• 検索結果がありません。

The Influence of High Temperature on Reproduction and Effect of Sugar Cane Extract in the Japanese Quail

N/A
N/A
Protected

Academic year: 2021

シェア "The Influence of High Temperature on Reproduction and Effect of Sugar Cane Extract in the Japanese Quail"

Copied!
5
0
0

読み込み中.... (全文を見る)

全文

(1)

(Summary) ) Author(s) Shaoxia PU Report No.(Doctoral Degree) 博士(獣医学) 甲第521号 Issue Date 2019-03-13 Type 博士論文 Version none URL http://hdl.handle.net/20.500.12099/77952 ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

(2)

                          Ặྡ㸦ᮏ㸦ᅜ㸧⡠㸧   6KDR[LD38㸦୰⳹ேẸඹ࿴ᅜ㸧 ୺ ᣦ ᑟ ᩍ ဨ Ặ ྡ    ᮾி㎰ᕤ኱Ꮫ ᩍᤵ Ώ ㎶   ඖ Ꮫ ఩ ࡢ ✀ 㢮    ༤ኈ㸦⋇་Ꮫ㸧 Ꮫ ఩ グ ␒ ྕ    ⋇་༤⏥➨㸳㸰㸯ྕ Ꮫ ఩ ᤵ ୚ ᖺ ᭶ ᪥   ᖹᡂ㸱㸯ᖺ㸱᭶㸯㸱᪥     Ꮫ ఩ ᤵ ୚ ࡢ せ ௳    Ꮫ఩つ๎➨㸲᮲➨㸯㡯ヱᙜ  ◊ ✲ ⛉ ཬ ࡧ ᑓ ᨷ    㐃ྜ⋇་Ꮫ◊✲⛉            ⋇་Ꮫᑓᨷ ◊✲ᣦᑟࢆཷࡅࡓ኱Ꮫ   ᮾி㎰ᕤ኱Ꮫ Ꮫ ఩ ㄽ ᩥ 㢟 ┠  7KH,QIOXHQFHRI+LJK7HPSHUDWXUHRQ5HSURGXFWLRQ DQG(IIHFWRI6XJDU&DQH([WUDFWLQWKH-DSDQHVH 4XDLO                ࢽ࣍ࣥ࢘ࢬࣛࡢ⦾Ṫ࡟ᑐࡍࡿᬬ⇕ࡢᙳ㡪࡜ࢧࢺ࢘࢟ࣅ ࢚࢟ࢫࡢຠᯝ㸧 ᑂ ᰝ ጤ ဨ    ୺ᰝ  ᮾி㎰ᕤ኱Ꮫ  ෸ᩍᤵ  బࠎᮌ ୍ ᫛             ๪ᰝ  ᖏᗈ␆⏘኱Ꮫ  ෸ᩍᤵ  ᐊ ஭ ႐ ᬒ             ๪ᰝ  ᒾ ᡭ ኱ Ꮫ  ᩍ ᤵ  㧗 ᶫ   ㏱             ๪ᰝ  ᮾி㎰ᕤ኱Ꮫ  ᩍ ᤵ  Ώ ㎶   ඖ             ๪ᰝ  ᒱ 㜧 ኱ Ꮫ  ෸ᩍᤵ  ᳝ ྡ ㈗ ᙪ Ꮫ఩ㄽᩥࡢෆᐜࡢせ᪨ ኟᏘࡢᬬ⇕ࢫࢺࣞࢫ࡟ࡼࡗ࡚⦾Ṫ㞀ᐖࡀ㉳ࡁࡿࡇ࡜ࡀࡼࡃ▱ࡽࢀ࡚࠸ࡿࡀ㸪ࡑࡢ࣓࢝ࢽ ࢬ࣒࡟ࡘ࠸࡚ࡣ୙᫂࡞㒊ศࡀከ࠸ࠋᮏ◊✲࡛ࡣ㸪ᬬ⇕࡟ࡼࡿ༸⬊Ⓨ⫱ᢚไࡢ࣓࢝ࢽࢬ࣒ࢆ ෆศἪᏛⓗ㸪࠾ࡼࡧᰤ㣴Ꮫⓗ࡟ゎᯒࡋࡓࠋ  ࢧࢺ࢘࢟ࣅ࢚࢟ࢫ㸦SCE㸧ࡣ, ࢧࢺ࢘࢟ࣅࡢ⤠ࡾỒ࠿ࡽࣈࢻ࢘⢾, ᯝ⢾, ࢩࣙ⢾ࢆศ㞳ࡋ ࡓṧࡾ࡛, ᢠ⅖⑕ཬࡧᢠ㓟໬⏕≀άᛶ≀㉁ࢆྵࡳ, ࡍ࡛࡟ື≀ࡢ㣫ᩱῧຍ≀࡜ࡋ࡚౑ࢃࢀ ࡚࠸ࡿࠋᮏ◊✲࡛ࡣ, 㞤㞝ࡢᡂ⇍࢘ࢬࣛࢆ⏝࠸࡚, ࣍ࣝࣔࣥ⃰ᗘ, ᛶ⭢ࡢࢫࢸࣟ࢖ࢻྜᡂ ࡟ᑐࡍࡿᬬ⇕ࡢᙳ㡪࡟ࡘ࠸࡚SCE ᢞ୚ࡢຠᯝࢆゎᯒࡋࡓࠋ  ➨2 ❶࡛ࡣ, ᡂ⇍㞤࢘ࢬࣛࢆ 10 ᪥㛫㐃⥆ࡋ࡚㧗 ࡟ᭀ㟢ࡋ㸪༸ࡢ㉁࡟㛵ࡍࡿᙳ㡪ࢆゎ ᯒࡋࡓࠋࡑࡢ⤖ᯝ㸪ᬬ⇕ฎ⌮⩌࡛ࡣ༸㔜㔞ࡀ᪥ẖ࡟ᚎࠎ࡟ῶᑡࡋ㸪⏘༸⋡ࡶ᭷ព࡟ῶᑡࡋ ࡓࠋᬬ⇕ฎ⌮⩌࡛ࡣ༸ᕢ㔜㔞ཬࡧ༸⟶㔜㔞ࡀ᭷ព࡟ῶᑡࡋࡓࠋࡲࡓ㸪㯤Ⰽ༸⬊ࡢᩘ࡜༸ᕢ 㔜㔞ࡶῶᑡࡋࡓࠋ୍᪉㸪⾑ᾮ୰ࢥࣝࢳࢥࢫࢸࣟࣥ⃰ᗘࡣᬬ⇕ฎ⌮࡟ࡼࡗ࡚᭷ព࡟ቑຍࡋ㸪 ༸㯤୰ࢥࣝࢳࢥࢫࢸࣟࣥ⃰ᗘࡶ㯤Ⰽ༸⬊㸦F1, F2, F3㸧࡛᭷ព࡟ቑຍࡋࡓࠋࢫࢸࣟ࢖ࢻྜ ᡂ㓝⣲ࡢ୍ࡘ࡛࠶ࡿ17ș-HSD 㑇ఏᏊࡢ༸ᕢ࡛ࡢⓎ⌧࡟ࡣኚ໬ࡀぢࡽࢀ࡞࠿ࡗࡓࡀ㸪๪⭈ ࡛ࡣ᭷ព࡟ቑຍࡋࡓࠋ௨ୖࡢ⤖ᯝࡣ㸪ᬬ⇕ฎ⌮࡟ࡼࡾ๪⭈࡟࠾࠸࡚ࢫࢸࣟ࢖ࢻྜᡂ㓝⣲ࡢ 㑇ఏᏊⓎ⌧ࡀቑຍࡋ㸪ࡑࡢ⤖ᯝ༸㯤࡬ࡢࢥࣝࢳࢥࢫࢸࣟࣥࡢ⵳✚ࡀቑຍࡋࡓࡇ࡜ࢆ♧၀ࡋ ࡓࠋ  ➨3 ❶࡛ࡣ㸪ᬬ⇕ฎ⌮ᙳ㡪ࡢ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟㸪⾑Ύ୰௦ㅰ≀ྵ᭷㔞ࢆ ゎᯒࡋࡓࠋ⾑Ύ୰࡟165 ࡢ௦ㅰ≀ࡀ᳨ฟࡉࢀ㸪ࡑࡢෆࡢ 7 ࡘ࡟ࡘ࠸࡚ᑐ↷⩌࡜ᬬ⇕ฎ⌮⩌ 㸦㸲㸧

(3)



