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Time (min) 0123025103060 0123025103060 Fig. 1 Time (min) 0102030405002510306001020304050025103060 02468025103060Time (min)

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(1)

(A) (B)

(C)

Fig. 1

0 2 4 6 8

0 2 5 10 30 60

Time (min) ERK1/2 activity (fold increase)

AII 0 2 5 10 30 60 (min) ERK1/2

activity

Time (min) JNK activity (fold increase)

JNK activity

Src kinase activity

Time (min) Srckinaseactivity (fold increase)

AII 0 2 5 10 30 60 (min)

AII 0 2 5 10 30 60 (min)

0 10 20 30 40 50

0 2 5 10 30 60

0 10 20 30 40 50

0 2 5 10 30 60

IB: Phospho-Src

0 1 2 3

0 2 5 10 30 60

IB: Phospho-Src

0 1 2 3

0 2 5 10 30 60

(2)

Fig. 2

(A) (B)

(C) 0 2 4 6 8

0 0.01 0.1 1 10 100 1000 ERK1/2 activity (fold increase)

Concentration (nM) ERK1/2

activity

AII 0 0.01 0.1 1 10 100 1000 (nM)

0 20 40 50

0 0.01 0.1 1 10 100 1000 JNK activity (fold increase)

Concentration (nM) JNK

activity

AII 0 0.01 0.1 1 10 100 1000 (nM)

AII 0 0.01 0.1 1 10 100 1000 (nM) Src kinase

activity

0 1 2

0 0.01 0.1 1 10 100 1000 Srckinaseactivity (fold increase)

Concentration (nM)

30

10

3

(3)

Fig. 3

(A)

(B)

ERK1/2 activity

Olm 0 100 0 0.1 1 10 100 (nM) AII (10 nM)

control

E R K 1/ 2 act iv it y (f o ld i n cr e ase)

AII (10 nM) Olm

control (nM)

0 2 4 6 8

100 0 0.1 1 10 100

0

** **

JNK activity

Olm 0 100 0 0.1 1 10 100 (nM) control AII (10 nM)

JN K act iv it y (f o ld i n cr e ase)

AII (10 nM) Olm

control (nM)

0 10 20 30 40 50

100 0 0.1 1 10 100

0

** **

(4)

(A)

(B)

ERK1/2 activity

control AII Olm PP2

AII

E R K 1/ 2 act iv it y (f o ld i n cr e ase) 0 2 4 6 8

Contol

AII

Olm PP2 AII Olm PP2

Olm PP2

**

**

JNK activity

JN K act iv it y (f o ld i n cr e ase) 0 10 20 30 40 50

Cont

AII

Olm PP2 AII Olm PP2

control AII Olm PP2

AII

Olm PP2

**

**

(5)

Fig. 5

control AII AII

+

Olm (100 µM)

C e ll m igr a tion (f o ld i n cr e ase)

AII (100 nM) (µM)

control 0

0.5 1 1.5 2 2.5 3

0 0.1 1 10 100

Olm 0

**

** **

*

AII (100 nM) (µM)

control 0

0.5 1 1.5 2 2.5 3

0 0.1 1 10 100

Olm 0

**

** **

*

(6)

c ont rol AI I Ol m U SP PP2 Ol m U SP PP2

AI I

Cell migration (fold increase)

** ** ** ** ** ** ** **

0 0.5 1 1.5 2 2.5 3

Fig. 6

Fig. 3 (A) (B) ERK1/2activityOlm0     100     0      0.1      1      10    100 (nM)AII (10 nM)control

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