福井大学高エネルギー医学研究センター年報 2014 利用統計を見る
122
0
0
全文
(2) . 高エネルギー医学研究センター年報 2014.
(3) ࡣࡌࡵ ̿3(705 ⨨ࡢᮇᚅ̿ ࢭࣥࢱ࣮㛗 ᒸἑ ⚽ᙪ 1994 ᖺタ❧ࡉࢀࠊᖺ 20 ᖺ┠ࢆ㏄࠼ࡓ㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮࡛ࡍࡀࠊタ❧ ᑟධࡉࢀࡓ㌟⏝ PET ⨨㸦GE Advance㸧ࡶྠࡌࡃ 20 ᖺ㛫⏝ࡋ࡚ཧࡾࡲࡋࡓࠋタ ❧ᙜࡣ᭱᪂ᆺࡢᶵ✀࡛࠶ࡗࡓ⨨ࡶࡉࡍࡀྂࡃ࡞ࡾࠊ ⌧ᅾ࡛ࡣ CT ୍యᆺ࡛࡞࠸ PET ༢⊂⨨ࡣࡴࡋࢁ㈗㔜࡞ࡶࡢ࡞ࡗ࡚࠸ࡲࡍࠋࡇࡢྂ࠸⨨ࡶࠊPET/CT ⨨࡛ࡣᐇࡋ࡙ ࡽ࠸⬻ࡢᐃ㔞᳨ᰝ࡞ࡣኚ౽࡛ࠊO-15 gas PET ᳨ᰝࢆࡣࡌࡵࡍࡿᐃ㔞᳨ᰝᗈࡃ ⏝ࡍࡿࡇࡀ࡛ࡁࡲࡋࡓࠋ㏆ᖺࡣࡀࢇࡸㄆ▱➼ࡢᛂ⏝ࡀὀ┠ࡉࢀ࡚࠸ࡲࡍࡀࠊ⬻ࡢ ᐃ㔞᳨ᰝࡢࡳ࡛࡞ࡃࠊN-13 ࣥࣔࢽࢆ⏝࠸ࡓᚰ➽⾑ὶࡢᐃ㔞ࡸࠊC-11 㓑㓟ࢆ⏝࠸ࡓᚰ➽ 㓟⣲௦ㅰࡢᐃ㔞ᣦᶆィ ࡞ࠊᗈࡃᐃ㔞㛵ࢃࡿ◊✲⏝࠸ࡽࢀࠊࡑࡢᛶ⬟ࡢ㧗ࡉࡼࡾ ከࡃࡢ◊✲ᴗ⦼㈉⊩࡛ࡁࡓᛮ࠸ࡲࡍࠋࡋࡋࠊࡇࡢ 20 ᖺ㛫࠾ࡅࡿ PET ⨨ࡢ㐍Ṍ ࡣ┠ぬࡲࡋࡃࠊ᭱᪂ࡢ㧗ゎീᗘ⨨࡛ࡣࠊ⬻ࡢ⓶㉁ࡀ࡞ࡾ᫂░ᥥฟࡉࢀࡿ⛬ᨵⰋࡉ ࢀࠊ୍᫇๓ࡢ CT ࡼࡾࡁࢀ࠸࡞⏬ീ࡞ࡗ࡚࠸ࡿࡢ࡛ࡣ࡞࠸ᛮࢃࢀࡿ⛬࡛ࡍࠋࡑ࠺࡞ࡗ ࡚ࡃࡿࠊࠕ࠸ᚤ⣽࡞ኚࡀᤊ࠼ࡽࢀࡿࠖ࠸࠺ࠊᚑ᮶ࡢ᰾་Ꮫ࡛ࡣ࠶ࡲࡾ࡞ࡗࡓ どⅬ࡛ࡢ◊✲ࡀᚋ㐍ᒎࡍࡿྍ⬟ᛶࡀ࠶ࡾࡲࡍࠋᩘᖺ๓ࡽ⮫ᗋ⏝ࡀጞࡲࡾࠊ᪤ᨺᑕ ⥺⛉᰾་Ꮫ㡿ᇦ࡛ࡣ୍ࡘࡢࡁ࡞ศ㔝࡞ࡾࡘࡘ࠶ࡿ PET/MR ⏬ീࡣࠊPET/CT ࡛ࡣデ᩿ ࡀᅔ㞴ࡔࡗࡓᝈࡢ᪂ࡓ࡞デ᩿ἲࡢ☜❧ࡸࠊ᪤࠶ࡿ⛬ᗘ☜❧ࡋ࡚࠸ࡿデ᩿ἲࡢぢ┤ࡋ ࡶ⧅ࡀࡿྍ⬟ᛶࡶ࠶ࡾࠊᑗ᮶ᛶࡢ㠀ᖖ㧗࠸⏬ീἲ࡞ࡿࡢ࡛ࡣ࡞࠸ᮇᚅࡀ⭾ࡽࡳࡲ ࡍࠋ ᖺࡢᕳ㢌ゝ࡛ࡶゐࢀࡲࡋࡓࡀࠊᮏࢭࣥࢱ࣮ࡢタ❧ 20 ࿘ᖺグᛕᴗࡢ୍⎔ࡋ࡚ࠊࡇࡢ ᑗ᮶ᛶࡀᮇᚅࡉࢀࡿ PET/MR ⨨ࢆࠊᖹᡂ 27 ᖺᗘ୰ᑟධࡋࡓ࠸⪃࠼࡚࠾ࡾࡲࡍࠋࡇ ࡢグᛕᴗࡢࡓࡵᖺ㸦ᖹᡂ 26 ᖺ㸧ᮎࡽເ㔠άືࢆ㛤ጞࡋࠊⓙᵝࡢࡈᨭࡈ༠ຊࢆ ࠾㢪࠸ࡋ࡚ཧࡾࡲࡋࡓࡀࠊኚከࡃࡢ᪉ࠎࡽࡈᨭࢆ࠸ࡓࡔࡁࠊPET/MR ⨨ࢆ⏝࠸ࡓ ᪂ࡋ࠸⏬ീ◊✲ᑐࡍࡿᮇᚅࡢ㧗ࡉࢆᨵࡵ࡚ឤࡌࡿࡶࠊ⚟Ꮫ࠾ࡅࡿ㧗࢚ࢿ◊ ࡢศᏊ࣓࣮ࢪࣥࢢ◊✲ࡀ࠸ὀ┠ࡉࢀ࡚࠸ࡿㄆ㆑ࡉࡏࡽࢀࡿࡇ࡞ࡾࠊ㈐௵ࡢ 㔜ࡉࢆᐇឤࡏࡎࡣ࠾ࢀࡲࡏࢇࠋࡇࢀࡲ࡛ࡢ⏕యᶵ⬟࣓࣮ࢪࣥࢢ࠾ࡼࡧศᏊ࣓࣮ࢪࣥ ࢢࡢᡂᯝࢆࡉࡽⓎᒎࡉࡏࡿࡓࡵࠊ༢ࠕᚑ᮶ࡢ PET ◊✲ࢆ PET/MR ࡛ࡶྍ⬟ࡋࡲࡋ ࡓࠖ࠸ࡗࡓᏳ᫆࡞᪉ྥὶࡉࢀࡿࡢ࡛ࡣ࡞ࡃࠊศᏊࣉ࣮ࣟࣈࡢ㛤Ⓨࡸ⦓ᐦ࡞⸆ືែࡢ.
(4) ゎᯒࠊྛ✀ᝈࡢែゎ᫂➼ࢆ◊✲ࡢᰕࡋ࡞ࡀࡽࠊᢏ⾡ࡢ㐍Ṍࡼࡾࡶࡓࡽࡉࢀࡿᜠᜨ ࢆ༑ศ⏕ࡋࡓ◊✲ࢆ㐍ࡵ࡚࠸ࡁࡓ࠸⪃࠼࡚࠾ࡾࡲࡍࠋグᛕᴗࡈ㈶ྠ࠸ࡓࡔࡁࡲ ࡋࡓⓙᵝ῝ࡃឤㅰ⏦ࡋୖࡆࡿࡶࠊⓙᵝࡢᚚᮇᚅἢ࠼ࡿࡼ࠺ࠊᚋࡶဨࡀ୍ ࡞ࡗ࡚ඛ➃◊✲ྲྀࡾ⤌ࡴᡤᏑ࡛ࡈࡊ࠸ࡲࡍࠋࡲࡓࠊᅜෆ࡛ࡶᩘᑡ࡞࠸ PET/MR ⨨ಖ ᭷タࡋ࡚ࠊඹྠ◊✲ࡸ⏬ീᩍ⫱ᗈࡃ㛛ᡞࢆ㛤ࡅࠊ᭱ඛ➃ PET/MR ◊✲ࡀ┈ࠎⓎᒎࡍ ࡿࡼ࠺ດࡵ࡚ཧࡾࡲࡍࠋᚋࡶࡼࡾ୍ᒙࡢࡈᣦᑟ࣭ࡈᨭࢆ㈷ࡾࡲࡍࡼ࠺࠾㢪࠸⏦ࡋୖ ࡆࡲࡍࠋ.
(5) ᅄᖺ┠ࢆ㏄࠼࡚ ศᏊࣉ࣮ࣟࣈ㛤Ⓨᛂ⏝㡿ᇦ ศᏊࣉ࣮ࣟࣈタィᏛ㒊㛛 ᩍᤵ Ύ㔝 Ὀ ᖹᡂ 24 ᖺ 1 ᭶ 1 ᪥ᙜࢭࣥࢱ࣮ࡢศᏊࣉ࣮ࣟࣈタィᏛ㒊㛛ࡢᩍᤵ╔௵ࡋ࡚ࡽᅄᖺ┠ ධࡾࡲࡋࡓࠋᩍᤵᑵ௵㝿ࡋ࡚ࠊᚋᖺ㛫ࡢ┠ᶆࢆ⮫ᗋศᏊ࣓࣮ࢪࣥࢢ◊✲᪂ࡓ ╔ᡭࡋࡓෆ↷ᑕ⒪ࣉ࣮ࣟࣈࡢ㛤Ⓨ◊✲ࢆ᥎㐍ࡍࡿࡇࡋ࡚࠾ࡾࡲࡋࡓࡀࠊᢡࡾ㏉ࡋ ᆅⅬࢆ㐣ࡂࡓ⌧ẁ㝵࡛ࡣࠊ㡰ㄪ㐍ࢇ࡛࠸ࡿࡢ࡛ࡣ࡞࠸⪃࠼࡚࠾ࡾࡲࡍࠋ ᖹᡂ 26 ᖺᗘࡣࠊ␃Ꮫ⏕༤ኈྕࡢᏛࢆྲྀᚓࡉࡏࡿ࠸࠺⚾ࡗ࡚ࡣึࡵ࡚ࡢ⤒㦂ࡀ ࠶ࡾࡲࡋࡓࠋṇ☜ࡣࠊࡲࡔᏛྲྀᚓࡲ࡛ࡣ⮳ࡗ࡚࠾ࡾࡲࡏࢇࡀࠊᖹᡂ 26 ᖺᗘᮎᏛ⾡බ 㛤ウㄽࢆ⾜࠸ࡲࡋࡓࡢ࡛ࠊࡰᏛࡀྲྀᚓ࡛ࡁࡿࡇࢁࡲ࡛ࡇࡂ╔ࡅࡽࢀࡓᛮࡗ࡚࠾ ࡾࡲࡍࠋຓᩍࠊᩍᤵ௦ࡶᏛ㝔⏕ࡢ◊✲ᣦᑟࡣཝࡋࡃ⾜ࡗ࡚ཧࡾࡲࡋࡓࡀࠊࡸࡣࡾ᭱ ᚋࡣᩍᤵࡢ㈐௵࠸࠺Ᏻᚰឤࡣ࠶ࡾࡲࡋࡓࠋࡋࡋࠊᅇࡣ࡚⮬ศࡢ㈐௵࡞ࡾࡲࡍࡢ ࡛ࠊㄽᩥసᡂࠊᏛ⏦ㄳಀࢃࡿ㈨ᩱࡢసᡂࠊⓎ⾲ࢫࣛࢻࡢ‽ഛ࡞ࢆࠊᏛ㝔⏕୍ ⥴ஂࡋࡪࡾ⥭ᙇឤࢆࡶࡗ࡚⾜࠸ࡲࡋࡓࠋⱝ࠸◊✲⪅୍⥴⥭ᙇឤࢆࡶࡗ࡚ࡋ࡚ ࠸ࡿࠊࡇࡕࡽࡶゐⓎࡉࢀ࡚ࠊㄽᩥᇳ➹ࢆ㛤ࡋࡓࡾஂࡋࡪࡾⱞࡋࡃࡶᴦࡋ࠸㛫ࢆ 㐣ࡈࡋࡲࡋࡓࠋウㄽࡀ↓⤊ࢃࡗࡓࡣࠊ⮬ศࡢⓎ⾲ࡢࡢఱಸࡶ⑂ࢀࡀฟ࡚ࠊࡇ ࢀࡀᣦᑟ⪅ࡢ㈐௵࡞ࡢࡔᐇឤࡋࡲࡋࡓࠋࡲࡓࠊ⮬ศࡢ࿘ࡾࡣ⮬ศࡢពぢࡀ∦ᐤࡗ࡚࠸ ࡞࠸࡞ࢆ┦ㄯ࡛ࡁࡿ௰㛫ࡀ࠸ࡿࡇࡶẼࡉࢀࠊ⮬ศࡀ㠀ᖖᜨࡲࢀࡓ⎔ቃ࠸ ࡿࡇࢆ☜ㄆ࡛ࡁࡲࡋࡓࠋᣦᑟࡋࡓᏛ⏕ࡣࡶࡕࢁࢇᡂ㛗ࡋࡓᛮ࠸ࡲࡍࡀࠊࡇࡢࡇࢆ ㏻ࡋ࡚⚾⮬㌟ࡶᣦᑟ⪅ࡋ࡚ᑡࡋࡣᡂ㛗࡛ࡁࡓࡢ࡛ࡣ࡞࠸ᛮࡗ࡚࠸ࡲࡍࠋࡇࢀࡲ࡛ࡣࠊ ⮬ศࡢ◊✲ࡀ㐍ࢇ࡛࠸ࡅࡤࡑࢀ࡛Ⰻ࠸⪃࠼ࡀࡕ࡛ࡋࡓࡀࠊᏛ㝔⏕ࠊⱝ࠸◊✲⪅ࠊࡑࡋ ࡚ࢫࢱࢵࣇ⮬ศࡢ▱㆑ࡸ⤒㦂ࢆఏ࠼࡚࠸ࡃࡇࡶ㔜せ࡞ᙺ┠ࡔẼࡁࡲࡋࡓࠋ ࡇࢀࡽࡶࢫࢱࢵࣇຊࢆ࠶ࢃࡏ࡚◊✲ࠊᩍ⫱㑌㐍ࡍࡿᡤᏑ࡛ࡈࡊ࠸ࡲࡍࡢ࡛ࠊ㛵ಀ ࡢⓙᵝ᪉࠾ࢀࡲࡋ࡚ࡣࠊᚋ୍ᒙࡢࡈᣦᑟࡈ㠴᧡ࢆ㈷ࡾࡲࡍࡼ࠺࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ.
(6)
(7) ࠕ⚟Ꮫ㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮ᖺሗࠖ9RO . ┠ ḟ ࡣࡌࡵ ࢭࣥࢱ࣮㛗 ᅄᖺ┠ࢆ㏄࠼࡚ ᩍᤵ Ϩ㸬ྛᩍဨࡼࡾ ϩ㸬ᖹᡂ㸰㸴ᖺᗘάື≧ἣ 㸯㸬◊✲ᴫせ 㸰㸬◊✲ᴗ⦼ 㸱㸬◊✲㈝ྲྀᚓ≧ἣ 㸲㸬ᇶ♏㓄ᒓᏛ⏕ࠕᐇ⩦ࢆ㏻ࡋ࡚ࡢឤࠖ 㸲㸬ᇶ♏㓄ᒓᏛ⏕ᐇ⩦ࢆ㏻ࡋ࡚ࡢឤ Ϫ㸬ᖹᡂ㸰㸴ᖺᗘ◊✲ᡂᯝሗ࿌ 㸯㸬◊✲୍ぴ 㸰㸬◊✲ᡂᯝ 㸦㸯㸧ᇶ♏◊✲ 㸦㸰㸧⮫ᗋ◊✲㸦3(7㸧 㸦㸱㸧⬻ᶵ⬟࣭⮫ᗋ◊✲㸦05,㸧 㸦㸲㸧ࣃࢼࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊㛛 ϫ㸬㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮ࡢᴫせ 㸯㸬タ❧ࡢ┠ⓗ 㸰㸬⤌⧊ᵓᡂ 㸱㸬ࡇࢀࡲ࡛ࡢṌࡳ Ϭ㸬ᖹᡂ㸰㸴ᖺᗘ㐠Ⴀయไ 㸯㸬◊✲⪅ࠊ⫋ဨ 㸯㸬⫋ဨࠊ◊✲⪅ 㸰㸬㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮㐠Ⴀጤဨ 㸱㸬ࣃࢼࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊㛛ᑠጤဨ. ᒸἑ ⚽ᙪ Ύ㔝 Ὀ. ࣭࣭࣭࣭࣭࣭࣭ۑ ࣭࣭࣭࣭࣭࣭࣭㸯. . . ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭㸵 ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭. . . ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭. ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ . ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭ ࣭࣭࣭࣭࣭࣭࣭.
(8)
(9) Ϩ ྛᩍဨࡼࡾ.