ࡢ㛫࡛᭷ព࡞ᕪࡀㄆࡵࡽࢀࡓࠋゎᯒࢯࣇࢺMetaboAnalyst ࡟ࡼࡗ࡚ゎᯒࡋࡓ࡜ࡇࢁ㸪ᬬ⇕

ฎ⌮ࡀbutanoate, propanoate, ࠾ࡼࡧ pyrimidine ࡢ௦ㅰ㸪ࢣࢺࣥయࡢྜᡂ࡜ศゎ㸪

cyanoamino acid ࡢ௦ㅰ࡟ᙳ㡪ࢆ୚࠼࡚࠸ࡓࡇ࡜ࡀ♧ࡉࢀࡓࠋࡉࡽ࡟㸪ᑠ⭠࡜⫢⮚ࢆ⤌⧊Ꮫ ⓗ࡟ゎᯒࡋࡓ⤖ᯝ㸪༑஧ᣦ⭠㸪✵⭠,ᅇ⭠ࡢ⤧ẟࡢ㧗ࡉࡀῶᑡࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ ⫢⮚ࡢ୰ᛶ⬡⫫, ࢥࣞࢫࢸ࣮ࣟࣝྵ㔞ࡀቑຍࡋࡓࡀ㸪⾑ᾮ୰ࢥࣞࢫࢸ࣮ࣟࣝࣞ࣋ࣝࡣపୗ ࡋࡓࠋ⫢⮚࡟࠾ࡅࡿ⬡㉁௦ㅰ࡟㛵㐃ࡋࡓ㑇ఏᏊࡢⓎ⌧㔞ࡀ᭷ព࡟ኚ໬ࡋࡓࠋ௨ୖࡢ⤖ᯝ࠿ ࡽ㸪ᬬ⇕ฎ⌮ࡀᑠ⭠㸪⫢⮚ࡢ㞀ᐖࢆ㉳ࡇࡋࡓ⤖ᯝ࡜ࡋ࡚㸪⬡㉁௦ㅰࡀᙳ㡪ࢆཷࡅࡓ࡜⪃࠼ ࡽࢀࡓࠋ  ➨4 ❶࡛ࡣ㸪20 ᪥㛫ࡢᬬ⇕ฎ⌮ࡢᙳ㡪࡟ࡘ࠸࡚ゎᯒࡋࡓࠋᡂ⇍ࡋࡓ㞤࢘ࢬࣛࢆ⏝࠸㸪 ⏕Ṫᶵ⬟࡬ࡢᙳ㡪ࢆゎᯒࡋࡓ⤖ᯝ㸪ᬬ⇕ฎ⌮࡟ࡼࡗ࡚㸪༸ᕢ㸪༸⟶㔜㔞࡜ࡶ࡟᭷ព࡟ῶᑡ ࡋ㸪㯤Ⰽ༸⬊ᩘ㸪㔜㔞ඹ࡟ῶᑡࡋ, ༸㔜㔞ࡀῶᑡࡋࡓࠋཷ⢭⋡࡟ࡣኚ໬ࡀ࡞࠿ࡗࡓࡀ, ᬬ ⇕ฎ⌮⩌࡛, ึ⏕㞮ࡢయ㔜ࡀ᭷ព࡟ῶᑡࡋࡓࠋ⾑୰ࢥࣝࢳࢥࢫࢸࣟࣥ⃰ᗘ㸪࢚ࢫࢺࣛࢪ࢜ ࣮ࣝ -17ș⃰ᗘࡀ࡝ࡕࡽࡶቑຍࡋࡓࠋ༸㯤୰ࡢࢥࣝࢳࢥࢫࢸࣟࣥ⃰ᗘ㸪࢚ࢫࢺࣛࢪ࣮࢜ࣝ-17ș⃰ᗘ࡜ࡶ࡟ྠᵝࡢഴྥࢆ♧ࡋࡓࠋ༸ᕢࢫࢸࣟ࢖ࢻྜᡂ㓝⣲ P450scc, ࢚ࢫࢺࣟࢪ࢙ࣥ ࣞࢭࣉࢱ࣮(ER)ࡢ㑇ఏᏊⓎ⌧ࡀୖ᪼ࡋࡓࠋࡋ࠿ࡋ࡞ࡀࡽ㸪FSH ࡢࣞࢭࣉࢱ࣮ࡢ㑇ఏᏊⓎ⌧ ࡣῶᑡࡋࡓࠋ௦ㅰゎᯒࡢ⤖ᯝ, ⾑Ύ୰࡟ 165 ࡢ௦ㅰ≀ࡀ᳨ฟࡉࢀ, 8 ࡘࡢ௦ㅰ≀࡟᭷ព࡞ᕪ ࡀㄆࡵࡽࢀࡓࠋMetaboAnalyst ࡛ࡢศᯒ⤖ᯝ, propanoate ௦ㅰ, beta-alanine ௦ㅰ, aspartate ࡜ histidine ௦ㅰ࡟ࡶᙳ㡪ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ⫢⮚ࡢ⤌⧊ゎᯒࡢ⤖ᯝࡣᬬ⇕ฎ⌮ࡀ⫢

