• 検索結果がありません。

To evaluate the efficacy and safety of goshuyuto for relieving chronic headache using as a control.

N/A
N/A
Protected

Academic year: 2018

シェア "To evaluate the efficacy and safety of goshuyuto for relieving chronic headache using as a control."

Copied!
1
0
0

読み込み中.... (全文を見る)

全文

(1)

Evidence Reports of Kampo Treatment

Task Force for Evidence Reports / Clinical Practice Guideline Committee for EBM, the Japan Society for Oriental Medicine

930023e

18. Symptoms and Signs References

Seki H, Tateyama M, Sahara M, et al. Pain-relieving effect of goshuyuto on chronic headache: comparison with keishininjinto (with randomization using the sealed-envelope method)*. Shinryo to Shinyaku (Medical

Consultation & New Remedies) 1991; 28: 573–6 (in Japanese). Ichushi Web ID: 1992103222

Seki H, Okita N, Takase S, et al. Pain-relieving effect of goshuyuto on chronic headache: comparison with keishininjinto (with randomization carried out using the sealed-envelope method)*. Pharma Medica 1993; 11: 288–91 (in Japanese). Ichushi Web ID: 1994170314

1. Objectives

To evaluate the efficacy and safety of goshuyuto (呉茱萸湯) for relieving chronic headache using

keishininjinto (桂枝人参湯) as a control.

2. Design

Randomized controlled trial using sealed envelopes for allocation (RCT-envelope).

3. Setting

The department of neurology of one hospital, Japan.

4. Participants

Eighty-eight patients with chronic headache.

5. Intervention

Arm 1: oral administration of goshuyuto (呉茱萸湯) (manufacturer unknown) 2.5 g t.i.d. for 4 weeks

(n=44).

Arm 2: oral administration of keishininjinto (桂枝人参湯) (manufacturer unknown) 2.5 g t.i.d. for 4

weeks (n=44).

6. Main outcome measures

Headache severity rated on a 4-point scale.

7. Main results

Headache severity was at least moderately improved in 56.8% and 38.6% of patients and at least slightly improved in 79.5% and 61.4% of patients in the goshuyuto (呉茱萸湯) group and keishininjinto (桂枝人

参湯) group, respectively.

8. Conclusions

The effect of goshuyuto on chronic headache is comparable to that of keishininjinto.

9. From Kampo medicine perspective

Goshuyuto was expected to be effective in patients prone to obesity and constipation and with cold limbs, whereas keishininjinto was expected to be effective in lean patients prone to loose stool.

10. Safety assessment in the article

Mild increase in gamma-glutamyltranspeptidase (γ-GTP), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) or prickly heat rash was noted in 3 patients in arm 1.

11. Abstractor’s comments

This clinical study investigated the efficacy of goshuyuto for chronic headache using keishininjinto as a control and is excellent because it reviewed the sho (証, pattern) of the responsive group with the intention

of elucidating the pathology of chronic headache according to Kampo concepts. Unfortunately, the results were not statistically significant. The failure to demonstrate a significant between-arm difference may be due to the use of only one measure of headache severity. Evaluating headache frequency, time to resolution, and frequency of use of as-needed drugs might have revealed differences in the efficacy of goshuyuto and keishininjinto. The names of the drug combinations and drug manufacturers should also have been specified. In addition, the sho (証, pattern) should have been used to identify the indications for

goshuyuto and keishininjinto rather than to compare the indications for these medicines. Nevertheless, this clinical study is valuable because it considered the difficulty of using a placebo in patients with clinical complaints. The article by Seki et al (1991) was the interim report for this study.

12. Abstractor and date

参照

関連したドキュメント

Lemma4.1.. This is not true if f is not positively homogeneous as the following example shows.. Let f be positively homogeneous. We shall give an example later to show that

It is suggested by our method that most of the quadratic algebras for all St¨ ackel equivalence classes of 3D second order quantum superintegrable systems on conformally flat

We show that a discrete fixed point theorem of Eilenberg is equivalent to the restriction of the contraction principle to the class of non-Archimedean bounded metric spaces.. We

Instead an elementary random occurrence will be denoted by the variable (though unpredictable) element x of the (now Cartesian) sample space, and a general random variable will

Keywords: continuous time random walk, Brownian motion, collision time, skew Young tableaux, tandem queue.. AMS 2000 Subject Classification: Primary:

Next, we prove bounds for the dimensions of p-adic MLV-spaces in Section 3, assuming results in Section 4, and make a conjecture about a special element in the motivic Galois group

Transirico, “Second order elliptic equations in weighted Sobolev spaces on unbounded domains,” Rendiconti della Accademia Nazionale delle Scienze detta dei XL.. Memorie di

In particular, we are able to prove that for Volterra scalar systems with a creep kernel a(t) such that a(0 + ) > 0; the finite-time and the infinite-time L 1 -admissibility