• 検索結果がありません。

Department of Internal Medicine Division of Rheumatology

N/A
N/A
Info
ダウンロード
Protected

Academic year: 2021

シェア "Department of Internal Medicine Division of Rheumatology"

Copied!
2
0
0

読み込み中.... (全文を見る)

今ダウンロードする ( 2 ページ )

全文

(1)

62

Department of Internal Medicine Division of Rheumatology

Akio Yamada, Professor Daitaro Kurosaka, Associate Professor Isamu Kingetsu, Assistant Professor

General Summary

An internist must aim to practice patient-oriented medicine that is well grounded in medi- cal science. Therefore, our department encourages its staff members to do basic and clinical research. Major fields of research are clinical and experimental immunology.

Research Activities

Clinical and experimental studies of autoimmune disease were performed.

1. Analysis of the relationship of neovascularization in autoimmune animal models Several studies have found that neovascularization inhibitors inhibit the development of arthritis in animal models of rheumatoid arthritis. We evaluated the effects of the neo- vascularization inhibitor endostatin in murine models of collagen-induced arthritis and bleomycin-induced pulmonary fibrosis.

Furthermore, we are investigating whether there was any relation between Bombina var- iegata peptide 8 and angiogenesis in autoimmune arthritis.

2. Evaluation and analysis of synovial blood flow signals on power Doppler ultrasonog- raphy in patients with rheumatoid arthritis

To assess synovial neovascularization in patients with rheumatoid arthritis, we have eval- uated the synovial blood flow signals in patient’s joints by means of power Doppler ultra- sonography and analyzed the correlation with serum levels of neovascularization-related factors (e.g., vascular endothelial growth factor) and disease activity.

3. Histopathological comparison between dermatomyositis and polymyositis

We have obtained specimens of muscle, fascia, and skin through “en-bloc biopsy” from patients with dermatomyositis or polymyositis under the guidance of magnetic resonance imaging. We then histopathologically investigated the severity of inflammation around the muscle, fascia, and subcutaneous tissue to determine differences between dermatomy- ositis and polymyositis.

4. Clinical studies aimed at standardizing immunosuppressant therapy for autoimmune diseases

Many immunosuppressant drugs have been used to treat severe autoimmune disease, such

as amyopathic dermatomyositis with interstitial pneumonia, but the efficiency of and

treatment strategies for these drugs have not been clarified. Clinical trials can help

establish treatment strategies for severe autoimmune disease. Clinical studies aimed at

standardizing immunosuppressant therapy for autoimmune diseases were performed.

(2)

63

Publications

Kurosaka D, Hirai K, Nishioka M, Miyamoto Y, Yoshida K, Noda K, Ukichi T, Yanagimachi M, Furuya K, Takahashi E, Kingetsu I, Fukuda K, Yamada A. Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin- 1, and angiopoietin- 2 in patients with rheumatoid arthritis. J Rheumatol 2010; 37: 1121

-

8.

Yoshida K, Kurosaka D, Joh K, Matsushima S,

Takahashi E, Hirai K, Noda K, Ukichi T, Furuya K, Yanagimachi M, Kingetsu I, Fukuda K, Yamada A. Fasciitis as a common lesion of der- matomyositis, demonstrated early after disease onset by en bloc biopsy combined with magnetic resonance imaging. Arthritis Rheum 2010; 62:

3751

-

9.

参照

今ダウンロードする ( PDF - 2 ページ - 249.82 KB )

関連したドキュメント

Stability in nonlinear evolution problems by means of fixed point theorems

In this work we study the stability and stabilization of solutions to nonlinear evolution problems by application of fixed point theorems in appropriate Banach spaces of functions

The extension of a local solution to a solu- tion in an arbitrary interval is carried out by means of an almost conservation property of theHs0norm of the solution

In this case, the extension from a local solution u to a solution in an arbitrary interval [0, T ] is carried out by keeping control of the norm ku(T )k sN with the use of

We study the stabilization problem by interior damping of the wave equation with boundary or internal time-varying delay feedback in a bounded and smooth domain

We study the stabilization problem by interior damping of the wave equation with boundary or internal time-varying delay feedback in a bounded and smooth domain.. By

IN RINGS OF DIFFERENTIAL OPERATORS by

The commutative case is treated in chapter I, where we recall the notions of a privileged exponent of a polynomial or a power series with respect to a convenient ordering,

(3.) In the statement of the criterion

Then it follows immediately from a suitable version of “Hensel’s Lemma” [cf., e.g., the argument of [4], Lemma 2.1] that S may be obtained, as the notation suggests, as the m A

The Symmetry of Intersection Numbers in Group Theory

Definition An embeddable tiled surface is a tiled surface which is actually achieved as the graph of singular leaves of some embedded orientable surface with closed braid

The Analysis of the Artifacts due to

While conducting an experiment regarding fetal move- ments as a result of Pulsed Wave Doppler (PWD) ultrasound, [8] we encountered the severe artifacts in the acquired image2.

Power-means of error-terms and distribution of L

Here we shall supply proofs for the estimates of some relevant arithmetic functions that are well-known in the number field case but not necessarily so in our function field case..