⮚ࡢ⬡㉁௦ㅰ␗ᖖࢆ㉳ࡇࡍࡇ࡜ࢆ♧ࡋࡓࠋ୰ᛶ⬡⫫, ࢥࣞࢫࢸ࣮ࣟࣝࡀ⫢⮚࡛ቑຍࡋ,

AGPAT5 mRNA ࡀቑຍࡋ࡚࠸ࡓࠋࡉࡽ࡟, ⫢⮚࡛࢔࣏ࢺ࣮ࢩࢫ࡟㛵㐃ࡋࡓ caspase3 ࡢ㑇ఏ ᏊⓎ⌧࡜, ࢧ࢖ࢺ࢝࢖ࣥࡢ IL-6 ࡜ TLR4 ࡢ㑇ఏᏊⓎ⌧ࡀቑຍࡋ࡚࠸ࡓࠋNF-ȡB ࡢ㑇ఏᏊ Ⓨ⌧ࡣῶᑡࡋ࡚࠸ࡓࠋ௨ୖࡢ⤖ᯝ࠿ࡽ㸪ᬬ⇕ฎ⌮ࡀ⫢⮚ࢆയᐖࡋ, ⬡㉁௦ㅰࡀᙳ㡪ࢆཷ ࡅ㸪apoptosis ࡜⅖⑕ࡀ⏕ࡌࡓ࡜ุ᩿ࡉࢀࡓࠋ⾑ᾮ୰࢚ࢫࢺࣛࢪ࣮࢜ࣝ-17șࡢ⫢⮚࡛ࡢ௦ ㅰࡶയᐖࡉࢀ, ༸ᕢࡢᶵ⬟୙඲, 㯤Ⰽ༸⬊ࡢῶᑡ, 㔜㔞ῶᑡ, ༸㔜㔞,ึ⏕㞮య㔜ࡢῶᑡ࡞ ࡝ࢆᘬࡁ㉳ࡇࡋࡓ࡜⪃࠼ࡽࢀࡓࠋ  ➨5 ❶࡛ࡣ, ᬬ⇕ฎ⌮࡟ᑐࡍࡿ SCE ࡢຠᯝࢆ㸪㞤㞝࢘ࢬࣛࢆ⏝࠸࡚ゎᯒࡋࡓࠋ㣵ᩱ࡟ SCE ࢆῧຍࡋࡓ⤖ᯝ, 㞤࡛ࡣᬬ⇕ฎ⌮࡟ࡼࡿ༸㔜㔞ࡢῶᑡࢆࢃࡎ࠿࡟⦆࿴ࡋࡓࠋ༸ᕢ, ༸ ⟶㔜㔞ࡀ6 ౛୰ 2 ౛࡛ῶᑡࡋࡓࠋࡑࡢ⾑୰ࢥࣝࢳࢥࢫࢸࣟࣥ࡜࢚ࢫࢺࣛࢪ࣮࢜ࣝ 17ș⃰ ᗘࡀῶᑡࡋࡓࠋ୍᪉㸪༸ᕢ࡛ࡢࢫࢸࣟ࢖ࢻྜᡂ㓝⣲P450scc ࡢ㑇ఏᏊⓎ⌧ࡀᬬ⇕ฎ⌮ᚋ࡟ ቑຍࡋࡓࠋ0.02㸣ࡢ SCE 㣫ᩱῧຍࡣ༸⏕⏘ࢆቑຍࡋࡓࡀ, P450scc ࡢ㑇ఏᏊⓎ⌧ࡶᬬ⇕ฎ ⌮࡟ࡼࡗ࡚ቑຍࡋࡓࠋ௒ᅇ౑⏝ࡋࡓ⃰ᗘࡢSCE ᦤྲྀࡢᬬ⇕ฎ⌮࡟ᑐࡍࡿຠᯝࡣ㝈ᐃⓗ࡛, ࡉࡽ࡞ࡿ᳨ウࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋSCE ᢞ୚ࡀ㞝࢘ࢬࣛࡢᛶ⾜ື࡜⢭ᕢᶵ⬟࡟୚࠼ ࡿస⏝ࢆ᳨ウࡋࡓ⤖ᯝ, ⾑୰ࢸࢫࢺࢫࢸࣟࣥ⃰ᗘࡀῶᑡࡋ㸪஺ᑿ⾜ືࡀῶᑡࡋࡓࠋ⢭ᕢࡢ ࢫࢸࣟ࢖ࢻྜᡂ㓝⣲P450c17, 17șHSD, P450scc, 3șHSD ࡢ㑇ఏᏊⓎ⌧ࢆゎᯒࡋࡓ⤖ᯝ, ࠸ ࡎࢀࡶῶᑡࡋࡓࠋ⺯ගච␿⤌⧊໬ᏛᰁⰍ࡜࢚࢘ࢫࢱࣥࣈࣟࢵࢸ࢕ࣥࢢἲ࡛⢭ᕢࡢ3șѸHSD ࢆゎᯒࡋࡓ⤖ᯝ, SCE ᢞ୚࡛࠸ࡎࢀࡶῶᑡࡋ࡚࠸ࡓࠋ⢭ᕢࡢ㛫㉁⣽⬊ࢆᇵ㣴ࡋ, SCE ࢆ ࣄࢶࢪLH ࡜࡜ࡶ࡟ᇵ㣴ᾮ࡟ῧຍࡋࡓ⤖ᯝ, ࢸࢫࢺࢫࢸࣟࣥศἪ, 3șHSD ࡢ㑇ఏᏊⓎ⌧࡜ ࡶ࡟, ῶᑡࡋࡓࠋSCE ࡣ┤᥋⢭ᕢࡢ㛫㉁⣽⬊࡟స⏝ࡋ, 3șHSD ࡢⓎ⌧ࢆᢚไࡋ࡚, ⢭ᕢᶵ ⬟ࢆᢚไࡍࡿ࡜⪃࠼ࡽࢀࡓࠋ ᬬ⇕ࢫࢺࣞࢫ࡟ࡼࡗ࡚ᐙ⚺ࡢ⦾Ṫ㞀ᐖࡀ㉳ࡁࡿ࣓࢝ࢽࢬ࣒࡟ࡘ࠸࡚, ࢘ࢬࣛࢆࣔࢹࣝ࡜ ࡋ࡚ᬬ⇕࡟ࡼࡿᙳ㡪ࢆෆศἪᏛⓗ࡟ゎᯒࡋࡓ⤖ᯝ, ༸㯤࡬ࡢࢥࣝࢳࢥࢫࢸࣟࣥࡢ⵳✚ࡀቑ ຍࡍࡿࡇ࡜, ᬬ⇕ฎ⌮ࡀᑠ⭠㸪⫢⮚ࡢ㞀ᐖࢆ㉳ࡇࡋࡓ⤖ᯝ㸪⬡㉁௦ㅰ࡟ᙳ㡪ࢆ୚࠼, ༸ᕢ ࡢᶵ⬟୙඲, 㯤Ⰽ༸⬊ࡢῶᑡ, 㔜㔞ῶᑡ, ༸㔜㔞, ึ⏕㞮య㔜ࡢῶᑡ࡞࡝ࢆᘬࡁ㉳ࡇࡋࡓࡇ ࡜㸪๪⭈࡜ᛶ⭢࡛ࢫࢸࣟ࢖ࢻ⏕ᡂ㓝⣲ࡢⓎ⌧ㄪ⠇࡟SCE ࡀ␗࡞ࡿస⏝ࢆ♧ࡍࡇ࡜ࡀ᫂ࡽ ࠿࡜࡞ࡗࡓࠋ