(10) ୕ᖺ┠ࢆ㏄࠼࡚ ศᏊ࣓࣮ࢪࣥࢢᒎ㛤㡿ᇦ ⬻⚄⤒ែゎᯒᏛ㒊㛛 ᩍᤵ ㎷ᕝ ဴஓ 2013 ᖺ 3 ᭶ᖐᅜࡋ࡚ࡽ᪩ 2 ᖺࡀ⤒ࡕࡲࡋࡓࠋ᭱ึࡢ༙ᖺ㛫ࡣ⮬ศᵝࡢ⎔ ቃࢆసࡿࡇ㈝ࡸࡋࡲࡋࡓࡀࠊࡇࡢ㛫ཎⴭㄽᩥࢆ㸯ᮏࡋฟࡏ࡚࠸࡞࠸⌧≧ࡣ฿ᗏチ ᐜ࡛ࡁࡿࡶࡢ࡛ࡣ࠶ࡾࡲࡏࢇࠋ୕ᖺ┠ࢆ㏄࠼ࠊᖹᡂ 27 ᖺᗘ୰ࡢ PET/MRI ⨨ࡢᑟධࡀ࠸ࡼ ࠸ࡼ⌧ᐇࢆᖏࡧࠊ⌧ᅾᢞ✏୰ࡢㄽᩥࡔࡅ࡛࡞ࡃ PET/MRI ✌ാࡲ࡛ୖࡆ࡚࠾ࡃࡁ࠸ ࡃࡘࡢࢸ࣮࣐ࢆ᪩ᛴࡲࡵࡿࡇࡀᙜ㠃ࡢ┠ᶆ࡛ࡍࠋ ⚾ࡀ 16 ᖺ๓Ꮫࢆ༞ᴗࡋᨺᑕ⥺⛉་ࡋ࡚ാࡁጞࡵࡓ㡭ࡽᚰࡢ୰࡛ᣢࡕ⥆ࡅ࡚࠸ࡓࠊ ⸆⨨ࡢ㐍ṌࡼࡿࠗศᏊ࣭ᶵ⬟࣭ᙧែ࣓࣮ࢪࣥࢢࡢ⼥ྜ࠘ࡀࡲࡉ┠ࡢ๓ࡲ࡛᮶ ࡚࠸ࡲࡍࠋᙜࢭࣥࢱ࣮࡛ྜᡂྍ⬟࡞ྛ✀ PET ⸆ຍ࠼ࠊ᭱᪂ࡢࢯࣇࢺ࢙࣭࢘ࣁ࣮ࢻ࢘ ࢙ࡢᑟධࡼࡾࠊࡰࣇࣝࢫ࣌ࢵࢡ࡛ࡇࡢࡁ࡞ࢸ࣮࣐ྥࡗ࡚࠸ࡃ‽ഛࡀᩚࡗ࡚࠸ ࡿᛮ࠸ࡲࡍࠋ◊✲ᑐ㇟ࡋ࡚⭘⒆ࠊ⬻⾑⟶㞀ᐖࠊ⚄⤒ኚᛶᝈࠊᚰᝈࠊࣜࣁࣅࣜࡣࡶ ࡕࢁࢇࡢࡇࠊᗣ࡞⏕άࢆ㏦ࡿࡓࡵࡢண㜵་Ꮫⓗ࡞ഃ㠃ࡽࡢࣉ࣮ࣟࢳࡶ᳨ウࡋࡼ࠺ ᛮ࠸ࡲࡍࠋ ㏆㡭ࠊᏛࡸ◊✲࡛Ꮫࡢඛ⏕᪉࠾ヰࡋࡍࡿࠊ⚟ᏛࡢⰋࡉࢆㄆ㆑ࡉࡏࡽ ࢀࡲࡍࠋ㸦࠸ࡗ࡚ࡶ⮬ศࡔࡅឤࡌ࡚࠸ࡿࡔࡅࡶࡋࢀࡲࡏࢇࡀ㸧ࡘࡲࡾࠊ◊✲ᑐࡍࡿ⥲ ண⟬࡞࡛ࡣᏛཬࡧࡲࡏࢇࡀࠊᮏᏛ࡛ࡣᇶ♏ࡸ⮫ᗋ⛉ࡢᇉ᰿ࡀపࡃࠊࡢ◊✲⛉㡿 ᇦࡢᙉ࠸⧅ࡀࡾࢆឤࡌࡲࡍࠋ࠼ࡤᙜࢭࣥࢱ࣮ࡢඹྠ◊✲ࢆ⾜࠺ሙྜ࠾࠸࡚ࡶ㠀ᖖ ࢫ࣒࣮ࢬ࡛᪩࠸ᑐᛂࡀྍ⬟࡛ࠊࡑࡢ㛫ࡁ࡞㞀ᐖ㸦ࡋࡀࡽࡳ㸧ࡣ࠶ࡾࡲࡏࢇࠋࡇࡢ࣓ ࣜࢵࢺࢆ⏕ࡍࡓࡵᚋࡶྛ◊✲⛉ࡢඛ⏕᪉ࡸᙜࢭࣥࢱ࣮ࢫࢱࢵࣇពぢࡢ࢟ࣕࢵࢳ࣮࣎ ࣝࢆ⥆ࡅࠊ⚟ᏛⓎಙࡢ◊✲ᡂᯝࢆฟࡋ࡚࠸ࡅࡿࡼ࠺ດຊࡍࡿࡘࡶࡾ࡛ࡍࠋ ᚋࡶࡈᣦᑟ࣭ࡈᨭࢆ㈷ࡾࡲࡍࡼ࠺ࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ. －1－.
(11) ㏆ἣሗ࿌ ศᏊ࣓࣮ࢪࣥࢢᒎ㛤㡿ᇦ PET ⸆〇㐀Ꮫ㒊㛛 ຓᩍ ᳃ ဴஓ ᑡࡋ๓ࡢヰ࡞ࡾࡲࡍࡀࠊM.J.Welch ඛ⏕ࡢࡶ Washington University in St.Louis School of Medicine ࡛ࡢ␃Ꮫࡽ⫋ࡋࠊࡲࡎࡾࡗࡓᴗࡀ PET ⸆〇㐀యไࡢ GMP ࡛ࡋࡓࠋᙜࡣࠊ⸨ᯘඛ⏕ࠊ⬥ඛ⏕ࠊΎ㔝ඛ⏕ࡀඛ⾜ࡋ࡚ࡾࡗ࡚࠸ࡓ࣍ࢵࢺ ࣛ࣎ࡢᨵ㐀ࢆ㐍ࡵࠊయไࢆᩚഛࡍࡿ࠸࠺ࢆ࠸ࡓࡔࡁࡲࡋࡓࠋࡍ࡛タィᅗࡣ᭱⤊ẁ 㝵ࡁ࡚࠾ࡾࠊᪧࢧࢡࣟࢺࣟࣥᐊࡢ㐽ⶸᡬࢆ᧔ཤࡋ㏻㊰ࢆ☜ಖࡋࡓ࠺࠼࡛ࠊ࣍ࢵࢺࣛ࣎ ୰ኸࡢࡁ࡞ᐇ㦂ྎࢆ࡞ࡃࡋ࡚ࢡ࣮ࣜࣥࣈ࣮ࢫ➼ࢆタ⨨ࡍࡿ⪺࠸ࡓࡁࠊࢫ࣌ࢵࢡࡣ㧗 ࡃ࡞ࡿࡀᐇົࡀ࠺ࡲࡃᶵ⬟ࡍࡿࡢᮇᚅᏳࡀධࡾࡾ࡞ࡀࡽㄪᩚࡋࡓグ᠈ࡀ࠶ࡾࡲ ࡍࠋࡑࡢᚋࠊ᭩㢮ᩚഛ➼㛫ࢆせࡋࡲࡋࡓࡀࠊᖹᡂ 25 ᖺ 1 ᭶ FDG ࡛Ꮫ〇㐀ᇶ‽㸦Ꮫ GMP㸧ㄆドࢆྲྀᚓࡍࡿࡇࡀ࡛ࡁࡲࡋࡓࠋࡇࡢ⤒㦂ࡣࠊ〇㐀┤ᚋࣄࢺᢞࡍࡿ࠸ ࠺㧗࠸ရ㉁ࢆせồࡉࢀࡿ PET ⸆ࡘ࠸࡚ࠊࡑࡢᕤ⛬⟶⌮ࢆ୍ࡽ㢳ࡳࡿⰋ࠸ᶵ࡞ࡾ ࡲࡋࡓࠋࡎࡋ࡞ࡀࡽࠊ᪥ᮏ⸆ᒁ᪉ࢆᗈࡆࡿᶵࡀࡇࢀࡲ୍࡛࡛␒ከࡗࡓࡼ࠺࡞Ẽࡀ ࡋࡲࡍࠋ⌧ᅾࠊㄆドྲྀᚓࡽ᪩ 2 ᖺࡀ㐣ࡂࠊேဨࡢ␗ືࡸᶵჾࡢ᭦᪂➼ࡀ࠶ࡾࡲࡋࡓࡀࠊ ⸆㒊ࢆࡣࡌࡵࡍࡿ㛵ಀ㒊⨫࠾ࡼࡧ㧗࢚ࢿ◊ࢫࢱࢵࣇࡢࡈ༠ຊࡼࡾࢫ࣒࣮ࢬ࡞㐠Ⴀࡀ 㐩ᡂࡉࢀ࡚࠸ࡲࡍࠋ᮶ᖺ 1 ᭶ࡣㄆドࡢ᭦᪂ᮇ࡞ࡾࡲࡍࡢ࡛ࠊẼࢆᘬࡁ⥾ࡵ࡚ 1 ᖺࢆ㐣 ࡈࡋࡓ࠸ᛮ࠸ࡲࡍࠋࡲࡓࠊࡇࡇ࡛ᇵࡗࡓ▱ぢࡣᨺ་◊➼࡛㛤ദࡉࢀ࡚࠸ࡿᩍ⫱ࣉࣟࢢࣛ ࣒࡛࠾ఏ࠼ࡍࡿᶵࡀ࠶ࡾࠊ᪂ࡓ࡞ே⬦సࡾࡢሙࡋ࡚ά⏝ࡉࡏ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍࠋ ࡉࡽࠊᖹᡂ 26 ᖺᗘࡣ⮫ᗋ◊✲⏝⸆ࡋ࡚[11C]PiB ࢆ᪂ࡓຍ࠼ࡿࡇࡀ࡛ࡁࡲࡋࡓࠋ C-11 ᶆ㆑⸆ࡣࡇࢀࡲ࡛ Acetate ࡢࡳࢆ࣮ࣝࢳࣥࡋ࡚࠾ࡾࠊ୍⯡ⓗ࡞[11C]࣓ࣚ࢘ࢳࣝ ࡸ[11C]࣓ࢳࣝࢺࣜࣇ࣮ࣞࢺࡽࡢᶆ㆑ᛂࢆせࡍࡿ⸆ࡘ࠸࡚ࡢ⤒㦂ࡀࢇ࠶ࡾࡲ ࡏࢇ࡛ࡋࡓࠋ≉ࠊྜᡂ㐣⛬࡛ࡢᏳᐃྠయ C-12 ࡢΰධࡣẚᨺᑕ⬟ࢆపୗࡉࡏデ᩿ᙳ㡪 ࢆཬࡰࡍࡓࡵࠊࢱ࣮ࢤࢵࢺ࿘㎶ࡢ⟶⌮ࡸヨ⸆ㄪ〇⣽ᚰࡢὀពࢆᡶ࠺ᚲせࡀ࠶ࡾࡲࡍࡀࠊ ⤒㦂㇏ᐩ࡞ᨺ་◊ࡢ⚟ᮧඛ⏕ྜᡂࡢὀពⅬ➼ࢆ┤᥋ࡈᣦᑟࡋ࡚࠸ࡓࡔࡃࡇ࡛ࠊၥ㢟 Ⅼࢆຠ⋡ࡼࡃゎỴࡍࡿࡇࡀ࡛ࡁࡲࡋࡓࠋࡉࡽࠊᇶ♏◊✲࡛せᮃࡢ࠶ࡗࡓᮎᲈᛶ࣋ࣥࢰ ࢪࢮࣆࣥཷᐜయ࣓࣮ࢪࣥࢢ⸆ࡢ[11C]PK11195 ࡘ࠸࡚ࡶ〇㐀ࢆヨࡳࠊ⏝ࢆጞࡵ࡚ ࠸ࡲࡍࠋ ࡲࡓࠊᇶ♏ᐇ㦂⏝⮬ືྜᡂ⨨ࢩࢫࢸ࣒ࡢ㛤Ⓨ࡛ࡣࠊᕤᏛ㒊ࡢᏛ⏕ࡶపண⟬࡛⸆ 〇㐀࡛ࡁࡿࡼ࠺ࢹࢆฟࡋ࡞ࡀࡽࠊࣘࢽࢵࢺࡢタィ࠾ࡼࡧヨసᣮᡓࡋ࡚࠸ࡲࡍࠋ ᚋࡶ⮫ᗋ◊✲ࢆ᥎㐍࡛ࡁࡿ⸆〇㐀యไࡢᵓ⠏ࢆ┠ᣦࡋ࡚ࡲ࠸ࡾࡲࡍࡢ࡛ࠊᘬࡁ⥆ࡁ ࡈᣦᑟࡈ㠴᧡ࢆ㈷ࡾࡲࡍࡼ࠺ᐅࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ. －2－.
(12) ୍ᖺࢆࡾ㏉ࡗ࡚ ศᏊࣉ࣮ࣟࣈ㛤Ⓨᛂ⏝㡿ᇦ ⣽⬊ᶵ⬟ゎᯒᏛ㒊㛛 ຓᩍ ∾㔝 㢧 ẖᖺᛮ࠺࡛ࡣ࠶ࡾࡲࡍࡀࠊᖹᡂ 26 ᖺᗘࡶ࠶ࡗ࠸࠺㛫㐣ࡂ࡚ࡋࡲ࠸ࡲࡋࡓࠋ ╔௵ᚋࡽ᭷ᶵྜᡂࡢࡓࡵࡢయไ࡙ࡃࡾࢆ㐍ࡵ࡚ࡁࡲࡋࡓࡀࠊᮏᏛᕤᏛ㒊 ᚨỌᩍᤵࡸᮏ ࢭࣥࢱ࣮ᡤᒓᩍဨࡈᨭ࠸ࡓࡔࡁࠊซࡢྜ≀ࡢྜᡂࡽྠᐃࡲ࡛ࡀࢫ࣒࣮ࢬ࡛ࡁ ࡿࡼ࠺࡞ࡾࡲࡋࡓࠋࡇࡢሙࢆࡾ࡚ࠊ῝ࡃᚚ♩⏦ࡋୖࡆࡲࡍࠋ ࡲࡓࠊᖹᡂ 26 ᖺ 4 ᭶ࡽࡢ⛉◊㈝ࡀ᥇ᢥࡉࢀࠊ㧗ศᏊ࣑ࢭࣝࢆ⏝ࡋࡓ࣓࣮ࢪࣥࢢ⸆ ࡞ࡽࡧෆ↷ᑕ⒪⸆ࡢ㛤Ⓨ㛵ࡍࡿ◊✲ࢆ㛤ጞࡋࡲࡋࡓࠋࡇࢀక࠸ࠊศᏊ㞟ྜయ ࡢ◊✲ࢆ㐍ࡵࡿୖ࡛ᚲせ࡞ࡿⱥᅜ࣭Malvern Instruments ♫〇 Zetasizer Nano ZSP ࢆ⟶⌮༊ ᇦෆᑟධࡋࡲࡋࡓ㸦┿㸧ࠋࡇࡢ⨨࡛ࡣࠊືⓗගᩓ㸦DLS㸧ࠊ㟼ⓗගᩓ㸦SLS㸧ࠊࢮ ࣮ࢱ㟁࡞ࡢ ᐃࢆ⡆౽⾜࠺ࡇࡀྍ⬟࡛࠶ࡾࠊࢼࣀ⢏Ꮚᆺࣉ࣮ࣟࣈࡢ≀ᛶホ౯ά ㌍ࡋ࡚ࡃࢀࡿࡶࡢᮇᚅࡋ࡚࠸ࡲࡍࠋࡲࡓࠊᮏ⨨ࢆᨺᑕ⥺⟶⌮༊ᇦෆタ⨨ࡋ࡚࠸ࡿ◊ ✲ᶵ㛵ࡣᴟࡵ࡚ᑡ࡞࠸ᛮ࠸ࡲࡍࡢ࡛ࠊ⯆ࡀ࠶ࡿ᪉ࡣࠊ㠀ࠊ⏝ࡋ࡚࠸ࡓࡔࡅࡿᎰ ࡋࡃᛮ࠸ࡲࡍࠋ. ⱥᅜ࣭Malvern Instruments ♫〇 Zetasizer Nano ZSP ᭱ᚋࠊ୍ᖺࢆ㏻ࡋ࡚ከࡃࡢඛ⏕᪉ࠊົဨࡢ᪉ࠎࡢࡈᨭࠊࡈᣦᑟࢆ㈷ࡾࡲࡋࡓࡇ ࢆᚚ♩⏦ࡋୖࡆࡲࡍࠋࡲࡔࡲࡔ◊✲⪅ࡋ࡚ᮍ⇍࡛ࡣ࠶ࡾࡲࡍࡀࠊ◊✲ᡂᯝࢆୖࡆࡿࡇ ࡼࡗ࡚ᮏࢭࣥࢱ࣮㈉⊩ࡋࡓ࠸ᛮࡗ࡚࠸ࡲࡍࡢ࡛ࠊᖹᡂ 27 ᖺᗘࡶᘬࡁ⥆ࡁࠊࡈᣦᑟࡈ 㠴᧡ࢆ㈷ࡾࡲࡍࡼ࠺ࠊఱ༞ࠊᐅࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ ᖹᡂ 27 ᖺ 4 ᭶ . －3－.
