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(1)日温 気 物 医 誌 第69巻3号2006年5月. The Dioxide. 167. Effects of Bathing with Inorganic Salts and on Body Temperature, Systemic Circulation, Ingestion and Absorption. Satoshi WATANABE1,2), Nobuyuki Shingo. Carbon and Food. IMANISHI2),Taichi ISHIZAWA2),. YANO1,2), Shuichi TAKEDA2), Ken-ichi MIYAMOTO1), Masaki ABURADA3), Junichi IIYAMA4), Kazumi KAWAHIRA5). 1)Dept, of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University 2) Central Research Laboratories, Tsumura & Co. 3) Dept. of Pharmaceutical Sciences, Facultyof Pharmacy, Musashino University 4) Orange Gakuen 5) Dept. of Rehabilitation and Physical Medicine, Facultyof Medicine, Kagoshima University. 炭酸 ガス含 有無機塩浴 の効果 体温 、体 循環 と食物 吸収 渡邊. 智1,2)、. 今 西 宣 行2)、 石 澤 太 市2)、 谷 野 伸 吾1,2)、. 竹 田 秀 一2)、. 宮 本 謙 一1)、 油 田 正 樹3)、 飯 山 準 一4)、 川 平 和 美5) 1)金 沢 大 学 大 学 院 自然 科 学 研 究 科 臨 床 薬 学 講 座. 抄. 2)株. 式 会 社 ツ ム ラ 中 央研 究 所. 3)武. 蔵 野 大 学 薬学 部 薬 学研 究 所. 4)オ. レン ジ学 園. 5)鹿. 児 島大 学 大 学 院 医 歯 学 総 合 研 究 科 運 動 機 能 修 復 学 講 座 機 能 再建 医 学 分野. 録. さ らに本入 浴剤 の食 物 吸収 に及 ぼす影 響 につ い て 、 健 常 人 に 対 す る 有 効 性 を検 討 した 。 そ の. 無 機 塩 類 と炭 酸 ガ スか ら構 成 され る 入 浴 剤 浴 の 末 梢 循 環 と消 化 吸 収 へ の影 響 を健 常 人 を 対 象. 結 果 、 入浴 剤 浴 群 で 、 淡 水 浴 群 と比 較 して 、 食. に検 討 した 。 前 腕 部 分 浴 にお い て は 、 入 浴 剤 浴. 物 摂 取 後 入 浴 時 の 血 糖 値 お よ び イ ンス リ ン の上. が 淡 水 浴 と比 較 して 、 入 浴 中 、入 浴 後 に 皮 膚 血. 昇 の抑 制傾 向 が 示 唆 され た 。 総 蛋 白、 総 コ レス. 流 が 増 加 した 。 そ の血 流 増 加 は 、濃 度 依 存 傾 向. テ ロール 、 中 性脂 肪 、HDLコ. で あ った 。 また 、 入 浴 剤 で の循 環 動 態 を検 討 し. よ び尿 酸 に 関 して は 、 各 群 間 で の 差 はみ られ な. た 結 果 、 淡 水 浴 と比 較 して 、皮 膚 深 部 温 、 皮 膚 表 面 温 、 皮 膚 血 流 につ いて 、浴 後 、有 意 に 高 値. かった。 これ らの結 果 か ら、 本 入 浴 剤 浴 が 、 循 環 改 善 な. で あ り、 循 環 改 善 が 認 め られ た。. ど健 康 増 進 に つ な が る もの と考 え られ た 。. Key words: inorganicsalts,carbondioxide, circulatoryfunctions,ingestion,glucose. レス テ ロー ル お.

