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Table 1 Baseline characteristics

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1 Age,; yr

Male gender,; n (%) Body mass index,; kg/m

2

Risk factors,; n (%) Hypertension Diabetes Dyslipidemia Smoking

Systolic blood pressure LDL-cholesterol,; mg/dL HDL-cholesterol,; mg/dL Triglyceride,; mg/dL Hemoglobin A1c,; % Creatinine,; mg/dL eGFR.; ml/min/1.73m

2

Medications,; n (%) ACE inhibitors/ARBs Sulfonylureas

Insulins Statins Basal disease

Stable angina pectoris Old myocardial infarction Coronary spastic angina Chest pain syndrome Affected vessel number No stenotic lesion Single vessel disease Multi-vessel disease

70±7 5 (71) 25.5±3.3

5 (71) 2 (29) 19 (83)

4 (57) 128±14

79±13 43±12 74±38 6.1±0.5 0.77±0.17

6.6±6.7

5 (71) 0 (0) 0 (0) 6 (86)

6 (86) 1 (14) 0 (0) 0 (0)

0 (0) 4 (57) 3 (43)

67±12 62 (77) 23.6±3.6

55 (68) 36 (44) 12 (80) 53 (65) 134±18 82±23 50±14 88±52 6.3±0.8 0.8±0.2 6.6±6.7

33 (41) 10 (12) 3 (4) 64 (79)

21 (68) 48 (59) 7 (9) 5 (6)

12 (15) 49 (60) 20 (25)

0.413 0.266 0.137

0.891 0.218 0.207 0.874 0.959 0.103 0.911 0.166 0.700 0.226 0.399

0.090 0.777 0.762 0.096

0.009 0.030 0.150 0.611

0.099 0.364 0.005 Normal FMD/

low RHI (n=7)

Low FMD/

normal RHI

(n=81) P value

Table 1 Baseline characteristics

FMD indicates flow-mediated dilation; RHI, reactive hyperemia index; LDL, low density llipoprotein;

HDL, high density lipoprotein; eGFR, estimated glomerular filtration rate; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker

Low FMD/

low RHI (n=21)

69±8 20 (95) 24.8±3.2

13 (62) 14 (67) 12 (80) 14 (67) 132±14 78±24 45±13 75±57 6.5±0.7 0.9±0.2 6.6±6.7

7 (33) 3 (14) 0 (0) 21 (100)

5 (23) 16 (76)

0 (0) 0 (0)

0 (0) 10 (48) 11 (52) 64±10

17 (77) 25.2±4.1

16 (73) 10 (45) 19 (83) 16 (72) 131±17 94±23 48±13 111±75 6.3±0.9 0.79±0.16 75.4±15.1

8 (36) 3 (14) 1 (5) 16 (73)

6 (27) 11 (50)

4 (18) 1 (5)

5 (23) 16 (73)

1 (5) Normal FMD/

normal RHI

(n=22)

Table 1  Baseline characteristics

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