(13) ㏆ἣሗ࿌ ศᏊ࣓࣮ࢪࣥࢢᒎ㛤㡿ᇦ ⬻⚄⤒ែゎᯒᏛ㒊㛛 ≉ᩍᤵ 㰻⸨ ㍜ ㄆ▱⛉Ꮫࡣࡁࡃኚࢃࡾࡘࡘ࠶ࡿࠋ᭱ࡢኚࡣㄆ▱⚄⤒⛉Ꮫ࠸ࢃࢀࡿศ㔝ࡢᛴ㏿࡞ 㐍Ṍ࡛࠶ࡿࠋࡇࢀࡣࠊ㏆ᖺࡢ⬻άືࡢグ㘓ศᯒᢏ⾡ࡢ㐍Ṍࡼࡿࡇࢁࡀࡁࡃࠊ࣏ࢪࢺ ᩿ࣟࣥᒙᙳἲ 3(7㸧ࠊᶵ⬟ⓗ☢Ẽඹ㬆⏬ീἲ I05,
(14) ࠊ⬻☢ᅗ 0(*
(15) ࡞ຍ࠼ࠊ㏆㉥እ⥺ ศගἲ 1,56
(16) ࡞ࡼࡿ◊✲ࡀቑ࠼࡚ࡁ࡚࠸ࡿࠋࡲࡓࠊᏳ㟼 I05, 5HVWLQJVWDWHI05,
(17) ࠊ G\QDPLFFDXVDOPRGHOLQJ '&0
(18) ࠸ࡗࡓ⬻ෆࡢᶵ⬟ⓗ㐃㛵ࢆㄪࡿᡭἲࡶ᪂ࡓ㛤Ⓨࡉࢀ ࡚࠾ࡾࠊࢥࢿࢡࢩࣙࢽࢫࢺ࣭ࣔࢹࣝࡸ⚄⤒ᅇ㊰⥙⌮ㄽ࡞ࡢⓎᒎࡶࡁࡃᐤࡋ࡚࠸ࡿࠋ ≉Ⓨ㐩◊✲࠾࠸࡚ࡣࠊࡇࢀࡽࡢ⌮ㄽⓗ◊✲ᇶ࡙ࡃ㆟ㄽࡀάⓎ࡞ࡉࢀ࡚࠾ࡾࠊⓎ㐩 ᚰ⌮Ꮫࡸ⚄⤒ᚰ⌮Ꮫࡢศ㔝࠾࠸࡚ࠊ⬻άືࡢグ㘓ࠊ⾜ືᐇ㦂ࠊࡑࢀࡽࡢࢹ࣮ࢱᇶ࡙ࡃ ࣔࢹࣝࢆᥦࡋࠊࢩ࣑࣮ࣗࣞࢩࣙࣥ➼ࡼࡗ࡚ࡑࡢጇᙜᛶࢆ᳨ドࡍࡿ࠸ࡗࡓ୍㐃ࡢ◊✲ ᡭ⥆ࡁࡀ⾜ࢃࢀ࡚࠸ࡿࠋ ࡲࡓࠊேࡢ⬻ࡢⓎ㐩ࢆㄪࡿ࠸࠺ࡇࡣ࠺࠸࠺ࡇ࡞ࡢࡔࢁ࠺ࠋᡃࠎࡣㄌ⏕ࡋࡓ ▐㛫ࡽ㛫㍈ἢࡗ୍࡚᪉ྥⓗ࡞ኚࢆࡋࠊࡑࡢ㐣⛬࡛ㄆ▱ࡸ㐠ືᶵ⬟࡞⎔ቃ┦ స⏝ࡋ࡚࠸ࡃࡓࡵᚲせ࡞ᵝࠎ࡞ᶵ⬟ࡀฟ⌧ࡋ࡚ࡃࡿࡇ࡞ࡗ࡚࠸ࡿࠋ࡛ࡣࠊࡇࡢࡼ࠺ ࡞✀ࠎࡢᶵ⬟ࡣࡢࡼ࠺ࡋ࡚ᙧᡂࡶࡋࡃࡣฟ⌧ࡋ࡚ࡁࡓࡢ࡛࠶ࢁ࠺㸽⏕≀ࡋ࡚ࡢࣄ ࢺࢆே㛫ࡍࡿࡢࡣఱ࡞ࡢ㸽࠸ࡗࡓࠊே㛫ࡀࡢࡼ࠺ኚࡍࡿࡢࠊࡲࡓࡑࡢࡼ࠺ ࡞ኚࢆసࡾฟࡋ࡚࠸ࡿࡶࡢࡣఱ࠸࠺ኚࡢᶵᵓࡢゎ᫂ࢆ⾜࠺ࡇࡣࠊⓎ㐩◊✲ࡑࡢ ࡶࡢࢆ♧ࡋࠊ⾜ືᏛⓗぢࡓࡁࡢே㛫⌮ゎࡢ୰ᚰ⨨࡙ࡅࡽࢀ࡚࠸ࡿࠋ ࡇ࠺ࡋࡓࠊㄆ▱࣭Ⓨ㐩◊✲ࡢᡂᯝࢆ♫㑏ඖࡍࡿࡇࡘ࠸࡚ᮇᚅࡉࢀࡿࡇࡣࠊ ⬻⛉Ꮫࡢ▱ぢࡀே㢮ࡢᖾ⚟ᐤࡍࡿࡇ࡛࠶ࡿࠋ࠼ࡤࠊே㛫ࡢㄆ▱ᶵ⬟ࡀ⬻ࡢࣞ࣋ࣝ ࡛ゎ᫂ࡉࢀࢀࡤ㸪⬻ࡢẼࡸⓎ㐩㞀ᐖࡢデ᩿࣭⒪࠸࠺㠃ࡽ㈉⊩ࡋ࠺ࡿࡋࠊㄆ▱ࡢ ᵝᘧࡑࡢⓎ㐩ࡘ࠸࡚ศࢀࡤࠊࡑࢀࡣᩍ⫱ࡢ㑏ඖࡀྍ⬟࡛࠶ࡿࡇࡀ⪃࠼ࡽࢀࡿࠋ ࡇࡢᵝ࡞⫼ᬒࢆᣢࡕࠊᡃࠎ⬻⚄⤒ែゎᯒᏛ㒊㛛࡛ࡣࠊேయくᛶࡢ࡞࠸࣓࣮ࢪࣥ ࢢἲ࡛࠶ࡿࠊ☢Ẽඹ㬆⏬ീἲ 05,
(19) ࠊ⾜ືᚰ⌮Ꮫⓗ࡞ᡭἲࢆ⏝࠸࡚ࠊࣄࢺࡢㄆ▱ᶵ⬟ࢆⓎ 㐩ࡢ㠃ࡽ◊✲ࢆࡋ࡚࠸ࡿࠋࡇࡢ⬻⚄⤒ែゎᯒᏛ㒊㛛࠾࠸࡚ࠊከࡃࡢᡂᯝ࡛◊✲ࡢά ᛶࢆᅗࢀࡿࡼ࠺ࠊຊࢆ࠶ࡆ࡚◊✲ྲྀࡾ⤌ࡴᡤᏑ࡛࠶ࡾࡲࡍࠋᚋࡶࡼࡾ୍ᒙࡢࡈ ᣦᑟ࣭ࡈᨭࢆ㈷ࡾࡲࡍࡼ࠺࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ. －4－.
(20) 㸰ᖺ┠ࢆ㏄࠼࡚ ศᏊ࣓࣮ࢪࣥࢢᒎ㛤㡿ᇦ ⬻⚄⤒ែゎᯒᏛ㒊㛛 ≉ຓᩍ ᓥ⏣ ᾈ ᖹᡂ 26 ᖺ 4 ᭶ 1 ᪥ࠊᏊࡶࡢࡇࡇࢁࡢⓎ㐩◊✲ࢭࣥࢱ࣮Ⓨ㐩⬻ᶵ⬟࣓࣮ࢪࣥࢢ㒊㛛 ࡢ≉ຓᩍ╔௵ࡋ࡚ࡽࠊࡲࡓࠊ㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮⬻⚄⤒ែゎᯒᏛ㒊㛛 වົࡋ࡚ࡽࠊ2 ᖺ┠ධࡾࡲࡋࡓࠋᑓ㛛ࡣࠊㄆ▱⚄⤒⛉Ꮫ࡞ࡾࠊ≉ࠊ☢Ẽඹ㬆⏬ീ ἲ㸦MRI㸧ࢆ⏝࠸࡚ࠊᏛ⩦ࡸⓎ㐩క࠺⬻ࡢᶵ⬟࠾ࡼࡧᵓ㐀ࡢኚ㛵ࡍࡿ◊✲ྲྀࡾ⤌ ࢇ࡛࠸ࡲࡍࠋ ㄆ▱⚄⤒⛉Ꮫࡢᇶ♏ࡢ⋓ᚓࡗ࡚ࡣࠊ௨๓ᡤᒓࡋ࡚࠸ࡓ⮬↛⛉Ꮫ◊✲ᶵᵓ⏕⌮Ꮫ◊ ✲ᡤ࠾ࡅࡿ⬻⏬ീ◊✲ศ㔝ࡢ◊㛑ࡀ㔜せ࡞ᙺࢆᢸࡗ࡚࠸ࡲࡍࠋ⬻⏬ീἲࡣࠊ࠶ࡿᚰⓗ 㐣⛬≉ᐃࡢ⬻ᵓ㐀ࢆ㠀くⓗᑐᛂ࡙ࡅࡿ᭷ຊ࡞᪉ἲ࡛࠶ࡾࠊࡑࡋ࡚ࠊ⬻࠸࠺ሙࢆไ ⣙᮲௳ࡋ࡚࠼ࡿࡇࡼࡗ࡚ࠊᏛ⩦ࡸⓎ㐩࡞ࡢᚰ⌮Ꮫⓗࣔࢹࣝࡢᵓᡂ᳨ドᐤ ࡍࡿࡉࢀࡲࡍࠋࡇࡢࡼ࠺࡞⬻⏬ീἲࡣࠊᚰ⌮Ꮫ⚄⤒⛉Ꮫࡢศ㔝㛫ࢆ⤖ࡧࡘࡅࡿ᥋Ⅼ㸦ㄆ ▱⚄⤒⛉Ꮫ㸧࡞ࡾࠊᚰ⌮Ꮫࣔࢹࣝࡢᵓᡂ᳨ド࠾࠸࡚ࠊ࠶ࡿᚰⓗ㐣⛬ࡑࢀ㝶ࡍ ࡿ⾜ືࡔࡅ࡛࡞ࡃࠊࡑࡢᚰⓗ㐣⛬ᑐᛂࡍࡿ⬻ᵓ㐀ࡢാࡁ㛵ࡍࡿ▱ぢࡶ⤫ྜࡍࡿࡇࡀ ࡛ࡁࡲࡍࠋ ⌧ᅾࠊࡇࡢ⚟Ꮫ࠾࠸࡚㸪⚾ࡣࡇࢀࡲ࡛ᇵࡗ࡚ࡁࡓᑓ㛛ศ㔝ࡢࢹࢩࣉࣜࣥࢆᅵ ྎࠊᏛ⩦ࡸⓎ㐩క࠺⬻ࡢᶵ⬟࠾ࡼࡧᵓ㐀ࡢኚ㛵ࡍࡿ◊✲ྲྀࡾ⤌ࢇ࡛࠸ࡲࡍࠋࡇ ࡢ 1 ᖺࡢ㛫ࡣࠊ࠼ࡤࠊᏊࡶࡢࡇࡇࢁࡢⓎ㐩◊✲ࢭࣥࢱ࣮Age2 ⏬ࡢ㐃ᦠ◊✲ࡋ ࡚ࠊᏊࡶ௦ࡢ㐺ษ࡞㣴⫱࠸࠺⤒㦂ࡀࠊ⬻ᵓ㐀㸦⅊ⓑ㉁ᐜ✚㸧ཬࡰࡍᙳ㡪㛵ࡍ ࡿ⬻⏬ീ◊✲ྲྀࡾ⤌ࢇ࡛ࡁࡲࡋࡓࠋ㐺ษ࡞㣴⫱㉳ᅉࡍࡿᛂᛶឡ╔㞀ᐖࡣឤไᚚ ᶵ⬟ၥ㢟ࢆᢪ࠼࡚࠾ࡾࠊࡑࡢ㞀ᐖ࠾ࡼࡧࡑࡢᚰⓗᶵ⬟ࡢၥ㢟㛵ࡍࡿ⬻ᵓ㐀␗ᖖࡘ ࠸࡚᫂ࡽࡍࡿࡇࡣࠊࡑࡢ㞀ᐖࢆࡵࡄࡿែࡢᢕᥱࡲࡓデ᩿࣭⒪᪉ἲࡢᨵၿࡘ࡞ ࡀࡿࡇࡀᮇᚅࡉࢀࡲࡍࠋࡇࡢ㐃ᦠ◊✲࡛᫂ࡽࡉࢀ࡚ࡁࡓᡂᯝࢆᏛ⾡ㄽᩥࡋ࡚බ⾲ ࡋ㈉⊩࡛ࡁࡿࡼ࠺ࡋࡓ࠸ᛮ࠸ࡲࡍࠋ ᭱ᚋ࡞ࡾࡲࡍࡀࠊ⚟Ꮫ࡛ࡣࠊᏊࡶࡢࡇࡇࢁࡢⓎ㐩◊✲ࢭࣥࢱ࣮ࡢタ⨨௨๓ࠊ ࠕ⬻ ࡢⓎ㐩ࡢ⤌ࡳࠖࡸࠕᏊࡶࡢࡇࡇࢁࠖࡢㅖၥ㢟ྲྀࡾ⤌ࢇ࡛ࡁࡓṔྐࡀ࠶ࡾࡲࡍࠋࡲࡓࠊ ࡑࡢṔྐࡢ୰࡛㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮ࡣ୰᰾ⓗ࡞ᙺࢆᢸࡗ࡚ࡁࡲࡋࡓࠋᚋࡣࠊ ㄆ▱⚄⤒⛉ᏛࡢࢹࢩࣉࣜࣥࢆᅵྎࠊࡇࡇࢁࡢⓎ㐩ࡢ⤌ࡳࡢゎ᫂ࢆ┠ᣦࡋ◊✲ྲྀࡾ ⤌ࡳࠊࡉࡽࡣᇶ♏ࡔࡅ࡛࡞ࡃᩍ⫱ࡸ⮫ᗋࡶᛂ⏝࡛ࡁࡿࡼ࠺࡞◊✲ࢆ᥎ࡋ㐍ࡵࡽࢀࡿࡼ ࠺⢭㐍ࡋࡓ࠸⪃࠼࡚࠸ࡲࡍࠋࡲࡔ◊✲⪅ࡋ࡚ᮍ⇍࡛ࡣ࠶ࡾࡲࡍࡀࠊ◊✲ᡂᯝࢆୖࡆ ࡿࡇࡼࡗ࡚୧ࢭࣥࢱ࣮㈉⊩࡛ࡁࡿࡼ࠺ࢆ㐍ࡵ࡚࠸ࡁࡓ࠸ᛮ࠸ࡲࡍࠋᚋ ࡶࡈᣦᑟࡈ㠴᧡ࡢࠊࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ. －5－.
(21) ࣃࢼࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊㛛ࡀ㸳ᖺ┠ࢆ㏄࠼࡚ ࣃࢼࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊㛛 ᣍ⪸ᩍᤵ Ύ㔝 ṇᶞ 2011 ᖺ 4 ᭶ࠊ㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ࢭࣥࢱ࣮ࡢ୰ࠊࣃࢼࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊 㛛ࡀ㛤タࡉࢀ࡚ࡽࠊᖺ࡛ 5 ᖺ┠ࢆ㏄࠼ࡲࡋࡓࠋ᭦ࡑࡢ 1 ᖺ๓ࡽ㢮ఝ᳨⣴ᢏ⾡ 㛵ࡍࡿඹྠ◊✲ࡣ㛤ጞࡋ࡚࠾ࡾࡲࡋࡓࡀࠊ1 ࢸ࣮࣐ࡔࡅࡢಶูࡢඹྠ◊✲࡛ࡣ࡞ࡃࠊ་ ⒪⌧ሙ࠾ࡅࡿㅖㄢ㢟ᑐࡍࡿ་ᕤ㐃ᦠࡼࡿゎỴࢆ┠ⓗࠊࡑࡢάືࡢሙࡋ࡚ࡢඹྠ ◊✲㒊㛛ࢆタ⨨ࡍࡿࡇྜពࡋࠊ⚟Ꮫࣃࢼࢯࢽࢵࢡࡢ㛫࡛ࡢໟᣓⓗ࡞ඹྠ◊✲ዎ ⣙ࡢ⥾⤖⮳ࡾࡲࡋࡓࠋࡑࡢዎ⣙ࡶ⌧ᅾ࡛ࡣ➨ 2 ᮇධࡾࠊࡑࢁࡑࢁලయⓗ࡞ᡂᯝࡀồࡵ ࡽࢀࡿᮇࡁ࡚࠾ࡾࡲࡍࠋᏛⓎ⾲ࡸ≉チฟ㢪࡞࡛ࡣࠊ᪤࠸ࡃࡘࡢ◊✲ᡂᯝࡀᚓ ࡽࢀ࡚࠾ࡾࡲࡍࡀࠊ⏘Ꮫ㐃ᦠࡢព⩏ࡋ࡚ࡣࠊ ͆◊✲͇ࡔࡅ⤊ࢃࡿࡇ࡞ࡃࠊ་⒪⌧ሙ࡛ ᐇ㝿࠼ࡿࢯ࣮ࣜࣗࢩࣙࣥࢆᥦ౪ࡍࡿࡇ࡛♫ⓗ࡞ࢆᯝࡓࡋ࡚ࡺࡁࡓ࠸⪃࠼࡚ ࠾ࡾࡲࡍࠋ ඹྠ◊✲㒊㛛ࡢ➨ 1 ᮇࡣࠊ⚟Ꮫࡢ࣐ࣝࢳࣔࢲࣜࢸ࣮࣭࣓࣮ࢪࣥࢢࡢ⮫ᗋ◊✲ ࠊࣃࢼࢯࢽࢵࢡࡢ㧗ᗘ࡞⏬ീฎ⌮ᢏ⾡࣭▱⬟ฎ⌮ᢏ⾡ࡢ⼥ྜࡼࡿࠊୡ⏺᭱ඛ➃ࡢ་⏝ ⏬ീฎ⌮ࢩࢫࢸ࣒ࢆ┠ᣦࡋࡓࢸ࣮࣐タᐃࢆ⾜࠸ࠊ⏬ീデ᩿࣭ᩍ⫱ࢆᨭࡍࡿࠕ㢮ఝ᳨ ⣴ࢩࢫࢸ࣒ࠖ ࠊ⌮デ᩿ࢆᨭࡍࡿ ࠕ㟁Ꮚࣉࣞࣃ࣮ࣛࢺ 㸦ࢥࣥࢱࢡࢺ࣓࣮ࢪࢭࣥࢩࣥࢢ㸧ࠖ ࠊ ᨺᑕ⥺་Ꮫ࣭ゎ๗Ꮫ࣭⌮Ꮫࢆ᭷ᶵⓗ⤖ࡧࡅࡿࠕࢹࢪࢱࣝᶆᮏᵓᡂࢩࢫࢸ࣒ࠖ࡞ ࡢࢸ࣮࣐ࢆ᥎㐍࠸ࡓࡋࡲࡋࡓࠋ≉ࠊ㢮ఝ᳨⣴ࢩࢫࢸ࣒ࡣࠊ་⒪ሗᏛ㐃ྜࡢඃ ⚽ㅮ₇㈹㸦2012㸧 ࠊ◊✲ዡບ㈹㸦2013㸧ࢆཷ㈹ࡋࠊRSNA ࡛ 2 ᖺ㐃⥆㸦2013࣭2014㸧ᐇ ᶵᒎ♧ࢆ⾜࠺ࡲ࡛㐍ᒎࡋ࡚࠾ࡾࠊᐇ⏝ࡲ࡛࠶୍Ṍ࠸࠺ࡇࢁ࡛ࡍࠋ ࡲࡓࠊ➨㸰ᮇࡣࠊ㉸㧗㱋♫ࡢ฿᮶ྜࢃࡏࠊ㧗㱋⪅ࡗ࡚᭱ࡶẼࡀࡾ࡞ࣟࢥࣔ ࢸࣈ࣭ࢩࣥࢻ࣮࣒ࣟㄆ▱ࢆព㆑ࡋࡓࢸ࣮࣐ࢆ➨ 2 ࡢᰕࡋࠊ࢙࢘ࣛࣈࣝ➃ᮎࢆ⏝ ࠸࡚ᐙᗞ࡛ࡢ᪥ᖖ⾜ືࡽ㐠ືᶵ⬟ࢆ ᐃࡍࡿࠕ㐠ືᶵ⬟ࣔࢹࣜࣥࢢࠖ ࠊ㟁ࢭࣥࢧゐࢀ ࡿࡔࡅ࡛⬦ὴఏ㛫ᇶ࡙࠸࡚⾑ᅽࢆ ᐃࡍࡿࠕ⡆᫆⾑ᅽ᥎ᐃࠖ࡞ࡢࢸ࣮࣐ࢆ᪂タࡋ ࡲࡋࡓࠋ ་ᕤ㐃ᦠࡼࡿඹྠ◊✲ࢆ㐍ࡵࡿ࠶ࡓࡗ࡚ࡣࠊࣃࢼࢯࢽࢵࢡࡢᢏ⾡⪅ࡀ་⒪⌧ሙࡢ୰ ධࡾ㎸ࡳࠊ┿ࡢࢽ࣮ࢬ㸦࠾ᅔࡾࡈ㸧ࢆ⌮ゎࡍࡿࡇࡀ᭱ࡶ㔜せ࡛ࠊඹྠ◊✲㒊㛛ࡀࡑ ࡢ㊊ሙࡋ࡚ࡢษ࡞ᙺࢆᯝࡓࡋ࡚࠸ࡲࡍࠋ⚟Ꮫࣃࢼࢯࢽࢵࢡࡢ᪉ࡢ◊✲⪅ࡀ ୍ᇽࡋࠊඹ㏻ࡢ┠ᶆྥࡅࡓ㆟ㄽࢆᒎ㛤ࡋࠊၥⅬࢆࡍࡄゎᾘࡍࡿࡇ࡛ࠊຠ⋡ⓗ ࡞◊✲㛤Ⓨࡀᮇᚅ࡛ࡁࡲࡍࠋࡲࡓࠊ◊✲ᡂᯝࢆホ౯ࡍࡿ་⒪⌧ሙࡀࡍࡄ㞄Ꮡᅾࡍࡿࡇ ࡛ࠊぢ㐣ࡈࡉࢀ࡚࠸ࡓㄢ㢟ࢆὙ࠸ฟࡋࠊࡍࡄ◊✲ᡂᯝࣇ࣮ࢻࣂࢵࢡࡍࡿࡇ࡛ࠊ▷ ᮇ㛫㧗࠸┠ᶆࢆ㐩ᡂࡋࠊ་⒪㈉⊩࣭♫㈉⊩ࢆᯝࡓࡋ࡚ࡺࡃᡤᏑ࡛ࡍࠋᚋࡶࠊࣃࢼ ࢯࢽࢵࢡ་ᕤᏛඹྠ◊✲㒊㛛ࡢάືᑐࡋࠊࡈᣦᑟ࣭ࡈᨭࢆ㈷ࡾࡲࡍࡼ࠺ࡼࢁࡋࡃ࠾㢪 ࠸⏦ࡋୖࡆࡲࡍࠋ. －6－.
