Nagoya City University Academic Repository
学 位 の 種 類 博士 (医学) 報 告 番 号 乙第１９０４号 学 位 記 番 号 論第１６６６号 氏 名 久保田 文洋 授 与 年 月 日 令和 2 年 3 月 25 日 学位論文の題名
Tilted disc syndrome associated with serous retinal detachment: long-term prognosis. A retrospective multicenter survey
(傾斜乳頭症候群に伴う漿液性網膜剥離の長期予後に関する多施設後ろ向き観 察研究)
Am J Ophthalmol 207: 313-318, 2019.
論文審査担当者 主査： 間瀬 光人
PURPOSE: This study evaluated the long-term visual prognosis of a serous retinal
detachment (SRD) secondary to tilted disc syndrome with or without an SRD at the final visit and the interventions.
DESIGN: A retrospective, observational case series.
METHODS: This was a multicenter study with an enrollment of 48 eyes of 41
treatment-naıve patients (14 men, 27 women) in whom tilted disc syndrome related SRD was diagnosed at the first visit. Investigators at each institution decided whether to observe the patients without interventions or to treat with intravitreous injections of antivascular endothelial growth factor agents, photodynamic therapy, or both therapies combined. The patients were followed for at least 12 months. Main outcome measurements were changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) from baseline.
RESULTS: Analyses of all eyes showed improvement from baseline when BCVA was
measured (P < 0.0001), although last BCVA was similar to BCVA at baseline (P =0.46). CRT significantly improved from that at baseline at the final visit (P < 0.0001). When eyes with or without SRD at the final visit were analyzed, baseline BCVAs (P=0.22) were similar, whereas BCVA (P=0.05) and last BCVA (P=0.005) were significantly better in eyes without SRD. When eyes with or without the interventions were analyzed, baseline (P=0.70), best (P=0.99), and last (P=0.70) BCVAs were similar. Last CRT significantly decreased from baseline CRT in eyes that had undergone interventions (P < 0.0001).
CONCLUSIONS: The visual prognosis of SRD secondary to tilted disc syndrome was
