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Efficacy of for relieving pain during colonoscopy.

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Evidence Reports of Kampo Treatment

Task Force for Evidence Reports / Clinical Practice Guideline Committee for EBM, the Japan Society for Oriental Medicine

940027e

21. Others Reference

Arai M, Sato H, Shirota F. An investigation into the relief of colonoscopy pain provided by shakuyaku-kanzo-to. Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine) 1994; 44: 385-90 (in Japanese with English abstract).

1. Objectives

To evaluate the efficacy of shakuyakukanzoto (芍薬甘草湯) for relieving pain during colonoscopy.

2. Design

Randomized controlled trial (RCT).

3. Setting

One general hospital, Japan.

4. Participants

Thirty-eight patients (30–60 years old) who underwent total colonoscopy.

5. Intervention

Arm 1: oral administration of TSUMURA Shakuyakukanzoto (芍薬甘草湯) Extract Granules 5.0 g before the examination (n=18).

Arm 2: no treatment (n=20).

Diazepam 10 mg was injected intramuscularly 5 minutes before the examination in both arms.

6. Main outcome measures

Subjective symptoms (visual pain score: VPS), systolic blood pressure, heart rate, and examination time.

7. Main results

VPS was significantly lower in arm 1 (4.89±0.42 vs. 6.20±0.34; P<0.05). There were no between-arm differences in the systolic blood pressure, heart rate, and examination time.

8. Conclusions

Shakuyakukanzoto relieves pain during colonoscopy.

9. From Kampo medicine perspective

None.

10. Safety assessment in the article

Not mentioned.

11. Abstractor’s comments

This paper is of clinical significance in that it demonstrated the efficacy of shakuyakukanzoto for relieving pain during colonoscopy in an RCT. The study would be more meaningful if it employed a design involving administration of placebo, such as lactose, instead of no-treatment.

12. Abstractor and date

参照

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