(22) ϩᖹᡂ ᖺᗘάື≧ἣ.
(23) 㻝㻚㻌 ◊✲ᴫせ㻌 㸦㸯㸧ᇶ♏◊✲ ᖹᡂ 26 ᖺᗘᇶ♏◊✲࡛ࡣ 13 ௳ࡢࣉࣟࢺࢥ࣮ࣝࡀᥦฟࡉࢀࡓࠋ๓ᖺᗘࡽᘬࡁ⥆ࡁ་Ꮫ 㒊ࠊᕤᏛ㒊ࡢㅮᗙࡸእ㒊◊✲ᶵ㛵ࡢ㐃ᦠ◊✲ࡶ㗦ពⓗ㐍ࡵࡽࢀ࡚࠸ࡿࠊ᪂ࡓ࡞ඹྠ ◊✲ࡶ㛤ጞࡉࢀ࡚࠸ࡿࠋୗグᖹᡂ 26 ᖺᗘࡢ◊✲ᴫせࢆ⧳ࡵࡿࠋ 㸺᪂つศᏊࣉ࣮ࣟࣈ㛤Ⓨ㛵ࡍࡿ◊✲㸼 㔠ἑᏛࡢඹྠ◊✲ࡋ࡚ࠊࢩࢢ࣐ཷᐜయࢆᶆⓗࡋࡓᨺᑕᛶ᭩ᶆ㆑ࣉ࣮ࣟࣈࡢ㛤 Ⓨࢆ㐍ࡵࡽࢀ࡚࠸ࡿࠋᖹᡂ 26 ᖺᗘ◊✲࡛ࡣࠊ㠀ᶆⓗ⤌⧊ࡢ㞟✚పῶࢆ┠ⓗࡋ࡚ࠊࡇࢀ ࡲ ࡛ ᳨ ウ ࢆ 㐍 ࡵ ࡚ ࡁ ࡓ (+)-p-bromovesamicol [(+)-pBrV] ࡼ ࡾ ࡶ Ỉ ⁐ ᛶ ࢆ 㧗 ࡵ ࡓ (+)-4-[1-(2-hydroxycyclohexyl) piperidine-4-yl]-2-bromophenol ((+)-BrV-OH)ࢆタィࡋࡓࠋࡲࡓࠊ ࢡ࣑ࣟࣛࣥ T ἲࡼࡾࠊ(+)-[77Br]-BrV-OH ྜᡂࡍࡿࡇᡂຌࡋࡓࠋ N-Fluoroacetyl-D-glucosamine ([18F]FAG)ࡣឤᰁ࣓࣮ࢪࣥࢢࣉ࣮ࣟࣈࡋ࡚㛤Ⓨࡉࢀࡓ ⸆࡛࠶ࡿࡀࠊࡇࢀࡲ࡛᭱⤊ᕤ⛬࡛ࡢ HPLC ⢭〇ࢫࢸࢵࣉၥ㢟ࡀṧࡉࢀ࡚࠸ࡓࠋᖹᡂ 26 ᖺᗘ◊✲࡛ࡣࠊࢺࢩࣝᇶࡸ࣓ࢩࣝᇶࢆ⬺㞳ᇶࡋࡓ๓㥑యࡽ[18F]FAG ࢆྜᡂࡍࡿ࣮ࣝࢺ ࢆ᳨ウࡋࡓࠋࡲࡓࠊHPLC ࡛ࡢศ㞳࣭⢭〇᮲௳ࢆ᳨ウࡋࠊⰋዲ࡞ HPLC ᮲௳ࢆぢฟࡋࡓࠋ ࣀ࢚ࣝࣆࢿࣇࣜࣥࢺࣛࣥࢫ࣏࣮ࢱ࣮ࢆᶆⓗࡋࡓࣉ࣮ࣟࣈࡢ㛤Ⓨ◊✲࡛ࡣࠊ⢭⚄་Ꮫ⛉ ᩍᐊࡢᑠಛඛ⏕ࡽࢆ୰ᚰࠊࣔࢹࣝື≀ࡢ♫ⓗ㝸㞳ள㖄Ḟஈࡢྠ㈇Ⲵᑐࡍࡿ௦ ⾲ⓗẼศᏳᐃ⸆࡛࠶ࡿࣜࢳ࣒࢘ࡢຠᯝࡸࠊ⚄⤒ྍረᛶࡢᙳ㡪ࡘ࠸࡚ホ౯ࢆ⾜ࡗࡓࠋࡇ ࢀࡼࡾࠊ⚄⤒ྍረᛶࡀ࠶ࡿ⛬ᗘ㞀ᐖࡉࢀࡿ࠺ࡘ≧ែࢆ࿊ࡍࡿࡀࠊ⚄⤒ྍረᛶࡀࡉࡽ 㞀ᐖࡉࢀࡿ࠺ࡘ≧ែࡀቑᝏࡍࡿࡢ࡛ࡣ࡞ࡃࠊ࠼ࡗ࡚㌄≧ែࢆ࿊ࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀ ࡓࠋ 㸺ศᏊ㞟ྜయࢆ⏝ࡋࡓ◊✲㸼 ⸆ࢆᶆⓗ㒊㑅ᢥⓗ㍺㏦ࡍࡿᡭẁࡋ࡚ࠊࢼࣀ⢏Ꮚࢆ࢟ࣕࣜࡋࡓࢻࣛࢵࢢ ࢹࣜࣂ࣮ࣜࢩࢫࢸ࣒㸦DDS㸧㛵ࡍࡿ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋᮏࢭࣥࢱ࣮࡛ࡣࠊ࣮࢜ࢪ࢙ 㟁Ꮚᨺฟෆ↷ᑕ⒪⏝⸆ࢆ㧗ศᏊ࣑ࢭࣝෆໟࡋࠊEnhanced Permeability and Retention 㸦EPR㸧ຠᯝࡼࡗ࡚ࠊࡀࢇ㑅ᢥⓗ࡞㍺㏦ࢆྍ⬟ࡍࡿࡇࢆ┠ⓗࡋ࡚࠸ࡿࠋᖹᡂ 26 ᖺ ᗘࡣࠊ࣮࢜ࢪ࢙㟁Ꮚᨺฟ᰾✀࡛࠶ࡿ. 77. Br ࡚ᶆ㆑ࡋࡓࣔࢹࣝ⸆ࢆࢼࣀ⢏Ꮚࡍࡿࡇࢆ. 㐩ᡂࡋࡓࠋࡲࡓࠊࢼࣀ⢏Ꮚࡽࡢࣔࢹࣝ⸆ᨺฟᣲືࡘ࠸࡚ᇶ♏᳨ウࢆ⾜࠸ࠊࢼࣀ⢏Ꮚ ࡽࡢ⸆ᨺฟᣲື┦ᛶࡀ࠶ࡿࡇࢆ᫂ࡽࡋࡓࠋ ࡲࡓࠊ㧗ศᏊ࣑ࢭࣝ㏆㉥እ⺯ගⰍ⣲࣏ࢪࢺࣟࣥ᰾✀ࢆෆໟࡋࡓࢹ࣓࣮ࣗࣝࢪࣥ. －7－.
(24) ࢢࣉ࣮ࣟࣈ㛵ࡍࡿ◊✲ࡀ㐍ࡵࡽࢀࡓࠋᮏࣉ࣮ࣟࣈࡣࠊඹྠ◊✲ඛ࡚㛤Ⓨ୰ࡢᐃ㔞ⓗ㏆ ㉥እ⺯ග࣓࣮ࢪࣥࢢ⨨ࡢᛶ⬟ホ౯⏝ࣉ࣮ࣟࣈࡋ࡚⏝ணᐃ࡛࠶ࡿࠋᖹᡂ 26 ᖺᗘ◊✲ ࡛ࡣࠊࣉ࣮ࣟࣈࡢ⤌ᡂࢆỴᐃࡋࠊᕷ㈍ࡢ࣓࣮ࢪࣥࢢ⨨ࡼࡿᢸࡀࢇࣛࢵࢺࡢࣥࣅ࣎ ࣓࣮ࢪࣥࢢࢆ㐩ᡂࡋࡓࠋ ᖹᡂ 26 ᖺᗘࡽ⏘⛉፬ே⛉ᩍᐊࡢすᓥඛ⏕ࡢඹྠ◊✲ࡀ㛤ጞࡉࢀࡓࠋ⨺Ỉ୰Ꮡᅾࡍ ࡿ⫵ࢧ࣮ࣇࢡࢱࣥࢺ⫾⬡ࡀ⫾࠼ࡿᙳ㡪ࢆ᫂ࡽࡍࡿࡇࢆ┠ⓗࡋࠊࣜ ࣥ⬡㉁ࡽᵓᡂࡉࢀࡓ⫵ࢧ࣮ࣇࢡࢱࣥࢺࢆ 125I ࡛ᶆ㆑ࡋࠊࡇࢀࢆዷፎ࢘ࢧࢠࡢ⨺Ỉ⭍ ᢞࡋࡓᚋࡢయෆືែࢆ⮚ჾฟἲ᳨࡚ウࡋ࡚࠸ࡿࠋࡇࢀࡼࡾࠊ⨺Ỉ⭍ᢞࡋࡓ 125I ᶆ㆑ࢧ࣮ࣇࢡࢱࣥࢺࡀ⫾┙ࢆࡋࡓ⫾ᚠ⎔ẕయᚠ⎔ࡼࡗ࡚ࠊ࡚ࡢ⫾ᙳ㡪 ࢆ࠼࡚࠸ࡿྍ⬟ᛶࡀぢฟࡉࢀࡓࠋ 㸺᪤Ꮡᨺᑕᛶࣉ࣮ࣟࣈࢆ⏝࠸ࡓ◊✲㸼 ⢏Ꮚ⥺↷ᑕࡼࡿࡀࢇࡢ⒪ຠᯝண 3'-Deoxy-3'-18F-fluorothymidine㸦[18F]-FLT㸧ࡀ᭷ ຠ࡛࠶ࡿࡘ࠸࡚ࠊⱝ⊃‴࢚ࢿࣝࢠ࣮◊✲ࢭࣥࢱ࣮ࡢඹྠ◊✲ࢆ㐍ࡵࡓࠋᢸࡀࢇ࣐࢘ ࢫ⢏Ꮚ⥺࠾ࡼࡧ㝧Ꮚ⥺↷ᑕࡋࠊ⥺㔞⭘⒆ࢧࢬࠊ[18F]-FLT PET ࡛ࡢ⸆㞟✚㔞ࡢ┦㛵 ࢆ᳨ウࡋࡓࡇࢁࠊ↷ᑕ⥺㔞౫Ꮡⓗ [18F]-FLT ࡢ⣽⬊ྲྀ㎸ࡳࡀῶᑡࡍࡿࡇࢆ♧ࡋࡓࠋ ࡲࡓࠊ⬻⬨㧊⚄⤒እ⛉ࡢ᰿▼ඛ⏕ࡽࡢඹྠ◊✲ࡋ࡚ࠊ18F-fluoroacetate㸦[18F]FA㸧ࡼ ࡾࠊ⬻ᝈ࠾ࡅࡿ⬻ࡢࢫࢺࣟࢧࢺ௦ㅰάᛶኚࢆ࣓࣮ࢪࣥࢢࡍࡿヨࡳࢆ㛤ጞࡋࡓࠋ ⬻ฟ⾑ࡸỈ㢌ࣔࢹࣝࣛࢵࢺࡢసᡂࡢ᳨ウࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋ 㸺⸆ྜᡂ㛵ࡍࡿ◊✲㸼 ⮫ᗋ◊✲⏝⸆ࡋ࡚ࠊ࣮࣋ࢱ࣑ࣟࢻᩬ࣓࣮ࢪࣥࢢ⏝ࢺ࣮ࣞࢧ࣮࡛࠶ࡿ[11C]PIB 㸦[NíPHWK\Oí11&@í ¶íPHWK\ODPLQRSKHQ\O
(25) ííK\GUR[\EHQ]RWKLD]ROH㸧ࡘ࠸࡚ࠊJFE ♫〇ࣁ ࣈࣜࢵࢻ⮬ືྜᡂ⨨ࢆ⏝࠸ࡓ㝔ෆ〇㐀ἲࡢ᳨ウࡀ⾜ࢃࢀࡓࠋྜᡂ㛫 35-38 ศࠊ㔞 2.73 ± 0.37 GBqࠊẚᨺᑕ⬟ 39.3 ± 7.6 GBq/µmol ࡚[11C]PIB ࢆᚓࡿࡇᡂຌࡋࡓࠋᛴᛶẘᛶヨ 㦂㸦༢ᅇ㸧ࡢᐇᚋࠊ7 ᭶㝔ෆ⌮ጤဨ࡛[11C]PIB ࡼࡿ⮫ᗋ◊✲ࡀᢎㄆࡉࢀࠊ8 ᭶ ࡽ⮫ᗋ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋ JFE ♫〇ࣁࣈࣜࢵࢻ⨨ࢆࡗࡓ⮫ᗋ◊✲⏝⸆ࡢྜᡂ࡛ࡣࠊி㒔Ꮫࡢᑠ㔝ඛ⏕ࡽ ࡼࡗ࡚㛤Ⓨࡉࢀࡓ࣮࣋ࢱ࣑ࣟࢻᩬ࣓࣮ࢪࣥࢢ⏝ࢺ࣮ࣞࢧ࣮ࠊ[18F]FBOX-2 ࡘ࠸࡚ࡶ ᳨ウࡀ㐍ࡵࡽࢀ࡚࠾ࡾࠊྜᡂ㛫 80 ศࠊᨺᑕᏛⓗ⋡ 20㸣㸦EOS㸧ࠊᨺᑕᏛⓗ⣧ᗘ > 99% ࠊ๓ᖺᗘẚࠊྜᡂ㛫ࡣ 10 ศ▷⦰ࠊ⋡ 10%ྥୖࢆ㐩ᡂࡋ࡚࠸ࡿࠋ ᨺᑕᛶ⸆ࢆ⡆౽ྜᡂࡍࡿࡇࡀྍ⬟࡞᪂つ⮬ືྜᡂࢩࢫࢸ࣒ࡢ㛤Ⓨࡀ㐍ࡵࡽࢀ࡚࠸ ࡿࠋᖹᡂ 26 ᖺᗘ◊✲࡛ࡣࠊ࢚ࢫࢺࣟࢤࣥཷᐜయ࣓࣮ࢪࣥࢢࣉ࣮ࣟࣈ࡛࠶ࡿࠊ[18F]FES. －8－.
(26) Į-[18F]fluoro-ȕ-estradiol)࡞ࡽࡧࠊࣥࢻࣟࢤࣥཷᐜయ࣓࣮ࢪࣥࢢࣉ࣮ࣟࣈ࡛࠶ࡿ [18)@)'+7 ȕ-[18F]fluoro-Į-dihydrotestosterone)ࢆࡑࢀࡒࢀ⋡Ⰻࡃྜᡂྍ⬟࡛࠶ࡿࡇࢆ ᫂ࡽࡋࠊ㛤Ⓨ୰ࡢ⨨ࡢỗ⏝ᛶࡢ㧗ࡉࢆᐇドࡋࡓࠋ 㸺d-PAT ࢆ⏝࠸ࡓ⬻ᶵ⬟ゎᯒ㛵ࡍࡿ◊✲㸼 㑅ᢥⓗ COX-2 㜼ᐖ࡛࠶ࡿ㠀ࢫࢸࣟࢻᛶᢠ⅖⸆ࢽ࣓ࢫࣜࢻࡼࡿ⬻⤌⧊ࢢࣝࢥ࣮ࢫ ௦ㅰஹ㐍ࡢస⏝ᶵᗎࡘ࠸᳨࡚ウࢆ⾜ࡗࡓࠋᖹᡂ 26 ᖺᗘࡣࠊRu360ࠊCyclosporin A ࡼࡗ ࡚ࠊ࣑ࢺࢥࣥࢻࣜࡢ࢝ࣝࢩ࣒࢘࢜ࣥ㍺㏦⤒㊰ࢆ㜼ᐖࡋࠊࢽ࣓ࢫࣜࢻῧຍࡼࡿ[18F]FDG ྲྀࡾ㎸ࡳ㔞ኚࢆㄪࡓ⤖ᯝࠊ࣑ࢺࢥࣥࢻࣜࡽࡢ Ca2+ᨺฟࡣࢽ࣓ࢫࣜࢻࡼࡿࢢࣝࢥ ࣮ࢫ௦ㅰஹ㐍㛵ࡋ࡚࠸࡞࠸ྍ⬟ᛶࡀ♧ࡉࢀࡓࠋ. －9－.