(4)

 ᑂ ᰝ ⤖ ᯝ ࡢ せ ᪨ ᮏ◊✲࡛ࡣ㸪ᬬ⇕ࢫࢺࣞࢫ࡟ࡼࡗ࡚ᐙ⚺ࡢ⦾Ṫ㞀ᐖࡀ㉳ࡁࡿ࣓࢝ࢽࢬ࣒࡟ࡘ࠸࡚, ࢘ࢬ ࣛࢆࣔࢹࣝ࡜ࡋ࡚⏝࠸㸪ᬬ⇕࡟ࡼࡿ༸⬊Ⓨ⫱ᢚไࢆෆศἪᏛⓗ࡟ゎᯒࡋࡓࠋ ࡲࡎ, ᡂ⇍㞤࢘ࢬࣛ࡟ 10 ᪥㛫㐃⥆ࡋ࡚㧗 ࡟ᭀ㟢ࡋ㸪༸ࡢ㉁࡟㛵ࡍࡿᙳ㡪ࢆゎᯒࡋ ࡓࠋࡑࡢ⤖ᯝ㸪ᬬ⇕ฎ⌮⩌࡛ࡣ༸㔜㔞ࡀ᪥ẖ࡟ᚎࠎ࡟ῶᑡࡋ㸪᭱ᚋࡢ2 ᪥㛫࡛ࡣ᭷ព࡟ῶ ᑡࢆ♧ࡋࡓࠋ⏘༸⋡ࡣ඲⩌࡟࠾࠸࡚᭷ពᕪࡀㄆࡵࡽࢀ࡞࠿ࡗࡓࡶࡢࡢ㸪ᬬ⇕ฎ⌮⩌࡛ࡣ༸ ᕢ㔜㔞ཬࡧ༸⟶㔜㔞ࡀ㍍㔞࡛࠶ࡾ㸪㯤Ⰽ༸⬊ࡢᩘ࡜༸ᕢ㔜㔞ࡀῶᑡࡋࡓࠋ⾑ᾮ୰ࢥࣝࢳࢥ ࢫࢸࣟࣥ⃰ᗘࡀ㸪ᬬ⇕ฎ⌮࡟ࡼࡗ࡚᭷ព࡟ቑຍࡋ, ༸㯤୰⃰ᗘࡀ㯤Ⰽ༸⬊㸦F1, F2, F3㸧࡛ ᭷ព࡟ቑຍࡋࡓࠋᬬ⇕ฎ⌮࡟ࡼࡾ๪⭈࡟࠾࠸࡚ࢫࢸࣟ࢖ࢻྜᡂ㓝⣲ࡢ㑇ఏᏊⓎ⌧ࡀቑຍ ࡋ㸪ࡑࡢ⤖ᯝ༸㯤࡬ࡢࢥࣝࢳࢥࢫࢸࣟࣥࡢ⵳✚ࡀቑຍࡍࡿࡇ࡜ࡀุ᫂ࡋࡓࠋ  ḟ࡟㸪ᬬ⇕ฎ⌮ᙳ㡪ࡢ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟㸪⾑Ύ୰௦ㅰ≀ྵ᭷㔞ࢆゎᯒࡋ ࡓࠋ⾑Ύ୰࡟165 ࡢ௦ㅰ≀ࡀ᳨ฟࡉࢀ㸪ࡑࡢෆࡢ 7 ࡘ࡟ࡘ࠸࡚ᑐ↷⩌࡜ᬬ⇕ฎ⌮⩌ࡢ㛫࡛