(2) 168. S. WATANABE. I. et al.. INTRODUCTION The. beneficial. thermal. effects. improve. motor. bathing. may. hot. These. are. are. springs. in. erals. By and. contrast,. patients. with. distribution. gases,. renowned. go. as. to hot. are. one. or. the. effects. These. springs. effects. to relax. sulfate,. sodium. considered. two. The. floating. system.. sodium. which. worldwide.. flow,. circulatory. such. comprising. of bath. additives. sulfate2-4) reports the. been. and. about. the. thermal. activity. have. has. such. few. as. sodium. minerals. of. and. for. bicarbon-. to. be. or. gasses. of. of. of. sodium. sodium. studies. on. carbon. dioxide6-8),. beneficial. to. found. in. inorganic. bicarbonate5),crude. effectiveness. effects. effects. very. other is. additives. of. or. study,. other. we. the. related. disease.. becoming. The. It is to. be. the. drugs9),. combination sulfate. sulfate. of. and. and. and. herb miner-. bicarbonate,. chloride. of. salts. different. sodium. sodium. effectiveness. increase. a major. by. days.. by to. have. a combination. through. in. Diabetes. chronic. been of min-. is. therapy. basal. level. and. metabolism,. of. many. number metabolism,. can. result blood.. it might. dis-. in necrosis In. If bathing. then. of. metabolic. in the. exercise.. westerniza-. the. a disorder causes. glucose. the. particular,. hyperglycemia. the. dietetic. Japan. in glucose. control. and. in. problem;. increase. caused. important. circulation. its. early. with. be. some. able. to. im-. disorders.. evaluated. the. effects. functions,. this. the. these. improved. systemic. of. on. resulting. circulation. circulatory. effectiveness. been. are. lifestyle-related. have. circulation,. clarify. poor. problems.. improve. have. dramatically. glucose.. considered. can. diabetes this. increased. and. among. systemic. II. effects. example,. absorption. diabetes. In. the. diseases. Arteriosclerosis. prove. blood. people. others,. additives,. diseases. diabetes and. leg,. bath. and. are. the. many. among. bathing increase. gasses14).. diet.. stages,. bath. of and. enhance. Japan,. minerals dioxide. a few. there. Lifestyle-related. the. In. humans.. magnesium. For. lifestyle-related. of. of. dismutase-like. of. orders.. effects. many. been. Recently, tion. hydrostatic. carbon. about. healthcare11-13).. reported.. effects vessels. Japan.. have. superoxide. floating. of blood. contain. and. sulfate1),. There. the. health. reports. sodium. on. and. sold. and. dilation. the. addition,. many. extracts10). als. the hot. In. springs,. including. and. sulfate. health.. There. cause. activity,. magnesium. human. hydrostatic. bathing. promote. healthcare. ate,. thermal, of. type. of. of. bathing. food. with. ingestion. bathing. on. inorganic. and. health. salts. and. absorption. promotion. in. and. on. carbon. dioxide. healthy. on. volunteers. prevention. of. to. lifestyle-. SUBJECTS The. from. study the. subjects. 1 female, forearm. latory 2 years) were seven. comprised were. 39•}2 (2) functions were. divided healthy. 27. years). Ten. healthy of. healthy. used. for. were. used. to. into. four. volunteers. three. examine groups (39•}3. examine (all. bathing. the. (mean. analyses. to. volunteers. whole-body. used. subjects. (3). effect. with years). males,. on. different took. age,. as. follows.. the. effect. 36•}1. 20. Five. used. of bathing. minutes. range,. healthy. before. to. flow the. males. food bathing.. and. bathing.. Data. males. and. immersion effect. of. on. circu-. 3 females, These. ingestion. In. years). (4. of. to examine (9. 51. volunteers. whole-body and. 24. blood. volunteers. absorption of. age. peripheral were. healthy. timing food. years; (1). on. years). Twelve food. 37•}1. In another. 37•}. subjects one. group,. group,. six.

