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612 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /-, No.+,, 0+, 0+2 (,**0) 16 * +,, *, *. * / * / * 0 * -, 1 * + *, * - *. * / * 0 * 1 The Hypolipidemic

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(1)612. Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /-, No. +,, 0+,º0+2 (,**0) »Ž¼. [ 16 b. 

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(3) *. */  */ *0 *-, 1 *+  !" *, #$%&'()* *- #$&'(! . * #$+,-./012345)*! */ #$+,-./01235)*! *0 678!9& 1 * :;<=>?!@&". The Hypolipidemic E#ects of Some Edible Mushrooms on Growing Rats Makoto Ohtsuki*+, ,, Kazuhiko Umeshita*,, Yasushi Kokean*., Takafumi Nishii*/, Hajime Sakakura*/, Teruyoshi Yanagita*0 and Yukio Furuichi*-, 1 *+ Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science, +**+ῌ+ Kishioka, Suzuka, Mie /+*ῌ*,3*, Graduate School of Bioresources, Mie University, +/11 Kurimamachiya, Tsu, Mie /+.ῌ2/*1 *- Faculty of Bioresources, Mie University, +/11 Kurimamachiya, Tsu, Mie /+.ῌ2/*1 *. Industrial Research Division, Mie Prefectural Science and Technology Promotion Center, /ῌ/ῌ./ Takachaya, Tsu, Mie /+.ῌ*2+3 */ Forestry Research Division, Mie Prefectural Science and Technology Promotion Center, -103ῌ+ Nihongi, Hakusan, Tsu, Mie /+/ῌ,0*, *0 Laboratory of Nutrition Biochemistry, Department of Applied Biological Science, Saga University, +-Honjo, Saga 2.*ῌ2/*, *1 Department of Food Science and Nutrition, Faculty of Human Life and Environmental Sciences, Nagoya Women’s University, -ῌ.* Shioji-cho, Mizuho-ku, Nagoya-shi, Aichi .01ῌ20+* ῍῍῍῍῍῍῍῍῍῍῍῍῍῍῍῍ The e#ects of four edible mushrooms (Shiitake, Hiratake, Eringi, Hatakeshimeji) on serum and hepatic lipid levels were investigated in rats. The experimental diets were prepared by adding +*ῌ (w/w) edible mushroom powder to a diet containing ,*ῌ fat and +ῌ cholesterol, and these were made freely available to male Sprague Dauley rats for - weeks. Body weight and food intake were recorded every , days, and serum and liver levels of triacylglycerols (TG), total cholesterol (TC), and phospholipids (PL) were analyzed at the end of the feeding period. The results showed that the body weight and food intake of the four mushroom groups were significantly lower than those of the control group (pA*.*/). The liver level of triacylglycerols was significantly lower in the Hiratake, Eringi and Hatakeshimeji groups than that in the control group. The serum cholesterol levels of the mushroom groups were also significantly lower than that of the control group (pA*.*/). These results show that the four edible mushrooms suppress hepatic triacylglycerols accumulation, and lower blood lipid levels. (Received Jun. +, ,**0 ; Accepted Sep. /, ,**0). BCDEF G -* HIJKLJMNOPQRSTU *+ ¤/+*ῌ*,3- #$+¥¦§ +**+ῌ+ * ¤/+.ῌ2/*1 #$+¨©ª§;§ +/11 *. ¤/+.ῌ*2+3 #$+¨N«; / ¬ / ­ ./ ® */ ¤/+/ῌ,0*, #$+’

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(5) -103ῌ+ *0 ¤2.*ῌ2/*, 67³´§ + *1 ¤.01ῌ20+* :;µ¶·¸ § -ῌ.*  ¹ [Corresponding authorb ohtsukim@suzuka-u.ac.jp ,, -. V @WMXYZ [\]^_ M`ab cdefgTU V hijFklT`am WnopqrstumvV wuxCyz{T|}vs~ uM€|WnopM‚ ƒF\]I„ †Tt‡mvˆ‰ \Š‹qUuxC‚ V \Š‹TF Œ|‡CŽ‘vVwC ’“” T•–—3–˜\Š‹x™•–—3–˜\Š‹Tš›z ‘ JjF œpqžŸmvVw ¡¢£w+b.

(6) tŸῌ> : 0;P)"]. X 17 2 Table + Ingredient. 613. Compositions of the experimental diets (wtῌ) Control. G-Shiitake. Hiratake. Eringi. Hatakeshimeji. ,* ,* *4+4* -4/ *4,/ +4* *4,/ +* +* ¼ ¼ ¼ ¼ to +**. ,* ,* *4+4* -4/ *4,/ +4* *4,/ +* ¼ +* ¼ ¼ ¼ to +**. ,* ,* *4+4* -4/ *4,/ +4* *4,/ +* ¼ ¼ +* ¼ ¼ to +**. ,* ,* *4+4* -4/ *4,/ +4* *4,/ +* ¼ ¼ ¼ +* ¼ to +**. ,* ,* *4+4* -4/ *4,/ +4* *4,/ +* ¼ ¼ ¼ ¼ +* to +**. Casein Lard DL-Methionine Vitamin mixture (AIN-3-) Mineral mixture (AIN-3-) Choline bitartrate Cholesterol Sodium cholate Cornstarch Cellulose G-Shiitake Hiratake Eringi Hatakeshimeji Sucrose. G-Shiitake, Genboku-Shiitake4.  .

