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To evaluate the efficacy of pretreatment with for upper tract endoscopy.

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Evidence Reports of Kampo Treatment

Task Force for Evidence Reports / Clinical Practice Guideline Committee for EBM, the Japan Society for Oriental Medicine

990010e 21. Others

Reference

Sugihara N. Effectiveness of shakuyaku-kanzo-to as a pretreatment for upper digestive tract endoscopic examination*. Kampo Shinryo 1999; 18: 17-9 (in Japanese).

1. Objectives

To evaluate the efficacy of pretreatment with shakuyakukanzoto (芍薬甘草湯) for upper gastrointestinal tract endoscopy.

2. Design

Quasi-randomized controlled trial (quasi-RCT).

3. Setting

Single facility (clinic), Japan.

4. Participants

Fifty-eight subjects who underwent endoscopy.

5. Intervention

Arm 1: shakuyakukanzoto (芍 薬 甘 草 湯) group (oral administration of 80 mg of dimethicone syrup followed by 5.0 g of shakuyakukanzoto (芍薬甘草湯) extract granules) (n=11).

Arm 2: anticholinergic drug group (oral administration of 80 mg of dimethicone syrup followed by subcutaneous injection of 40 mg of scopolamine butylbromide) (n=28).

6. Main outcome measures

Symptoms during endoscopy (pain evaluated subjectively on a visual analogue scale), peristalsis (Niwa’s classification).

7. Main results

Among those under 70 years, the anticholinergic drug was significantly superior to shakuyakukanzoto in suppression of peristalsis, but was more frequently associated with experience of pain/discomfort.

8. Conclusions

Shakuyakukanzoto provides as much pain relief as the anticholinergic drug.

9. From Kampo medicine perspective

None.

10. Safety assessment in the article

Not mentioned.

11. Abstractor’s comments

Of 58 subjects, only 39 were actually assigned to either group (arm 1, n=11; arm 2, n=28). This sample size seems to be slightly too small to evaluate efficacy.

12. Abstractor and date

参照

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