(3) Effects of bathing. with inorganic. salts and carbon dioxide. 169. Table 1 Subjects of each group in examination. healthy. volunteers. The. procedures. consent. ‡V. was. (36•}3. years). complied. obtained. took with. food. the. from. all. of. the. used. in. the. 10 minutes. 1975. after. Declaration. subjects. bathing of. (Table. Helsinki,. in accordance. with. 1).. as. the. revised. ethics. in. rules. 1983.. Informed. of the. laboratory.. sodium. sulfate,. Carbon. dioxide. METHODS 1. Bath. additives. The. bath. dium. additive. bicarbonate,. generated. by. bicarbonate each. organic dissolving. in. The. the. sure. the. of. forearm. was. the. of. 3. Measurement. of. Peripheral ity.. blood. Volunteers. peripheral then. were blood. soaked. of the er. additive. minutes climate. or. later.. The. Co.. of. artificial for. were. before. 10. their climate. minutes.. additive. which. acid,. in. the. and sodium. in a bath 200e. bath. dye.. of. carbonate. tub. or. and. container. was sodium. just. before. water. gave. a concentration. of. was. dissolved. was. as. additive. defined. container on. flow. for of. the. water. as. peripheral. this. forearm. blood. of. easy. two. different. method. by. whole-body. methods.. which. bathing. was was. at 25•}0.5•Ž. climate.. measured.. receptacle. flow. room. artificial. The. for by. and. to. was. mea-. used. forearm. was 15. of. to. humidthe. each. 30,. or. from. flow. was. 150g/200e the. thereafter. doppler. basal. volunteer. 90. removed. minutes. a laser. 50•}2%. acclimatization,. containing. forearm. monitored measured. After. The. container,. at 39°C.. flow. by. forearm. climate. was. Q. a control, blood. peripheral. and. Second,. immersion. in. 25. studied. a simple. flow.. artificial. 1 hour. was. circulation.. by. in an. as. blood. systemic. examined. system. contain-. in the. meter. artifi-. (ALF21R,. Ltd.).. 4. Measurement Volunteers. organic in water. circulation. on. blood. inside. plain. The. room.. ADVANCE. hour. of. fragrance. so-. system. additive. acclimatized. flow. in. a 25e. bathing. was. bath. water. in a temperature-controlled. bath. 10. cial. in. peripheral flow. of. peripheral. bath. of. of. sulfate,. (ISCD).. the. the. amount. dissolved. circulation. immersed. effectiveness. magnesium. containing. 30g. The. contained. small. was. of. of on. a very. additive. dioxide. bathing. study. additive. 33ppm.. carbon. effectiveness. measure. bath. dissolution. about. and. and. bath. of measurement. effect. First,. of. salt. 2. Methods. The. The. dioxide. inorganic. the. water.. experiment.. carbon. acid,. current. circulatory. functions. acclimatized basal. circulatory. room. where. The. bath. in the. by artificial. functions they. contained. whole-body. took either. climate were. a bath bath. in. bathing room. at 25±0.5°C. measured.. The. a sitting. position. additive. at 30g/200 e. and. volunteers with. 50•}2% then. slightly or. plain. humidity. moved bent. water. to knees for. the. for a second at. 39•Ž. control. 1.

(4) 170. S. WATANABE. group.. After. moved. back. functions. the. were. skin. surface. sured. by. of. palm. the. the. first. measured. of. (BP),. resistance. heart. (TPR). the. by. rate. were. clothes. room,. artificial. (HR),. measuring on. (CO),. on. Co.. (ALF21R,. the. The. rate. product. (PRP). system. the. forearm,. instep. Co. and. the. were. mea-. blood. flow. Ltd.).. (GP-303,. and. circulation. peripheral. ADVANCE. measurement. All. of. of. Ltd.).. functions. a bed.. temperature. temperature. pressure. a circulation. circulatory backs. core. surface. meter. their. skin. TERUMO. flow. output. by. lay. The. skin. 205,. doppler. cardiac. measured. the. (CTM. for. they. room.. and. device a laser. suitable. where. climate. forearm,. monitor. measured. wore. climate. in the. temperature. was. volunteers. artificial. a temperature. pressure. Co.. bath,. to the. et al.. The. total. blood. peripheral. PARAMA-TECH. Ltd.).. 5. Food. absorption. The. effects. food,. MA. mate. room. climate tion. of. the. additive. wards. until. min. in. absorption CO.. humidity.. 150g1200. insulin,. Ltd.).. food. protein,. were. the. total. studied. The. test. were at. bath,. before. was. 39°C. the. using. in. for. for. 10. ingestion. an. 1 hour. artificial. in this. minutes.. The. wore. clothes. HDL. cholesterol. triglyceride,. food. a calorie-controlled. conducted. volunteers. cholesterol,. sampled. by. acclimatized. position. Q . After. total. blood. were. Subjects. a semi-recumbent. was. after. food. (CLINICO. peripheral. 