(27) 㸦㸰㸧⮫ᗋ◊✲ ᖹᡂ 26 ᖺᗘࡣࠕศᏊ࣓࣮ࢪࣥࢢ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ(J-AMP)ࠖࡢ᭱⤊ᖺᗘ࡛࠶ࡾࠊ ◊✲ㄢ㢟࡛࠶ࡗࡓ 62Cu-ATSM ࢆ⏝࠸ࡓ⭘⒆ప㓟⣲࣓࣮ࢪࣥࢢ PET ࡢࠊ⚄⤒ኚᛶᝈ ࡃࣃ࣮࢟ࣥࢯࣥࡸ➽ⴎ⦰ᛶഃ⣴◳࠾ࡅࡿ⬻ෆ㓟ࢫࢺࣞࢫ PET ◊✲ࡀάⓎ ⾜ࢃࢀࡓࠋࡲࡓࠊ፬ே⛉⭘⒆ࡸங⒴࠾ࡅࡿ 18F-Fluoroestradiol (FES)࢚ࢫࢺࣟࢤࣥཷᐜయ PETࠊ ⫵⒴࠾ࡅࡿ DNA ྜᡂ㸦⣽⬊ቑṪ㸧ࡢᣦᶆ࡛࠶ࡿ 18F-fluorothymidine (FLT) PET ࡀᘬࡁ⥆ࡁ ⾜ࢃࢀࡓࠋ⭘⒆௨እ࡛ࡣࠊࡧࡲࢇᛶ⫵ᝈࡢ FDG dual-time point ࣓࣮ࢪࣥࢢ◊✲ࠊ⬻༞୰ ᚋ㑇ᝈ⪅࠾ࡅࡿ㧗࿘Ἴ࢟ࣕࣜἼࢆ⏝࠸ࡓ㟁Ẽ่⃭⒪ἲࡢຠᯝุᐃࡋ࡚ࡢ⬻⾑ὶ PET ◊✲ࠊ∦ഃᛶࡢෆ㢁ື⬦⊃✽ᝈ⪅࠾ࡅࡿ㠀㐀ᙳ ASL-MRI 15O-࢞ࢫࠊỈ PET ࡼࡿ ⬻⾑ὶ㔞ᐃ㔞ᛶࡢ᳨ウ࡞ࡀᘬࡁ⥆ࡁ⾜ࢃࢀࡓࠋᖹᡂ 26 ᖺᗘࡽጞࡲࡗࡓࡶࡢࡋ࡚ࠊ⢾ ᒀྜే៏ᛶᚰᝈ⪅࠾ࡅࡿࣥࢫࣜࣥᢠᛶᚰ➽ຠ⋡ࡢ◊✲㸦133H㸧ࡀ࠶ࡿࠋ 㸺⭘⒆࣭⅖࣭௦ㅰ PET㸼 ᝏᛶᝈࢆᑐ㇟ࡋࡓ⮫ᗋ◊✲࡛࠶ࡿࠕศᏊ࣓࣮ࢪࣥࢢ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛ (J-AMP)ࠖ(JST)࠾࠸࡚ࡣࠊᙜࢭࣥࢱ࣮ࡀ௦⾲タࢆດࡵࡿከタඹྠ◊✲ࠕ㞴ᛶࡀࢇ ⒪ྥࡅࡓᶵ⬟⏬ീἲࡢ㛤Ⓨ(FACT)ࠖࡀᖹᡂ 22 ᖺᗘ⛅ࡽ㛤ጞࡉࢀࠊ5 ᖺ㛫ࡢணᐃ࡛ᨺᑕ ⥺་Ꮫ⥲ྜ◊✲ᡤࡽࡢ 62Cu/62Zn ࢪ࢙ࢿ࣮ࣞࢱ࣮ࡀ౪⤥ࡉࢀࡓࠋᖹᡂ 24 ᖺᗘ୰㛫ホ౯ࡀ ࠶ࡾᖹᡂ 26 ᖺᗘࡀ᭱⤊ᖺᗘ࡛࠶ࡗࡓ㸦ᖹᡂ 27 ᖺ 3 ᭶⤊㸧 ࠋ㢌㢕㒊ࡀࢇࠊ⫵ࡀࢇࠊ⬻⭘⒆ࠊ Ἢᒀჾ⛉⭘⒆ࠊ፬ே⛉⭘⒆࡞ࡢࢹ࣮ࢱࡀ㞟✚ࡉࢀࠊ᭱ࡶᩘࡢከࡗࡓ㢌㢕㒊ࡀࢇ ࠾࠸࡚ 62Cu-ATSM 㞟✚⛬ᗘ㸦SUV ࠾ࡼࡧ⭘⒆➽⫗ẚ㸧㛗ᮇணᚋࡢ㛵㐃ࡀ⡿ᅜ⮫ᗋ᰾་ Ꮫㄅ㸦Clinical Nuclear Medicine㸧ᥖ㍕ࡉࢀࡓࠋ ፬ே⛉ 18F-FES PET ◊✲࡛ࡣࠊᖹᡂ 25 ᖺᗘ J Nucl Med ᥖ㍕ࡉࢀࡓᏊᐑ➽⭘⫗⭘࠾ ࡅࡿ⾡๓ PET ⾡ᚋ⌮චᰁⰍࡢᑐẚ◊✲ࡘ࠸࡚ࢆ㏣ຍࡋࡓࠋࡉࡽᏊᐑ➽⭘ ࣍ࣝࣔࣥ⒪ἲࡢ FES PET ࡼࡿ⒪๓ຠᯝண 㛵ࡍࡿ◊✲ࡶྠᵝࢆቑࡸࡋࡓࠋங ⭢እ⛉ࡢඹྠ◊✲࡛ࡣ FES PET ࡼࡿ㌿⛣ᛶஙࡀࢇࡢ࣍ࣝࣔࣥ⒪ἲឤཷᛶண 㛵ࡋ࡚ࠊ ཎⓎ⭘⒆ࡢࣉࣟࢤࢫࢸࣟࣥཷᐜయⓎ⌧ࡸ mTOR άᛶࡢᣦᶆ࡞ࡿ pS6 kinase ࡢⓎ⌧ FES 㞟✚࠾ࡼࡧ⒪ຠᯝࡢ㛵㐃ࡸࠊ㦵◳ࡀᙉࡃ FES 㞟✚ࡀప࠸ࡶࡢࡢ࣍ࣝࣔࣥ⒪ຠᯝࡀ ࡳࡽࢀࡿ㦵㌿⛣࠾ࡅࡿ⿵ṇ FES SUV ್ࡢᑟධ࡞᳨ウࡀ㐍ࢇ࡛࠸ࡿࠋ 18. F-FLT PET ࡼࡿ⣽⬊ቑṪ⬟ホ౯ࡢ⮫ᗋᛂ⏝࡛ࡣࠊ⫵⒴࠾࠸࡚ FLT ࡢ㞟✚య✚ࢆຍ. ࡋࡓᣦᶆࡼࡿ᪩ᮇ⒪ຠᯝุᐃࡢ᭷⏝ᛶࡀ♧ࡉࢀࡓࠋἪᒀჾ⛉㡿ᇦ࠾࠸࡚ࡶᑡᩘ ࡞ࡀࡽࠊ⭈⒴๓❧⭢⒴࠾࠸࡚ศᏊᶆⓗ⸆ࡸᏛ⒪ἲᚋ᪩ᮇࡢⅬ࠾࠸࡚ࡢ FLT PET ࡼࡿຠᯝண ⬟ࡀ♧ࡉࢀࡓࠋ ࡧࡲࢇᛶ⫵ᝈࡢ FDG dual-time point ࣓࣮ࢪࣥࢢ PET ◊✲࡛ࡣࠊ41 ࡢ㏻ᖖᆺ㛫㉁ᛶ ⫵⅖࠾࠸࡚ SUV ࡢ Retention index (RI-SUV) ࡀ⊂❧ࡋࡓணᚋᅉᏊ࡞ࡾ࠺ࡿࡇࡀ♧ ࡉࢀࡓࠋ. －10－.
(28) 㸺ᚰ⮚ PET> ᚰ⮚ PET ◊✲࡛ࡣࠊࡇࢀࡲ࡛ࡢᛴᛶᮇᚰ➽᱾ሰ࠾ࡅࡿ FDG /. 11. C-㓑㓟 PET ࡢᑐẚ◊✲. ௦࠼࡚ࠊᖹᡂ 26 ᖺᗘࡽ᪂ࡓࠗ⢾ᒀྜే៏ᛶᚰᝈ⪅࠾ࡅࡿࣥࢫࣜࣥᢠᛶ ᚰ➽ຠ⋡ࡢ㛵㐃ࡘ࠸࡚ࡢ᳨ウ࠘ࡀ㛤ጞࡉࢀࡓࠋࣥࢫࣜࣥᢠᛶࡣᚰᝈ⪅ ࠾࠸࡚⊂❧ࡋࡓணᚋⰋᅉᏊࡢ୍ࡘ࡛࠶ࡿሗ࿌ࡉࢀ࡚࠾ࡾࠊࣥࢫࣜࣥᢠᛶࡀ㧗࠸ ᝈ⪅࡛ࡣࠊࣈࢻ࢘⢾⏝ࡢపୗࡸ㓟ࢫࢺࣞࢫࡸ⅖ᛂࡢⓎ⏕ࡼࡾᚰ➽ࡢ௦ㅰຠ ⋡ࡀపୗࡋ࡚࠸ࡿࡇࡀᐃࡉࢀࡿࠋࡲࡔᑡᩘ࡛ࡢ᳨ウ࡛࠶ࡿࡀ. 11. C-㓑㓟 PET ࡚៏ᛶ. ᚰᝈ⪅ࡢᚰ➽㓟⣲௦ㅰ㸦kmono㸧ࡸ Work Metabolic Index ࢆ ᐃࡋࡓ⤖ᯝࠊࣥࢫࣜࣥ ᢠᛶࡣᚰ➽ࡢ௦ㅰຠ⋡ࢆపୗࡉࡏࡿྍ⬟ᛶࡀ♧ࡉࢀ࡚࠸ࡿࠋ ࡲࡓࠊ11C-㓑㓟 PET ࡼࡿ⾑ὶ࣭㓟⣲௦ㅰ࣭ᕥᐊᶵ⬟ྠィ ࡢ᳨ウࡀࠊ㛗ᓮᕤ⸨ᩍᤵ ࡢඹྠ◊✲࡛⥅⥆ࡉࢀ࡚࠸ࡿࠋ 㸺⬻࣭⚄⤒ PET㸼 ⬻ᚠ⎔௦ㅰືែࡢホ౯◊✲ࢆ┠ⓗࡋࡓ PET ࡣࠊ⮫ᗋែホ౯ࡶවࡡ࡚ࠊ៏ᛶ⬻⾑⟶㞀 ᐖᝈ⪅ᑐࡍࡿ⬻ PET ࡀ∦ഃᛶࡢෆ㢁ື⬦⊃✽ࢆ୰ᚰᖹᡂ 26 ᖺᗘࡶ⥅⥆ࡉࢀࡓࠋ 3T-MRI ࡚฿㐩㛫㸸Transit time㸦TT㸧࣐ࢵࣉࢆసᡂࡋࠊᒁᡤࡢ⬻⾑ὶࢆ TT ࡛⿵ṇࡍࡿ ࣉࣟࢢ࣒ࣛ㸦enhanced ASL㸸eASL㸧࡚ᚓࡽࢀࡓ⬻⾑ὶ㔞ࢆ PET ࡢᐃ㔞್ẚ㍑ࡋࡓࠋ13 260 ಶࡢ ROI ゎᯒ࡛ࡣ୧⾑ὶ㔞㛫᭷ព࡞┦㛵ࢆㄆࡵࡓࡶࡢࡢࠊಶࠎ࡛ࡣ eASL ࡢࡤ ࡽࡘࡁࡀࡁ࠸⤖ᯝ࡛࠶ࡗࡓࠋ ➨ෆ⛉(⚄⤒ෆ⛉)ࡢඹྠ◊✲࡛ࡣࠊ62Cu-ATSM PET ࢆ⏝࠸ࡓ⬻ෆࡢ㓟ࢫࢺࣞࢫࡢ ࣓࣮ࢪࣥࢢࢆ㑇ఏᛶࣃ࣮࢟ࣥࢯࣥ㸦ཎᅉ㑇ఏᏊ Parkin㸧ᝈ⪅࡛⾜ࡗࡓࠊ๓ᖺᗘࡶ⾜ ࡗ࡚࠸ࡓ➽ⴎ⦰ᛶഃ⣴◳(ALS)࠾ࡅࡿ⬻ෆ㓟ࢫࢺࣞࢫホ౯࡛ࡣṇᖖ⪅ࡢ SPM ゎ ᯒࡼࡿẚ㍑࡛㐠ື㔝ࢆ୰ᚰࡍࡿ㡿ᇦࡢ㐣㑏ඖ≧ែࢆࡣࡌࡵ࡚⏕య᳨࡛ฟ࡛ࡁࠊ⡿ᅜ⚄ ⤒Ꮫㄅ㸦Neurology㸧ࢡࢭࣉࢺࡉࢀࡿࡶࣉࣞࢫ࣮ࣜࣜࢫࢆ⾜ࡗࡓࠋࡉࡽᑐ㇟ ࢆከ⣔⤫ጤ⦰(MSA)ࡶᗈࡆࠊኚᛶ㒊࡛࠶ࡿᑠ⬻ࡸ⿕Ẇࡢ㐣㑏ඖ≧ែࡘ࠸࡚ࡶホ౯ࡍ ࡿணᐃ࡛࠶ࡿࠋ ⬻⓶㉁ᇶᗏ᰾ኚᛶ㸦CBD㸧࠾ࡅࡿ⒪⸆(CDP-choline)ࡢຠᯝࢆ FDG PET ࡛ホ౯ࡍ ࡿ◊✲࡛ࡣࠊ13 ୰ 12 ୍࡛㒊≧ࡢᨵၿ࡞ࡀぢࡽࢀࠊFDG PET ࡛ࡣ⒪ᚋ㔜ഃ ࡢ୰ᚰ๓ᅇࠊどᗋࠊᑿ≧᰾ࠊ⿕Ẇࠊ㢌㡬ⴥ࡛⢾௦ㅰࡢ᭷ព࡞పୗࢆㄆࡵࡓࠋࡲࡓᑠ⬻࠾ ࠸࡚ࡣ Crossed cerebellar diaschisis ᛮࢃࢀࡿᡤぢࢆㄆࡵࡓࠋ ࡲࡓࠊ⬻༞୰ᚋ㑇ᑐࡍࡿ㧗࿘Ἴᩘᖏᒙ࢟ࣟ࣊ࣝࢶὶἼࢆ⏝࠸ࡓᶵ⬟ⓗ㟁Ẽ่ ⃭⒪ἲ㸦functional electrical stimulation : FES㸧ࡼࡿ⬻⚄⤒ᶵ⬟ᅇࡢᶵᗎࢆゎ᫂ࡍࡿࡓࡵࠊ ࣜࣁࣅࣜ๓ࠊ1 ᭶㛫ࡢ㏻ᖖࣜࣁࣅࣜᚋࠊ1 ᭶㛫ࡢ FES ే⏝ࣜࣁࣅࣜᚋࡢィ 3 ᅇ O-15 Ỉ PET ᳨ᰝࢆ⾜ࡗࡓࠋPET ᙳࡢ⬻㈿άࢱࢫࢡࡣᑓ⏝ࡢࣞࢵࢢࣉࣞࢫ⨨ࢆ⏝࠸ࡓ⭸ᒅ᭤ ఙᒎ㐠ື࡛࠶ࡾࠊ⬻㈿ά⠊ᅖ୍ᐃࡢኚࡀ࠶ࡿࡇࡀ♧ࡉࢀࡓࠋ㸦⌧ᅾㄽᩥ‽ഛ୰㸧. －11－.
(29) 㸦㸱㸧MRI ◊✲ ᪂ࡋ࠸ศᏊࣉ࣮ࣟࣈࡼࡿ PET(࣏ࢪࢺ᩿ࣟࣥᒙἲ)ࡸ MRI(☢Ẽඹ㬆⏬ീἲ)㸪 CT(ࢥࣥࣆ ࣮ࣗࢱ᩿ᒙᙳ)࡛ࡢ⬻ෆ≀㉁ືែࡢゎᯒࠊែゎ᫂ࠊデ᩿ἲࡢ㛤Ⓨ࡞ࢆ⾜࠺ࠋ ⌧ᅾࡣࠊ fMRI(ᶵ⬟ⓗ MRI)ࢆ⏝࠸ࡓ◊✲ࢆ⾜ࡗ࡚࠾ࡾࠊ⬻ࡑࢀࡘ࡞ࡀࡿ㐠ື࣭ ឤぬ࣭ឤ࣭ㄆ▱➼ࡢ⏕య㧗ḟᶵ⬟ࡢാࡁࡸ⤌ࡳࢆ᥈ࡗ࡚࠸ࡿࠋ㧗࢚ࢿࣝࢠ࣮་Ꮫ◊✲ ࢭࣥࢱ࣮タ⨨ࡉࢀ࡚࠸ࡿ PET ࡸ MRIࠊࡉࡽ NIRS(㏆㉥እ⥺ศගἲ)࡞ࡢ་⏝⏬ീᶵჾ ࢆ⏝ࡍࡿࡇ࡛ࠊࡇࢀࡲ࡛ศࡽ࡞ࡗࡓ⬻ࡢാࡁࡸⓎ㐩㐣⛬ࢆゎ᫂ࡍࡿ◊✲ࢆ⾜࠺ࠋ ⚟Ꮫෆእඹྠ◊✲ࡶ⾜ࡗ࡚࠾ࡾࠊ1) ⢭⚄⛉࣭⚄⤒ෆ⛉⣔ᝈࢆᑐ㇟ࡋࡓ⮫ᗋ◊ ✲(⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ࣭ᛂᛶឡ╔㞀ᐖ࣭ࣃ࣮࢟ࣥࢯࣥ࡞ࡢែゎ᫂)ࠊ2) ⬻ᶵ ⬟ࡢⓎ㐩◊✲(⬻άື࣭⬻ᐜ✚࣭⬻⚄⤒㉮⾜ࡢⓎ㐩ⓗኚࡢゎ᫂)ࡀ࡞◊✲ࡢᰕ࡛࠶ࡿࠋࡇ ࢀࡽࡢࠊ⬻ᶵ⬟⏬ീࡼࡿ⬻άືゎᯒࡸࠊ⚄⤒㉮⾜ゎᯒࡸ⬻ᐜ✚ࡢゎᯒࢆ⾜࠺ࡇ࡛ࠊ⢭ ⚄⚄⤒ᝈ࠾ࡅࡿែゎᯒࢆ⾜࠸ࠊ᪩ᮇࡢ␗ᖖⓎぢࡀྍ⬟࡞ࡿ⏬ീデ᩿ἲࡢ㛤Ⓨࢆ⾜ ࠺ࡇࡸࠊṇᖖ⬻ࡢ⤒㦂ࡼࡿኚࡸⓎ㐩㛵ࡍࡿ◊✲⤖ᯝࢆࠊᚅ㜵ṆࡸᏛ❺ᩍ⫱࡞ ୍⯡♫㑏ඖࡍࡿࡇࢆ┠ᣦࡋ࡚࠸ࡿࠋ ᖺᗘࡢ⬻⚄⤒ែゎᯒᏛ㒊㛛࡛ࡣࠊ๓ᖺᗘᘬࡁ⥆ࡁࠊ♫ⓗᗣ࡞⏕άࢆ㏦ࡿࡓ ࡵࡢᅵྎ(ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡞)ࢆ᥈ࡿ◊✲ຍ࠼ࠊ⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ࣭ᛂᛶឡ ╔㞀ᐖ࣭ࣃ࣮࢟ࣥࢯࣥ࡞ࡢែゎ᫂࠸ࡗࡓ⮫ᗋᛂ⏝ࡀ┠ᣦࡏࡿ◊✲ࡀከࡃぢࡽࢀࠊ ♫ࡸ⮫ᗋᑐࡋ࡚⬻⛉Ꮫࡀ㈉⊩࡛ࡁࡿࡇࢆ♧ࡋࡓ᭷ព⩏࡞◊✲⤖ᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ ࡲࡓ๓ᖺࡲ࡛ࡣ࠶ࡲࡾぢࡽࢀ࡞ࡗࡓࠊᖖᡂேࡢᚰ⌮ᶵ⬟ࢆㄪࡿࡼ࠺࡞◊✲ࡶ᪂ࡓ ຍࢃࡾࠊ◊✲ࢸ࣮࣐ཌࡳࡀຍ࠼ࡽࢀࠊࡇࡢ◊✲ศ㔝ࡢ┒ࡾୖࡀࡾࡀぢࡽࢀࡿࠋ ୗグࡑࡢ࡞ᡂᯝᴫせࢆิᣲࡍࡿࠋ 㸺⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ⪅࠾ࡅࡿᏳ㟼ࡢ⬻άື㸼 Ᏻ 㟼 䛾 fMRI(rs-fMRI) 䜢 ⏝ 䛔 䛶 䚸 ⮬ 㛢 䝇 䝨 䜽 䝖 䝷 䝮 㞀 ᐖ (ASD) ⩌ 䛾 Default Mode Network(DMN)䛾ᶵ⬟⤖ྜ䜢ᐃᆺⓎ㐩(TD)⩌䛸ẚ㍑᳨ウ䛧䛯䚹䛭䛾⤖ᯝ䚸DMN 㡿ᇦ(๓㢌๓㔝䚸 ᖏ≧ᅇ)䛾ᶵ⬟ⓗ㐃⤖䛾ᙉ䛥䛻㐪䛔䛜ぢ䜙䜜䚸䛣䛾ゎᯒ᪉ἲ䛜⮬㛢䝇䝨䜽䝖䝷䝮䛾 social biomarker 䛻䛺䜛ྍ⬟ᛶ䛜♧၀䛥䜜䜛⤖ᯝ䛜ᚓ䜙䜜䛯䚹 㸺⮬㛢ࢫ࣌ࢡࢺ࣒ࣛ㞀ᐖ⪅࠾ࡅࡿ♫ⓗࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ㸼 $6' ࡢᝈඣࡣࠊ♫ⓗࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࡢ୍ࡘ࡛࠶ࡿᶍೌ㛵ࡋ࡚ࠊᖖඣ␗࡞ࡿ ᛂࢆ♧ࡍࡇࡀ▱ࡽࢀ࡚࠸ࡿࠋࡑࡇ࡛ࠊࡇࡢ㐪࠸ࢆᘬࡁ㉳ࡇࡍ⬻㡿ᇦࡘ࠸࡚ࠊfMRI ࢆ⏝ ࠸᳨࡚ウࡋࡓࠋࡑࡢ⤖ᯝࠊ㌟య㒊ࡢどぬ࿊♧ᑐࡋ࡚≉␗ⓗᛂ⟅ࢆ♧ࡍ EBA(extrastriate body area)࠾࠸࡚㐪࠸ࡀぢࡽࢀࠊࡑࡢάືࡣࠊ⮬㛢ഴྥࡢᙉࡉࡶ┦㛵ࡍࡿ⤖ᯝࡀᚓࡽ ࢀࡓࠋࡇࢀࡽࡼࡾࠊASD ⪅ᖖ⪅ࡢ⬻ᶵ⬟ࡢ㐪࠸ࡀ᫂ࡽ࡞ࡿඹࠊEBA ࡀࢥ࣑ ࣗࢽࢣ࣮ࢩࣙࣥ㛵ࢃࡗ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡿ⤖ᯝࡀᚓࡽࢀࡓࠋ. －12－.
