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Table 3. Cox regression analysis for various potential prognostic factors in recurrence-free survival in 108 N0M0 cases at radical nephrectomy

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Relativ e risk

95%

confidential P value Relativ e risk

95%

confidential P value VEGF high / low 54 / 54 8.131 2.392 - 27.639 0.0008 3.055 0.786 - 11.881 0.1070 B7-H4 high / low 54 / 54 5.398 1.969 - 14.796 0.0010 1.680 0.532 - 5.301 0.3761 B7-H3 high / low 54 / 54 2.105 0.502 - 8.827 0.3089

PD-1 high / low 54 / 54 1.936 0.232 - 3.776 0.9264

PD-L1 high / low 54 / 54 9.221 2.6965 - 31.538 0.0004 5.675 1.109 - 29.049 0.0372 CTLA-4 low / high 54 / 54 1.732 0.414 - 7.253 0.4521

CD28 high / low 54 / 54 3.625 0.730 - 17.997 0.1152 CD80 (B7.1) high / low 54 / 54 7.425 0.912 - 60.457 0.0609 CD86 (B7.2) high / low 54 / 54 1.662 0.395 - 6.991 0.4885

Grade 4 / 3 / 2 / 1 3 / 23 / 56 / 26 6.041 3.011 - 12.123 0.00007 2.770 0.170 - 6.557 0.0205 pT 4,3 / 2,1 24 / 84 7.914 2.869 - 21.832 0.00009 2.414 0.485 - 12.003 0.2815 vascular

invasion 1 / 0 42 / 66 6.467 2.123 - 19.698 0.0010 1.308 0.338 - 5.064 0.6976 Variable

Unfavorable / favorable

No. of Patients

Univariate (U) Multivariate (M) Table 3. Cox regression analysis for various potential prognostic factors in recurrence-free survival in 108 N0M0 cases at radical nephrectomy

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