120. Statistical The. the. on. 50•}10%. a bath. Glucose, in. bathing. and. taking. bath. level. bathing. 600kcal/375ia. at 25•}2•Ž. measurement. acid. whole-body. whole-body. pochi,. before of. by. and. cli-. artificial concentra-. suitable. for. and. at 20-min. intervals. to. statistically. uric after-. ingestion.. methods data. nificant. were. analyzed. using. Student's. t-test.. Differences. were. considered. be. sig-. at p<0.05.. ‡W. RESULTS. 1. Peripheral The. blood. peripheral. blood. flow in. that. peak. at. 10. in. compared in each. Skin The. skin. and. after. and with. after the. then was. change. immersion. immersion, but. were. almost. decreased.. The. as blood. immersion,. the. water. test. immediately. manner,. not. in the. plain. forearm. increased. 150g/200e. flow. last. sharp. blood. occurred. group.. The. blood. pattern. until. the. of. flow. the. increased. rose. change. in. The. flow. after. was. a dose-dependent flow. increase. induced. blood. again and. This. 7 minutes.. blood. immersion, in. peripheral. of. Thereafter,. flow. during. immersion.. decreased. level. same.. 1). forearm. then. peak. the. as. flow. after and. the. (Fig.. 12. in. blood. the flow. by. 90g/200e. increased. again. minutes.. followed. by. This. to third. a gradual. de-. manner. significantly. the. blood. in flow. the was. ISCD almost. group the. as same. group.. 2. Circulatory 1). by. blood. This. Both. flow. 3 minutes. minutes. in. crease.. the. a dose-dependent. induced. increase. in. blood. peaked. increased and. flow. functions. surface skin. surface. in whole-body. temperature. surface. temperature. temperatures. bathing. of forearm. at. was 10,. 20,. (Fig.2). higher 30. and. after 45. ISCD minutes. bathing after. than ISCD. after bathing. plain. water. bathing.. were. significantly. The higher.

(5) Effects of bathing with inorganic. salts and carbon dioxide. 171. than that before bathing. The skin surface temperatures at 10 and 20 minutes after plain water bathing were significantly higher than that before bathing. 2) Skin core temperature. (Fig.2). The skin core temperatures. at 20, 30, 45 and 60 minutes after ISCD bathing were significantly. higher than those after plain water bathing. The skin core temperatures at 10, 20, 30, 45 and 60 minutes after ISCD bathing were significantly higher than that before bathing. The skin core temperatures at 10, 20, 30, 45 minutes after plain water bathing were significantly higher than that before bathing. 3) Peripheral. blood flow (Fig.3). The peripheral blood flow after ISCD bathing was significantly higher than after plain water. Fig.1. The. effects. peripheral. blood. Fig.3. Changes. volunteers. of the. bath. additive. on the. flow. of peripheral. blood. flow in healthy. Fig.2 Changes temperature. of forearm and instep. surface temperature,core surface temperature.

(6) 172. S. WATANABE. et al.. bathing at 10, 20, 30, 45, and 60 minutes after bathing. The peripheral blood flow was significantly higher at 10, 20, 30, 45, and 60 minutes after ISCD bathing than that before bathing. The peripheral blood flow was significantly higher at 10 minutes after plain water bathing than that before bathing. 4) Skin surface temperature. in the instep (Fig.2). The skin surface temperature. was significantly. higher after ISCD bathing than after plain wa-. ter bathing at 30, 45, and 60 minutes after bathing. The skin surface temperature was significantly higher at 10, 20, 30, 45, and 60 minutes after ISCD bathing than before bathing. The skin surface temperature was significantly higher at 10, 20, 30, 45, and 60 minutes alter plain water bathing than before bathing. 5) BP,HR,CO,PRP. (Fig.4). Diastolic BP was significantly lower at 10 minutes after ISCD bathing than before bathing. There was no difference between the ISCD and control groups in systolic BP, FIR, CO or PRP. 6) TPR (Fig.5) There was no difference in TPR between the ISCD and plain water groups . TPR was significantly lower at 10, 20, and 30 minutes after ISCD bathing than before bathing . TPR of plain water bathing was significantly higher at 10, 20, and 30 minutes after bathing than before bathing .. Fig.4. Circulatory. changes. in healthy. volunteers. before. and after bathing.

