ㐍ࢆㄏⓎࡍࡿ࡟ࡣ ୙༑ศ࡛࠶ࡿࡇ࡜ࡀ᥎ ࡉࢀࡓࠋ ᐇ㦂Ϫ࡛ࡣ㸪7$. ࠾ࡼࡧ % ࢆྠ᫬࡟㟼⬦ෆᢞ୚ࡋࡓ࡜ࡇࢁ㸪ᢞ୚ᚋ /+ ศἪࡢ ୖ᪼ࡣ☜ㄆࡉࢀࡎ㸪ᢞ୚ᚋࡢ⾑୰ /+ ⃰ᗘࡣ㸪7$. ࠾ࡼࡧ % ࡢ༢⊂ᢞ୚ࡢ⤖ᯝ࡟ ẚ࡭࡚ప್࡛࠶ࡗࡓࠋ࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀㉁࡜ 1. ࣞࢭࣉࢱ࣮సື⸆࡟ࡼࡿ /+ ศἪ่⃭స ⏝ࡀྠ᫬ᢞ୚࡟ࡼࡾῶ㏥ࡍࡿࡇ࡜ࡀ᥎ ࡉࢀࡓࠋ  ⤖ㄽ࡜ࡋ࡚㸪࢟ࢫ࣌ࣉࢳࣥ㢮⦕≀㉁࠾ࡼࡧ 1. ࣞࢭࣉࢱ࣮సື⸆ࡢ /+ ศἪ࠾ࡼࡧ༸ᕢᶵ ⬟࡟ཬࡰࡍᙳ㡪࡟ࡘ࠸࡚᪂ࡓ࡞▱ぢࡀᚓࡽࢀࡓࠋ  ௨ୖ࡟ࡘ࠸࡚㸪ᑂᰝጤဨ඲ဨ୍⮴࡛ᮏㄽᩥࡀᒱ㜧኱Ꮫ኱Ꮫ㝔㐃ྜ⋇་Ꮫ◊✲⛉ࡢᏛ఩ㄽ ᩥ࡜ࡋ࡚༑ศ౯್ࡀ࠶ࡿ࡜ㄆࡵࡓࠋ  ᇶ♏࡜࡞ࡿᏛ⾡ㄽᩥ 㸯㸧㢟   ┠㸸(IIHFWRILQYHVWLJDWLRQDONLVVSHSWLQPHWDVWLQDQDORJ7$.RQ OXWHLQL]LQJKRUPRQHVHFUHWLRQDWGLIIHUHQWVWDJHVRIWKHOXWHDO SKDVHLQJRDWV  ⴭ ⪅ ྡ㸸5DKD\X/3(,%HKLU\0(QGR1DQG7DQDND7   Ꮫ⾡㞧ㄅྡ㸸-RXUQDORI5HSURGXFWLRQDQG'HYHORSPHQW   ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸㸦㸧㸸㸪  ᪤Ⓨ⾲Ꮫ⾡ㄽᩥ 㸯㸧㢟 ┠㸸2YDULDQDQGKRUPRQDOUHVSRQVHVWRVLQJOHRUFRQWLQXRXVSHULSKHUDO DGPLQLVWUDWLRQRIVHQNWLGHDQHXURNLQLQUHFHSWRUDJRQLVWGXULQJ WKHIROOLFXODUSKDVHLQJRDWV   ⴭ ⪅ ྡ㸸(QGR15DKD\X/3,WR<DQG7DQDND7   Ꮫ⾡㞧ㄅྡ㸸'RPHVWLF$QLPDO(QGRFULQRORJ\   ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸㸸㸪 㸰㸧㢟 ┠㸸9LGHRWUDFNLQJGDWDDQDO\VLVRIEHKDYLRUDOSDWWHUQVGXULQJHVWUXV LQJRDWV   ⴭ ⪅ ྡ㸸(QGR15DKD\X/3$UDNDZD7DQG7DQDND7   Ꮫ⾡㞧ㄅྡ㸸-RXUQDORI5HSURGXFWLRQDQG'HYHORSPHQW   ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸㸦㸧㸸㸪 

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