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Non Invasive Evaluation of Liver Fibrosis in Patients with Chronic Liver Diseases

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―  1  ― 肝線維化の非侵襲的評価(松本・他)

Non Invasive Evaluation of Liver Fibrosis in Patients with Chronic Liver Diseases

Teruo M

ATSUMOTO

,   Tetsuro S

OHDA

, Shinya N

ISIZAWA

, Daisuke M

ORIHARA

, Takashi T

ANAKA

, Shuichi U

EDA

,

Akira A

NAN

, Yasuaki T

AKEYAMA

, Makoto I

RIE

, Kaoru I

WATA

, Satoshi S

HAKADO

 and Shotaro S

AKISAKA

Department of Gastroenterology, Faculty of Medicine, Fukuoka University

Abstract:We recently evaluated the use of transient elastography(FibroScan)to measure liver  stiffness. In this study, 93 patients with chronic liver diseases were examined by transient elas- tography,  and  we  compared  their  liver  stiffness  to  the  results  obtained  using  several  other  evaluation  methods  for  liver  fibrosis  based  on  a  simple  blood  test. Liver  stiffness  was  signifi- cantly correlated with FIB4, which is calculated by age×AST[IU/l]/(platelet count[10/l]×

ALT[IU/l]0.5). Thus, we speculated that FIB4 is a useful noninvasive method for diagnos- ing liver fibrosis. However, in three cases, there was no association between the results of FIB 4 and liver stiffness which appeared to be due to thrombocytepenia. In these patients, the per- formance of transient elastography is therefore necessary to evaluate the extent of liver fibrosis.

Key words:Transient elastography(FibroScan), Liver stiffness, FIB4, Chronic liver diseases

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