(7) Effects of bathing. with inorganic. salts and carbon dioxide. 173. 3. Ingestion and Food absorption with ISCD bathing (Fig.6-8) The effects of ISCD bathing on the blood glucose level were determined in two tests. In the first, the volunteers ingested food before bathing (FBB). In the second, the volunteers ingested food after bathing (FAB). The volunteers in each test were assigned to the plain water and ISCD bathing groups at random. In the FBB test, the blood glucose level in the plain water group reached its highest level at 80 to 100 minutes after ingestion. By contrast, the blood glucose level in the ISCD group remained at about 3/4 of the level in the plain water group (Fig.6). The blood insulin level in the plain water group reached its highest level at 100 minutes after ingestion. By contrast, the blood insulin level in the ISCD group remained half of the level in the plain water group (Fig.6). In the FAB test, the blood glucose and insulin levels were almost the same in the plain water and ISCD groups (Fig.7). Total cholesterol and total protein levels in the blood did not differ in each group after bathing. The blood triglyceride level in each group increased after bathing. The blood triglyceride level in the ISCD group bathing before ingestion did not increase as much as the plain water bathing group by 60 min (Fig.8). There was no change in HDL cholesterol or uric acid level in the blood before and after bathing, respectively.. Fig.5 Changes of total peripheral in healthy volunteers. resistance. index. Fig.6. Changes. after bathing. in healthy. volunteers. before. and.

(8) 174. S. WATANABE. Fig.7. Changes. after bathing. in healthy. volunteers. before. et al.. and Fig.8. Changes. in healthy. volunteers. before. and. after bathing. V. DISCUSSION Since ancient times, the Japanese have enjoyed hot springs very much. Many people go to hot springs to recover their health in Japan. Such hot springs contain minerals including sodium sulfate, sodium chloride and magnesium sulfate, and gasses like carbon dioxide. These hot springs post notices to people about the beneficial effects of the water. These effects are considered to be dependent on the minerals, ions and/or gasses contained within the hot springs. Many researchers have studied the effectiveness of hot springs in terms of their heat, minerals and gasses and in terms of the environment. Many bath additives have been composed on the basis of such research. Some of them comprise only minerals, whereas others contain materials that generate carbon dioxide when dissolved in water. In this experiment, we aimed to clarify the effectiveness of a combination of inorganic salts and carbon dioxide on health promotion. Our results suggest that the bath additive used in this study intensifies the thermal effects of bathing. In the forearm immersion test, there were three peaks of blood flow change; the first occurred shortly after the start of immersion; the second occurred just before the end of immersion; the third occurred after the immersion. The first peak rose more sharply than the other peaks. This first rise of the blood flow showed saturation in relation to the concentration of the bath additive, which suggests that the blood vessels are dilated by thermal of.

(9) Effects of bathing. fects. of. the. has. proposed. the. expansion. that. the. minus. bath. If. is. may. of blood. of. so,. the. bath. peak. third. rise. in. There. vessels,. and. inorganic. that. of. the. caused. peak. by. nervous. level.. bathing,. system25~.. control. factor24~.. and. carbon. as. been. the. kidney,. reported. that. is increased. blood. by. system. Tanaka. influences Iriki. suggests. whereby. Thus,. the. decrease. control. for. the. glucose,. the. was. results. methods. absorption. of used.. from. peripheral. In the. that. in blood reported. our. high. that. an. promotes may. the. a plus. or. observed. transient. in. increase. be. others.. increased. results. the. extension. and. magnesium. of. first. in-. , but. it was. suggest. that. of. blood. in. carbon. of and. work. course6).. Our. after and. than. the. extent. in. after. during. even. longer. in. are. in. a