主成分分析を用いた教師なし学習による筋萎縮性側索硬化症とがんの遺伝的関連性の解明

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(1)Vol.2017-BIO-52 No.4 2017/12/4. ØCrg¶qZ€C IPSJ SIG Technical Report. Rüüs› ;Mh-£s` ¶6t‘ ” Ò¤VQ q Uœw¨;$ ÈQwrÌ >±y³Â1,a). g×=±. &y2ï2,b). “A• Ò¤VQ g×=±¢ ALS£ xz •Ë$s &!QìñpK” { ALS pK” æ çº”ç¢ Riluzole£ xz IT ¢ HCC£ t0` o 2 mwŸs” Å ®L› ‹b” \ q UÔ^ •o M” { \ wŒ_› •‡ Q z f‘ xz ALS q z ›t HCC q w › ü \ú¶$s :T’ s” [1]{ f‘ xz ALS ñ q H×0 °q › à pV ” Ì ¦ Ú”§ ”› ¬qb” { -£s` ›Ã¨Z¢ FE£ › ;Mh Rüüs¢ PCA£ t, nMo z Ú. « éžè. ¨; CqÃ”» t,nMo ALS w¨; Ì. ¦ Ú”§ ”› _mZ” { \ wMO. t,nMo z 101 wÓé ”Ò U ALS ñ q 0°q › Ý b” hŠt 95 Ëw^Sp ALS wÌ ¦ Ú”§ ” q ` o ¬R^ •h{ \ •’ wÓé ”Ò t0 b ” ¨; wGæüxz 7‘ s t Èb ” \ q UÔ^ •o M” { \ •’ wŒ_xz ALS S‘ | sŽo› ™b ” T‹ ` •sM{. w†MwhŠwý` MÏ•¬R¶‡ hx. ú› ‰Cb” hŠwýh. Genetic Association between Amyotrophic Lateral Sclerosis and Cancer Y-h. Taguchi1,a). Wang Hsiuying2,b). Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological viewpoint[1]. We establish biomarkers that can discriminate between ALS patients and healthy controls. A principal component analysis (PCA) based unsupervised feature extraction (FE) is used to find gene biomarkers of ALS based on microarray gene expression data. Based on this method, 101 probes were selected as biomarkers for ALS with 95. €ß [1]. 1. 2. a) b). Y Taguchi, Y.-H.; Wang, H. Genetic Association between Amyotrophic Lateral Sclerosis and Cancer. Genes 2017, 8, 243.. ¤ G¶g»¶æúg¶J f˜N, 112-8551, ÔŠ sq¦èG w- Z€t F÷z ý›¢ tag@granular.com hsiuyingwang@nctu.edu.tw. ⓒ 2017 Information Processing Society of Japan. 1.

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