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つくばリポジトリ SR 7 1 2364

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Figure 1.   Glucokinase activation was associated with upregulation of Fbln5 gene expression in pancreatic islets
Figure 2.   Glucose-signal induced Fbln5 upregulation via the glucokinase/K ATP  channel/calcineurin/NFAT
Fig.  S1a ). his result in islets from wild-type mice is consistent with the observation that glucokinase activation  enhances insulin gene expression and insulin secretion in β-cells 12, 34
Figure 4.   Fbln5 overexpression in INS-1 cells enhanced glucose-stimulated insulin secretion, but inhibited  β-cell proliferation
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