similar. forearm. im-. of. carbon. dioxide. results. indicate. ISCD. act. plain. in. orally,. plain. to. the. whole-body. dilate. water.. dioxide. the. blood. Although. contribution. strong. muscle21).. dioxide.. In. bathing, to. study,. be. that. shown. the. both of. each. due ISCD. to. in. is the. results. suggest bath. additive. different. dos-. may. affect. immediately Fuku. and. others. promotes men19,20). that. small. determined inconsistent. bathing. increase.. expansion. or-. to the. delivered. healthy. internal F-Wave15-17). as. administration. vessel. the. like. which. is an. insulin. blood. These this. water. glucose in. on. absorption,. absorbed. not. influence. administration. food. implies. after. increase. through. direct. study,. glucose. would. an. nerves. considered. which. if the. an. its. our. is. have. peripheral. after. discrepancy. glucose. bathing on. 18). In. than. carbon. skeletal. in due. rise. tests.. occurs. maintained. effects,. at 41•Ž. of. flow. that. the bathing. that. different. sulfate. maintain. dioxide than. immediately. acetaminophen. without. in blood. carbon. in. to. whole-body. longer. flow. dilation. intestine. dosed. level. is. of. and. differ. are. effects. bathing. was. salts. for. may. these. sodium. results. salts. absorbed. Alternatively,. blood. by. and. the. so sharp. clear.. This. food. uptake. after. not. These. flow. in. is drained. be. cause. of. ISCD. inhalation. glucose. decrease was. inorganic. blood. this. and. concentration increase. may. bathing. intestine.. then. glucose. in. study,. blood. maintained. flow. thermal. level. water. and. small. organs,. reported. organ. Tanaka. that. blood. lower. the. immersion.. Our. energy. blood. is not. stomach,. plain. of. immersion,. bathing. these. capillaries. the. could. reported. of. inorganic. maintain. function. the. the. in peripheral. dioxide may. liver,. controls. was. thermal. in. dioxide. et al.. water. bathing.. that. in the. carbon. circulatory. plain. of. after. increase. rise. salts. control the. effects. bathing of. the. the. the. effect. suggests. absorbed and. that. Tanaka. such. on. inorganic. to the. intestine. each. half. that. feedback. after. thermal. water. amount. dioxide. suggests. Recently,. dioxide. a feedback. feedback. that. the. plain. This. reports. after. characteristic. the. effects. salts. component. been. by. 175. effects.. whole-body. that. thermal This. crease. autonomic. and. occurred. seen. on. than. after. Carbon. the. have. to as. the. environmental. a mechanism. reports. reports.. flow. many. bathing.. to. an. following. also. The. those. are. bathing6,8.. age. decreased such. homeostasis. which. thermal. a few. suggesting. There. emerge. on. longer. blood. mersion,. with. act with. been. with The. It has. to of. flow,. was. temperature1-4).. keeping. by. may. temperature. gans. may. rise. accordance have. body. that. via. is regulated. response. in blood. This. additive. vessels. way.. in. vessel. body. maintenance. flow. temperature,. a blood. human. generated. second. The. body. of. the. represent. dose-dependent.. on. blood. salts and carbon dioxide. flow.. crease.. the. the. in environmental. shrinkage. temperature. study. Subsequently,. a change. and. signal. our. additive.. that. with inorganic. caused glucose used. a de-. . It has by. also. carbon. uptake. included. to inor-.

(10) 176. S. WATANABE. et al.. ganic salts and materials to generate carbon dioxide. In one sense, the inorganic salts show almost the same effects as carbon dioxide; therefore, the effects on blood glucose level may be due to the combination of inorganic salts and carbon dioxide. There have been many reports on blood glucose and skin function. In diabetic mice, for example, both the epidermal proliferation and water content in the stratum corneum, without any accompanying impairment in the stratum corneum barrier function, are similar to what is found in aged human skin22).Hanefeld has pointed out that hyperglycemia. is related to the convalescence. of type 2 diabe-. tes, myocardial infarction and the otal number of deaths23). These reports suggest