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JAIST Repository: ポリプロピレン表面に関する基礎的研究とその生医学的応用

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(1)JAIST Repository https://dspace.jaist.ac.jp/. Title. ポリプロピレン表面に関する基礎的研究とその生医学 的応用. Author(s). 川本, 尚史. Citation Issue Date. 1998-03. Type. Thesis or Dissertation. Text version. none. URL. http://hdl.handle.net/10119/2049. Rights Description. Supervisor:寺野 稔, 材料科学研究科, 博士. Japan Advanced Institute of Science and Technology.

(2) Physicochemical Properties of Polypropylene Surfaces and Their Biomedical Application Naoshi Kawamoto1 Supervised by Prof. Dr. Minoru Terano. School of Materials Science, Japan Advanced Institure of Science and Technology. keywords polypropylene, surface, crystalline-amorphous microstructure, crystallinity, orientation, blood, protein, platelet, sorbed water. 1. Abstract. The present dissertation describes a basis of the surface physics and chemistry of polypropylene, and blood-contacting properties of their surfaces. Polypropylene molded articles as sheets and

(3) lms with various crystallineamorphous microstructures were prepared by compression-molding and/or drawing using a series of polypropylene having several comonomer contents as starting materials. Physicochemical evaluation by way of spectroscopic, morphological, crystallographic, viscoelastic and mechanical methods, and biomedical evaluation in terms of protein adsorption and platelet activation were performed on the molded articles in order to clarify the crystalline structure at their surfaces. 1 Note:The. author was delegated fromCHISSO CORPORATION.. 2-7-3 Marunouchi, Chiyoda, Tokyo 100, Japan. 1.

(4) Crystallinity of the surface layer for the compression-molded polypropylene sheets was signi

(5) cantly lower compared with that of the bulk. Di erences in crystallinity between the bulk and the surface layer were enhanced by increasing comonomer content of polypropylene as a starting material. Polypropylene formed into the monoclinic crystal form even at the outermost surfaces. Remarkable lattice distortion of crystal unit-cell occurred at surfaces during compression molding. The distortion was ascribed to residual stress during processing. Aggregation state was quite di erent in the continuity of amorphous phase between the bulk and the surface layer for the sheets. Mechanical strength such as tensile and exural strengths decreased drastically with decreasing surface layer crystallinity. Even at the outermost surfaces, c-axis orientation of crystallites parallel to the machine direction was proceeded in similar to the bulk by uniaxial drawing. The orientation of crystalline part was comparable to that of the amorphous part at the surfaces. Protein adsorption onto polypropylene surfaces and platelet activation that were coming in contact with the surfaces changed with the variation of crystalline-amorphous microstructure such as crystallinity, long period, and orientation, resulting in improving blood-contacting properties at the surface with a particular microstructure. Adhesiveness of polypropylene surfaces and the structure of sorbed water into polypropylene were evaluated by peel test and IR spectroscopy, respectively. The blood-contacting properties were affected signi

(6) cantly by the macromolecular interaction, that is a probability in interaction between proteins and amorphous chains at polypropylene surfaces, and by the hydrophobic interaction in terms of structure of sorbed water. Excellent blood-contacting properties were achieved by the reduction in these interactions via optimizing the crystallinity and the orientation.. 2.

(7) 2. List of Publication and Patents. 2.1. Original Articles. 1. N. Kawamoto, H. Mori, K. Nitta, N. Yui and M. Terano, Characterization of the di erences in the crystallinity from surface to bulk of compression-molded polypropene sheets using attenuated total re ection Fourier-transform IR spectroscopy, Macromolecular Chemistry and Physics, 197, 3523-3530 (1996). 2. N. Kawamoto, H. Mori, N. Yui, K. Nitta and M. Terano, E ects of surface crystallinity on dynamic mechanical properties for compressionmolded polypropene sheets, Die Angewandte Makromolekulare Chemie, 243, 87-98 (1996). 3. N. Kawamoto, H. Mori, N. Yui, K. Nitta and M. Terano, Tensile and exural behavior of polypropene sheets with di erent crystallinities of surface layer, Die Angewandte Makromolekulare Chemie, in press (1998). 4. N. Kawamoto, H. Mori, K. Nitta, S. Sasaki, N. Yui and M. Terano, Microstructural characterization of polypropene surfaces using grazing incidence X-ray di raction, Macromolecular Chemistry and Physics, in press (1998). 5. N. Kawamoto, H. Mori, M. Terano and N. Yui, Blood compatibility of polypropylene surfaces in relation to crystalline-amorphous microstructure, Journal of Biomaterials Science, Polymer Edition, 8, 859-877 (1997). 6. N. Kawamoto, H. Mori, K. Nitta, N. Yui and M. Terano, Crystalline structure at surfaces of uniaxially drawn polypropylene

(8) lms, Die Angewandte Makromolekulare Chemie, in press (1998). 7. N. Kawamoto, H. Mori, N. Yui and M. Terano, Mechanistic aspects on blood-contacting properties of polypropylene surfaces-from the viewpoint of macromolecular entanglement and hydrophobic interaction via water molecules, Journal of Biomaterials Science, Polymer Edition, in press (1998). 3.

(9) 8. N. Kawamoto, M. Terano and N. Yui, Blood-contacting properties of polypropylene surfaces, Journal of Arti

(10) cial Organs, submitted (1998). 2.2. Reviews. 1. N. Kawamoto, H. Mori, K. Nitta, N. Yui and M. Terano, Estimation of surface crystallinity for compression-molded polypropylene

(11) lms using ATR-FT-IR Technique, Surface Science of Crystalline Polymers, N. Yui and M. Terano Eds., Kodansha Scienti

(12) c, Tokyo 1996, p.45-50. 2. N. Kawamoto, H. Mori, N. Yui, K. Nitta and M. Terano, Characterization of surface layer in compression-molded polypropylene

(13) lms using dynamic mechanical spectroscopy, Surface Science of Crystalline Polymers, N. Yui and M. Terano Eds., Kodansha Scienti

(14) c, Tokyo 1996, p.61-68. 3. N. Yui, N. Kawamoto and M. Terano, Design of blood compatible polypropylene surfaces by controlling crystalline-amorphous microstructure, Advances in Polymeric Biomaterials Science, T. Akaike, T. Okano, M. Akashi, M. Terano, and N. Yui Eds., CMC, Tokyo 1997, p.15-32. 4. N. Kawamoto, H. Mori, N. Yui and M. Terano, Recent research tendency of the polypropylene surface properties, Fine Chemicals, 25, 5-13 (1996). 5. N. Kawamoto, H. Mori, N. Yui and M. Terano, Feasibility of blood compatible polypropylene surfaces, Function & Materials, 17, 41-53 (1997). 2.3. Patent Application. 1. JP 8-219286 (Application Number) N. Kawamoto, M. Terano (patent rights for Chisso Corporation) 2. JP 8-219287 (Application Number) N. Kawamoto, M. Terano (patent rights for Chisso Corporation) 4.

(15) 3. JP 8-277476 (Application Number) N. Kawamoto, N. Yui, M. Terano (patent rights for Chisso Corporation and Terumo Corporation) 4. JP 9-123205 (Application Number) N. Kawamoto, Y. Shiraishi, N. Yui, M. Terano (patent rights for Chisso Corporation and Terumo Corporation) 5. JP 9-264892 (Application Number) N. Kawamoto, Y. Shiraishi, N. Yui, M. Terano (patent rights for Chisso Corporation and Terumo Corporation) February 20, 1998. Copyright c 1998 by Naoshi Kawamoto. 5.

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