資源開発研究部門 Medicinal Resources

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資源開発研究部門

Medicinal Resources 天然物化学分野 Natural Products Chemistry

教授森田洋行 Hiroyuki Morita 准教授伊藤卓也 Takuya Ito 助教松井崇 Takashi Matsui

◆ 原著

1) Yang X*, Matsui T, Mori T, Taura F, Noguchi H, Abe I, Morita H. Expression, purification, and crystallization of a plant polyketide cyclase from Cannabis sativa. Acta Crystallogr F Struct Biol Commun. 2015 Dec; 71(Pt 12): 1470-4.

2) Win NN, Ito T, Aimaiti S, Kodama T, Tanaka M, Ngwe H, Asakawa Y, Abe I, Morita H. Kaempulchraols PT: diterpenoids from the Kaempferia pulchra rhizomes collected in Myanmar. J Nat Prod. 2015 Sep; 78(9): 2306-9.

3) Mori T, Hoshino S, Sahashi S, Wakimoto T, Matsui T, Morita H, Abe I. Structural basis for the -carboline alkaloids production by the microbial homodimeric enzyme McbB. Chem&Biol. 2015 Jul; 22(7): 898-906.

4) Win NN, Ito T, Aimaiti S, Kodama T, Imagawa H, Ngwe H, Asakawa Y, Abe I, Morita H. Kaempulchraols IO: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity.

Tetrahedron. 2015 Jul; 71(29): 4707-13.

5) Ho DV, Kodama T, Le HTB, Phan KV, Do TT, Bui TH, Le AT, Win NN, Imagawa H, Ito T, Morita H, Nguyen HT. A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. Bioorg Med Chem Lett. 2015 Aug;

25(16): 3246-50.

6) Win NN, Ito T, Aimaiti S, Imagawa H, Ngwe H, Abe I, Morita H. Kaempulchraols A−H, diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar. J Nat Prod. 2015 May; 78(5): 1113-8.

7) Lee S*, Morita H, Tezuka Y. Preferentially cytotoxic constituents of Andrographis paniculata and their preferential cytotoxicity against human pancreatic cancer cell lines. Nat Prod Commun. 2015 Jul; 10(7): 1153-8.

8) Lee S*, Dibwe DF, Li F, Morita H, Tezuka Y. Preferential cytotoxicity of crude drugs used in Japanese Kampo medicines against human pancreatic cancer PANC-1 and PSN-1 cells. Tradit Kampo Med. 2015 Feb; 2(2): 35-42.

9) Dibwe DF*, Awale S, Morita H, Tezuka Y. Anti-austeritic constituents of the Congolese medicinal plant Aframomum melegueta. Nat Prod Commun. 2015 Jun; 10(6): 997-9.

10) Mori T, Yang D, Matsui T, Hashimoto M, Morita H, Fujii I, Abe I. Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB. J Biol Chem. 2015 Feb; 290(8): 5214-25.

11) Subehan, Rifai Y, Mufidah, Ismail, Aswad M, Morita H. Phytochemical investigation of the active constituents from Caesalpinia sappan on stimulation of osteoblastic cells. Plant Biotech. 2014 Dec; 31(5): 505-9.（2014年未掲載分）

◆ 総説

1) 森田洋行．植物由来Ⅲ型ポリケタイド合成酵素の触媒機能の拡張．日応酵素協会誌．2014；49：1-8．（2014年未掲載分）

◆ 学会報告

1) Morita H. Characterization of two novel plant type III polykeitde synthases obtained from medicinal plant Evodia rutaecarpa.

Pacifichem2015; 2015 Dec 20; Honolulu. (Invited lecture)

2) Ito T, Kodama T, Noguchi H, Abe I, Morita H. Precursor-directed biosynthesis of unnatural novel alkaloids by using a plant type III polyketide synthase obtained from Evodia rutaecarpa. Pacifichem2015; 2015 Dec 18; Honolulu.

3) Kodama T, MatsuiT, MoriT, TadakoshiT, NoguchiH, AbeI, Morita H. Structure-function analyses of two novel plant type III polyketide synthases obtained from medicinal plant Evodia rutaecarpa. Pacifichem2015; 2015 Dec 18; Honolulu.

和漢医薬学総合研究所

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4) Win NN, ItoT, AimaitiS, KodamaT, MoritaH. Kaempulchraols A-O, New diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity. ISPSA2015; 2015 Aug 30-Sep 2; Tokushima.

5) Yang X*, MatsuiT, KodamaT, Abe I, Morita H. Structural basis of polyketide cyclase from Cannabis sativa. ISPSA2015;

2015 Aug 30-Sep 2; Tokushima.

6) Ito T, Nguyen HT, Duc HV, Kodama T, Hien LTB, Imagawa H, Win NN, Morita H. A new polyoxygenated cyclohexene and a new megastigmane glycoside from aerial part of Uvaria grandiflora and their cytotoxicity. ISPSA2015; 2015 Aug 30-Sep 2;

Tokushima.

7) 森田洋行，楊新美，松井崇，児玉猛，周暁希，森貴裕，野口博司，阿部郁朗．アサ由来ポリケタイド閉環酵素のX線結晶構造解析．酵素工学研究会第74回講演会；2015 Oct 16；東京．

8) Morita H, NguyenHT, KodamaT, WinNN, ImagawaH, Ito T. A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. 日本生薬学会第62回年会；2014 Sep 11-12；岐阜．（2014年未掲載分）

9) 森田洋行．植物ポリケタイド骨格形成酵素群を利用した非天然型化合物群の創出．理研NMR天然物シンポジウム；

2015 Aug 21；横浜．（招待講演）

10) 児玉猛，野口博司，阿部郁朗，森田洋行．ゴシュユ由来新規Ⅲ型ポリケタイド合成酵素のcDNAクローニングと

機能解析．日本薬学会第135年会；2015 Mar 26-28；神戸．

11) Win NN, Ito T, Aimaiti S, Morita H. New secondary metabolites, Kaempuchraols A-J from Rhizomes of Kaempferia pulchra and their antiproliferative activity．日本薬学会第135年会；2015 Mar 26-28；神戸．

12) 李雪林*，森田洋行，手塚康弘．穿心蓮中の栄養飢餓状態選択的な殺細胞活性成分．日本薬学会第135年会；2015

Mar 26-28；神戸．

◆ その他

1) Morita H. Structure-based engineering of enzymes to produce new compounds. Scientific Workshop on Natural Products Chemistry; 2015 Nov 2; Yangon.

2) Ito T. Biological active compounds from microorganism: Isolation and biosynthesis. Scientific Workshop on Natural Products Chemistry; 2015 Nov 2; Yangon.

3) Morita H. Structure-based engineering of enzymes to produce new compounds. Scientific Workshop on Natural Products Chemistry; 2015 Nov 4; Myiek, Myanmar.

4) Nisa K. Studies on the bioactive constituents of Indonesian medicinal plants. 2014 Joint Symposium of The Natural Products Research Institute at Seoul National University & The Institute of Natural Medicine at University of Toyama; 2014 Dec 10;

Seoul.（2014年未掲載分）

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