that control of the blood glucose level is really important for health promotion. In turn, our results suggest that bathing with inorganic salts and carbon dioxide could be a method of health promotion. Regarding the lower absorption of glucose from the small intestine following food ingestion associated with ISCD bathing, in the future it will be necessary to study the uptake of blood glucose to muscle and other tissue. In addition, the combined effects of bathing in carbon dioxide or inorganic salts on blood flow increase and thermal maintenance have been studied,, but the individual contributions of each remain unclear, representing a future problem that we should examine. VI. CONCLUSION. 1. The effects of ISCD immersion of the forearm on the peripheral blood flow of healthy volunteers was measured. Peripheral blood flow tended to increase in a dose-dependent. manner after the im-. mersion, indicating that ISCD immersion improves peripheral circulation due to vasodilation. 2. The effects of whole-body. ISCD bathing were studied in healthy volunteers. After bathing, the. skin core temperature of the forearm, the skin surface temperature of the instep, and peripheral blood flow of the palm were significantly higher with ISCD than with plain water bathing. Furthermore, the skin surface temperature of the forearm was high with ISCD as compared with plain water bathing. Diastolic BP was significantly decreased after ISCD bathing, whereas systolic BP, HR, CO and PRP did not differ before and after ISCD bathing. TPR was significantly decreased after ISCD bathing. These results indicate that ISCD bathing may be have beneficial effects on circulatory functions. 3. The influence of bathing on glucose absorption was studied in healthy volunteers. After ingestion, blood glucose and insulin levels after ingestion tended to be suppressed with ISCD as compared with plain water bathing. There was no change in total protein, total cholesterol, triglyceride,. HDL. cholesterol and uric acid levels in the blood among the ISCD and plain water bathing groups. References 1) Ito M, Fujiwara T, Amano K, et al.: Studies on the thermal preservability of bath preparations.. latory systems and stratum corneum J.J.Biometeor. 3) Nagai K, Watanabe S, Kawasaki Y, et al.:. Journal of Japanese Cosmetic Science Society. fects of Hot Water Immersion. 1982; 6: 399-404.. Cardiopulmonary. 2) Nagai K, Watanabe S, Kawasaki Y: Effects of water immersion with the components upon circu-. in humans.. 1992; 29: 25-33. Ef-. with MgSO4 for. System and Thermal Preserv-. ability. J Jpn Assoc Phys Med Balneol Climatol 1994; 58: 54-55..

(11) Effects of bathing. with inorganic. salts and carbon dioxide. 4) Nagai K, Watanabe S, Kawasaki Y, et al.: Studies on the Thermal Preservability of Water Immer-. 15-17. 13). Watanabe. sion with MgSO4. J Jpn Assoc Phys Med Balneol. on. Climatol 1992; 56: 58.. Chloride.. 5) Watanabe S, Nagai K, Kawasaki Y, et al.: Studies on Skin Elasticity, Viscoelasticity and Hydra-. S,. Bathing. tol. with. : 235-239.. Iiyama. J.. Kawahira. Effects. of. Carbon. Dioxide. Balneol Climatol 1994; 57(4): 272-277.. Assoc. 15) fects. 1992; 55: 207-214.. of. 7) Maeda M, Obuchi S, Shiba Y, et al.: The ef-. Phys. J,. Kawahira Water. Liver. and. J,. 2003. ; 66:. 8) Maeda M, Nagasawa H, Shimizu S, et al.: The 17). of. F-Waves. Med Balneol Climatol 2003; 66: 180-184.. Healthy. 9) Watanabe S, Imanishi N, Fujiwara T, et al.: Ef-. al. fects of Bathing with Cutting Crude Drugs. J Jpn. al.:. The. Between J Jpn. 2004;. 18). 68:. 10) Horikiri Y, Hiyoshi T, Kawahira K, et al.: Cir-. Med Balneol Climatol 1998; 61(2): 95-100.. of. stracts. Hemodynamic Functions, Deep Body Tempera-. P014: 20). CO2. Climatol 1987; 50: 187-196.. duced. 12) Watanabe S : Bath Additive and Skin -Effects. N,. on. et. al.:. The. Renal. Balneol. : Changes. FuncClimatol. of. Bathing. in. Tibial. Nerve. (41•Ž,10min) of. SITH. 38th. in. Internation-. collaboration. Rehabilitation. therapy. with. -Possible. preserving. Assoc. Phys. Kobayashi. high. ef-. internal. Med. organ. Balneol. Climatol. K,. carbon. dioxide. during of. Narusawa. X. et. inhalation. OGTT X. M,. X ‡V. in. on. healthy. IUPS,. al.:. Ef-. glucose men.. Rusia.. Ab-. 