᭷ព࡞ᕪࡀㄆࡵࡽࢀ, butanoate, propanoate,࠾ࡼࡧ pyrimidine ࡢ௦ㅰ㸪ࢣࢺࣥయࡢྜᡂ࡜ศ

ゎ㸪cyanoamino acid ࡢ௦ㅰ࡟ᙳ㡪ࢆ୚࠼࡚࠸ࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋࡉࡽ࡟㸪ᑠ⭠࡜⫢⮚ࢆ⤌ ⧊Ꮫⓗ࡟ゎᯒࡋࡓ⤖ᯝ㸪ᬬ⇕ฎ⌮ࡀ༑஧ᣦ⭠㸪✵⭠, ᅇ⭠ࡢ⤧ẟࡢ㧗ࡉࢆῶᑡࡉࡏࡿࡇ࡜ ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ௨ୖࡢ⤖ᯝࡣ㸪ᬬ⇕ฎ⌮ࡀᑠ⭠㸪⫢⮚ࡢ㞀ᐖࢆ㉳ࡇࡋࡓ⤖ᯝ㸪⬡㉁௦ㅰ ࡟ᙳ㡪ࢆ୚࠼ࡓࡇ࡜ࢆ♧၀ࡋࡓࠋᬬ⇕ୗ࡛⫢⮚ࢆಖㆤࡍࡿࡇ࡜࡟ࡼࡾ㸪ኟᏘࡢ㧗 ࡟ᑐᢠ ࡛ࡁࡿྍ⬟ᛶࢆ♧ࡋࡓࠋ  ࡉࡽ࡟㛗࠸ᮇ㛫㸪20 ᪥㛫㸪ࡢᙳ㡪࡟ࡘ࠸࡚㸪ᡂ⇍ࡋࡓ㞤࢘ࢬࣛࢆ⏝࠸㸪⏕Ṫᶵ⬟࡬ࡢ ᙳ㡪ࢆゎᯒࡋࡓࠋᬬ⇕ฎ⌮࡟ࡼࡗ࡚㸪༸ᕢ㸪༸⟶㔜㔞࡜ࡶ࡟᭷ព࡟ῶᑡࡋ㸪㯤Ⰽ༸⬊ᩘ㸪 㔜㔞ඹ࡟ῶᑡࡋ, ༸㔜㔞ࡀῶᑡࡋࡓࠋཷ⢭⋡࡟ࡣኚ໬ࡀ࡞࠿ࡗࡓࡀ, ᬬ⇕ฎ⌮⩌࡛, ึ⏕ 㞮ࡢయ㔜ࡀ᭷ព࡟ῶᑡࡋࡓࠋ⫢⮚ࡢ⤌⧊ゎᯒࡢ⤖ᯝࡣᬬ⇕ฎ⌮ࡀ⫢⮚ࡢ⬡㉁௦ㅰ␗ᖖࢆ㉳ ࡇࡍࡇ࡜ࢆ♧ࡋࡓࠋ⾑ᾮ୰࢚ࢫࢺࣛࢪ࣮࢜ࣝ-17șࡢ⫢⮚࡛ࡢ௦ㅰࡶയᐖࡉࢀ, ༸ᕢࡢᶵ⬟ ୙඲, 㯤Ⰽ༸⬊ࡢῶᑡ, 㔜㔞ῶᑡ, ༸㔜㔞, ึ⏕㞮య㔜ࡢῶᑡ࡞࡝ࢆᘬࡁ㉳ࡇࡋࡓ࡜⪃࠼ࡽ ࢀࡓࠋ  ᬬ⇕ฎ⌮࡟ᑐࡍࡿࢧࢺ࢘࢟ࣅ࢚࢟ࢫ㸦SCE㸧ࡢຠᯝࢆ, 