(30) 㸺⚄⤒ኚᛶᝈࡢ⚄⤒ᇶ┙ࡑࡢ⒪ຠᯝ㸼 ⚄⤒ኚᛶᝈ ࣃ࣮࢟ࣥࢯࣥ
(31) ࡢࠊ㐠ື㞀ᐖ㛵ࡋ࡚࠸ࡿ⚄⤒ᇶ┙ࠊᢠࣃ࣮࢟ࣥࢯ ࣥ⸆ࡼࡿᙳ㡪ࢆᶵ⬟ⓗ MRI ࡚᫂ࡽࡍࡿࡇࢆ┠ⓗࡋࡓ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ⌧ᅾࡣࠊ ࡲࡔゎᯒ࣭⤖ᯝࡢ᳨ウ୰࡛࠶ࡿࠋ. 㸺ᛂᛶឡ╔㞀ᐖࡢ⚄⤒ᇶ┙㸼 ᛂᛶឡ╔㞀ᐖ(RAD)ࡣࠊᏊࡶࡢ㐺ษ࡞㣴⫱(ᚅ࣭ࢿࢢࣞࢡࢺ)ࡼࡿぶᏊ㛫ࡢឡ ╔ᙧᡂࡢṍࡳࡽᘬࡁ㉳ࡇࡉࢀࠊᏛ⩦ࡸᑐே㛵ಀࠊ♫άືᨭ㞀ࢆࡁࡓࡍࡇࡀၥ㢟 ࡞ࡗ࡚࠸ࡿࠋࡑࡋ࡚ࠊࡇࡢ㞀ᐖ㛵ࡍࡿ⚄⤒࣓࢝ࢽࢬ࣒ࢆ⌮ゎࡍࡿࡇ࡛ண㜵ἲ࣭⒪ ἲࡢ㛤Ⓨࢆ┠ᣦࡋ࡚࠸ࡿࠋࡲࡓࠊRAD ⩌ᐃᆺⓎ㐩⩌ࡢ⬻άືࢆ fMRI ࡛ẚ㍑ࡍࡿࡇ ࡼࡾࠊ㔠㖹ሗ㓘ᑐࡍࡿ⥺᮲యࡢάື㐪࠸ࡀぢࡽࢀࡓࠋࡇࢀࡼࡾࠊࡼࡃఝࡓ≧࡛࠶ ࡿ ADHD 㚷ูࡍࡿ࣐࣮࣮࢝࡞ࡿ⬻άືࠊ୪ࡧ⒪ຠᯝࢆุᐃ࡛ࡁࡿᛮࢃࢀࡿ⬻ά ືࢆほᐹࡍࡿࡇࡀฟ᮶ࡓࠋ 㸺⬻ᶵ⬟࣭⬻ᐜ✚ࡢⓎ㐩ࡼࡿኚ㸼 Ⓨ㐩క࠸⋓ᚓࡍࡿ⬟ຊ(ὀព࣭グ᠈࣭♫ᛶ࡞)ࡘ࠸࡚ࡢ◊✲ࢆ⾜࠸ࠊࡑࡢ▱ぢࢆ་ ⒪ࡸᩍ⫱ࡢᛂ⏝ࢆࡵࡊࡋ࡚࠸ࡿࠋὀព⬟ຊࢆ Attention Network Test ࢆ⏝࠸࡚ fMRI ࡚ ᐃࡋ᳨ウࢆ⾜ࡗࡓࠋࡲࡓࡑࡢ㝿ࡢࠊᖺ㱋ඹኚࡍࡿ⬻άືࡸ⎔ቃ࣭⤒㦂ඹኚࡍ ࡿ⬻άືࡘ࠸࡚ࡶ᳨ウࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊᵝࠎ࡞᪥ᖖ⾜ືࡀ⬻ࡢάືᙳ㡪ࢆ࠼࡚ ࠸ࡿࡇࡀ᫂ࡽ࡞ࡾࠊࡑࢀࡽࡢಶேᕪࢆ⪃៖ࡋࡓ㣴⫱᪉ἲࡢ㛤Ⓨࡸࠊ᪥ᖖ⾜ືࡢᨵၿ ࡞ࡢຠᯝⓗ࡞ධ᪉ἲ㛤Ⓨࡢྍ⬟ᛶࡀ♧၀ࡉࢀࡿ⤖ᯝࡀᚓࡽࢀࡓࠋ 㸺ᚰ⌮᳨ᰝࡣࠊࡢࡼ࠺࡞⬻ᶵ⬟ࢆ ࡗ࡚࠸ࡿࡢ㸽㸼 ᚰࡢၥ㢟ᝎࡴᝈ⪅ᑐࡋ࡚ࠊලయⓗ࡞デ᩿⒪᪉㔪ࢆỴᐃࡍࡿୖ࡛ࡢཧ⪃ሗࢆᚓ ࡿࡇࡢฟ᮶ࡿࢶ࣮ࣝࡋ࡚ࠊᢞᙳἲࡤࢀࡿᚰ⌮᳨ᰝࡀ࠶ࡿࠋࡋࡋࠊࡇ࠺ࡋࡓᚰ⌮ ᳨ᰝࡀࡢࡼ࠺࡞⬻ᶵ⬟ࢆᫎࡋ࡚࠸ࡿࡢࠊ࡛᫂࠶ࡗࡓࠋࡑࡇ࡛ࠊfMRI ࢆ⏝࠸࡚ᢞᙳ ἲ᳨ᰝ㛵ࡍࡿ⬻ᶵ⬟ࡘ࠸᳨࡚ウࡋࡓ⤖ᯝࠊࣃ࣮ࢯࢼࣜࢸࡀ㛵ࡋ࡚࠸ࡿࡉࢀࡿ ๓㢌๓㔝άືࡀぢࡽࢀࠊᢞᙳἲ᳨ᰝࡢጇᙜᛶࡀ♧ࡉࢀࡿࡼ࠺࡞⤖ᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ. －13－.
(32) 㻞㻚㻌 ◊✲ᴗ⦼㻌 㻞㻚㻌 ◊✲ᴗ⦼㻌. 㸦㸯㸧ⴭ᭩ ྡ ඹⴭ㸸᪥ᮏ᰾་Ꮫᢏ⾡Ꮫ⦅㸪ࠕ᰾་Ꮫᢏ⾡⥲ㄽࠖ㸦➨㸱∧ᨵゞ∧㸧 ඹⴭ㸸᪥ᮏ᰾་Ꮫᢏ⾡Ꮫ⦅㸪ࠕ᰾་Ꮫᢏ⾡⥲ㄽࠖ㸦➨㸱∧ᨵゞ∧㸧 ᕝ ᜨ୍㸪 ྡ. ➨ 㒊⌮ᕤᏛ➼㛵ࡍࡿᇶ♏▱㆑➨ ❶ᨺᑕ⥺⏕≀ᏛSS 㡫ᒣ௦༳ๅ ி㒔 ᕝ ṇ㐨㸪⡿⏣ ㄔ㸸0(55) ௦ㅰᛶ࣑࢜ࣃࢳ࣮⥲⦅㞟 ᮡỤ⚽ኵศᢸ⦅㞟 ⚟⏣ ᏘᏊ㸪す㔝୍୕㸪ྂ㈡㟹ᩄデ᩿⒪♫ᮾிSS ⡿⏣ ㄔ㸪ᕝ ṇ㐨㸪ᒸἑ ⚽ᙪ㸸ࣃ࣮࢟ࣥࢯࣥ࠾ࡼࡧ㛵㐃⚄⤒ኚᛶᝈࡢ 3(7 㓟ࢫ 㓟ࢫ ࢺࣞࢫ࣓࣮ࢪࣥࢢࠕ⬻ෆ⎔ቃᜏᖖᛶ⥔ᣢᶵᵓࡢ◚⥢Ẽࠖ⦅㞟 㧗ᶫⰋ㍜㸪㇂ ┿㸪ᒣ୰ᏹ㸪ᵽཱྀ┿ே022. 㑇ఏ་Ꮫ࣓ࢹ࢝ࣝࢻ࣮♫ᆏSS ᕝ ᜨ୍㸸 ࠕᨺᑕ⥺㛵ಀἲつᴫㄝ Ѹ་⒪ศ㔝ࡶྵࡵ࡚Ѹࠖ 㸦➨㸴∧㸧⦅ 㸦➨㸴∧㸧⦅SS SS 㡫㏻ၟ⏘ᴗ◊✲♫ᮾி $UDNDZD.,NDZD07DGD+2ND]DZD+<RQHGD0㸸0LWRFKRQGULDOFDUGLRP\RSDWK\DQGXVDJH RI/DUJLQLQH$UJLQLQHLQ&OLQLFDO1XWULWLRQ(G9LFWRU53UHHG\6SULQJHU1< 86$ LQSUHVV
(33) ⡿⏣ㄔ㸸࣑ࢺࢥࣥࢻࣜ⬻➽༡ᒣᇽ་Ꮫ㎡ 㸦➨ ∧㸧༡ᒣᇽᮾிSS 㸦㸰㸧ㄽᩥ .RED\DVKL01DNDQLVKL71LVKL.+LJDNL<2NXGDLUD+2QR07VXMLXFKL70L]XWDQL $1LVKLL57DPDL,$UDQR<DQG.DZDL.㸸7UDQVSRUW0HFKDQLVPVRI+HSDWLF8SWDNH DQG%LOH([FUHWLRQLQ&OLQLFDO+HSDWRELOLDU\6FLQWLJUDSK\ZLWK P. 7F1S\ULGR[\OPHWK\OWU\SWRSKDQ1XFO0HG%LRO
(34) P7F1S\ULGR[\OPHWK\OWU\SWRSKDQ1XFO0HG%LRO
(35) . 2ND62NXGDLUD+2QR06FKXVWHU'0*RRGPDQ00.DZDL.DQG6KLUDNDPL<㸸 'LIIHUHQFHVLQ7UDQVSRUW0HFKDQLVPVRI )@IOXRURF\FOREXWDQHFDUER[\OLF$FLGLQ,QIODPPDWRU\3URVWDWH 7UDQVDPLQR> )@IOXRURF\FOREXWDQHFDUER[\OLF$FLGLQ,QIODPPDWRU\3URVWDWH &@PHWKLRQLQHDQG &DQFHUDQG*OLRPD&HOOV &RPSDULVRQZLWK/>0HWK\O &DQFHUDQG*OLRPD&HOOV &RPSDULVRQZLWK/>0HWK\O&@PHWKLRQLQHDQG. )@IOXRUR'JOXFRVH0RO,PDJLQJ%LRO
(36) 'HR[\> )@IOXRUR'JOXFRVH0RO,PDJLQJ%LRO
(37) . 0DWVXQDUL,0L\D]DNL<.RED\DVKL01LVKL.0L]XWDQL$.DZDL.+D\DVKL$.RPDWVX 5<RQH]DZD6DQG.LQX\D6㸸3HUIRUPDQFH(YDOXDWLRQRIWKHH;SORUHVSH&=73UHFOLQLFDO ,PDJLQJ6\VWHP$QQ1XFO0HG
(38) 0L\D]DNL<.RED\DVKL0.RPDWVX5+D\DVKL$<RQH]DZD6.DZDL.0DWVXGDLUD0 6KLR]DNL-DQG0DWVXQDUL,㸸(IIHFWRI6XUURXQGLQJ0DWHULDOVRQ,WHUDWLYH 5HFRQVWUXFWLRQ%DVHG/LQH6RXUFH5HVSRQVH)XQFWLRQDQG$QQLKLODWLRQVRXWVLGHWKH 6RXUFH$VVHVVHGE\D6PDOO$QLPDO3(76FDQQHU$QQ1XFO0HG
(39) . －14－.
(40) .RED\DVKL0:DNDED\DVKL+.D\DQR'.RQLVKL7.RMLPD+<RQH\DPD+2NXGD.7VXVKLPD +2QRJXFKL0.DZDL.DQG.LQX\D6㸸$SSOLFDWLRQRID0HGLXPHQHUJ\&ROOLPDWRUIRU ,,PDJLQJDIWHU$EODWLRQ7UHDWPHQWRI'LIIHUHQWLDWHG7K\URLG&DQFHU$QQ1XFO 0HG
(41) 7DNHGD5,VKLGD<(ELKDUD.$EH+0DWVXR+,NHGD7.RJDQHPDUX*.XUDPDVKL$ )XQDKDVKL+0DJDWD<.DZDL.DQG1LVKLPRUL7㸸,QWUDVWULDWDO*UDIWVRI)HWDO9HQWUDO 0HVHQFHSKDORQ,PSURYH$OORG\QLDOLNH:LWKGUDZDO5HVSRQVHWR0HFKDQLFDO6WLPXODWLRQ LQD5DW0RGHORI3DUNLQVRQ V'LVHDVH1HXURVFL/HWW &
(42) 2NXGDLUD+2ND62QR01DNDQLVKL76FKXVWHU'0.RED\DVKL0*RRGPDQ007DPDL ,.DZDL.DQG6KLUDNDPL<㸸$FFXPXODWLRQRI WUDQV$PLQR)IOXRURF\FOREXWDQHFDUER[\OLF$FLGLQ3URVWDWH&DQFHUGXHWR $QGURJHQLQGXFHG([SUHVVLRQRI$PLQRDFLG7UDQVSRUWHUV0RO,PDJLQJ%LRO
(43) $QPH77DQDND(7RNXWDNH.:DWDQDEH77RPLVDNL(0RFKL]XNL<:X%6KLQRKDUD 56XJLVDZD<2ND]DNL6DQG6DGDWR1 $VVHVVLQJ*HQGHU'LIIHUHQFHVLQ6RFLDELOOLW\ 7RZDUGV6WUDQJHUV2YHU7LPH8VLQJWKH,QWHUDFWLRQ5DWLQJ6FDOH$GYDQFHG ,56$
(44) ,QWHUQDWLRQDO-RXUQDORI$SSOLHG3V\FKRORJ\
(45) 0RULWD77DQDEH+&6DVDNL$76KLPDGD..DNLJL56DGDWR1 7KHDQWHULRULQVXODU DQGDQWHULRUFLQJXODWHFRUWLFHVLQHPRWLRQDOSURFHVVLQJIRUVHOIIDFHUHFRJQLWLRQ 6RF&RJQ$IIHFW1HXURVFL
(46) 3DVFXDO0DUTXL5'%LVFD\5-%RVFK%D\DUG-/HKPDQQ'.RFKL..LQRVKLWD7<DPDGD 1DQG6DGDWR1 $VVHVVLQJGLUHFWSDWKVRILQWUDFRUWLFDOFDXVDOLQIRUPDWLRQIORZRI RVFLOODWRU\DFWLYLW\ZLWKWKHLVRODWHGHIIHFWLYHFRKHUHQFH L&RK
(47) )URQW+XP 1HXURVFL .LWDGD5<RVKLKDUD.6DVDNL$+DVKLJXFKL0.RFKL\DPD7DQG6DGDWR1 7KH%UDLQ 1HWZRUN8QGHUO\LQJWKH5HFRJQLWLRQRI+DQG*HVWXUHVLQWKH%OLQG 7KH6XSUDPRGDO5ROH RIWKH([WUDVWULDWH%RG\$UHD7KH-RXUQDORI1HXURVFLHQFH
(48) 1DNDMLPD.0LQDPL77DQDEH+&6DGDWR11DNDXFKL6 )DFLDOFRORUSURFHVVLQJLQ WKHIDFHVHOHFWLYHUHJLRQV $QI05,VWXG\+XP%UDLQ0DSS
(49) .LWDGD56DVDNL$72NDPRWR<.RFKL\DPD76DGDWR1 5ROHRIWKHSUHFXQHXVLQWKH GHWHFWLRQRILQFRQJUXHQF\EHWZHHQWDFWLOHDQGYLVXDOWH[WXUHLQIRUPDWLRQ $IXQFWLRQDO 05,VWXG\1HXURSV\FKRORJLD ,LGDND7+DUDGD76DGDWR1 )DOVHPHPRU\IRUIDFHLQVKRUWWHUPPHPRU\DQGQHXUDO DFWLYLW\LQKXPDQDP\JGDOD%UDLQ5HV . －15－.