1997;. 04. N,. Oshida. inhalation. Y, on. diabetic. rats. Sports.2001;. Asian tion. Con-. 26-28.. book. Fitness, 21). N. Visceral. curve. Fuku. Gas Concentration. J Jpn Assoc Phys Med Balneol. 38th. Techniques. K,. Med. Water. of. thermal. tolerance. fects of Artificial Mineral Spring (Basukurin) on. The. des. Proceedings. J Jpn. Fuku. Ef-. ; 267-269.. J:. 68:. fects. 11) Tanaka N, Hiyoshi T, Takesako K, et al.: Ef-. Phys. Warm. 2003. Iiyama. 19). of. Bathing. S, Tanaka. Conference. 2004;. al.:. 85-90.. function-.. culatory Effects of Bath Agent with Senkyu and. et. Hemodynamics. Kawahira. Water. Subjects.. of. Y,. on. 97-101. Y,. Assoc. by. fects. Horikiri. Internationale. Warm. Jpn. OMTH. 135-140.. 67:. Clima-. Bathing.. Proceedings. Horikiri. Matsumoto. ing and the skin blood flow. J Jpn Assoc Phys. J Jpn As-. Sodium. et. Climatol. Bathing. 2003:. Iiyama. J. soc Phys Med Balneol Climatol 2003;. Water. K,. Societe. Hydrothermales 16). tion.. of Bath Additive Based on Skin Care-.. Y,. Studies. Function. Plain. Kidney.. of. 2000; 63: 173-180.. ture, Autonomic Nervous Functions and Blood. Balneol. Horikiri. Balneol. Warm. Effects. Chimpi Extract in Healthy Men. J Jpn Assoc Phys. Med. of. arthritis. J Jpn Assoc Phys Med Balneol Climatol. Assoc Phys Med Balneol Climatol 1998; 61(3):. and. Med. Metabolic and. Iiyama. ference. fects of artificial high concentration CO2 warm. concentration of artificial CO2 warm water bath-. Lactate. al.:. Sulfate Phys. K,. S, et. 53-54.. rabbits. J Jpn Assoc Phys Med Balneol Climatol. water bathing on low back pain and rheumatoid. Sodium. 60. sion with Alkaline Salts. J Jpn Assoc Phys Med. T, Yano. Assoc. 1997;. 14). 6) Yorozu H, Sunagawa T, Komoto Y: Percutane-. Fujiwara. J Jpn. tion State of Stratum Corneum after Water Immer-. ous absorption of 14CO2during 14CO2-bathingin. 177. between. DB,. Manal insulin. Han. Y,. glucose. et. Nagoya 24: T,. al.:. Effects. tolerance J.. in. Health,. of. high. STZ-inPhysical. 25-28. Ginger. sensitivity. H, and. et. al.: muscle. Interacperfu-.

(12) 178. S. WATANABE. et al.. sion on glucose uptake in human skeletal muscle.. farction and death in newly detected NIDDM :the. evidence for capillary recruitment.. Diabetes. Diabetes. 2000. 49(5): 768-774.. up.Diabetologia. 22) Sakai S, Endo Y, Ozawa N, et al.: Characteris-. less mice with experimentally. induced diabetes. M, Fischer. follow-. 1996; 39: 1577-1583. Bunk-. 25) Tanaka N : Balneology, Climatology and Physical Medicine. J Jpn Assoc Phys Med Balneol Cli-. S, Julius U, et al.: The factors for myocardial. 11-year. oudou, Tokyo, 2003; p118-128.. mellitus. J.Invest. Dermatol 2003; 120: 79-85.. DIS Group(1996)Risk. Study,. 24) Iriki M: Body temperature physiology.. tics of the epidermis and stratum corneum of hair-. 23) Hanefeld. Intervention. matol, Tokyo, 2004; p139-145.. in-. Summary The effects of bathing with inorganic salts and carbon dioxide (ISCD) on body temperature, systemic circulation, food ingestion and absorption have been studied in healthy volunteers. The peripheral blood flow in the forearm was found to increase in and after immersion of the forearm into a 25e bathing receptacle containing ISCD, as compared with plain water. The peripheral blood flow tended to increase in a dose-dependent manner with ISCD bathing. The skin core temperature, the skin surface temperature and the peripheral blood flow were significantly higher after ISCD bathing than after plain water bathing. The influences of ISCD bathing on food ingestion and absorption were also studied in healthy volunteers. Blood glucose and insulin levels after food ingestion tended to be suppressed by ISCD bathing as compared with plain water bathing. There was no difference between ISCD and plain water bathing in total protein, total cholesterol, triglyceride, HDL cholesterol, and uric acid levels in the blood. These results suggest that ISCD bathing may contribute to the promotion of human health.. 連 絡 先:〒300‑1192茨. 城 県 稲 敷 郡 阿 見 町 吉 原3586 株 式会 社 ツム ラ. (Tel. 中央 研究 所. 0298‑89‑3824) 渡 邊. 智.

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