㞤࢘ࢬࣛࢆ⏝࠸᳨࡚ウࡋࡓࠋヨ ᩱ࡟ῧຍࡋࡓ⤖ᯝ, ᬬ⇕ฎ⌮࡟ࡼࡿ༸㔜㔞ࡢῶᑡࢆࢃࡎ࠿࡟⦆࿴ࡋࡓࠋࡋ࠿ࡋ࡞ࡀࡽ SCE ᦤྲྀࡢᬬ⇕ฎ⌮࡟ᑐࡍࡿຠᯝࡣ㝈ᐃⓗ࡛࠶ࡗࡓࠋ  㞝࢘ࢬࣛࢆ⏝࠸࡚SCE ᦤྲྀࡢຠᯝࢆ᳨ウࡍࡿࡓࡵ㸪㞝࢘ࢬࣛࡢᛶ⾜ື࡜⢭ᕢᶵ⬟࡟୚ ࠼ࡿస⏝ࢆ᳨ウࡋࡓ⤖ᯝ, ஺ᑿ⾜ື㸪⾑୰ࢸࢫࢺࢫࢸࣟࣥ⃰ᗘࡀῶᑡࡋࡓࠋSCE ࡣ┤᥋⢭ ᕢࡢ㛫㉁⣽⬊࡟స⏝ࡋ, 3șHSD ࡢⓎ⌧ࢆᢚไࡋ࡚⢭ᕢᶵ⬟ࢆᢚไࡍࡿ࡜⪃࠼ࡽࢀࡓࠋ  ୖグࡢࡼ࠺࡟⏦ㄳ⪅ࡣ, ᬬ⇕ࢫࢺࣞࢫ࡟ࡼࡗ࡚ᐙ⚺ࡢ⦾Ṫ㞀ᐖࡀ㉳ࡁࡿ࣓࢝ࢽࢬ࣒࡟ࡘ ࠸࡚, ࢘ࢬࣛࢆࣔࢹࣝ࡜ࡋ࡚ᬬ⇕࡟ࡼࡿ༸⬊Ⓨ⫱ᢚไࢆෆศἪᏛⓗ࡟ゎᯒࡋ, ༸㯤࡬ࡢࢥ ࣝࢳࢥࢫࢸࣟࣥࡢ⵳✚ࡀቑຍࡍࡿࡇ࡜, ᬬ⇕ฎ⌮ࡀᑠ⭠㸪⫢⮚ࡢ㞀ᐖࢆ㉳ࡇࡋࡓ⤖ᯝ㸪⬡ ㉁௦ㅰ࡟ᙳ㡪ࢆ୚࠼, ༸ᕢࡢᶵ⬟୙඲, 㯤Ⰽ༸⬊ࡢῶᑡ, 㔜㔞ῶᑡ, ༸㔜㔞, ึ⏕㞮య㔜ࡢ ῶᑡ࡞࡝ࢆᘬࡁ㉳ࡇࡋࡓࡇ࡜ࢆ♧၀ࡋ, 㠀ᖖ࡟ព⩏ࡀ࠶ࡿࡶࡢ࡜ㄆࡵࡿࠋ  ௨ୖ࡟ࡘ࠸࡚, ᑂᰝጤဨ඲ဨ୍⮴࡛ᮏㄽᩥࡀᒱ㜧኱Ꮫ኱Ꮫ㝔㐃ྜ⋇་Ꮫ◊✲⛉ࡢᏛ఩ㄽ ᩥ࡜ࡋ࡚඘ศ౯್ࡀ࠶ࡿ࡜ㄆࡵࡓࠋ ᇶ♏࡜࡞ࡿᏛ⾡ㄽᩥ 㸯㸧㢟   ┠㸸+HDWFKDOOHQJHLQIOXHQFHVVHUXPPHWDEROLWHVFRQFHQWUDWLRQVDQG OLYHUOLSLGPHWDEROLVPLQ-DSDQHVHTXDLO &RWXUQL[MDSRQLFD 