(50) 6DNDL+8FKL\DPD<7DQDND66XJDZDUD6.6DGDWR1 3UHIURQWDOWUDQVFUDQLDOGLUHFW GXUUHQWVWLPXODWLRQLPSURYHVIXQGDPHQWDOYHKLFOHFRQWURODELOLWLHV%HKDULRXUDO%UDLQ 5HVHDUFK 0XHOOHU-/5XHVFKHPH\HU6$2QR.6XJLXUD06DGDWR11DNDPXUD$ 1HXUDOQHWZRUNV LQYROYHGLQOHDUQLQJOH[LFDOVHPDQWLFDQGV\QWDFWLFLQIRUPDWLRQLQDVHFRQGODQJXDJH )URQW3V\FKRO 6XJDZDUD6.7DQDND67DQDND'6HNL$8FKL\DPD+72ND]DNL6.RHGD7DQG6DGDWR 1 6OHHSLVDVVRFLDWHGZLWKRIIOLQHLPSURYHPHQWRIPRWRUVHTXHQFHVNLOOLQFKLOGUHQ 3/R621(
(51) H 6DVDL6+RPDH):DWDQDEH+6DVDNL$77DQDEH+&6DGDWR17DJD* )UHTXHQF\VSHFLILF QHWZRUNWRSRORJLHVLQWKHUHVWLQJKXPDQEUDLQ)URQW+XP1HXURVFL $RNL1DNDQR0)XUXVDZD<8]DZD$0DWVXPRWR<+LUD\DPD57VXUXRND&2JLQR71LVKLR 7.DJDZD.0XUDNDPL0.DJL\D*.XPH.+DWDVKLWD0)XNXGD6<DPDPRWR.)XML +0XUD\DPD6+DWD06DNDH70DWVXPRWR+㸸5HODWLYHELRORJLFDOHIIHFWLYHQHVVRI WKHUDSHXWLFSURWRQEHDPVIRU+6*FHOOVDW-DSDQHVHSURWRQWKHUDS\IDFLOLWLHV- 5DGLDW5HV 7DNDPDWVX6<DPDPRWR..RQGRX7.DZDPXUD0$VDKL67DPHVKLJH<0DHGD<6DVDNL 07DPDPXUD+7VXML$.DL]DNL<.XPDQR77DNDQDND7 %DVDORLGVTXDPRXVFHOO FDUFLQRPDLQQDVDOFDYLW\WUHDWHGZLWKSURWRQEHDPWKHUDS\FRQFXUUHQWZLWKFLVSODWLQ DFDVHUHSRUW-0HG&DVH5HSRUWV
(52) 0RULWD77DQDEH+&6DVDNL$76KLPDGD..DNLJL56DGDWR1㸸7KHDQWHULRULQVXODU DQGDQWHULRUFLQJXODWHFRUWLFHVLQHPRWLRQDOSURFHVVLQJIRUVHOIIDFHUHFRJQLWLRQ 6RFLDO&RJQLWLYHDQG$IIHFWLYH1HXURVFLHQFH㸹
(53) 㸸 )XUXNDZD7<XDQ4-LQ=+$XQJ:<RVKLL<+DVHJDZD6(QGR+,QRXH0=KDQJ 05)XMLED\DVKL)6DJD7㸸&RPSDULVRQRILQWUDWXPRUDO)'*DQG&X$760GLVWULEXWLRQV LQFDQFHUWLVVXHRULJLQDWHGVSKHURLG &726
(54) [HQRJUDIWVDWXPRUPRGHOUHWDLQLQJWKH RULJLQDOWXPRUSURSHUWLHV1XFOHDUPHGLFLQHDQGELRORJ\
(55) '2, MQXFPHGELR -XQJ0.RVDND+6DLWR'1,VKLWREL00RUL7,QRKDUD.$VDQR0$UDL60XQHVXH 77RPRGD$:DGD<6DGDWR12ND]DZD+,LGDND7㸸'HIDXOWPRGHQHWZRUNLQ\RXQJ PDOHDGXOWVZLWKDXWLVPVSHFWUXPGLVRUGHU UHODWLRQVKLSZLWKDXWLVPVSHFWUXPWUDLWV 0RO$XWLVP㸹㸸. －16－.
(56) 0XUDPDWVX7,NDZD0<RQHGD06XJLPRWR.0DWVXQDJD$<DPDPXUD2+DPDQR72ND]DZD +1DNDPRWR<㸸3DWKRSK\VLRORJLFDOGHFUHDVHLQWKHUHJLRQDOFHUHEUDOEORRGIORZLQ +DVKLPRWR̓VHQFHSKDORSDWK\ DPXOWLSOHFDVH63(&7VWXG\(XU1HXURORJ\㸹
(57) 㸸 +DUD(8HGD00DNLQR$&KHRO-RR.LP+DUD,2]HNL(.LPXUD6㸸6XSSUHVVLYHLPPXQH UHVSRQVHRISRO\ VDUFRVLQH
(58) FKDLQVLQSHSWLGHQDQRVKHHWVLQFRQWUDVWWRSRO\PHULF PLFHOOHV-RXUQDORI3HSWLGH6FLHQFH㸹
(59) 㸸 $RNL1DNDQR0)XUXVDZD<8]DZD$0DWVXPRWR<+LUD\DPD57VXUXRND&2JLQR71LVKLR 7.DJDZD.0XUDNDPL0.DJL\D*.XPH.+DWDVKLWD0)XNXGD6<DPDPRWR.)XML +0XUD\DPD6+DWD06DNDH70DWVXPRWR+ 5HODWLYHELRORJLFDOHIIHFWLYHQHVVRI WKHUDSHXWLFSURWRQEHDPVIRU+6*FHOOVDW-DSDQHVHSURWRQWKHUDS\IDFLOLWLHV-5DGLDW 5HV
(60) 7VXML..LVKL67VXFKLGD7<DPDXFKL7,NHJD\D68UDVDNL<)XMLZDUD<8HGD7 2ND]DZD+.LPXUD+㸸(YDOXDWLRQRIVWDJLQJDQGHDUO\UHVSRQVHWRFKHPRWKHUDS\ZLWK ZKROHERG\GLIIXVLRQZHLJKWHGPDJQHWLFUHVRQDQFHLPDJLQJLQPDOLJQDQWO\PSKRPD SDWLHQWV $FRPSDULVRQZLWK)'*3(7&7-RXUQDORI0DJQHWLF5HVRQDQFH,PDJLQJ 6KLPL]X<7HPPD7+DUD,0DNLQR$.RQGR12]HNL(2QR06DML+㸸,QYLYRLPDJLQJ RIPHPEUDQHW\SHPDWUL[PHWDOORSURWHLQDVHZLWKDQRYHODFWLYDWDEOHQHDULQIUDUHG IOXRUHVFHQFHSUREH&DQFHU6FLHQFH㸹
(61) 㸸 +DUD(8HGD00DNLQR$+DUD,2]HNL(.LPXUD6㸸)DFWRUV,QIOXHQFLQJLQ9LYR 'LVSRVLWLRQRI3RO\PHULF0LFHOOHVRQ0XOWLSOH$GPLQLVWUDWLRQV$&60HG&KHP/HWW 㸹
(62) 㸸 )XMLVDZD7;7DQDND66DLWR'1.RVDND+7RPRGD$㸸9LVXDODWWHQWLRQIRUVRFLDO LQIRUPDWLRQDQGVDOLYDU\R[\WRFLQOHYHOVLQSUHVFKRROFKLOGUHQZLWKDXWLVPVSHFWUXP GLVRUGHUV $QH\HWUDFNLQJVWXG\)URQW1HXURVFL 㸹㸸 ఀ⸨ ᾏ㸸⫵࣭㠀⭘⒆ᛶᝈ ⫵ᝈࡢ❧యⓗ⌮ゎྥࡅ࡚
(63) Ϩ㸸⥲ㄽ࠾ࡼࡧ㛫㉁ᛶ⫵⅖⫵ ᇶᮏᵓ㐀ࡢ❧యⓗ⌮ゎ 㸫⏬ീデ᩿ࡢ❧ሙࡽ㸫⌮⮫ᗋ 㸹
(64) 㸸 .DQD]DNL.6DQR.0DNLQR$7DNDKDVKL$'HJXFKL-2KDVKL07HPPD72QR06DML +㸸'HYHORSPHQWRIKXPDQVHUXPDOEXPLQFRQMXJDWHGZLWKQHDULQIUDUHGG\HIRU SKRWRDFRXVWLFWXPRULPDJLQJ-RXUQDORIELRPHGLFDORSWLFV 㸹
(65) 㸸 2NDPRWR<.LWDGD57DQDEH+&+D\DVKL0-.RFKL\DPD70XQHVXH7,VKLWREL06DLWR '1<DQDND+72PRUL0:DGD<2ND]DZD+6DVDNL$70RUL7,WDNXUD6.RVDND+ 6DGDWR1㸸$WWHQXDWLRQRIWKHFRQWLQJHQF\GHWHFWLRQHIIHFWLQWKHH[WUDVWULDWHERG\ DUHDLQDXWLVPVSHFWUXPGLVRUGHU1HXURVFLHQFH5HVHDUFK. －17－.
(66) 0RKDPPDG$QZDUXO$]LP.R]DND78QR,0LZD'.LWDPXUD<2JDZD.0DNLQR$.L\RQR <6KLED.㸸7KH3RWHQWLDORIR%URPRWUDQVGHFDOLQYHVDPLFRODVD1HZ3(7/LJDQGIRU 9HVLFXODU$FHW\OFKROLQH7UDQVSRUWHU,PDJLQJ6\QDSVH㸹
(67) 㸸 2PDWD10L]XQR70LWVX\D+0LWD.+LJDVKL<.DPLFKLND7.L\RQR<2ND]DZD+ :DGD<㸸1HXURQDOSODVWLFLW\LQGHSUHVVLYHRUPDQLFVWDWHV1HZDVVHVVPHQWRIRXU K\SRWKHVLV 0DQLDLVDQH[WHQVLRQRIGHSUHVVLRQIURPWKHSHUVSHFWLYHRIQHXURQDO SODVWLFLW\0HG+\SRWKHVHV㸹
(68) 㸸 7DNDPDWVX6<DPDPRWR..DZDPXUD06DWR<$VDKL6.RQGRX77DPHVKLJH<0DHGD <6DVDNL0.XPDQR7*DEDWD7 8WLOLW\RIDQLQLWLDODGDSWLYHEODGGHUYROXPHFRQWURO ZLWKXOWUDVRQRJUDSK\IRUSURWRQEHDPLUUDGLDWLRQIRUSURVWDWHFDQFHU-SQ-5DGLRO
(69) ⬥ ཌ⏕᳃ ဴஓすᔱ ୍ᮏᇛ ⩏ⴛ㔝 ຬ୍㑻▮㔝 Ⰻ୍ⓑ▼ ᾈᕭ 㧗ᒸ ᩥΎ㔝 Ὀ⸨ᯘ 㟹ஂ㸸࢚ࣥࢻࢺ࢟ࢩࣥಖᏑ᳨㔞⥺ࡢタ࡛ࡢ⏝ࡢྍ⬟ᛶࡢ ᳨ウ᰾་Ꮫ㸹
(70) 㸸 6DWR<7VXMLNDZD72K00RUL7.L\RQR<)XMLHGD6.LPXUD+2ND]DZD+㸸$VVHVVLQJ 7XPRU+\SR[LDLQ+HDGDQG1HFN&DQFHUE\3(7:LWK . &X'LDFHW\O%LV 10HWK\OWKLRVHPLFDUED]RQH
(71) &OLQ1XFO0HG㸹
(72) 㸸. 1LVKL.0L]XWDQL$6KLNDQR1)XMLWD..RED\DVKL02QR01LVKLL56DVDNL<.LQX\D 6DQG.DZDL.㸸,Q9LYR5DGLRDFWLYH0HWDEROLWH$QDO\VLVIRU,QGLYLGXDOL]HG0HGLFLQH $%DVLF6WXG\RID1HZ0HWKRGRI&<3$FWLYLW\$VVD\XVLQJ,,031XFO0HG%LRO
(73) 7DJXFKL.&KXDQJ97<DPDVDNL.8UDWD<7DQDND5$QUDNX06HR+.DZDL.0DUX\DPD 7.RPDWVX7DQG2WDJLUL0㸸&URVVOLQNHG+XPDQ6HUXP$OEXPLQ'LPHUKDVWKH3RWHQWLDO IRU8VHDVD3ODVPDUHWDLQLQJ$JHQWIRUWKH)DWW\$FLGFRQMXJDWHG$QWLGLDEHWLF'UXJV -3KDUP3KDUPDFRO
(74) .RLNH77DQDEH+&6DGDWR1 +\SHUVFDQQLQJQHXURLPDJLQJWHFKQLTXHWRUHYHDOWKH WZRLQRQHV\VWHPLQVRFLDOLQWHUDFWLRQV1HXURVFL5HV & .DZDPLFKL+<RVKLKDUD.6DVDNL$76XJDZDUD6.7DQDEH+&6KLQRKDUD56XJLVDZD <7RNXWDNH.0RFKL]XNL<$QPH76DGDWR1 3HUFHLYLQJDFWLYHOLVWHQLQJDFWLYDWHV WKHUHZDUGV\VWHPDQGLPSURYHVWKHLPSUHVVLRQRIUHOHYDQWH[SHULHQFHV6RF1HXURVFL
(75) .R\DPD67DQDND67DQDEH66DGDWR1 'XDOKHPLVSKHUHWUDQVFUDQLDOGLUHFWFXUUHQW VWLPXODWLRQRYHUSULPDU\PRWRUFRUWH[HQKDQFHVFRQVROLGDWLRQRIDEDOOLVWLFWKXPE PRYHPHQW1HXURVFL/HWW . －18－.
(76) .DZDPLFKL+.LWDGD5<RVKLKDUD.7DNDKDVKL+DQG6DGDWR1 ,QWHUSHUVRQDO7RXFK 6XSSUHVVHV9LVXDO3URFHVVLQJRI$YHUVLYH6WLPXOL)URQW+XP1HXURVFL HTXDOO\FRQWULEXWHGDXWKRUV 0DWVX\RVKL'0RULWD7.RFKL\DPD77DQDEH+&6DGDWR1.DNLJL5 'LVVRFLDEOH FRUWLFDOSDWKZD\VIRUTXDOLWDWLYHDQGTXDQWLWDWLYHPHFKDQLVPVLQWKHIDFHLQYHUVLRQ HIIHFW-1HXURVFL
(77) 6DNDPRWR.1DNDWD+<XPRWR06DGDWR1.DNLJL5 0DVWLFDWLRQDFFHOHUDWHV*R1RJR GHFLVLRQDOSURFHVVLQJ $QHYHQWUHODWHGSRWHQWLDOVWXG\&OLQ1HXURSK\VLRO LQ SUHVV
(78) ,NDZD02ND]DZD+7VXMLNDZD70DWVXQDJD$<DPDPXUD20RUL7+DPDQR7.L\RQR <1DNDPRWR<<RQHGD0㸸,QFUHDVHGR[LGDWLYHVWUHVVLVUHODWHGWRGLVHDVHVHYHULW\ LQWKH$/6PRWRUFRUWH[ $3(7VWXG\1HXURORJ\ LQSUHVV
(79) 0LWVX\D+2PDWD1.L\RQR<0L]XQR70XUDWD70LWD.2ND]DZD+:DGD<㸸7KH FRRFFXUUHQFHRI]LQFGHILFLHQF\DQGVRFLDOLVRODWLRQKDVWKHRSSRVLWHHIIHFWVRQPRRG FRPSDUHGZLWKHLWKHUFRQGLWLRQDORQHGXHWRFKDQJHVLQWKHFHQWUDOQRUHSLQHSKULQH V\VWHP%HKDYLRXUDO%UDLQ5HVHDUFK㸹
(80) 㸸 .RPHGD+.RVDND+6DLWR'10DQR<-XQJ0)XMLL7<DQDND+<0XQHVXH7,VKLWREL 0VDWR02ND]DZD+㸸$XWLVWLFHPSDWK\WRZDUGDXWLVWLFRWKHUV6RF&RJQ$IIHFW1HXURVFL 㸹
(81) 㸸 <RVKLL<)XUXNDZD7:DNL$2NX\DPD+,QRXH0,WRK0=KDQJ05:DNL]DND +6RJDZD&.L\RQR<<RVKLL+)XMLED\DVKL<6DJD7㸸+LJKWKURXJKSXWVFUHHQLQJ ZLWKQDQRLPSULQWLQJ'FXOWXUHIRUHIILFLHQWGUXJGHYHORSPHQWE\PLPLFNLQJWKHWXPRU HQYLURQPHQW%LRPDWHULDOV '2, GRL MELRPDWHULDOV 7DPXUD76XJDQXPD1.*+HULQJ79HKPDV,WRX+0DNLQR$7DNDVKLPD<+LUDQR+ .XVDND<㸸5HODWLRQVKLSV ,,
(82) RI,QWHUQDWLRQDO&ODVVLILFDWLRQRI+LJKUHVROXWLRQ &RPSXWHG7RPRJUDSK\IRU2FFXSDWLRQDODQG(QYLURQPHQWDO5HVSLUDWRU\'LVHDVHVZLWK YHQWLODWRU\IXQFWLRQVLQGLFHVIRUSDUHQFK\PDODEQRUPDOLWLHV,QG+HDOWK 7DPXUD76XJDQXPD1.*+HULQJ79HKPDV,WRX+0DNLQR$7DNDVKLPD<+LUDQR+ .XVDND<㸸5HODWLRQVKLSV ,
(83) RI,QWHUQDWLRQDO&ODVVLILFDWLRQRI+LJKUHVROXWLRQ &RPSXWHG7RPRJUDSK\IRU2FFXSDWLRQDODQG(QYLURQPHQWDO5HVSLUDWRU\'LVHDVHVZLWKWKH ,/2,QWHUQDWLRQDO&ODVVLILFDWLRQRI5DGLRJUDSKVRI3QHXPRFRQLRVLVIRUSDUHQFK\PDO DEQRUPDOLWLHV,QG+HDOWK . －19－.