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(44) LMNOPQR +SEM. DS. rs1tqD‚ƒD‰]  PL K opq_I. TR UKVWXYZ[ +One-Way ANOVA.. rs1t xb1tjky1tr@zqD T|}M. \], Duncan ^-_`U. S +Fig. ,.. ,+.. 5 Ta. P 3/ῌ \]. - '(+,/. lmŠ‹Œ Fig. - SH Š‹ŒK rs1t qŽ - qDopq5 T|}MS lm TG K opq_Ixb1t 0uvwjky1tr@ zqD T|}M„ † V rs1tqD T |‘’S€† lm TC K opq_I xb1 tqD T|}M„ † lm PL K / qD T|RK„ †|‡] . %& 01. -K opq_` rs1tqy1tr@ zqD T|}MS V‰5 “”•–— K opq_` rs1t 0uvw y1tr@ zqDnA˜™š† xb1tqDK T|}› œ† +Fig. .. |j V‰5 “ “žŸ Fig. +. Growth curves of the rats. Each point represents the mean body weight of five rats. G-Shiitake, Genboku-Shiitake. * p«*.*/, ** p«*.*+ vs the control group at the end of the feeding period. ¬, Control ; ­, G-Shiitake ; ®, Hiratake ; ¯, Eringi ; °, Hatakeshimeji.. Table ,. Control G-Shiitake Hiratake Eringi Hatakeshimeji.  =34—GK / qD T|RK„ † |‡] 2. 3. ¡¢£¤ ¥¡ 0¦4w3hi § Š‹0¦4w3 ¨K +3/* ©ªD +*ῌ Ž›D. Growth parameters and liver weights of the rats. Initial B4W4 (g). B4W4 gain (g). Food intake (g/day). Total food intake (g)/B4W4 gain (g). 024,N/4+ 0043N.41 0/41N/4/ 0040N-42 0-43N-43. +0241N++4,a +/*42N14+b +-.41N34-c +.241N.42b +/-4*N+*41b. +.4.N+4*a +,4-N*40b ++4-N*41c +,41N*4/b +,43N*41b. +41*N*4+a +40.N*4+b +401N*4+b +41+N*4+a +403N*4+a. Liver weight (g/+** g B4W4) 043.N*4-a 040.N*40a /4--N*4.b 04*1N*4.c /43/N*4.c. Values are meanNSEM (n±/)4 B4W4, body weight ; G-Shiitake, Genboku-Shiitake4 a, b, c, Values in the same column without common superscript letters denote significant di#erence (p«*4*/)4.

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(46) .  19 . Fig. ,. Serum lipid concentration. Values are meanSEM (n/). G-Shiitake, Genboku-Shiitake. a, b, c, Values without common superscript letters denote significant di#erence (p*.*/).. Fig. -. Hepatic lipid contents. Values are meanSEM (n/). G-Shiitake, Genboku-Shiitake. a, b, c, Values without common superscript letters denote significant di#erence (p*.*/).. Fig. .. Fecal dry weight , fecal neutral sterol and fecal bile acids. Values are meanSEM (n/). G-Shiitake, Genboku-Shiitake. a, b, c, Values without common superscript letters denote significant di#erence (p*.*/).. 615.

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(104) I 7JKLMN= $%OPQRSTUK AVW(X0=Y Z[+ . G6+23 TC. +0I. >UK9\VW(]:Y +1I. ῍. ῌ. +I ^_`a bc d e f ghi$jk l$%7m no pq . r Hstuvw xyI pp. ,*/῍,+- H+32*I ,I Murase, T., Nagasawa, A., Suzaki, J., Hase, T. and Tokimitsu, T., Beneficial e#ects of tea catechins on diet-induced obesity : stimulation of lipid catabolism in the liver. Int. J. Obes., ,0, +./3῍+.0. H,**,I -I Readerstor#, D.G., Schlachter, M.F., Elste, V. and Weber, P., E#ect of EGCG on lipid absorption and plasma lipid levels in rats. J. Nutr. Biochem., +., -,0῍--, H,**-I .I Sayama, K., Lin, S., Zheng, G. and Oguni, I., E#ects of green tea on growth, food utilization and lipid metabolism in mice. In Vivo, +., .2+῍.2. H,***I /I Sambaiah, K., Satyanarayana, M.N., Stimulation of liver triglyceride secretion in rats by capsaicin. Current. Sci., /0, 231῍232 H+321I 0I Tani, Y., Fujioka, T., Sumioka, M., Furuichi, Y., Hamada, H. and Watanabe, T., E#ects of capsinoid on serum and liver lipids in hyperlipidemic rats. J. Nutr. Sci. 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