(5)

 ⴭ ⪅ ྡ㸸3868VXGD.1DJDRND.DQG:DWDQDEH* Ꮫ⾡㞧ㄅྡ㸸7KH-RXUQDORI9HWHULQDU\0HGLFDO6FLHQFH ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸,Q3UHVV  ᪤Ⓨ⾲Ꮫ⾡ㄽᩥ 㸯㸧㢟   ┠㸸7HUWEXW\OK\GURTXLQRQHDWWHQXDWHVVFURWDOKHDWLQGXFHGGDPDJH E\UHJXODWLQJ1UIDQWLR[LGDQWV\VWHPLQWKHPRXVHWHVWLV ⴭ ⪅ ྡ㸸<DQVHQ/<XQ&)HL:6KDR[LD3<RQJKXL=DQG &KXQ0HL/ Ꮫ⾡㞧ㄅྡ㸸*HQHUDODQG&RPSDUDWLYH(QGRFULQRORJ\ ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸   㸰㸧㢟   ┠㸸6XSSOHPHQWDOGLHWDU\SK\WRVWHULQSURWHFWVDJDLQVW QLWURSKHQROLQGXFHGR[LGDWLYHVWUHVVDQGDSRSWRVLVLQUDW WHVWHV ⴭ ⪅ ྡ㸸<RQJKXL=0HL\DQ6;LDROL56KDR[LD3<DQVHQ/ DQG&KXQ0HL/ Ꮫ⾡㞧ㄅྡ㸸7R[LFRORJ\5HSRUWV ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸   㸱㸧㢟   ┠㸸([SUHVVLRQRIQHUYHJURZWKIDFWRU 1*) DQGLWVUHFHSWRUV7UN$ DQGSLQWKHUHSURGXFWLYHRUJDQVRIOD\LQJKHQV ⴭ ⪅ ྡ㸸6KDR[LD3&KDQJZHL4=KL/<DQVHQ/DQG&KXQPHL/ Ꮫ⾡㞧ㄅྡ㸸%UD]LOLDQ-RXUQDORI3RXOWU\6FLHQFH ᕳ࣭ྕ࣭㡫࣭Ⓨ⾜ᖺ㸸                  

参照

関連したドキュメント

Standard domino tableaux have already been considered by many authors [33], [6], [34], [8], [1], but, to the best of our knowledge, the expression of the

An easy-to-use procedure is presented for improving the ε-constraint method for computing the efficient frontier of the portfolio selection problem endowed with additional cardinality

If condition (2) holds then no line intersects all the segments AB, BC, DE, EA (if such line exists then it also intersects the segment CD by condition (2) which is impossible due

The inclusion of the cell shedding mechanism leads to modification of the boundary conditions employed in the model of Ward and King (199910) and it will be

Now it makes sense to ask if the curve x(s) has a tangent at the limit point x 0 ; this is exactly the formulation of the gradient conjecture in the Riemannian case.. By the

Then it follows immediately from a suitable version of “Hensel’s Lemma” [cf., e.g., the argument of [4], Lemma 2.1] that S may be obtained, as the notation suggests, as the m A

Classical definitions of locally complete intersection (l.c.i.) homomor- phisms of commutative rings are limited to maps that are essentially of finite type, or flat.. The

Yin, “Global existence and blow-up phenomena for an integrable two-component Camassa-Holm shallow water system,” Journal of Differential Equations, vol.. Yin, “Global weak