(84) 㸦㸱㸧⥲ㄝ ᒸἑ⚽ᙪ㸸3(7 ࡼࡿ⬻ᚠ⎔௦ㅰィ ࠾ࡼࡧศᏊ࣓࣮ࢪࣥࢢ⬻ᚠ⎔௦ㅰ
(85) Ύ㔝 Ὀᮌᮧ ᐶஅ㸸⮅ș⣽⬊࣓࣮ࢪࣥࢢ⫹⮅㸹
(86) 㸸 ᐃ⸨ つᘯ㸸♫⚄⤒⛉Ꮫࡢㅖㄢ㢟ᒎᮃ㸬&OLQLFDO1HXURVFLHQFH㸬
(87) ᐃ⸨ つᘯ㸸 ࠕ⚾ࡓࡕࠖࡢ⬻⛉Ꮫྥࡅ࡚㸸 ಶேྠィ 05, ◊✲㸬⮫ᗋ⚄⤒⛉Ꮫ㸬
(88) ᐃ⸨ つᘯ㸸ᶵ⬟ⓗ 05, ࡼࡿ♫⬟ຊⓎ㐩࠾ࡅࡿ⚄⤒ᇶ┙ࡢゎ᫂㸬⬻⚄⤒እ⛉ࢪ࣮ࣕࢼ ࣝ㸬
(89) ྜྷ ᖾᜨᯇᮏ ༤ᶞྂᕝ 㧗Ꮚㅖ㉺ ᖾᜨ᭮ᕝ ༓㭯ᙇ ᫂ᰤ⬥ᆏ ⚽ඞྜྷ ⿱⸨ᯘ ᗣஂబ㈡ ᜏኵ㸸&X$760 ࡼࡿ⭘⒆ෆࡀࢇᖿ⣽⬊ࢽࢵࢳࢆ ᶆⓗࡋࡓ࣓࣮ࢪࣥࢢ㸭ෆ↷ᑕ⒪ࡢᒎᮃ㸫ᐇ⏝ྥࡅࡓస⏝పῶἲࡢ㛤Ⓨ-60, 5HSRUW
(90) ⸨ᯘ ᗣஂ㸸0ROHFXODU,PDJLQJศᏊ࣓࣮ࢪࣥࢢࡣࡇࡲ࡛㐍ࢇࡔ,11(59,6,21
(91) ᒣᮏ 㧗㸸⚟┴❧㝔㝧Ꮚ⥺ࡀࢇ⒪ࢭࣥࢱ࣮ࡢ᪂⒪ᐊࡢ㐠⏝᭶ห᪂་⒪➨ ᕳ➨ ྕS ⸨ᯘ ᗣஂ㸸≉㞟 ᭱᪂ࣂ࣓࣮࢜ࢪࣥࢢᢏ⾡ࡢ⏝ᣑaᝈࡢ㉁ⓗデ᩿ࡽ⒪ྥ ࡅࡓ࣓࣮ࢪࣥࢢᢏ⾡ࡢ㛤Ⓨືྥa%,2,1'8675<
(92) 0DNLQR$㸸0RUSKRORJ\FRQWURORIPROHFXODUDVVHPEOLHVSUHSDUHGIURPELREDVHG DPSKLSKLOLFSRO\PHUVZLWKDKHOLFDOK\GURSKRELFXQLWDQGDSSOLFDWLRQDVQDQRFDUULHUV IRUFRQWUDVWDJHQWVDQGRUGUXJGHOLYHU\3RO\PHU-RXUQDO㸹㸸 ㎷ᕝ ဴஓ๓⏣ ᾈᖾᒸἑ ⚽ᙪ㸸))(63(7 ࡼࡿங⒴ࡢ࢚ࢫࢺࣟࢤࣥཷᐜయ࣓࣮ ࢪࣥࢢங⒴ࡢ⮫ᗋ 0DNLQR$.LPXUD6㸸6ROLG7XPRU7DUJHWLQJ7KHUDQRVWLF3RO\PHU1DQRSDUWLFOHLQ1XFOHDU 0HGLFLQDO)LHOGV7KH6FLHQWLILF:RUOG-RXUQDO㸹㸸$UWLFOH,' <RVKLL<)XUXNDZD76DJD7)XMLED\DVKL<㸸$FHWDWHDFHW\O&R$PHWDEROLVPDVVRFLDWHG ZLWKFDQFHUIDWW\DFLGV\QWKHVLV RYHUYLHZDQGDSSOLFDWLRQ&DQFHU/HWWHUV&DQFHU /HWWHUV ᒸἑ ⚽ᙪ㸸⬻ᶵ⬟⏬ീἲࡢ⌧≧ᒎᮃ᰾་Ꮫ⏬ീデ᩿㸹
(93) 㸸 ᙇ ᫂ᰤ⸨ᯘ ᗣஂ㸸3(7 ⏝⸆ࡢ㛤Ⓨ5DG)DQ
(94) ⸨ᯘ ᗣஂ㸸ศᏊ࣓࣮ࢪࣥࢢࢆ⏝࠸ࡓ ''6 ศᏊᶆⓗࣛࢪ࢜ࢯࢺ࣮ࣉ⒪⮫ቑหྕ ''6 ◊✲㸱㸮ᖺ ᨾ▱᪂
(95) ᒸἑ ⚽ᙪ㸸࢜ࣇࣝࣃࣥ㸦,㸧᪥ᮏ་ᖌ㞧ㄅ㸹
(96) 㸸. －20－.
(97) ᕝ ṇ㐨⡿⏣ ㄔ㸸0(55)᪥ᮏ⮫ᗋูϭ Ⲩᕝ ୍㑻⡿⏣ ㄔ㸸࣑ࢺࢥࣥࢻࣜᚰ➽ᑐࡍࡿ௦ㅰ⒪⣽⬊ 2ND]DZD+,NDZD07VXMLNDZD7.L\RQR<<RQHGD0㸸%UDLQLPDJLQJIRUR[LGDWLYHVWUHVV DQGPLWRFKRQGULDOG\VIXQFWLRQLQQHXURGHJHQHUDWLYHGLVHDVH4-1XFO0HG0RO,PDJLQJ 㸹
(98) 㸸 ᮌᮧ ᾈᙪ㇏ᒸ 㯞㔛Ꮚᆏ ㇏ᙪ⏣୰ 㞞ேΎ㔝 ṇᶞᒣୗ ⰾ⠊ᇉෆ ከᚨྜྷ㔝 Ꮥ༤㯮ᕝ ဴྖᏳ㐩 Ⓩᚿᶞఀ⸨ ᾏෆᮌ ᏹᘏ㸸⏬ീሗࢆ୰ᚰ ࡋࡓ་⒪ሗ⤫ྜໟᣓⓗᩍ⫱ᨭࡢྲྀࡾ⤌ࡳ㹼㸳ᖺ㛫ࡢ⤒㦂▱ぢ㹼ᫎീሗ 0HGLFDO㸹
(99) 㸸 ᯇ⏣ ༤ྐⲨ㔝 Ὀᒸἑ ⚽ᙪỈᮧ ┤ᶓᒣ 㑥ᙪྜྷᮧ ┿ዉ㸸ᨺᑕᛶ་⸆ရ స⏝ㄪᰝሗ࿌➨ ሗ 㸦ᖹᡂ ᖺᗘ➨ ᅇㄪᰝ㸧᰾་Ꮫ㸹
(100) 㸸 ᒸἑ ⚽ᙪ㸸㠉᪂ⓗ࡞ศᏊ࣓࣮ࢪࣥࢢᢏ⾡ࡼࡿ⮫ᗋ⏬ീデ᩿᪥ᮏᏛ⾡㆟୰㒊ᆅ༊ ㆟ࢽ࣮ࣗࢫ㸹㸸 㸦㸲㸧ᏛⓎ⾲ <DPDVKLWD$=KDR<0DWVXXUD<<DPDVDNL.0RULJXFKL*RWR6,ZDNLUL72NX\DPD1 .RVKLPRWR&.DZDL.7DPDNL1=KDR6.XJH<DQG$VDGD<㸸,QFUHDVHG0HWDEROLWH/HYHOV RI*O\FRO\VLVDQG3HQWRVH3KRVSKDWH3DWKZD\LQ5DEELW$WKHURVFOHURWLF$UWHULHVDQG +\SR[LF0DFURSKDJH$UWHULRVFOHURVLV7KURPERVLVDQG9DVFXODU%LRORJ\ <RVKLPRWR0.LPXUD6+LUDWD02KPRPR<.DZDL.DQG)XMLL+㸸3KDUPDFRNLQHWLFVDQG $QWLWXPRU$FWLYLW\RI$<ZLWK+LJK$IILQLW\WR(*)57.7KH6RFLHW\RI1XFOHDU 0HGLFLQHWK$QQXDO0HHWLQJ .DJDZD61LVKLL5+LJDVKL7<DPDXFKL+.DZDL.:DWDQDEH+.LPXUD+2QR0DQG 6DML+㸸5DGLRV\QWKHVLVRI>)@)3<%)D1RYHO3(7,PDJLQJ3UREHIRUș$P\ORLG3ODTXHV LQ%UDLQ7KH6RFLHW\RI1XFOHDU0HGLFLQHWK$QQXDO0HHWLQJ $]LP0$.RVDND78QR,0LZD'.LWDPXUD<2JDZD..DZDL..L\RQR<DQG6KLED .㸸,QWURGXFWLRQRI5DGLREURPLQH/DEHOHG'HFDOLQYHVDPLFRO$QDORJXHDVD1HZDQG 3URPLVLQJ3(79HVLFXODU$FHW\OFKROLQH7UDQVSRUWHU 9$&K7
(101) ,PDJLQJ3UREH7KH6RFLHW\ RI1XFOHDU0HGLFLQHWK$QQXDO0HHWLQJ 2QR0'RL<2ND62NXGDLUD+6FKXVWHU'0*RRGPDQ000DWVXPRWR+.DZDL.DQG 6KLUDNDPL<㸸7UDQVSRUW0HFKDQLVPRIWKH$PLQR$FLG3RVLWURQ(PLVVLRQ7RPRJUDSK\7UDFHU >)@)OXFLFORYLQHDQGLWV$SSOLFDWLRQWR*OLRPD'LDJQRVLV WK1RUWK$PHULFDQ,66; 0HHWLQJ WK-66;0HHWLQJ ᒣୗ ⠜㸪㉿ ⰶ㸪ᯇᾆ ♸அ㸪ᒣᓮ ୍ㄹ㸪┒ཱྀ Ύ㤶㸪㉺ᮏ ▱㸪ᕝ ᜨ୍㸪㉿ ᯇྜྷ㸪ஂୗ ⿱ྖ㸪ὸ⏣ ♸ኈ㑻㸸ື⬦◳⾑⟶ࡢ௦ㅰゎᯒ➨ ᅇ᪥ᮏ⌮Ꮫ⥲ . －21－.
(102) ఀ⸨ ᾏ㸸0RUSKRORJLFDOEDVHVRI+5&7GLDJQRVLVRISXOPRQDU\GLVHDVHVWK:&%,3 :&%( 6SHFLDO/HFWXUH ᒣ ఙᖾ㛗㇂ᕝ 㝧Ꮚ✄ᮧ ⪽ከ㈡ ᓠඞᅵᒣ ඞᶞఀ⸨ ⚽᫂୕㍯ ྜྷ ྖ⛅㔝 ⿱ಙ㎷ᕝ ဴஓᒸἑ ⚽ᙪᶓᒣ ಟ㸸⭈⣽⬊⒴࠾ࡅࡿ $&66 Ⓨ⌧ホ౯ࢆ ┠ⓗࡋࡓ &DFHWDWH3(7 ࡢ⮫ᗋ◊✲➨ ᅇ᪥ᮏἪᒀჾ⛉Ꮫ⥲ ๓⏣ ᾈᖾ୰⃝ 㞞Ꮚ⸨ᮏ ⿱⃝ ḟ᳃ᕝ ὒᑠ⦎ ◊ྖᮧୖ ┿ ᘅ㔝 㟹ኵ Ꮥ᠇㣤⏣ ᩔ∦ᒣ ᐶḟᮧ ዲ❶ᅵ⏣ 㱟㑻᳃ ဴஓ ㎷ᕝ ဴஓᒸἑ ⚽ᙪᒣཱྀ ᫂ኵ㸸)(63(7 ᳨ᰝࡼࡿ㌿⛣Ⓨங⒴ࡢෆศἪ⒪ຠᯝ ண ➨ ᅇ᪥ᮏእ⛉ᏛᐃᮇᏛ⾡㞟ி㒔ᕷ ᱵ⏣ ᖾᐶᮏᐃ ༓▱㓇 ၨ⾜㛛⬥ 㯞⾰ᏊᏳ㰻 ṇᶞ᳃ᕝ ⨾⩚㣩ᔱ ឵࿃▼㷂 Ṋᚿᒸἑ ⚽ᙪ▼ሯ 㸸㐍⾜ᮇ㠀ᑠ⣽⬊⫵⒴ࡢ⏕ணᚋண ࠾ࡅࡿ . ))'* ࠾ࡼࡧ ))/73(7 ࡢ᭷⏝ᛶ➨ ᅇ᪥ᮏ྾ჾᏛᏛ⾡ㅮ₇㜰. ᒸἑ ⚽ᙪᕝ ṇ㐨㎷ᕝ ဴஓ⡿⏣ ㄔ᳃ ဴஓΎ㔝 Ὀ㸸&X$7603(7 ࡼ ࡿ➽ⴎ⦰ᛶഃ⣴◳ $/6
(103) ࡢホ౯➨ ᅇ᪥ᮏ་Ꮫᨺᑕ⥺Ꮫ⥲ᶓᕷ ㎷ᕝ ဴஓబ⸨ ⩏㧗࿋ ᫂⨾ᅵ⏣ 㱟㑻⸨ᯞ 㔜ᒸἑ ⚽ᙪ㸸$VVHVVLQJ WXPRUK\SR[LDLQKHDGDQGQHFNFDQFHUE\3(7ZLWK&X$760➨ ᅇ᪥ᮏ་Ꮫᨺᑕ⥺ Ꮫ⥲ ᒸἑ ⚽ᙪ㸸࢜ࣇࣝࣃࣥデ⒪࢞ࢻࣛࣥࡢ⤂➨ ᅇ᪥ᮏ་Ꮫᨺᑕ⥺Ꮫ⥲ᶓ ᕷ ᆏ ㇏ᙪ⏣୰ 㞞ேᮌᮧ ᾈᙪ㏆⸨ ሀྖ㧗⏣ ㇏ᑠሯ ⣖Ύ㔝 ṇ ᶞ㸸⫵ &7 ࠾ࡅࡿㄞᙳ▱㆑ᇶ࡙ࡃ⏬ീ㢮ఝ᳨⣴ࢩࢫࢸ࣒ࡢ㛤Ⓨ➨ ᅇ᪥ᮏ་Ꮫᨺ ᑕ⥺Ꮫ⥲ 7DNDPDWVX6<DPDPRWR.6DWR<.DZDPXUD0$VDKL6.RQGRX77DPDPXUD+ ([SHULHQFH RISURWRQEHDPWKHUDS\IRUKHSDWRFHOOXODUFDUFLQRPD7KHUG$QQXDO0HHWLQJRIWKH -DSDQ5DGLRORJLFDO6RFLHW\<RNRKDPD 6DGDWR1 +RZWKHEOLQGVHHEUDLOOH /HVVRQVIURP3(7I05,RQWKHFURVVPRGDO SODVWLFLW\LQWHJUDWLRQDQGOHDUQLQJ1,1'66\PSRVLXP+XPDQ0RWRU&RQWURO \HDUV RI5HVHDUFKDW1,+DQG%H\RQG 0'86$
(104) ,NDZD02ND]DZD+7VXMLNDZD70XUDPDWVX7.LVKLWDQL7.DPLVDZD70DWVXQDJD$ <DPDPXUD20RUL7+DPDQR7.L\RQR<1DNDPRWR<<RQHGD0㸸,QFUHDVHGFHUHEUDO R[LGDWLYHVWUHVVLQDP\RWURSKLFODWHUDOVFOHURVLV D&X$7603(7VWXG\$$1 3KLODGHOSKLD .DPLVDZD7,NDZD06DLWR<0XUDPDWVX70DWVXQDJD$<DPDPXUD2+DPDQR71DNDPRWR <0XUD\DPD62ND]DZD+<RQHGD0㸸3DWKRSK\VLRORJLFDOGHFUHDVHLQWKHUHJLRQDOFHUHEUDO EORRGIORZLQSXUHDXWRQRPLFIDLOXUHZLWK/HZ\ERG\$$13KLODGHOSKLD. －22－.
(105) 2\DPD1+DVHJDZD<7VXFKL\DPD.7DJD0,WR+$NLQR+2ND]DZD+<RNR\DPD2㸸 3UHFOLQLFDODVVHVVPHQWRIHDUO\WKHUDSHXWLFHIIHFWRIVXQLWLQLERQUHQDOFHOOFDUFLQRPD XVLQJ)IOXRURWK\PLGLQHSRVLWURQHPLVVLRQWRPRJUDSK\LQD[HQRJUDIWPRGHO$8$$QQXDO 0HHWLQJ ஂಖ⏣ 㞞ྐ⚄⃝ ᭸Ꮚ༑ᔒ ༓⛅ᒣᮧ ಟᔱ⏣ ㄔ୍㑻ᯇᑿ ⱥ᫂ᡂ℩ ᘅுᒸἑ ⚽ᙪຍ⸨ 㱟ᶓ ᾈྐෆ⏣ ◊㐀㤿ሙ ஂᩄ㸸᭶㛫ࡢ㞟୰ⓗ࡞ ᶵ⬟ⓗ㟁Ẽ่⃭⒪ἲ๓ᚋࡢ㐠ືᶵ⬟⬻ᶵ⬟⏬ീࡢኚ㸸ሗ࿌➨ ᅇ᪥ᮏ⌮Ꮫ⒪ἲ Ꮫ⾡ᶓᕷ ༑ᔒ ༓⛅ஂಖ⏣ 㞞ྐ⚄⃝ ᭸Ꮚᒣᮧ ಟᒸἑ ⚽ᙪຍ⸨ 㱟ᶓ ᾈ ྐᔱ⏣ ㄔ୍㑻㤿ሙ ஂᩄ㸸⬻༞୰ᝈ⪅ᑐࡍࡿ㟁Ẽ่⃭ࢆే⏝ࡋࡓୗ⫥ఙᒎ㐠ືㄢ㢟 ࡀ⬻άື࠼ࡿᙳ㡪➨ ᅇ᪥ᮏ⌮Ꮫ⒪ἲᏛ⾡ᶓᕷ ᒸἑ ⚽ᙪ㸸ࢻࣃ࣑ࣥ '$
図
関連したドキュメント
In the main square of Pilsen, an annual event where people can experience hands-on science and technology demonstrations is held, involving the whole region, with the University
Abstract: This paper describes a study about a vapor compression heat pump cycle simulation for buildings.. Efficiency improvement of an air conditioner is important from
toursofthesehandsinFig6,Fig.７(a)ａｎｄFig.７(b).A changeoftangentialdirection,Tbover90゜meansaconvex
[r]
[r]
向井 康夫 ： 東北大学大学院 生命科学研究科 助教 牧野 渡 ： 東北大学大学院 生命科学研究科 助教 占部 城太郎 ：
ｃ・昭和3７（1962）年５月25曰，東京，曰比谷公会堂で開かれた参院選の
化学物質は，環境条件が異なることにより，さまざまな性質が現れること
