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＜総 説＞ Review 活性酸素種と抗酸化能の観点からの放射線適応応答の考察

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放射線生物研究 Radiation Biology Research Communications 49(4), 396-409, 2014

- 396 -

＜総 説＞ Review

活性酸素種と抗酸化能の観点からの放射線適応応答の考察

放射線医学総合研究所 放射線防護研究センター リスク低減化研究プログラム 二宮康晴

*

、王冰、根井充

（2014 年 11 月 15 日掲載決定）

Radioadaptive response viewed from the relationship with reactive oxygen species and antioxidative cellular capability

Research Center for Radiation Protection, Radiation Risk Reduction Research Program, National Institute of Radiological Sciences

Yasuharu Ninomiya*, Bing Wang, Mitsuru Nenoi (Accepted for publication 15 November 2014)

放射線適応応答は、事前に低線量の放射線を照射すると、その後の高線量の放射線の障害が低減 される現象である。放射線抵抗性誘導の研究には、放射線照射により生じた活性酸素種を消去する 抗酸化能と、生じた DNA 損傷の修復能の２つの観点からの解析が重要と思われる。ここでは、DNA 損傷の１つの原因である活性酸素種と、これを消去する抗酸化能にまず着目して、これまでの放射 線適応応答に関する知見を整理し、抗酸化能と放射線適応応答の関連について考察してみたい。

キーワード： 放射線適応応答、活性酸素種、抗酸化能

Radiation-induced adaptive response (RAR) is a phenomenon manifesting as a priming low dose-induced resistance against a subsequent irradiation at higher dose. To understand this biological defensive phenomenon against radiation, it is important to study from the mechanistic point of view of two basic aspects: One is the antioxidative capability to scavenge the reactive oxygen species generated by radiation, and the other is the capability to repair radiation-induced damages. In this review, we summarize the knowledge of reactive oxygen species, and discuss the relationship between the low dose-induced increase in antioxidative activity and RAR.

*

〒263-8555 千葉市稲毛区穴川 4-9-1

9-1, Anagawa-4-chome, Inage-ku, Chiba, 263-8555 Japan

TEL: +81-43-206-3079, FAX: +81-43-255-6802, E-mail: [email protected]

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